CDH13 (cadherin 13)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1012
Gene name Gene Name - the full gene name approved by the HGNC.
Cadherin 13
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CDH13
Synonyms (NCBI Gene) Gene synonyms aliases
CDHH, P105
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q23.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(75)
miRTarBase ID miRNA Experiments Reference
MIRT021007 hsa-miR-155-5p Proteomics 18668040
MIRT024070 hsa-miR-1-3p Proteomics 18668040
MIRT053689 hsa-miR-181a-5p Microarray 22942087
MIRT617196 hsa-miR-1266-3p HITS-CLIP 23824327
MIRT617195 hsa-miR-367-5p HITS-CLIP 23824327
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
POU3F2 Unknown 23069940
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0000902 Process Cell morphogenesis IBA
GO:0001938 Process Positive regulation of endothelial cell proliferation IMP 15364621
GO:0001954 Process Positive regulation of cell-matrix adhesion IMP 17573778
GO:0002040 Process Sprouting angiogenesis IDA 16873731
GO:0005509 Function Calcium ion binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
601364 1753 ENSG00000140945
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P55290
Protein name Cadherin-13 (Heart cadherin) (H-cadherin) (P105) (Truncated cadherin) (T-cad) (T-cadherin)
Protein function Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regu
PDB 2V37
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08758 Cadherin_pro 26 → 112 Cadherin prodomain like Domain
PF00028 Cadherin 143 → 236 Cadherin domain Domain
PF00028 Cadherin 250 → 354 Cadherin domain Domain
PF00028 Cadherin 368 → 469 Cadherin domain Domain
PF00028 Cadherin 483 → 576 Cadherin domain Domain
PF00028 Cadherin 588 → 680 Cadherin domain Domain
Tissue specificity TISSUE SPECIFICITY: Highly expressed in heart. In the CNS, expressed in cerebral cortex, medulla, hippocampus, amygdala, thalamus and substantia nigra. No expression detected in cerebellum or spinal cord. {ECO:0000269|PubMed:10737605, ECO:0000269|PubMed:8
Sequence
Sequence length 713
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Adherens junctions interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (16)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Attention Deficit Hyperactivity Disorder Attention deficit hyperactivity disorder N/A N/A GWAS
Bipolar Disorder Bipolar disorder N/A N/A GWAS
Coronary artery disease Coronary artery disease N/A N/A GWAS
Show/Hide Text Mining Associations (117)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Adenocarcinoma Associate 16598760, 17967182, 18729198, 25565774
Adenocarcinoma of Lung Associate 17967182, 21731750, 27610375
Adenoma Inhibit 14997203
Adenoma Associate 17873891
Agnosia Associate 25065733
Alcoholism Associate 22064162
Alzheimer Disease Associate 29771432, 35627222, 36553611
Apraxias Associate 22738016
Arthritis Rheumatoid Associate 20090771
Asthma Associate 32186396