Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	1006
Gene name Gene Name - the full gene name approved by the HGNC.	Cadherin 8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	CDH8
Synonyms (NCBI Gene) Gene synonyms aliases	Nbla04261
Chromosome Chromosome number	16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	16q21
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a type II classical cadherin from the cadherin superfamily, integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane

Show/Hide all(216)

miRTarBase ID	miRNA	Experiments	Reference
MIRT708314	hsa-miR-3183	HITS-CLIP	19536157
MIRT708313	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT708312	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT708311	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT613412	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT640161	hsa-miR-4287	HITS-CLIP	19536157
MIRT640160	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT708310	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT613410	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT708309	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT613409	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT708308	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT616315	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT616314	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT609202	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT609201	hsa-miR-4469	HITS-CLIP	23824327
MIRT616313	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT609200	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT609199	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT609198	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT609197	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT609196	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609195	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT609194	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT609193	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT609192	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609191	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT609190	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT609189	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT609202	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT609201	hsa-miR-4469	HITS-CLIP	23824327
MIRT640161	hsa-miR-4287	HITS-CLIP	23824327
MIRT640160	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT609200	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT609199	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT609198	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT609197	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT609196	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609195	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT609194	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT609193	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT609192	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609191	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT609190	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT609189	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT616315	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT616314	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT609202	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT609201	hsa-miR-4469	HITS-CLIP	23824327
MIRT616313	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT609200	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT609199	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT609198	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT609197	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT609196	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609195	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT609194	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT609193	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT609192	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609191	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT609190	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT609189	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT613415	hsa-miR-1470	HITS-CLIP	23824327
MIRT613414	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT613413	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT613412	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT613411	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613410	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613409	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT609195	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT609194	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT609193	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT609192	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT613408	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT609202	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT609201	hsa-miR-4469	HITS-CLIP	23824327
MIRT609200	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT609199	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT609198	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT609197	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT609196	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609195	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT609194	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT609193	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT609192	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609191	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT609190	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT609189	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT708314	hsa-miR-3183	HITS-CLIP	19536157
MIRT708313	hsa-miR-4723-3p	HITS-CLIP	19536157
MIRT708312	hsa-miR-6769b-3p	HITS-CLIP	19536157
MIRT708311	hsa-miR-1304-3p	HITS-CLIP	19536157
MIRT613412	hsa-miR-7113-3p	HITS-CLIP	19536157
MIRT640161	hsa-miR-4287	HITS-CLIP	19536157
MIRT640160	hsa-miR-4685-3p	HITS-CLIP	19536157
MIRT708310	hsa-miR-7110-3p	HITS-CLIP	19536157
MIRT613410	hsa-miR-6817-3p	HITS-CLIP	19536157
MIRT708309	hsa-miR-4713-5p	HITS-CLIP	19536157
MIRT613409	hsa-miR-6867-3p	HITS-CLIP	19536157
MIRT708308	hsa-miR-629-3p	HITS-CLIP	19536157
MIRT616315	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT616314	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT609202	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT609201	hsa-miR-4469	HITS-CLIP	23824327
MIRT616313	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT609200	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT609199	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT609198	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT609197	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT609196	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609195	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT609194	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT609193	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT609192	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609191	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT609190	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT609189	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT609202	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT609201	hsa-miR-4469	HITS-CLIP	23824327
MIRT640161	hsa-miR-4287	HITS-CLIP	23824327
MIRT640160	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT609200	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT609199	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT609198	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT609197	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT609196	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609195	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT609194	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT609193	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT609192	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609191	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT609190	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT609189	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT616315	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT616314	hsa-miR-2276-5p	HITS-CLIP	23824327
MIRT609202	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT609201	hsa-miR-4469	HITS-CLIP	23824327
MIRT616313	hsa-miR-642a-5p	HITS-CLIP	23824327
MIRT609200	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT609199	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT609198	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT609197	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT609196	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609195	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT609194	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT609193	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT609192	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609191	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT609190	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT609189	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT613415	hsa-miR-1470	HITS-CLIP	23824327
MIRT613414	hsa-miR-4667-3p	HITS-CLIP	23824327
MIRT613413	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT613412	hsa-miR-7113-3p	HITS-CLIP	23824327
MIRT613411	hsa-miR-6845-3p	HITS-CLIP	23824327
MIRT613410	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT613409	hsa-miR-6867-3p	HITS-CLIP	23824327
MIRT609195	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT609194	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT609193	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT609192	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT613408	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT609202	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT609201	hsa-miR-4469	HITS-CLIP	23824327
MIRT609200	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT609199	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT609198	hsa-miR-4691-5p	HITS-CLIP	23824327
MIRT609197	hsa-miR-6792-3p	HITS-CLIP	23824327
MIRT609196	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT609195	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT609194	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT609193	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT609192	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT609191	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT609190	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT609189	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT879948	hsa-miR-1276	CLIP-seq
MIRT879949	hsa-miR-25	CLIP-seq
MIRT879950	hsa-miR-32	CLIP-seq
MIRT879951	hsa-miR-338-5p	CLIP-seq
MIRT879952	hsa-miR-33a	CLIP-seq
MIRT879953	hsa-miR-33b	CLIP-seq
MIRT879954	hsa-miR-363	CLIP-seq
MIRT879955	hsa-miR-367	CLIP-seq
MIRT879956	hsa-miR-4270	CLIP-seq
MIRT879957	hsa-miR-4311	CLIP-seq
MIRT879958	hsa-miR-4422	CLIP-seq
MIRT879959	hsa-miR-4441	CLIP-seq
MIRT879960	hsa-miR-4509	CLIP-seq
MIRT879961	hsa-miR-4699-5p	CLIP-seq
MIRT879962	hsa-miR-4744	CLIP-seq
MIRT879963	hsa-miR-4772-5p	CLIP-seq
MIRT879964	hsa-miR-583	CLIP-seq
MIRT879965	hsa-miR-92a	CLIP-seq
MIRT879966	hsa-miR-92b	CLIP-seq
MIRT1960737	hsa-miR-3665	CLIP-seq
MIRT1960738	hsa-miR-657	CLIP-seq
MIRT2197402	hsa-miR-3973	CLIP-seq
MIRT2197403	hsa-miR-4261	CLIP-seq
MIRT2197404	hsa-miR-4433	CLIP-seq
MIRT2197405	hsa-miR-4496	CLIP-seq
MIRT2197406	hsa-miR-4700-3p	CLIP-seq
MIRT2197407	hsa-miR-4719	CLIP-seq
MIRT2197408	hsa-miR-518d-5p	CLIP-seq
MIRT2197409	hsa-miR-519b-5p	CLIP-seq
MIRT2197410	hsa-miR-519c-5p	CLIP-seq
MIRT2197411	hsa-miR-520c-5p	CLIP-seq
MIRT2197412	hsa-miR-526a	CLIP-seq
MIRT2197402	hsa-miR-3973	CLIP-seq
MIRT2197403	hsa-miR-4261	CLIP-seq
MIRT2197404	hsa-miR-4433	CLIP-seq
MIRT2197405	hsa-miR-4496	CLIP-seq
MIRT2197406	hsa-miR-4700-3p	CLIP-seq
MIRT2197407	hsa-miR-4719	CLIP-seq
MIRT2385844	hsa-miR-513b	CLIP-seq
MIRT2427255	hsa-miR-3152-5p	CLIP-seq

