TSPAN3 (tetraspanin 3)

Gene

• Entrez ID: 10099
• Gene name: Tetraspanin 3
• Gene symbol: TSPAN3
• Synonyms (NCBI Gene): TM4-A, TM4SF8, TSPAN-3
• Chromosome: 15
• Chromosome location: 15q24.3
• Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT000215	hsa-miR-197-3p	Microarray, qRT-PCR	16822819
MIRT020952	hsa-miR-155-5p	Proteomics	18668040
MIRT030069	hsa-miR-26b-5p	Microarray	19088304
MIRT031979	hsa-miR-16-5p	Proteomics	18668040
MIRT052616	hsa-let-7a-5p	CLASH	23622248
MIRT052340	hsa-let-7b-5p	CLASH	23622248
MIRT051380	hsa-let-7f-5p	CLASH	23622248
MIRT031979	hsa-miR-16-5p	CLASH	23622248
MIRT000215	hsa-miR-197-3p	CLASH	23622248
MIRT046454	hsa-miR-15b-5p	CLASH	23622248
MIRT041737	hsa-miR-484	CLASH	23622248
MIRT041737	hsa-miR-484	CLASH	23622248
MIRT553318	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT553317	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT553316	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT553315	hsa-miR-483-3p	PAR-CLIP	21572407
MIRT553314	hsa-miR-323a-3p	PAR-CLIP	21572407
MIRT553313	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT553312	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT553311	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT553310	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT553309	hsa-miR-3666	PAR-CLIP	21572407
MIRT553308	hsa-miR-4295	PAR-CLIP	21572407
MIRT553307	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT553306	hsa-miR-199a-3p	PAR-CLIP	21572407
MIRT553305	hsa-miR-199b-3p	PAR-CLIP	21572407
MIRT553304	hsa-miR-3129-5p	PAR-CLIP	21572407
MIRT553303	hsa-miR-548ac	PAR-CLIP	21572407
MIRT553302	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT553301	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT553300	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT553299	hsa-miR-548z	PAR-CLIP	21572407
MIRT553298	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT553297	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT553296	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT553295	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT553294	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT553293	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT553292	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT553291	hsa-miR-548aa	PAR-CLIP	21572407
MIRT553290	hsa-miR-548ap-3p	PAR-CLIP	21572407
MIRT553289	hsa-miR-548t-3p	PAR-CLIP	21572407
MIRT553288	hsa-miR-497-3p	PAR-CLIP	21572407
