Gene Gene information from NCBI Gene database.
Entrez ID 10106
Gene name CTD small phosphatase 2
Gene symbol CTDSP2
Synonyms (NCBI Gene)
OS4PSR2SCP2
Chromosome 12
Chromosome location 12q14.1
miRNA miRNA information provided by mirtarbase database.
1104
miRTarBase ID miRNA Experiments Reference
MIRT002613 hsa-miR-124-3p Microarray 15685193
MIRT016407 hsa-miR-193b-3p Microarray 20304954
MIRT017775 hsa-miR-335-5p Microarray 18185580
MIRT019804 hsa-miR-375 Microarray 20215506
MIRT002613 hsa-miR-124-3p Microarray 15685193
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0004721 Function Phosphoprotein phosphatase activity IEA
GO:0004722 Function Protein serine/threonine phosphatase activity IEA
GO:0005515 Function Protein binding IPI 16724108, 16882717, 22458338, 25416956, 27880917, 28514442, 32296183, 33961781
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
608711 17077 ENSG00000175215
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O14595
Protein name Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2 (EC 3.1.3.16) (Nuclear LIM interactor-interacting factor 2) (NLI-interacting factor 2) (Protein OS-4) (Small C-terminal domain phosphatase 2) (Small CTD phosphatase 2) (SCP2)
Protein function Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by contr
PDB 2Q5E
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03031 NIF 102 262 NLI interacting factor-like phosphatase Family
Tissue specificity TISSUE SPECIFICITY: Expression is restricted to non-neuronal tissues. Highest expression in pancreas and lowest in liver. {ECO:0000269|PubMed:15681389}.
Sequence
MEHGSIITQARREDALVLTKQGLVSKSSPKKPRGRNIFKALFCCFRAQHVGQSSSSTELA
AYKEEANTIAKSDLLQCLQYQFYQIPGTCLLPEVTEEDQGRICVVIDLDETLVHSSFKPI
NNADFIVPIEIEGTTHQVYVLKRPYVDEFLRRMGELFECVLFTASLAKYADPVTDLLDRC
GVFRARLFRESCVFHQGCYVKDLSRLGRDLRKTLILDNSPASYIFHPENAVPVQSWFDDM
ADTELLNLIPIFEELSGAEDVY
TSLGQLRAP
Sequence length 271
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    XBP1(S) activates chaperone genes
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATRIAL FIBRILLATION GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CTDSP2-related disorder Likely benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Carcinogenesis Associate 31774910, 37629167
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 31774910, 40007122
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Associate 37629167
★☆☆☆☆
Found in Text Mining only
Liposarcoma Associate 31831742
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 31660073
★☆☆☆☆
Found in Text Mining only
Periodontal Diseases Associate 23066400
★☆☆☆☆
Found in Text Mining only
Respiratory Sounds Associate 37053215
★☆☆☆☆
Found in Text Mining only