Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	10100
Gene name	Tetraspanin 2
Gene symbol	TSPAN2
Synonyms (NCBI Gene)	NET3TSN2TSPAN-2
Chromosome	1
Chromosome location	1p13.2
Summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate

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Show/Hide all (231)

miRTarBase ID	miRNA	Experiments	Reference
MIRT520451	hsa-miR-6074	HITS-CLIP	19536157
MIRT520450	hsa-miR-664a-3p	HITS-CLIP	19536157
MIRT520445	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT509193	hsa-miR-8485	HITS-CLIP	19536157
MIRT509192	hsa-miR-329-3p	HITS-CLIP	19536157
MIRT509191	hsa-miR-362-3p	HITS-CLIP	19536157
MIRT509190	hsa-miR-603	HITS-CLIP	19536157
MIRT509189	hsa-miR-5011-5p	HITS-CLIP	19536157
MIRT520444	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT509185	hsa-miR-3941	HITS-CLIP	19536157
MIRT509184	hsa-miR-4789-5p	HITS-CLIP	19536157
MIRT509183	hsa-miR-190a-3p	HITS-CLIP	19536157
MIRT509180	hsa-miR-1277-5p	HITS-CLIP	19536157
MIRT520452	hsa-miR-5683	HITS-CLIP	21572407
MIRT520451	hsa-miR-6074	HITS-CLIP	21572407
MIRT520450	hsa-miR-664a-3p	HITS-CLIP	21572407
MIRT520449	hsa-miR-1284	HITS-CLIP	21572407
MIRT520448	hsa-let-7f-2-3p	HITS-CLIP	21572407
MIRT520447	hsa-miR-1185-1-3p	HITS-CLIP	21572407
MIRT520446	hsa-miR-1185-2-3p	HITS-CLIP	21572407
MIRT520445	hsa-miR-452-3p	HITS-CLIP	21572407
MIRT509193	hsa-miR-8485	HITS-CLIP	21572407
MIRT509192	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT509191	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT509190	hsa-miR-603	HITS-CLIP	21572407
MIRT509189	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509188	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT520444	hsa-miR-4742-3p	HITS-CLIP	21572407
MIRT509187	hsa-miR-567	HITS-CLIP	21572407
MIRT509186	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT509185	hsa-miR-3941	HITS-CLIP	21572407
MIRT509184	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT509183	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509182	hsa-miR-3924	HITS-CLIP	21572407
MIRT509181	hsa-miR-297	HITS-CLIP	21572407
MIRT509180	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT520452	hsa-miR-5683	PAR-CLIP	21572407
MIRT520451	hsa-miR-6074	PAR-CLIP	21572407
MIRT520450	hsa-miR-664a-3p	PAR-CLIP	21572407
MIRT520449	hsa-miR-1284	PAR-CLIP	21572407
MIRT520448	hsa-let-7f-2-3p	PAR-CLIP	21572407
MIRT520447	hsa-miR-1185-1-3p	PAR-CLIP	21572407
MIRT520446	hsa-miR-1185-2-3p	PAR-CLIP	21572407
MIRT520445	hsa-miR-452-3p	PAR-CLIP	21572407
MIRT541940	hsa-miR-4282	PAR-CLIP	21572407
MIRT509193	hsa-miR-8485	PAR-CLIP	21572407
MIRT509192	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT509191	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT509190	hsa-miR-603	PAR-CLIP	21572407
MIRT509189	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509188	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509187	hsa-miR-567	PAR-CLIP	21572407
MIRT509186	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509185	hsa-miR-3941	PAR-CLIP	21572407
MIRT509184	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT509183	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509182	hsa-miR-3924	PAR-CLIP	21572407
MIRT509181	hsa-miR-297	PAR-CLIP	21572407
MIRT509180	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT520452	hsa-miR-5683	PAR-CLIP	23446348
MIRT520451	hsa-miR-6074	PAR-CLIP	23446348
MIRT520450	hsa-miR-664a-3p	PAR-CLIP	23446348
MIRT520449	hsa-miR-1284	PAR-CLIP	23446348
MIRT520448	hsa-let-7f-2-3p	PAR-CLIP	23446348
MIRT520447	hsa-miR-1185-1-3p	PAR-CLIP	23446348
MIRT520446	hsa-miR-1185-2-3p	PAR-CLIP	23446348
MIRT520445	hsa-miR-452-3p	PAR-CLIP	23446348
MIRT509193	hsa-miR-8485	PAR-CLIP	23446348
MIRT509192	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT509191	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT509190	hsa-miR-603	PAR-CLIP	23446348
