Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10105
Gene name Gene Name - the full gene name approved by the HGNC.
Peptidylprolyl isomerase F
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PPIF
Synonyms (NCBI Gene) Gene synonyms aliases
CYP3, CyP-M, Cyp-D, CypD
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10q22.3
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001429 hsa-miR-16-5p pSILAC 18668040
MIRT005331 hsa-miR-21-5p Luciferase reporter assay, qRT-PCR 18829576
MIRT022323 hsa-miR-124-3p Proteomics;Microarray 18668037
MIRT025721 hsa-miR-7-5p Sequencing 20371350
MIRT025721 hsa-miR-7-5p Microarray 19073608
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000413 Process Protein peptidyl-prolyl isomerization IBA 21873635
GO:0000413 Process Protein peptidyl-prolyl isomerization IDA 20676357
GO:0002931 Process Response to ischemia ISS
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IBA 21873635
GO:0003755 Function Peptidyl-prolyl cis-trans isomerase activity IDA 20676357
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
604486 9259 ENSG00000108179
Protein
UniProt ID P30405
Protein name Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIase F) (EC 5.2.1.8) (Cyclophilin D) (CyP-D) (CypD) (Cyclophilin F) (Mitochondrial cyclophilin) (CyP-M) (Rotamase F)
Protein function PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding (PubMed:20676357). Involved in regulation of the mitochondrial permeability transition pore (mPTP) (PubMe
PDB 2BIT , 2BIU , 2Z6W , 3QYU , 3R49 , 3R4G , 3R54 , 3R56 , 3R57 , 3R59 , 3RCF , 3RCG , 3RCI , 3RCK , 3RCL , 3RD9 , 3RDA , 3RDB , 3RDC , 4J58 , 4J59 , 4J5A , 4J5B , 4J5C , 4J5D , 4J5E , 4O8H , 4O8I , 4XNC , 4ZSC , 4ZSD , 5A0E , 5CBT , 5CBU , 5CBV , 5CBW , 5CCN , 5CCQ , 5CCR , 5CCS , 6R8L , 6R8O , 6R8W , 6R9S , 6R9U , 6R9X , 6RA1 , 6Y3E , 6YBM , 7OGI , 7PMT
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00160 Pro_isomerase 49 205 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Domain
Sequence
Sequence length 207
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Calcium signaling pathway
cGMP-PKG signaling pathway
Neutrophil extracellular trap formation
Alzheimer disease
Parkinson disease
Huntington disease
Spinocerebellar ataxia
Prion disease
Pathways of neurodegeneration - multiple diseases
Toxoplasmosis
Chemical carcinogenesis - reactive oxygen species
Diabetic cardiomyopathy
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 25971350
Drug Related Side Effects and Adverse Reactions Associate 12846892
Endometrial Neoplasms Associate 33495413
Inflammatory Bowel Diseases Associate 33828297
Leukemia Associate 39216403
Leukemia Lymphoid Associate 39216403
Neoplasms Associate 24113185
Thyroid Neoplasms Associate 35748101