Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	10085
Gene name	EGF like repeats and discoidin domains 3
Gene symbol	EDIL3
Synonyms (NCBI Gene)	DEL1
Chromosome	5
Chromosome location	5q14.3
Summary	The protein encoded by this gene is an integrin ligand. It plays an important role in mediating angiogenesis and may be important in vessel wall remodeling and development. It also influences endothelial cell behavior. [provided by RefSeq, Jul 2008]

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Show/Hide all (179)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030686	hsa-miR-21-5p	Microarray	18591254
MIRT611638	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611637	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611636	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611635	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611634	hsa-miR-548z	HITS-CLIP	23824327
MIRT611633	hsa-miR-548aa	HITS-CLIP	23824327
MIRT611632	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT611631	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT648501	hsa-miR-8060	HITS-CLIP	23824327
MIRT648500	hsa-miR-7154-5p	HITS-CLIP	23824327
MIRT611629	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611638	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611637	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611636	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611635	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611634	hsa-miR-548z	HITS-CLIP	23824327
MIRT611633	hsa-miR-548aa	HITS-CLIP	23824327
MIRT611632	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT611631	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT611630	hsa-miR-4328	HITS-CLIP	23824327
MIRT648501	hsa-miR-8060	HITS-CLIP	23824327
MIRT648500	hsa-miR-7154-5p	HITS-CLIP	23824327
MIRT611629	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611638	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611637	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611636	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611635	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611634	hsa-miR-548z	HITS-CLIP	23824327
MIRT611633	hsa-miR-548aa	HITS-CLIP	23824327
MIRT611632	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT611631	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT611630	hsa-miR-4328	HITS-CLIP	23824327
MIRT611629	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611638	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611637	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611636	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611635	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611634	hsa-miR-548z	HITS-CLIP	23824327
MIRT611633	hsa-miR-548aa	HITS-CLIP	23824327
MIRT611632	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT611631	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT611630	hsa-miR-4328	HITS-CLIP	23824327
MIRT611629	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT530958	hsa-miR-1264	PAR-CLIP	22012620
MIRT530957	hsa-miR-8063	PAR-CLIP	22012620
MIRT530956	hsa-miR-4698	PAR-CLIP	22012620
MIRT530955	hsa-miR-1228-3p	PAR-CLIP	22012620
MIRT530954	hsa-miR-3691-3p	PAR-CLIP	22012620
MIRT530953	hsa-miR-676-5p	PAR-CLIP	22012620
MIRT530952	hsa-miR-377-3p	PAR-CLIP	22012620
MIRT611638	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611637	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611636	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611635	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611634	hsa-miR-548z	HITS-CLIP	23824327
MIRT611633	hsa-miR-548aa	HITS-CLIP	23824327
MIRT611632	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT611631	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT648501	hsa-miR-8060	HITS-CLIP	23824327
MIRT648500	hsa-miR-7154-5p	HITS-CLIP	23824327
MIRT611629	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611638	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611637	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611636	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611635	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611634	hsa-miR-548z	HITS-CLIP	23824327
MIRT611633	hsa-miR-548aa	HITS-CLIP	23824327