MIRT553287	hsa-miR-4528	PAR-CLIP	21572407
MIRT553286	hsa-miR-5689	PAR-CLIP	21572407
MIRT553285	hsa-miR-4671-3p	PAR-CLIP	21572407
MIRT553284	hsa-miR-337-3p	PAR-CLIP	21572407
MIRT465088	hsa-miR-562	PAR-CLIP	23592263
MIRT465087	hsa-miR-196a-5p	PAR-CLIP	23592263
MIRT465086	hsa-miR-196b-5p	PAR-CLIP	23592263
MIRT465084	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT465085	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT282122	hsa-miR-5589-3p	PAR-CLIP	23592263
MIRT465083	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT465082	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT465081	hsa-miR-6802-5p	PAR-CLIP	23592263
MIRT000215	hsa-miR-197-3p	qRT-PCR	28418912
MIRT000215	hsa-miR-197-3p	qRT-PCR	28418912
MIRT553318	hsa-miR-340-5p	PAR-CLIP	21572407
MIRT553317	hsa-miR-142-5p	PAR-CLIP	21572407
MIRT553316	hsa-miR-5590-3p	PAR-CLIP	21572407
MIRT553315	hsa-miR-483-3p	PAR-CLIP	21572407
MIRT553314	hsa-miR-323a-3p	PAR-CLIP	21572407
MIRT553313	hsa-miR-130b-3p	PAR-CLIP	21572407
MIRT553312	hsa-miR-130a-3p	PAR-CLIP	21572407
MIRT553311	hsa-miR-301a-3p	PAR-CLIP	21572407
MIRT553310	hsa-miR-301b-3p	PAR-CLIP	21572407
MIRT553309	hsa-miR-3666	PAR-CLIP	21572407
MIRT553308	hsa-miR-4295	PAR-CLIP	21572407
MIRT553307	hsa-miR-454-3p	PAR-CLIP	21572407
MIRT553306	hsa-miR-199a-3p	PAR-CLIP	21572407
MIRT553305	hsa-miR-199b-3p	PAR-CLIP	21572407
MIRT553304	hsa-miR-3129-5p	PAR-CLIP	21572407
MIRT553303	hsa-miR-548ac	PAR-CLIP	21572407
MIRT553302	hsa-miR-548bb-3p	PAR-CLIP	21572407
MIRT553301	hsa-miR-548d-3p	PAR-CLIP	21572407
MIRT553300	hsa-miR-548h-3p	PAR-CLIP	21572407
MIRT553299	hsa-miR-548z	PAR-CLIP	21572407
MIRT553298	hsa-miR-548ae-3p	PAR-CLIP	21572407
MIRT553297	hsa-miR-548ah-3p	PAR-CLIP	21572407
MIRT553296	hsa-miR-548aj-3p	PAR-CLIP	21572407
MIRT553295	hsa-miR-548am-3p	PAR-CLIP	21572407
MIRT553294	hsa-miR-548aq-3p	PAR-CLIP	21572407
MIRT553293	hsa-miR-548j-3p	PAR-CLIP	21572407
MIRT553292	hsa-miR-548x-3p	PAR-CLIP	21572407
MIRT553291	hsa-miR-548aa	PAR-CLIP	21572407
MIRT553290	hsa-miR-548ap-3p	PAR-CLIP	21572407
MIRT553289	hsa-miR-548t-3p	PAR-CLIP	21572407
MIRT553288	hsa-miR-497-3p	PAR-CLIP	21572407
MIRT553287	hsa-miR-4528	PAR-CLIP	21572407
MIRT553286	hsa-miR-5689	PAR-CLIP	21572407
MIRT553285	hsa-miR-4671-3p	PAR-CLIP	21572407
MIRT553284	hsa-miR-337-3p	PAR-CLIP	21572407
MIRT465088	hsa-miR-562	PAR-CLIP	23592263
MIRT465087	hsa-miR-196a-5p	PAR-CLIP	23592263
MIRT465086	hsa-miR-196b-5p	PAR-CLIP	23592263