Show/Hide all(24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000902	Process	Cell morphogenesis	IBA	21873635
GO:0005509	Function	Calcium ion binding	IBA	21873635
GO:0005886	Component	Plasma membrane	IDA
GO:0005886	Component	Plasma membrane	TAS
GO:0005912	Component	Adherens junction	IBA	21873635
GO:0007043	Process	Cell-cell junction assembly	IBA	21873635
GO:0007155	Process	Cell adhesion	TAS	2059658
GO:0007156	Process	Homophilic cell adhesion via plasma membrane adhesion molecules	IEA
GO:0007275	Process	Multicellular organism development	IBA	21873635
GO:0009409	Process	Response to cold	IEA
GO:0016021	Component	Integral component of membrane	IEA
GO:0016339	Process	Calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules	IBA	21873635
GO:0016342	Component	Catenin complex	IBA	21873635
GO:0034332	Process	Adherens junction organization	IBA	21873635
GO:0034332	Process	Adherens junction organization	TAS
GO:0035249	Process	Synaptic transmission, glutamatergic	IBA	21873635
GO:0042802	Function	Identical protein binding	IEA
GO:0043083	Component	Synaptic cleft	IBA	21873635
GO:0043679	Component	Axon terminus	IBA	21873635
GO:0045296	Function	Cadherin binding	IBA	21873635
GO:0050807	Process	Regulation of synapse organization	IEA
GO:0097060	Component	Synaptic membrane	IEA
GO:0098742	Process	Cell-cell adhesion via plasma-membrane adhesion molecules	IBA	21873635
GO:0098978	Component	Glutamatergic synapse	IEA

