Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10112
Gene name Gene Name - the full gene name approved by the HGNC.
Kinesin family member 20A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
KIF20A
Synonyms (NCBI Gene) Gene synonyms aliases
MKLP2, RAB6KIFL, RCM6
Disease Acronyms (UniProt) Disease acronyms from UniProt database
RCM6
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q31.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT023002 hsa-miR-124-3p Proteomics 18668037
MIRT024718 hsa-miR-215-5p Microarray 19074876
MIRT026859 hsa-miR-192-5p Microarray 19074876
MIRT050411 hsa-miR-23a-3p CLASH 23622248
MIRT049540 hsa-miR-92a-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000281 Process Mitotic cytokinesis IMP 15843429
GO:0001578 Process Microtubule bundle formation IDA 12939256
GO:0003777 Function Microtubule motor activity IBA 21873635
GO:0005515 Function Protein binding IPI 16431929, 25416956, 31515488
GO:0005524 Function ATP binding IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605664 9787 ENSG00000112984
Protein
UniProt ID O95235
Protein name Kinesin-like protein KIF20A (GG10_2) (Mitotic kinesin-like protein 2) (MKlp2) (Rab6-interacting kinesin-like protein) (Rabkinesin-6)
Protein function Mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. Following phosphorylation by PLK1, involved in recruitment of PLK1 to the central spindle. Interacts with guanosine triphosphate (GTP)-bound forms of RAB6A and
PDB 6YIP
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00225 Kinesin 70 507 Kinesin motor domain Domain
Sequence
MSQGILSPPAGLLSDDDVVVSPMFESTAADLGSVVRKNLLSDCSVVSTSLEDKQQVPSED
SMEKVKVYLRVRPLLPSELERQEDQGCVRIENVETLVLQAPKDSFALKSNERGIGQATHR
FTFSQIFGPEVGQASFFNLTVKEMVKDVLKGQNWLIYTYGVTNSGKTHTIQGTIKDGGIL
PRSLALIFNSLQGQLHPTPDLKPLLSNEVIWLDSKQIRQEEMKKLSLLNGGLQEEELSTS
LKRSVYIESRIGTSTSFDSGIAGLSSISQCTSSSQLDETSHRWAQPDTAPLPVPANIRFS
IWISFFEIYNELLYDLLEPPSQQRKRQTLRLCEDQNGNPYVKDLNWIHVQDAEEAWKLLK
VGRKNQSFASTHLNQNSSRSHSIFSIRILHLQGEGDIVPKISELSLCDLAGSERCKDQKS
GERLKEAGNINTSLHTLGRCIAALRQNQQNRSKQNLVPFRDSKLTRVFQGFFTGRGRSCM
IVNVNPCASTYDETLHVAKFSAIASQL
VHAPPMQLGFPSLHSFIKEHSLQVSPSLEKGAK
ADTGLDDDIENEADISMYGKEELLQVVEAMKTLLLKERQEKLQLEMHLRDEICNEMVEQM
QQREQWCSEHLDTQKELLEEMYEEKLNILKESLTSFYQEEIQERDEKIEELEALLQEARQ
QSVAHQQSGSELALRRSQRLAASASTQQLQEVKAKLQQCKAELNSTTEELHKYQKMLEPP
PSAKPFTIDVDKKLEEGQKNIRLLRTELQKLGESLQSAERACCHSTGAGKLRQALTTCDD
ILIKQDQTLAELQNNMVLVKLDLRKKAACIAEQYHTVLKLQGQVSAKKRLGTNQENQQPN
QQPPGKKPFLRNLLPRTPTCQSSTDCSPYARILRSRRSPLLKSGPFGKKY
Sequence length 890
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Motor proteins   MHC class II antigen presentation
COPI-dependent Golgi-to-ER retrograde traffic
Mitotic Telophase/Cytokinesis
Kinesins
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Cardiomyopathy Familial isolated restrictive cardiomyopathy rs267607003, rs267607002, rs267607004, rs63750743, rs121908333, rs121908334, rs104894655, rs121434420, rs121434421, rs193922674, rs111517471, rs121908987, rs193922384, rs121909374, rs121909377
View all (900 more)
Restrictive cardiomyopathy Other restrictive cardiomyopathy rs104894729, rs397516153, rs727503513, rs727503499, rs727503504, rs730880231, rs1554401403, rs1563005534, rs1420394583 29357359
Unknown
Disease term Disease name Evidence References Source
Myopathy cardiomyopathy, familial restrictive, 6 GenCC
Associations from Text Mining
Disease Name Relationship Type References
Acute Aortic Syndrome Associate 31721906
Adenocarcinoma of Lung Associate 31322267, 35810236, 36524130, 37322027, 37752167, 38281298
Aortic Dissection Associate 31721906
Breast Neoplasms Stimulate 24391143
Breast Neoplasms Associate 30593585, 31895772, 34384030, 36930083
Carcinogenesis Associate 28901457, 32695240
Carcinoma Hepatocellular Associate 28901457, 29500859, 31811111, 32046048, 32382568, 32722976, 33102593, 33736645, 33784984, 34112092, 34315286, 34491228, 34746301, 35123420, 35322101
View all (2 more)
Carcinoma Non Small Cell Lung Associate 31775549, 33126319
Carcinoma Ovarian Epithelial Associate 33726773, 36768616
Carcinoma Renal Cell Associate 29749467, 33232285, 33287763, 33836688, 36637953, 37310408