MIRT465084	hsa-miR-6815-5p	PAR-CLIP	23592263
MIRT465085	hsa-miR-6865-5p	PAR-CLIP	23592263
MIRT282122	hsa-miR-5589-3p	PAR-CLIP	23592263
MIRT465083	hsa-miR-541-3p	PAR-CLIP	23592263
MIRT465082	hsa-miR-654-5p	PAR-CLIP	23592263
MIRT465081	hsa-miR-6802-5p	PAR-CLIP	23592263
MIRT1459789	hsa-miR-4717-3p	CLIP-seq
MIRT1459790	hsa-miR-605	CLIP-seq
MIRT1459791	hsa-miR-130a	CLIP-seq
MIRT1459792	hsa-miR-130b	CLIP-seq
MIRT1459793	hsa-miR-15a	CLIP-seq
MIRT1459794	hsa-miR-15b	CLIP-seq
MIRT1459795	hsa-miR-16	CLIP-seq
MIRT1459796	hsa-miR-195	CLIP-seq
MIRT1459797	hsa-miR-208a	CLIP-seq
MIRT1459798	hsa-miR-208b	CLIP-seq
MIRT1459799	hsa-miR-301a	CLIP-seq
MIRT1459800	hsa-miR-301b	CLIP-seq
MIRT1459801	hsa-miR-323-3p	CLIP-seq
MIRT1459802	hsa-miR-3611	CLIP-seq
MIRT1459803	hsa-miR-3646	CLIP-seq
MIRT1459804	hsa-miR-424	CLIP-seq
MIRT1459805	hsa-miR-4432	CLIP-seq
MIRT1459806	hsa-miR-4499	CLIP-seq
MIRT1459807	hsa-miR-454	CLIP-seq
MIRT1459808	hsa-miR-4680-5p	CLIP-seq
MIRT1459809	hsa-miR-4720-3p	CLIP-seq
MIRT1459810	hsa-miR-497	CLIP-seq
MIRT1459811	hsa-miR-499-5p	CLIP-seq
MIRT1459812	hsa-miR-508-5p	CLIP-seq
MIRT1459813	hsa-miR-515-5p	CLIP-seq
MIRT1459814	hsa-miR-520a-5p	CLIP-seq
MIRT1459815	hsa-miR-525-5p	CLIP-seq
MIRT1459816	hsa-miR-767-3p	CLIP-seq
MIRT1459817	hsa-miR-922	CLIP-seq
MIRT1459793	hsa-miR-15a	CLIP-seq
MIRT1459794	hsa-miR-15b	CLIP-seq
MIRT1459795	hsa-miR-16	CLIP-seq
MIRT1459796	hsa-miR-195	CLIP-seq
MIRT1459818	hsa-miR-323-5p	CLIP-seq
MIRT1459819	hsa-miR-3606	CLIP-seq
MIRT1459820	hsa-miR-3689d	CLIP-seq
MIRT1459804	hsa-miR-424	CLIP-seq
MIRT1459821	hsa-miR-4536	CLIP-seq
MIRT1459822	hsa-miR-4723-5p	CLIP-seq
MIRT1459823	hsa-miR-4787-5p	CLIP-seq
MIRT1459810	hsa-miR-497	CLIP-seq
MIRT1459814	hsa-miR-520a-5p	CLIP-seq
MIRT1459815	hsa-miR-525-5p	CLIP-seq
MIRT1459824	hsa-miR-876-3p	CLIP-seq
MIRT1459817	hsa-miR-922	CLIP-seq
MIRT1555218	hsa-miR-196a	CLIP-seq
MIRT1555219	hsa-miR-196b	CLIP-seq
MIRT1555220	hsa-miR-3148	CLIP-seq
MIRT1555221	hsa-miR-4709-3p	CLIP-seq
MIRT1555222	hsa-miR-4773	CLIP-seq
MIRT2137977	hsa-miR-3127-3p	CLIP-seq
MIRT2137978	hsa-miR-3926	CLIP-seq
MIRT2137979	hsa-miR-548s	CLIP-seq
MIRT2137980	hsa-miR-1227	CLIP-seq
MIRT2137981	hsa-miR-3910	CLIP-seq
MIRT2137982	hsa-miR-548an	CLIP-seq
MIRT2358904	hsa-miR-197	CLIP-seq
MIRT2358905	hsa-miR-3194-3p	CLIP-seq
MIRT2358906	hsa-miR-4264	CLIP-seq
MIRT1555221	hsa-miR-4709-3p	CLIP-seq
MIRT2358907	hsa-miR-942	CLIP-seq
MIRT2358908	hsa-miR-4529-3p	CLIP-seq
