Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10109
Gene name Gene Name - the full gene name approved by the HGNC.
Actin related protein 2/3 complex subunit 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ARPC2
Synonyms (NCBI Gene) Gene synonyms aliases
ARC34, PNAS-139, PRO2446, p34-Arc
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2q35
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT050988 hsa-miR-17-5p CLASH 23622248
MIRT050616 hsa-miR-20a-5p CLASH 23622248
MIRT049237 hsa-miR-92a-3p CLASH 23622248
MIRT048830 hsa-miR-93-5p CLASH 23622248
MIRT045659 hsa-miR-149-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005200 Function Structural constituent of cytoskeleton IBA
GO:0005200 Function Structural constituent of cytoskeleton IDA 11741539
GO:0005200 Function Structural constituent of cytoskeleton TAS 9230079
GO:0005515 Function Protein binding IPI 11162547, 12473693, 16027158, 17350576, 24132237, 32911434
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604224 705 ENSG00000163466
Protein
UniProt ID O15144
Protein name Actin-related protein 2/3 complex subunit 2 (Arp2/3 complex 34 kDa subunit) (p34-ARC)
Protein function Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks
PDB 6UHC , 6YW6 , 6YW7 , 8P94
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04045 P34-Arc 57 284 Arp2/3 complex, 34 kD subunit p34-Arc Family
Sequence
Sequence length 300
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Endocytosis
Tight junction
Fc gamma R-mediated phagocytosis
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Yersinia infection
  Regulation of actin dynamics for phagocytic cup formation
EPHB-mediated forward signaling
RHO GTPases Activate WASPs and WAVEs
Clathrin-mediated endocytosis
FCGR3A-mediated phagocytosis
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Colorectal Cancer Colorectal cancer N/A N/A GWAS
Inflammatory Bowel Disease Inflammatory bowel disease N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 31002363
Carcinogenesis Associate 31002363
Carcinoma Hepatocellular Associate 33960941
Colonic Neoplasms Associate 25107436
Colorectal Neoplasms Associate 34938284
Dysentery Bacillary Associate 34938284
Melanoma Stimulate 19332774
Neoplasm Metastasis Associate 31002363
Neoplasms Associate 28694563
Stomach Neoplasms Associate 28694563