MIM	HGNC	e!Ensembl
603008	1767	ENSG00000150394

Protein

UniProt ID

P55286

Protein name

Cadherin-8

Protein function

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00028	Cadherin	67 → 158	Cadherin domain	Domain
PF00028	Cadherin	172 → 267	Cadherin domain	Domain
PF00028	Cadherin	281 → 383	Cadherin domain	Domain
PF00028	Cadherin	396 → 487	Cadherin domain	Domain
PF00028	Cadherin	500 → 597	Cadherin domain	Domain
PF01049	Cadherin_C	645 → 793	Cadherin cytoplasmic region	Family

Tissue specificity

TISSUE SPECIFICITY: Mainly expressed in brain. Found in certain nerve cell lines, such as retinoblasts, glioma cells and neuroblasts.

Sequence

MPERLAEMLLDLWTPLIILWITLPPCIYMAPMNQSQVLMSGSPLELNSLGEEQRILNRSK
RGWVWNQMFVLEEFSGPEPILVGRLHTDLDPGSKKIKYILSGDGAGTIFQINDVTGDIHA
IKRLDREEKAEYTLTAQAVDWETSKPLEPPSEFIIKVQDINDNAPEFLNGPYHATVPEMS
ILGTSVTNVTATDADDPVYGNSAKLVYSILEGQPYFSIEPETAIIKTALPNMDREAKEEY
LVVIQAKDMGGHSGGLSGTTTLTVTLTDVNDNPPKFAQSLYHFSVPEDVVLGTAIGRVKA
NDQDIGENAQSSYDIIDGDGTALFEITSDAQAQDGIIRLRKPLDFETKKSYTLKVEAANV
HIDPRFSGRGPFKDTATVKIVVEDADEPPVFSSPTYLLEVHENAALNSVIGQVTARDPDI
TSSPIRFSIDRHTDLERQFNINADDGKITLATPLDRELSVWHNITIIATEIRNHSQISRV
PVAIKVLDVNDNAPEFASEYEAFLCENGKPGQVIQTVSAMDKDDPKNGHYFLYSLLPEMV
NNPNFTIKKNEDNSLSILAKHNGFNRQKQEVYLLPIIISDSGNPPLSSTSTLTIRVCGCS
NDGVVQSCNVEAYVLPIGLSMGALIAILACIILLLVIVVLFVTLRRHKNEPLIIKDDEDV
RENIIRYDDEGGGEEDTEAFDIATLQNPDGINGFLPRKDIKPDLQFMPRQGLAPVPNGVD
VDEFINVRLHEADNDPTAPPYDSIQIYGYEGRGSVAGSLSSLESTTSDSDQNFDYLSDWG
PRFKRLGELYSVGESDKET

Sequence length

799

Interactions

View interactions

	Reactome
			Adherens junctions interactions

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Parkinson disease	Parkinson Disease	rs33939927, rs35801418, rs34805604, rs35870237, rs34995376, rs74315355, rs28940284, rs74315356, rs74315357, rs28940285, rs730880302, rs750664040, rs74315359, rs74315360, rs45539432 View all (84 more)	21812969

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Major Depressive Disorder		27622933	ClinVar
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Insomnia	Insomnia			GWAS
Oligodendroglioma	Oligodendroglioma			GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining
Autism Spectrum Disorder	Associate	23879678
Autistic Disorder	Associate	20972252, 23575222
Carcinoma Squamous Cell	Associate	28177435
Cysts	Associate	21389276
Learning Disabilities	Associate	20972252
Neoplasms	Inhibit	27651839
Pemphigus	Associate	23505434
Polycystic Kidney Autosomal Dominant	Associate	21389276
Pterygium	Associate	40033254

CDH8 (cadherin 8)