MIRT1459813	hsa-miR-515-5p	CLIP-seq
MIRT2462501	hsa-miR-4722-3p	CLIP-seq
MIRT1555218	hsa-miR-196a	CLIP-seq
MIRT1555219	hsa-miR-196b	CLIP-seq
MIRT1555220	hsa-miR-3148	CLIP-seq
MIRT2652138	hsa-miR-1225-5p	CLIP-seq
MIRT2652139	hsa-miR-1236	CLIP-seq
MIRT1459791	hsa-miR-130a	CLIP-seq
MIRT1459792	hsa-miR-130b	CLIP-seq
MIRT2652140	hsa-miR-1910	CLIP-seq
MIRT1459797	hsa-miR-208a	CLIP-seq
MIRT1459798	hsa-miR-208b	CLIP-seq
MIRT1459799	hsa-miR-301a	CLIP-seq
MIRT1459800	hsa-miR-301b	CLIP-seq
MIRT1459801	hsa-miR-323-3p	CLIP-seq
MIRT2652141	hsa-miR-330-3p	CLIP-seq
MIRT2652142	hsa-miR-340	CLIP-seq
MIRT2652143	hsa-miR-3614-5p	CLIP-seq
MIRT2652144	hsa-miR-3618	CLIP-seq
MIRT2652145	hsa-miR-3661	CLIP-seq
MIRT1459820	hsa-miR-3689d	CLIP-seq
MIRT2652146	hsa-miR-3920	CLIP-seq
MIRT2652147	hsa-miR-3921	CLIP-seq
MIRT2358906	hsa-miR-4264	CLIP-seq
MIRT2652148	hsa-miR-4299	CLIP-seq
MIRT2652149	hsa-miR-4304	CLIP-seq
MIRT2652150	hsa-miR-432	CLIP-seq
MIRT1459805	hsa-miR-4432	CLIP-seq
MIRT2652151	hsa-miR-4437	CLIP-seq
MIRT2652152	hsa-miR-4443	CLIP-seq
MIRT2652153	hsa-miR-4452	CLIP-seq
MIRT1459807	hsa-miR-454	CLIP-seq
MIRT2652154	hsa-miR-455-3p	CLIP-seq
MIRT2652155	hsa-miR-4653-5p	CLIP-seq
MIRT2652156	hsa-miR-4674	CLIP-seq
MIRT2652157	hsa-miR-4699-3p	CLIP-seq
MIRT2652158	hsa-miR-4699-5p	CLIP-seq
MIRT1555221	hsa-miR-4709-3p	CLIP-seq
MIRT2652159	hsa-miR-4711-5p	CLIP-seq
MIRT1459809	hsa-miR-4720-3p	CLIP-seq
MIRT2652160	hsa-miR-4753-3p	CLIP-seq
MIRT2652161	hsa-miR-4760-5p	CLIP-seq
MIRT2652162	hsa-miR-4790-3p	CLIP-seq
MIRT2652163	hsa-miR-4793-5p	CLIP-seq
MIRT2652164	hsa-miR-4797-5p	CLIP-seq
MIRT2652165	hsa-miR-4802-3p	CLIP-seq
MIRT2652166	hsa-miR-488	CLIP-seq
MIRT2652167	hsa-miR-492	CLIP-seq
MIRT1459811	hsa-miR-499-5p	CLIP-seq
MIRT2652168	hsa-miR-548ae	CLIP-seq
MIRT2652169	hsa-miR-548aj	CLIP-seq
MIRT2652170	hsa-miR-548am	CLIP-seq
MIRT2652171	hsa-miR-548x	CLIP-seq
MIRT2652172	hsa-miR-593	CLIP-seq
MIRT2652173	hsa-miR-607	CLIP-seq
MIRT2652174	hsa-miR-622	CLIP-seq
MIRT2652175	hsa-miR-627	CLIP-seq
MIRT2652176	hsa-miR-631	CLIP-seq
MIRT2652177	hsa-miR-890	CLIP-seq
MIRT2652178	hsa-miR-924	CLIP-seq
MIRT2358907	hsa-miR-942	CLIP-seq
MIRT2652138	hsa-miR-1225-5p	CLIP-seq
MIRT2652139	hsa-miR-1236	CLIP-seq
MIRT1459791	hsa-miR-130a	CLIP-seq
MIRT1459792	hsa-miR-130b	CLIP-seq
MIRT2652140	hsa-miR-1910	CLIP-seq
MIRT1459797	hsa-miR-208a	CLIP-seq
MIRT1459798	hsa-miR-208b	CLIP-seq
MIRT1459799	hsa-miR-301a	CLIP-seq
MIRT1459800	hsa-miR-301b	CLIP-seq