MIRT509189	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509188	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT520444	hsa-miR-4742-3p	PAR-CLIP	23446348
MIRT509187	hsa-miR-567	PAR-CLIP	23446348
MIRT509186	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509185	hsa-miR-3941	PAR-CLIP	23446348
MIRT509184	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT509183	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509182	hsa-miR-3924	PAR-CLIP	23446348
MIRT509181	hsa-miR-297	PAR-CLIP	23446348
MIRT509180	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509193	hsa-miR-8485	PAR-CLIP	23446348
MIRT509192	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT509191	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT509190	hsa-miR-603	PAR-CLIP	23446348
MIRT509189	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509188	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509187	hsa-miR-567	PAR-CLIP	23446348
MIRT509186	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509185	hsa-miR-3941	PAR-CLIP	23446348
MIRT509184	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT509183	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509182	hsa-miR-3924	PAR-CLIP	23446348
MIRT509181	hsa-miR-297	PAR-CLIP	23446348
MIRT509180	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT520451	hsa-miR-6074	HITS-CLIP	19536157
MIRT520450	hsa-miR-664a-3p	HITS-CLIP	19536157
MIRT520445	hsa-miR-452-3p	HITS-CLIP	19536157
MIRT509193	hsa-miR-8485	HITS-CLIP	19536157
MIRT509192	hsa-miR-329-3p	HITS-CLIP	19536157
MIRT509191	hsa-miR-362-3p	HITS-CLIP	19536157
MIRT509190	hsa-miR-603	HITS-CLIP	19536157
MIRT509189	hsa-miR-5011-5p	HITS-CLIP	19536157
MIRT520444	hsa-miR-4742-3p	HITS-CLIP	19536157
MIRT509185	hsa-miR-3941	HITS-CLIP	19536157
MIRT509184	hsa-miR-4789-5p	HITS-CLIP	19536157
MIRT509183	hsa-miR-190a-3p	HITS-CLIP	19536157
MIRT509180	hsa-miR-1277-5p	HITS-CLIP	19536157
MIRT520452	hsa-miR-5683	HITS-CLIP	21572407
MIRT520451	hsa-miR-6074	HITS-CLIP	21572407
MIRT520450	hsa-miR-664a-3p	HITS-CLIP	21572407
MIRT520449	hsa-miR-1284	HITS-CLIP	21572407
MIRT520448	hsa-let-7f-2-3p	HITS-CLIP	21572407
MIRT520447	hsa-miR-1185-1-3p	HITS-CLIP	21572407
MIRT520446	hsa-miR-1185-2-3p	HITS-CLIP	21572407
MIRT520445	hsa-miR-452-3p	HITS-CLIP	21572407
MIRT509193	hsa-miR-8485	HITS-CLIP	21572407
MIRT509192	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT509191	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT509190	hsa-miR-603	HITS-CLIP	21572407
MIRT509189	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT509188	hsa-miR-511-3p	HITS-CLIP	21572407
MIRT520444	hsa-miR-4742-3p	HITS-CLIP	21572407
MIRT509187	hsa-miR-567	HITS-CLIP	21572407
MIRT509186	hsa-miR-223-5p	HITS-CLIP	21572407
MIRT509185	hsa-miR-3941	HITS-CLIP	21572407
MIRT509184	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT509183	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT509182	hsa-miR-3924	HITS-CLIP	21572407
MIRT509181	hsa-miR-297	HITS-CLIP	21572407
MIRT509180	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT520452	hsa-miR-5683	PAR-CLIP	21572407
MIRT520451	hsa-miR-6074	PAR-CLIP	21572407
MIRT520450	hsa-miR-664a-3p	PAR-CLIP	21572407
MIRT520449	hsa-miR-1284	PAR-CLIP	21572407
MIRT520448	hsa-let-7f-2-3p	PAR-CLIP	21572407
MIRT520447	hsa-miR-1185-1-3p	PAR-CLIP	21572407
MIRT520446	hsa-miR-1185-2-3p	PAR-CLIP	21572407
MIRT520445	hsa-miR-452-3p	PAR-CLIP	21572407
MIRT541940	hsa-miR-4282	PAR-CLIP	21572407
MIRT509193	hsa-miR-8485	PAR-CLIP	21572407
MIRT509192	hsa-miR-329-3p	PAR-CLIP	21572407
MIRT509191	hsa-miR-362-3p	PAR-CLIP	21572407
MIRT509190	hsa-miR-603	PAR-CLIP	21572407
MIRT509189	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT509188	hsa-miR-511-3p	PAR-CLIP	21572407
MIRT509187	hsa-miR-567	PAR-CLIP	21572407
MIRT509186	hsa-miR-223-5p	PAR-CLIP	21572407
MIRT509185	hsa-miR-3941	PAR-CLIP	21572407
MIRT509184	hsa-miR-4789-5p	PAR-CLIP	21572407
