Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10090
Gene name Gene Name - the full gene name approved by the HGNC.
Uronyl 2-sulfotransferase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
UST
Synonyms (NCBI Gene) Gene synonyms aliases
2OST, CS-2OST
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6q25.1
Summary Summary of gene provided in NCBI Entrez Gene.
Uronyl 2-sulfotransferase transfers sulfate to the 2-position of uronyl residues, such as iduronyl residues in dermatan sulfate and glucuronyl residues in chondroitin sulfate (Kobayashi et al., 1999 [PubMed 10187838]).[supplied by OMIM, Mar 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT002811 hsa-miR-1-3p Microarray 15685193
MIRT019065 hsa-miR-335-5p Microarray 18185580
MIRT002811 hsa-miR-1-3p Microarray 15685193
MIRT002811 hsa-miR-1-3p Microarray 18668037
MIRT027844 hsa-miR-98-5p Microarray 19088304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0005794 Component Golgi apparatus IEA
GO:0008146 Function Sulfotransferase activity IBA
GO:0008146 Function Sulfotransferase activity IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
610752 17223 ENSG00000111962
Protein
UniProt ID Q9Y2C2
Protein name Uronyl 2-sulfotransferase (EC 2.8.2.-) (Chondroitin sulfate 2-O-sulfotransferase) (CS-2OST)
Protein function Sulfotransferase that catalyzes the transfer of sulfate to the position 2 of uronyl residues in glycosaminoglycan chains (PubMed:10187838, PubMed:17227754). Has mainly activity toward iduronyl residues in dermatan sulfate, and weaker activity to
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03567 Sulfotransfer_2 97 358 Sulfotransferase family Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:10187838}.
Sequence
Sequence length 406
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate   Dermatan sulfate biosynthesis
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Atrial Fibrillation Atrial fibrillation N/A N/A GWAS
Diabetic Retinopathy Diabetic retinopathy N/A N/A GWAS
Diverticulitis Diverticulitis N/A N/A GWAS
Glaucoma Glaucoma N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Colorectal Neoplasms Associate 38466182
Kashin Beck Disease Inhibit 28274888
Kashin Beck Disease Associate 34151604
Lead Poisoning Nervous System Associate 34151604
Osteoarthritis Associate 28274888