MIRT611632	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT611631	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT611630	hsa-miR-4328	HITS-CLIP	23824327
MIRT648501	hsa-miR-8060	HITS-CLIP	23824327
MIRT648500	hsa-miR-7154-5p	HITS-CLIP	23824327
MIRT611629	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611638	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611637	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611636	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611635	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611634	hsa-miR-548z	HITS-CLIP	23824327
MIRT611633	hsa-miR-548aa	HITS-CLIP	23824327
MIRT611632	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT611631	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT611630	hsa-miR-4328	HITS-CLIP	23824327
MIRT611629	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT611638	hsa-miR-548ac	HITS-CLIP	23824327
MIRT611637	hsa-miR-548bb-3p	HITS-CLIP	23824327
MIRT611636	hsa-miR-548d-3p	HITS-CLIP	23824327
MIRT611635	hsa-miR-548h-3p	HITS-CLIP	23824327
MIRT611634	hsa-miR-548z	HITS-CLIP	23824327
MIRT611633	hsa-miR-548aa	HITS-CLIP	23824327
MIRT611632	hsa-miR-548ap-3p	HITS-CLIP	23824327
MIRT611631	hsa-miR-548t-3p	HITS-CLIP	23824327
MIRT611630	hsa-miR-4328	HITS-CLIP	23824327
MIRT611629	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT530958	hsa-miR-1264	PAR-CLIP	22012620
MIRT530957	hsa-miR-8063	PAR-CLIP	22012620
MIRT530956	hsa-miR-4698	PAR-CLIP	22012620
MIRT530955	hsa-miR-1228-3p	PAR-CLIP	22012620
MIRT530954	hsa-miR-3691-3p	PAR-CLIP	22012620
MIRT530953	hsa-miR-676-5p	PAR-CLIP	22012620
MIRT530952	hsa-miR-377-3p	PAR-CLIP	22012620
MIRT952652	hsa-miR-3672	CLIP-seq
MIRT1548157	hsa-miR-103a	CLIP-seq
MIRT1548158	hsa-miR-107	CLIP-seq
MIRT1548159	hsa-miR-3117-5p	CLIP-seq
MIRT1548160	hsa-miR-3129-3p	CLIP-seq
MIRT1548161	hsa-miR-361-5p	CLIP-seq
MIRT1548162	hsa-miR-425	CLIP-seq
MIRT1548163	hsa-miR-4496	CLIP-seq
MIRT1548164	hsa-miR-4639-5p	CLIP-seq
MIRT1548165	hsa-miR-496	CLIP-seq
MIRT1548166	hsa-miR-656	CLIP-seq
MIRT1548167	hsa-miR-889	CLIP-seq
MIRT1548157	hsa-miR-103a	CLIP-seq
MIRT1548158	hsa-miR-107	CLIP-seq
MIRT2216946	hsa-miR-19a	CLIP-seq
MIRT2216947	hsa-miR-19b	CLIP-seq
MIRT2216948	hsa-miR-2113	CLIP-seq
MIRT2216949	hsa-miR-2116	CLIP-seq
MIRT2216950	hsa-miR-375	CLIP-seq
MIRT2216951	hsa-miR-4273	CLIP-seq
MIRT2216952	hsa-miR-4677-5p	CLIP-seq
MIRT2216953	hsa-miR-4693-3p	CLIP-seq
MIRT1548166	hsa-miR-656	CLIP-seq
MIRT2448668	hsa-miR-3163	CLIP-seq
MIRT2448668	hsa-miR-3163	CLIP-seq
MIRT2465198	hsa-miR-3685	CLIP-seq
MIRT2465199	hsa-miR-384	CLIP-seq
MIRT2521071	hsa-miR-1277	CLIP-seq
MIRT2521072	hsa-miR-137	CLIP-seq
MIRT1548159	hsa-miR-3117-5p	CLIP-seq
MIRT2521073	hsa-miR-3121-3p	CLIP-seq
MIRT1548160	hsa-miR-3129-3p	CLIP-seq
MIRT2521074	hsa-miR-3143	CLIP-seq
MIRT2448668	hsa-miR-3163	CLIP-seq
MIRT1548161	hsa-miR-361-5p	CLIP-seq
MIRT2521075	hsa-miR-3622a-5p	CLIP-seq
MIRT952652	hsa-miR-3672	CLIP-seq
MIRT2521076	hsa-miR-3684	CLIP-seq
MIRT2521077	hsa-miR-3714	CLIP-seq
MIRT2521078	hsa-miR-3978	CLIP-seq
MIRT2521079	hsa-miR-4261	CLIP-seq
MIRT2521080	hsa-miR-4275	CLIP-seq
MIRT2521081	hsa-miR-4423-3p	CLIP-seq
MIRT1548163	hsa-miR-4496	CLIP-seq
MIRT1548164	hsa-miR-4639-5p	CLIP-seq
MIRT2521082	hsa-miR-4645-3p	CLIP-seq
MIRT2521083	hsa-miR-4668-3p	CLIP-seq
MIRT1548165	hsa-miR-496	CLIP-seq
MIRT2521084	hsa-miR-543	CLIP-seq
MIRT2521085	hsa-miR-548ae	CLIP-seq
MIRT2521086	hsa-miR-548aj	CLIP-seq
MIRT2521087	hsa-miR-548am	CLIP-seq
MIRT2521088	hsa-miR-548an	CLIP-seq
MIRT2521089	hsa-miR-548x	CLIP-seq
MIRT2521090	hsa-miR-940	CLIP-seq
MIRT2521091	hsa-miR-944	CLIP-seq
MIRT2521071	hsa-miR-1277	CLIP-seq
MIRT2521072	hsa-miR-137	CLIP-seq
MIRT2521074	hsa-miR-3143	CLIP-seq
MIRT2448668	hsa-miR-3163	CLIP-seq
MIRT1548161	hsa-miR-361-5p	CLIP-seq
MIRT2521075	hsa-miR-3622a-5p	CLIP-seq
MIRT952652	hsa-miR-3672	CLIP-seq
MIRT2521076	hsa-miR-3684	CLIP-seq
MIRT2521077	hsa-miR-3714	CLIP-seq
MIRT2521079	hsa-miR-4261	CLIP-seq
MIRT2521081	hsa-miR-4423-3p	CLIP-seq
MIRT1548164	hsa-miR-4639-5p	CLIP-seq
MIRT2679768	hsa-miR-4640-3p	CLIP-seq
MIRT2521082	hsa-miR-4645-3p	CLIP-seq
MIRT2521083	hsa-miR-4668-3p	CLIP-seq
MIRT2521084	hsa-miR-543	CLIP-seq
MIRT2521085	hsa-miR-548ae	CLIP-seq
MIRT2521086	hsa-miR-548aj	CLIP-seq
MIRT2521087	hsa-miR-548am	CLIP-seq
MIRT2521088	hsa-miR-548an	CLIP-seq
MIRT2521089	hsa-miR-548x	CLIP-seq
MIRT2521090	hsa-miR-940	CLIP-seq

Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005178	Function	Integrin binding	TAS	9420328
GO:0005201	Function	Extracellular matrix structural constituent	RCA	23979707, 27068509, 28327460
GO:0005509	Function	Calcium ion binding	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IBA
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IEA
GO:0031012	Component	Extracellular matrix	HDA	23979707, 27068509, 28327460
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	21362503
GO:1903561	Component	Extracellular vesicle	HDA	24769233

MIM	HGNC	e!Ensembl
606018	3173	ENSG00000164176

O43854

Protein name

EGF-like repeat and discoidin I-like domain-containing protein 3 (Developmentally-regulated endothelial cell locus 1 protein) (Integrin-binding protein DEL1)

Protein function

Promotes adhesion of endothelial cells through interaction with the alpha-v/beta-3 integrin receptor. Inhibits formation of vascular-like structures. May be involved in regulation of vascular morphogenesis of remodeling in embryonic development.

PDB

4D90

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00008	EGF	26 → 58	EGF-like domain	Domain
PF00008	EGF	78 → 115	EGF-like domain	Domain
PF12661	hEGF	128 → 146	Human growth factor-like EGF	Domain
PF00754	F5_F8_type_C	173 → 311	F5/8 type C domain	Domain
PF00754	F5_F8_type_C	334 → 473	F5/8 type C domain	Domain

Sequence

MKRSVAVWLLVGLSLGVPQFGKGDICDPNPCENGGICLPGLADGSFSCECPDGFTDPNCS
SVVEVASDEEEPTSAGPCTPNPCHNGGTCEISEAYRGDTFIGYVCKCPRGFNGIHCQHNI
NECEVEPCKNGGICTDLVANYSCECPGEFMGRNCQYKCSGPLGIEGGIISNQQITASSTH
RALFGLQKWYPYYARLNKKGLINAWTAAENDRWPWIQINLQRKMRVTGVITQGAKRIGSP
EYIKSYKIAYSNDGKTWAMYKVKGTNEDMVFRGNIDNNTPYANSFTPPIKAQYVRLYPQV
CRRHCTLRMELLGCELSGCSEPLGMKSGHIQDYQITASSIFRTLNMDMFTWEPRKARLDK
QGKVNAWTSGHNDQSQWLQVDLLVPTKVTGIITQGAKDFGHVQFVGSYKLAYSNDGEHWT
VYQDEKQRKDKVFQGNFDNDTHRKNVIDPPIYARHIRILPWSWYGRITLRSELLGCTEEE

Sequence length

480

Interactions

View interactions

EDIL3 (EGF like repeats and discoidin domains 3)