MIRT509183	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT509182	hsa-miR-3924	PAR-CLIP	21572407
MIRT509181	hsa-miR-297	PAR-CLIP	21572407
MIRT509180	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT520452	hsa-miR-5683	PAR-CLIP	23446348
MIRT520451	hsa-miR-6074	PAR-CLIP	23446348
MIRT520450	hsa-miR-664a-3p	PAR-CLIP	23446348
MIRT520449	hsa-miR-1284	PAR-CLIP	23446348
MIRT520448	hsa-let-7f-2-3p	PAR-CLIP	23446348
MIRT520447	hsa-miR-1185-1-3p	PAR-CLIP	23446348
MIRT520446	hsa-miR-1185-2-3p	PAR-CLIP	23446348
MIRT520445	hsa-miR-452-3p	PAR-CLIP	23446348
MIRT509193	hsa-miR-8485	PAR-CLIP	23446348
MIRT509192	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT509191	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT509190	hsa-miR-603	PAR-CLIP	23446348
MIRT509189	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509188	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT520444	hsa-miR-4742-3p	PAR-CLIP	23446348
MIRT509187	hsa-miR-567	PAR-CLIP	23446348
MIRT509186	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509185	hsa-miR-3941	PAR-CLIP	23446348
MIRT509184	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT509183	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509182	hsa-miR-3924	PAR-CLIP	23446348
MIRT509181	hsa-miR-297	PAR-CLIP	23446348
MIRT509180	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT509193	hsa-miR-8485	PAR-CLIP	23446348
MIRT509192	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT509191	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT509190	hsa-miR-603	PAR-CLIP	23446348
MIRT509189	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT509188	hsa-miR-511-3p	PAR-CLIP	23446348
MIRT509187	hsa-miR-567	PAR-CLIP	23446348
MIRT509186	hsa-miR-223-5p	PAR-CLIP	23446348
MIRT509185	hsa-miR-3941	PAR-CLIP	23446348
MIRT509184	hsa-miR-4789-5p	PAR-CLIP	23446348
MIRT509183	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT509182	hsa-miR-3924	PAR-CLIP	23446348
MIRT509181	hsa-miR-297	PAR-CLIP	23446348
MIRT509180	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1459703	hsa-miR-300	CLIP-seq
MIRT1459704	hsa-miR-3163	CLIP-seq
MIRT1459705	hsa-miR-3175	CLIP-seq
MIRT1459706	hsa-miR-381	CLIP-seq
MIRT1459707	hsa-miR-410	CLIP-seq
MIRT1459708	hsa-miR-4495	CLIP-seq
MIRT1459709	hsa-miR-4666-3p	CLIP-seq
MIRT1459710	hsa-miR-4776-3p	CLIP-seq
MIRT1459711	hsa-miR-513a-3p	CLIP-seq
MIRT1459712	hsa-miR-548ac	CLIP-seq
MIRT1459713	hsa-miR-548d-3p	CLIP-seq
MIRT1459714	hsa-miR-548z	CLIP-seq
MIRT1459715	hsa-miR-605	CLIP-seq
MIRT2137959	hsa-miR-3124-3p	CLIP-seq
MIRT2137960	hsa-miR-3125	CLIP-seq
MIRT2137961	hsa-miR-3180-5p	CLIP-seq
MIRT2137962	hsa-miR-3916	CLIP-seq
MIRT2137963	hsa-miR-4753-3p	CLIP-seq
MIRT2137964	hsa-miR-520a-5p	CLIP-seq
MIRT2137965	hsa-miR-525-5p	CLIP-seq
MIRT2137966	hsa-miR-548c-3p	CLIP-seq
MIRT2137967	hsa-miR-7	CLIP-seq
MIRT2358878	hsa-miR-1183	CLIP-seq
MIRT2358879	hsa-miR-139-5p	CLIP-seq
MIRT2358880	hsa-miR-3168	CLIP-seq
MIRT2358881	hsa-miR-3662	CLIP-seq
MIRT2358882	hsa-miR-4251	CLIP-seq
MIRT2358883	hsa-miR-4329	CLIP-seq
MIRT2358884	hsa-miR-4703-3p	CLIP-seq
MIRT2358885	hsa-miR-4738-3p	CLIP-seq
MIRT2358886	hsa-miR-539	CLIP-seq
MIRT2358887	hsa-miR-548a-3p	CLIP-seq
MIRT2358888	hsa-miR-548e	CLIP-seq
MIRT2358889	hsa-miR-548f	CLIP-seq
MIRT2358890	hsa-miR-548g	CLIP-seq
MIRT2358891	hsa-miR-548v	CLIP-seq
MIRT2358892	hsa-miR-570	CLIP-seq
MIRT2358893	hsa-miR-616	CLIP-seq
MIRT2358894	hsa-miR-622	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25814554, 32296183, 32814053
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006954	Process	Inflammatory response	IEA
GO:0014002	Process	Astrocyte development	IEA
GO:0014005	Process	Microglia development	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	9714763
GO:0042552	Process	Myelination	IEA
GO:0043209	Component	Myelin sheath	IEA
GO:0048709	Process	Oligodendrocyte differentiation	IEA
GO:0061564	Process	Axon development	IEA