MIRT1459801	hsa-miR-323-3p	CLIP-seq
MIRT2652141	hsa-miR-330-3p	CLIP-seq
MIRT2652142	hsa-miR-340	CLIP-seq
MIRT2652143	hsa-miR-3614-5p	CLIP-seq
MIRT2652144	hsa-miR-3618	CLIP-seq
MIRT2652145	hsa-miR-3661	CLIP-seq
MIRT1459820	hsa-miR-3689d	CLIP-seq
MIRT2652146	hsa-miR-3920	CLIP-seq
MIRT2652147	hsa-miR-3921	CLIP-seq
MIRT2358906	hsa-miR-4264	CLIP-seq
MIRT2652148	hsa-miR-4299	CLIP-seq
MIRT2652149	hsa-miR-4304	CLIP-seq
MIRT2652150	hsa-miR-432	CLIP-seq
MIRT1459805	hsa-miR-4432	CLIP-seq
MIRT2652151	hsa-miR-4437	CLIP-seq
MIRT2652152	hsa-miR-4443	CLIP-seq
MIRT2652153	hsa-miR-4452	CLIP-seq
MIRT1459807	hsa-miR-454	CLIP-seq
MIRT2652154	hsa-miR-455-3p	CLIP-seq
MIRT2652155	hsa-miR-4653-5p	CLIP-seq
MIRT2652156	hsa-miR-4674	CLIP-seq
MIRT2652157	hsa-miR-4699-3p	CLIP-seq
MIRT2652158	hsa-miR-4699-5p	CLIP-seq
MIRT1555221	hsa-miR-4709-3p	CLIP-seq
MIRT2652159	hsa-miR-4711-5p	CLIP-seq
MIRT1459809	hsa-miR-4720-3p	CLIP-seq
MIRT2652160	hsa-miR-4753-3p	CLIP-seq
MIRT2652161	hsa-miR-4760-5p	CLIP-seq
MIRT2652162	hsa-miR-4790-3p	CLIP-seq
MIRT2652163	hsa-miR-4793-5p	CLIP-seq
MIRT2652164	hsa-miR-4797-5p	CLIP-seq
MIRT2652165	hsa-miR-4802-3p	CLIP-seq
MIRT2694359	hsa-miR-485-3p	CLIP-seq
MIRT2652166	hsa-miR-488	CLIP-seq
MIRT2652167	hsa-miR-492	CLIP-seq
MIRT1459811	hsa-miR-499-5p	CLIP-seq
MIRT2652168	hsa-miR-548ae	CLIP-seq
MIRT2652169	hsa-miR-548aj	CLIP-seq
MIRT2652170	hsa-miR-548am	CLIP-seq
MIRT2652171	hsa-miR-548x	CLIP-seq
MIRT2652172	hsa-miR-593	CLIP-seq
MIRT2652173	hsa-miR-607	CLIP-seq
MIRT2652174	hsa-miR-622	CLIP-seq
MIRT2652175	hsa-miR-627	CLIP-seq
MIRT2652176	hsa-miR-631	CLIP-seq
MIRT2652177	hsa-miR-890	CLIP-seq
MIRT2652178	hsa-miR-924	CLIP-seq
MIRT2358907	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 613134
• HGNC: 17752
• e!Ensembl: ENSG00000140391

Protein

• UniProt ID: O60637
• Protein name: Tetraspanin-3 (Tspan-3) (Tetraspanin TM4-A) (Transmembrane 4 superfamily member 8)
• Protein function: Regulates the proliferation and migration of oligodendrocytes, a process essential for normal myelination and repair.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00335	Tetraspanin	9 → 236	Tetraspanin family	Family

• Sequence:

  MGQCGITSSKTVLVFLNLIFWGAAGILCYVGAYVFITYDDYDHFFEDVYTLIPAVVIIAV
  GALLFIIGLIGCCATIRESRCGLATFVIILLLVFVTEVVVVVLGYVYRAKVENEVDRSIQ
  KVYKTYNGTNPDAASRAIDYVQRQLHCCGIHNYSDWENTDWFKETKNQSVPLSCCRETAS
  NCNGSLAHPSDLYAEGCEALVVKKLQEIMMHVIWAALAFAAIQLLGMLCACIVLCRRSRD
  PAYELLITGGTYA

• Sequence length: 253