NOTCH2NLC (notch 2 N-terminal like C)

Gene
Gene Gene ontology Other IDs Protein
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
100996717
Gene name Gene Name - the full gene name approved by the HGNC.
Notch 2 N-terminal like C
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NOTCH2NLC
Synonyms (NCBI Gene) Gene synonyms aliases
ETM6, N2N, NIID, NOTCH2NL, NOTCH2NLA, OPDM3
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q21.2
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene Gene ontology Other IDs Protein
Show/Hide all(10)
GO ID Ontology Definition Evidence Reference
GO:0005509 Function Calcium ion binding IEA
GO:0005515 Function Protein binding IPI 29856954, 32296183
GO:0005576 Component Extracellular region IDA 29856954
GO:0005576 Component Extracellular region IEA
GO:0005576 Component Extracellular region TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene Gene ontology Other IDs Protein
MIM HGNC e!Ensembl
618025 53924 ENSG00000286219
Protein
Gene Gene ontology Other IDs Protein
UniProt ID P0DPK4
Protein name Notch homolog 2 N-terminal-like protein C
Protein function Human-specific protein that promotes neural progenitor proliferation and evolutionary expansion of the brain neocortex by regulating the Notch signaling pathway (PubMed:29561261, PubMed:29856954, PubMed:29856955). Able to promote neural progenit
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00008 EGF 29 → 61 EGF-like domain Domain
PF00008 EGF 69 → 102 EGF-like domain Domain
PF00008 EGF 109 → 139 EGF-like domain Domain
PF07645 EGF_CA 143 → 186 Calcium-binding EGF domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in radial glia neural stem cells during cortical development. {ECO:0000269|PubMed:29856954}.
Sequence 
MCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE
DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTC
TTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD
SLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWERDREVWNGKEHDEN
Sequence length 236
Interactions View interactions
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