MIM	HGNC	e!Ensembl
613133	20659	ENSG00000134198

O60636

Protein name

Tetraspanin-2 (Tspan-2) (Tetraspan NET-3)

Protein function

May play a role in signalling in oligodendrocytes in the early stages of their terminal differentiation into myelin-forming glia and may also function in stabilizing the mature sheath.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00335	Tetraspanin	11 → 213	Tetraspanin family	Family

Sequence

MGRFRGGLRCIKYLLLGFNLLFWLAGSAVIAFGLWFRFGGAIKELSSEDKSPEYFYVGLY
VLVGAGALMMAVGFFGCCGAMRESQCVLGSFFTCLLVIFAAEVTTGVFAFIGKGVAIRHV
QTMYEEAYNDYLKDRGKGNGTLITFHSTFQCCGKESSEQVQPTCPKELLGHKNCIDEIET
IISVKLQLIGIVGIGIAGLTIFGMIFSMVLCCAIRNSRDVI

Sequence length

221

Interactions

View interactions

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs9659602	RCV005910616
Colon adenocarcinoma	Benign	rs9659602	RCV005910615
Lung cancer	Benign	rs9659602	RCV005910620
Ovarian serous cystadenocarcinoma	Benign	rs9659602	RCV005910618
Sarcoma	Benign	rs9659602	RCV005910617
Thyroid cancer, nonmedullary, 1	Benign	rs9659602	RCV005910619
Uterine corpus endometrial carcinoma	Benign	rs9659602	RCV005910621

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Arteriovenous Fistula	Associate	28258189
Atherosclerosis	Associate	26708676
Bipolar Disorder	Associate	36624117
Cerebral Infarction	Associate	26708676
Cognition Disorders	Associate	36624117
Disruptive Impulse Control and Conduct Disorders	Associate	36624117
Migraine Disorders	Associate	26231841
Neoplasm Metastasis	Associate	16164832
Renal Insufficiency	Associate	27247127
Stroke	Associate	26708676
Vascular Diseases	Associate	28258189

TSPAN2 (tetraspanin 2)