Gene Gene information from NCBI Gene database.
Entrez ID 10109
Gene name Actin related protein 2/3 complex subunit 2
Gene symbol ARPC2
Synonyms (NCBI Gene)
ARC34PNAS-139PRO2446p34-Arc
Chromosome 2
Chromosome location 2q35
Summary This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by
miRNA miRNA information provided by mirtarbase database.
263
miRTarBase ID miRNA Experiments Reference
MIRT050988 hsa-miR-17-5p CLASH 23622248
MIRT050616 hsa-miR-20a-5p CLASH 23622248
MIRT049237 hsa-miR-92a-3p CLASH 23622248
MIRT048830 hsa-miR-93-5p CLASH 23622248
MIRT045659 hsa-miR-149-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
45
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005200 Function Structural constituent of cytoskeleton IBA
GO:0005200 Function Structural constituent of cytoskeleton IDA 11741539
GO:0005200 Function Structural constituent of cytoskeleton TAS 9230079
GO:0005515 Function Protein binding IPI 11162547, 12473693, 16027158, 17350576, 24132237, 32911434
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604224 705 ENSG00000163466
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15144
Protein name Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)
Protein function Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks
PDB 6UHC , 6YW6 , 6YW7 , 8P94
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04045 P34-Arc 57 284 Arp2/3 complex, 34 kD subunit p34-Arc Family
Sequence
Sequence length 300
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocytosis
Tight junction
Fc gamma R-mediated phagocytosis
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Yersinia infection
  Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
RHO GTPases Activate WASPs and WAVEs
Clathrin-mediated endocytosis
FCGR3A-mediated phagocytosis
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
10
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Cervical cancer Benign rs74349827 RCV005910623
Clear cell carcinoma of kidney Benign rs74349827 RCV005910624
Colon adenocarcinoma Benign rs74349827 RCV005910622
Gastric cancer Benign rs74349827 RCV005910626
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 31002363
Carcinogenesis Associate 31002363
Carcinoma Hepatocellular Associate 33960941
Colonic Neoplasms Associate 25107436
Colorectal Neoplasms Associate 34938284
Dysentery Bacillary Associate 34938284
Melanoma Stimulate 19332774
Neoplasm Metastasis Associate 31002363
Neoplasms Associate 28694563
Stomach Neoplasms Associate 28694563