Gene Gene information from NCBI Gene database.
Entrez ID 10105
Gene name Peptidylprolyl isomerase F
Gene symbol PPIF
Synonyms (NCBI Gene)
CYP3CyP-MCyp-DCypD
Chromosome 10
Chromosome location 10q22.3
Summary The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is
miRNA miRNA information provided by mirtarbase database.
506
miRTarBase ID miRNA Experiments Reference
MIRT001429 hsa-miR-16-5p pSILAC 18668040
MIRT005331 hsa-miR-21-5p Luciferase reporter assayqRT-PCR 18829576
MIRT022323 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT025721 hsa-miR-7-5p Sequencing 20371350
MIRT025721 hsa-miR-7-5p Microarray 19073608
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
49
GO ID Ontology Definition Evidence Reference
GO:0002931 Process Response to ischemia IEA
GO:0002931 Process Response to ischemia ISS
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IBA
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IDA 20676357
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604486 9259 ENSG00000108179
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P30405
Protein name Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F)
Protein function PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMe
PDB 2BIT , 2BIU , 2Z6W , 3QYU , 3R49 , 3R4G , 3R54 , 3R56 , 3R57 , 3R59 , 3RCF , 3RCG , 3RCI , 3RCK , 3RCL , 3RD9 , 3RDA , 3RDB , 3RDC , 4J58 , 4J59 , 4J5A , 4J5B , 4J5C , 4J5D , 4J5E , 4O8H , 4O8I , 4XNC , 4ZSC , 4ZSD , 5A0E , 5CBT , 5CBU , 5CBV , 5CBW , 5CCN , 5CCQ , 5CCR , 5CCS , 6R8L , 6R8O , 6R8W , 6R9S , 6R9U , 6R9X , 6RA1 , 6Y3E , 6YBM , 7OGI , 7PMT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00160 Pro_isomerase 49 205 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Domain
Sequence
Sequence length 207
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG 
  Calcium signaling pathway
cGMP-PKG signaling pathway
Neutrophil extracellular trap formation
Alzheimer disease
Parkinson disease
Huntington disease
Spinocerebellar ataxia
Prion disease
Pathways of neurodegeneration - multiple diseases
Toxoplasmosis
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy