Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10055
Gene name Gene Name - the full gene name approved by the HGNC.	SUMO1 activating enzyme subunit 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	SAE1
Synonyms (NCBI Gene) Gene synonyms aliases	AOS1, HSPC140, SUA1, UBLE1A
Disease Acronyms (UniProt) Disease acronyms from UniProt database	AOS1
Chromosome Chromosome number	19
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	19q13.32
Summary Summary of gene provided in NCBI Entrez Gene.	Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUM

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miRTarBase ID	miRNA	Experiments	Reference
MIRT043603	hsa-miR-151a-3p	CLASH	23622248
MIRT042940	hsa-miR-324-3p	CLASH	23622248
MIRT040267	hsa-miR-615-3p	CLASH	23622248
MIRT036348	hsa-miR-1229-3p	CLASH	23622248
MIRT293793	hsa-miR-6816-3p	PAR-CLIP	21572407
MIRT554505	hsa-miR-4687-5p	PAR-CLIP	21572407
MIRT399446	hsa-miR-6779-3p	PAR-CLIP	21572407
MIRT554504	hsa-miR-129-1-3p	PAR-CLIP	21572407
MIRT554503	hsa-miR-129-2-3p	PAR-CLIP	21572407
MIRT293790	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT293791	hsa-miR-4779	PAR-CLIP	21572407
MIRT399442	hsa-miR-3651	PAR-CLIP	21572407
MIRT554502	hsa-miR-103b	PAR-CLIP	21572407
MIRT399450	hsa-miR-7976	PAR-CLIP	21572407
MIRT554501	hsa-miR-299-5p	PAR-CLIP	21572407
MIRT293782	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT293786	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT293783	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT293784	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT293788	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT293785	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT293792	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT293789	hsa-miR-4266	PAR-CLIP	21572407
MIRT554500	hsa-miR-651-5p	PAR-CLIP	21572407
MIRT735754	hsa-miR-129-5p	Luciferase reporter assay, qRT-PCR	31933971
MIRT293793	hsa-miR-6816-3p	PAR-CLIP	21572407
MIRT554505	hsa-miR-4687-5p	PAR-CLIP	21572407
MIRT399446	hsa-miR-6779-3p	PAR-CLIP	21572407
MIRT554504	hsa-miR-129-1-3p	PAR-CLIP	21572407
MIRT554503	hsa-miR-129-2-3p	PAR-CLIP	21572407
MIRT293790	hsa-miR-4695-5p	PAR-CLIP	21572407
MIRT293791	hsa-miR-4779	PAR-CLIP	21572407
MIRT399442	hsa-miR-3651	PAR-CLIP	21572407
MIRT554502	hsa-miR-103b	PAR-CLIP	21572407
MIRT399450	hsa-miR-7976	PAR-CLIP	21572407
MIRT554501	hsa-miR-299-5p	PAR-CLIP	21572407
MIRT293782	hsa-miR-30a-5p	PAR-CLIP	21572407
MIRT293786	hsa-miR-30b-5p	PAR-CLIP	21572407
MIRT293783	hsa-miR-30c-5p	PAR-CLIP	21572407
MIRT293784	hsa-miR-30d-5p	PAR-CLIP	21572407
MIRT293788	hsa-miR-30e-5p	PAR-CLIP	21572407
MIRT293785	hsa-miR-203a-5p	PAR-CLIP	21572407
MIRT293792	hsa-miR-1273g-5p	PAR-CLIP	21572407
MIRT293789	hsa-miR-4266	PAR-CLIP	21572407
MIRT554500	hsa-miR-651-5p	PAR-CLIP	21572407
MIRT756166	hsa-miR-382-3p	Luciferase reporter assay, Western blotting, qRT-PCR, Immunoprecipitaion (IP), Immunohistochemistry (IHC)	35720620
MIRT1324797	hsa-miR-1254	CLIP-seq
MIRT1324798	hsa-miR-1270	CLIP-seq
MIRT1324799	hsa-miR-1273g	CLIP-seq
MIRT1324800	hsa-miR-1286	CLIP-seq
MIRT1324801	hsa-miR-129-3p	CLIP-seq
MIRT1324802	hsa-miR-134	CLIP-seq
MIRT1324803	hsa-miR-138	CLIP-seq
MIRT1324804	hsa-miR-15a	CLIP-seq
MIRT1324805	hsa-miR-15b	CLIP-seq
MIRT1324806	hsa-miR-16	CLIP-seq
MIRT1324807	hsa-miR-186	CLIP-seq
MIRT1324808	hsa-miR-195	CLIP-seq
MIRT1324809	hsa-miR-203	CLIP-seq
MIRT1324810	hsa-miR-2052	CLIP-seq
MIRT1324811	hsa-miR-2467-3p	CLIP-seq
MIRT1324812	hsa-miR-2861	CLIP-seq
MIRT1324813	hsa-miR-30a	CLIP-seq
MIRT1324814	hsa-miR-30b	CLIP-seq
MIRT1324815	hsa-miR-30c	CLIP-seq
MIRT1324816	hsa-miR-30d	CLIP-seq
MIRT1324817	hsa-miR-30e	CLIP-seq
MIRT1324818	hsa-miR-3116	CLIP-seq
MIRT1324819	hsa-miR-3118	CLIP-seq
MIRT1324820	hsa-miR-3133	CLIP-seq
MIRT1324821	hsa-miR-3140-5p	CLIP-seq
MIRT1324822	hsa-miR-3149	CLIP-seq
MIRT1324823	hsa-miR-3155	CLIP-seq
MIRT1324824	hsa-miR-3155b	CLIP-seq
MIRT1324825	hsa-miR-3164	CLIP-seq
MIRT1324826	hsa-miR-3170	CLIP-seq
MIRT1324827	hsa-miR-3181	CLIP-seq
MIRT1324828	hsa-miR-342-5p	CLIP-seq
MIRT1324829	hsa-miR-3607-5p	CLIP-seq
MIRT1324830	hsa-miR-3622a-3p	CLIP-seq
MIRT1324831	hsa-miR-3622b-3p	CLIP-seq
MIRT1324832	hsa-miR-3675-5p	CLIP-seq
MIRT1324833	hsa-miR-377	CLIP-seq
MIRT1324834	hsa-miR-3919	CLIP-seq
MIRT1324835	hsa-miR-424	CLIP-seq
MIRT1324836	hsa-miR-4254	CLIP-seq
MIRT1324837	hsa-miR-4299	CLIP-seq
MIRT1324838	hsa-miR-4307	CLIP-seq
MIRT1324839	hsa-miR-4328	CLIP-seq
MIRT1324840	hsa-miR-4436b-3p	CLIP-seq
MIRT1324841	hsa-miR-4452	CLIP-seq
MIRT1324842	hsa-miR-4501	CLIP-seq
MIRT1324843	hsa-miR-451b	CLIP-seq
MIRT1324844	hsa-miR-4537	CLIP-seq
MIRT1324845	hsa-miR-4652-3p	CLIP-seq
MIRT1324846	hsa-miR-4664-5p	CLIP-seq
MIRT1324847	hsa-miR-4680-3p	CLIP-seq
MIRT1324848	hsa-miR-4683	CLIP-seq
MIRT1324849	hsa-miR-4684-5p	CLIP-seq
MIRT1324850	hsa-miR-4708-5p	CLIP-seq
MIRT1324851	hsa-miR-4722-5p	CLIP-seq
MIRT1324852	hsa-miR-4731-3p	CLIP-seq
MIRT1324853	hsa-miR-4747-5p	CLIP-seq
MIRT1324854	hsa-miR-4768-5p	CLIP-seq
MIRT1324855	hsa-miR-4773	CLIP-seq
MIRT1324856	hsa-miR-4801	CLIP-seq
MIRT1324857	hsa-miR-484	CLIP-seq
MIRT1324858	hsa-miR-494	CLIP-seq
MIRT1324859	hsa-miR-497	CLIP-seq
MIRT1324860	hsa-miR-500a	CLIP-seq
MIRT1324861	hsa-miR-502-5p	CLIP-seq
MIRT1324862	hsa-miR-548q	CLIP-seq
MIRT1324863	hsa-miR-617	CLIP-seq
MIRT1324864	hsa-miR-620	CLIP-seq
MIRT1324865	hsa-miR-636	CLIP-seq
MIRT1324866	hsa-miR-651	CLIP-seq
MIRT1324867	hsa-miR-661	CLIP-seq
MIRT1324868	hsa-miR-1182	CLIP-seq
MIRT1324869	hsa-miR-1249	CLIP-seq
MIRT1324870	hsa-miR-1287	CLIP-seq
MIRT1324803	hsa-miR-138	CLIP-seq
MIRT1324871	hsa-miR-1539	CLIP-seq
MIRT1324872	hsa-miR-1909	CLIP-seq
MIRT1324873	hsa-miR-200b	CLIP-seq
MIRT1324874	hsa-miR-200c	CLIP-seq
MIRT1324875	hsa-miR-3129-3p	CLIP-seq
MIRT1324876	hsa-miR-3135b	CLIP-seq
MIRT1324822	hsa-miR-3149	CLIP-seq
MIRT1324827	hsa-miR-3181	CLIP-seq
MIRT1324877	hsa-miR-3620	CLIP-seq
MIRT1324878	hsa-miR-3655	CLIP-seq
MIRT1324879	hsa-miR-3914	CLIP-seq
MIRT1324880	hsa-miR-429	CLIP-seq
MIRT1324837	hsa-miR-4299	CLIP-seq
MIRT1324881	hsa-miR-4312	CLIP-seq
MIRT1324882	hsa-miR-4323	CLIP-seq
MIRT1324883	hsa-miR-4691-3p	CLIP-seq
MIRT1324853	hsa-miR-4747-5p	CLIP-seq
MIRT1324884	hsa-miR-488	CLIP-seq
MIRT1324860	hsa-miR-500a	CLIP-seq
MIRT1324885	hsa-miR-512-3p	CLIP-seq
MIRT1324863	hsa-miR-617	CLIP-seq
MIRT1324886	hsa-miR-646	CLIP-seq
MIRT1324887	hsa-miR-873	CLIP-seq
MIRT1324888	hsa-miR-888	CLIP-seq
MIRT2096414	hsa-miR-1207-3p	CLIP-seq
MIRT2096415	hsa-miR-1207-5p	CLIP-seq
MIRT2096416	hsa-miR-1266	CLIP-seq
MIRT1324799	hsa-miR-1273g	CLIP-seq
MIRT1324870	hsa-miR-1287	CLIP-seq
MIRT1324803	hsa-miR-138	CLIP-seq
MIRT2096417	hsa-miR-150	CLIP-seq
MIRT2096418	hsa-miR-1538	CLIP-seq
MIRT1324871	hsa-miR-1539	CLIP-seq
MIRT2096419	hsa-miR-188-3p	CLIP-seq
MIRT1324812	hsa-miR-2861	CLIP-seq
MIRT1324813	hsa-miR-30a	CLIP-seq
MIRT1324814	hsa-miR-30b	CLIP-seq
MIRT1324815	hsa-miR-30c	CLIP-seq
MIRT1324816	hsa-miR-30d	CLIP-seq
MIRT1324817	hsa-miR-30e	CLIP-seq
MIRT1324875	hsa-miR-3129-3p	CLIP-seq
MIRT1324876	hsa-miR-3135b	CLIP-seq
MIRT1324821	hsa-miR-3140-5p	CLIP-seq
MIRT2096420	hsa-miR-3189-5p	CLIP-seq
MIRT1324877	hsa-miR-3620	CLIP-seq
MIRT1324830	hsa-miR-3622a-3p	CLIP-seq
MIRT1324831	hsa-miR-3622b-3p	CLIP-seq
MIRT2096421	hsa-miR-365	CLIP-seq
MIRT1324878	hsa-miR-3655	CLIP-seq
MIRT1324832	hsa-miR-3675-5p	CLIP-seq
MIRT1324833	hsa-miR-377	CLIP-seq
MIRT1324834	hsa-miR-3919	CLIP-seq
MIRT2096422	hsa-miR-3938	CLIP-seq
MIRT2096423	hsa-miR-4293	CLIP-seq
MIRT1324837	hsa-miR-4299	CLIP-seq
MIRT2096424	hsa-miR-4300	CLIP-seq
MIRT2096425	hsa-miR-4446-3p	CLIP-seq
MIRT1324841	hsa-miR-4452	CLIP-seq
MIRT2096426	hsa-miR-4487	CLIP-seq
MIRT2096427	hsa-miR-4492	CLIP-seq
MIRT2096428	hsa-miR-4498	CLIP-seq
MIRT2096429	hsa-miR-4514	CLIP-seq
MIRT2096430	hsa-miR-4518	CLIP-seq
MIRT2096431	hsa-miR-4661-3p	CLIP-seq
MIRT1324847	hsa-miR-4680-3p	CLIP-seq
MIRT1324849	hsa-miR-4684-5p	CLIP-seq
MIRT1324883	hsa-miR-4691-3p	CLIP-seq
MIRT2096432	hsa-miR-4692	CLIP-seq
MIRT2096433	hsa-miR-4713-5p	CLIP-seq
MIRT2096434	hsa-miR-4721	CLIP-seq
MIRT2096435	hsa-miR-4736	CLIP-seq
MIRT2096436	hsa-miR-4745-3p	CLIP-seq
MIRT2096437	hsa-miR-4747-3p	CLIP-seq
MIRT1324853	hsa-miR-4747-5p	CLIP-seq
MIRT2096438	hsa-miR-4758-3p	CLIP-seq
MIRT2096439	hsa-miR-4763-3p	CLIP-seq
MIRT1324854	hsa-miR-4768-5p	CLIP-seq
MIRT1324855	hsa-miR-4773	CLIP-seq
MIRT1324860	hsa-miR-500a	CLIP-seq
MIRT2096440	hsa-miR-510	CLIP-seq
MIRT1324885	hsa-miR-512-3p	CLIP-seq
MIRT2096441	hsa-miR-532-3p	CLIP-seq
MIRT1324862	hsa-miR-548q	CLIP-seq
MIRT2096442	hsa-miR-582-3p	CLIP-seq
MIRT1324886	hsa-miR-646	CLIP-seq
MIRT1324866	hsa-miR-651	CLIP-seq
MIRT1324867	hsa-miR-661	CLIP-seq
MIRT2096443	hsa-miR-762	CLIP-seq
MIRT2096444	hsa-miR-920	CLIP-seq
MIRT2096445	hsa-miR-939	CLIP-seq
MIRT1324868	hsa-miR-1182	CLIP-seq
MIRT2096415	hsa-miR-1207-5p	CLIP-seq
MIRT2320613	hsa-miR-1238	CLIP-seq
MIRT2096416	hsa-miR-1266	CLIP-seq
MIRT1324799	hsa-miR-1273g	CLIP-seq
MIRT1324801	hsa-miR-129-3p	CLIP-seq
MIRT2096417	hsa-miR-150	CLIP-seq
MIRT2096418	hsa-miR-1538	CLIP-seq
MIRT2096419	hsa-miR-188-3p	CLIP-seq
MIRT1324809	hsa-miR-203	CLIP-seq
MIRT2320614	hsa-miR-2115	CLIP-seq
MIRT2320615	hsa-miR-218	CLIP-seq
MIRT1324813	hsa-miR-30a	CLIP-seq
MIRT1324814	hsa-miR-30b	CLIP-seq
MIRT1324815	hsa-miR-30c	CLIP-seq
MIRT1324816	hsa-miR-30d	CLIP-seq
MIRT1324817	hsa-miR-30e	CLIP-seq
MIRT2320616	hsa-miR-3120-5p	CLIP-seq
MIRT1324825	hsa-miR-3164	CLIP-seq
MIRT2320617	hsa-miR-3183	CLIP-seq
MIRT2096420	hsa-miR-3189-5p	CLIP-seq
MIRT2320618	hsa-miR-323b-3p	CLIP-seq
MIRT2320619	hsa-miR-3647-3p	CLIP-seq
MIRT2096421	hsa-miR-365	CLIP-seq
MIRT2320620	hsa-miR-3663-5p	CLIP-seq
MIRT2320621	hsa-miR-371-5p	CLIP-seq
MIRT2320622	hsa-miR-371b-5p	CLIP-seq
MIRT1324834	hsa-miR-3919	CLIP-seq
MIRT2320623	hsa-miR-3921	CLIP-seq
MIRT2096424	hsa-miR-4300	CLIP-seq
MIRT1324838	hsa-miR-4307	CLIP-seq
MIRT2320624	hsa-miR-432	CLIP-seq
MIRT2320625	hsa-miR-4421	CLIP-seq
MIRT1324840	hsa-miR-4436b-3p	CLIP-seq
MIRT2320626	hsa-miR-4436b-5p	CLIP-seq
MIRT2096425	hsa-miR-4446-3p	CLIP-seq
MIRT2096426	hsa-miR-4487	CLIP-seq
MIRT2096427	hsa-miR-4492	CLIP-seq
MIRT2096428	hsa-miR-4498	CLIP-seq
MIRT1324842	hsa-miR-4501	CLIP-seq
MIRT2096430	hsa-miR-4518	CLIP-seq
MIRT2320627	hsa-miR-4521	CLIP-seq
MIRT2320628	hsa-miR-4539	CLIP-seq
MIRT2320629	hsa-miR-4633-3p	CLIP-seq
MIRT2320630	hsa-miR-4653-5p	CLIP-seq
MIRT2320631	hsa-miR-4682	CLIP-seq
MIRT2096433	hsa-miR-4713-5p	CLIP-seq
MIRT2096434	hsa-miR-4721	CLIP-seq
MIRT2320632	hsa-miR-4723-3p	CLIP-seq
MIRT2096435	hsa-miR-4736	CLIP-seq
MIRT2096436	hsa-miR-4745-3p	CLIP-seq
MIRT2096437	hsa-miR-4747-3p	CLIP-seq
MIRT2096438	hsa-miR-4758-3p	CLIP-seq
MIRT2096439	hsa-miR-4763-3p	CLIP-seq
MIRT2320633	hsa-miR-4765	CLIP-seq
MIRT1324858	hsa-miR-494	CLIP-seq
MIRT2096440	hsa-miR-510	CLIP-seq
MIRT2320634	hsa-miR-513b	CLIP-seq
MIRT2320635	hsa-miR-516a-3p	CLIP-seq
MIRT2096441	hsa-miR-532-3p	CLIP-seq
MIRT1324865	hsa-miR-636	CLIP-seq
MIRT1324866	hsa-miR-651	CLIP-seq
MIRT2096443	hsa-miR-762	CLIP-seq
MIRT2320636	hsa-miR-890	CLIP-seq
MIRT2096444	hsa-miR-920	CLIP-seq
MIRT2096445	hsa-miR-939	CLIP-seq
MIRT2096415	hsa-miR-1207-5p	CLIP-seq
MIRT2096416	hsa-miR-1266	CLIP-seq
MIRT1324870	hsa-miR-1287	CLIP-seq
MIRT2096418	hsa-miR-1538	CLIP-seq
MIRT1324876	hsa-miR-3135b	CLIP-seq
MIRT2096423	hsa-miR-4293	CLIP-seq
MIRT2096424	hsa-miR-4300	CLIP-seq
MIRT2096426	hsa-miR-4487	CLIP-seq
MIRT2096429	hsa-miR-4514	CLIP-seq
MIRT2096430	hsa-miR-4518	CLIP-seq
MIRT2096432	hsa-miR-4692	CLIP-seq
MIRT2096435	hsa-miR-4736	CLIP-seq
MIRT2096436	hsa-miR-4745-3p	CLIP-seq
MIRT2096437	hsa-miR-4747-3p	CLIP-seq
MIRT2096439	hsa-miR-4763-3p	CLIP-seq
MIRT2096440	hsa-miR-510	CLIP-seq
MIRT1324885	hsa-miR-512-3p	CLIP-seq
MIRT2096444	hsa-miR-920	CLIP-seq
MIRT2096445	hsa-miR-939	CLIP-seq
MIRT1324800	hsa-miR-1286	CLIP-seq
MIRT1324803	hsa-miR-138	CLIP-seq
MIRT1324871	hsa-miR-1539	CLIP-seq
MIRT1324804	hsa-miR-15a	CLIP-seq
MIRT1324805	hsa-miR-15b	CLIP-seq
MIRT1324806	hsa-miR-16	CLIP-seq
MIRT1324808	hsa-miR-195	CLIP-seq
MIRT1324810	hsa-miR-2052	CLIP-seq
MIRT1324822	hsa-miR-3149	CLIP-seq
MIRT1324827	hsa-miR-3181	CLIP-seq
MIRT1324877	hsa-miR-3620	CLIP-seq
MIRT1324878	hsa-miR-3655	CLIP-seq
MIRT1324835	hsa-miR-424	CLIP-seq
MIRT1324837	hsa-miR-4299	CLIP-seq
MIRT1324838	hsa-miR-4307	CLIP-seq
MIRT1324851	hsa-miR-4722-5p	CLIP-seq
MIRT1324853	hsa-miR-4747-5p	CLIP-seq
MIRT1324859	hsa-miR-497	CLIP-seq
MIRT1324863	hsa-miR-617	CLIP-seq
MIRT1324886	hsa-miR-646	CLIP-seq
MIRT1324800	hsa-miR-1286	CLIP-seq
MIRT1324803	hsa-miR-138	CLIP-seq
MIRT1324871	hsa-miR-1539	CLIP-seq
MIRT1324804	hsa-miR-15a	CLIP-seq
MIRT1324805	hsa-miR-15b	CLIP-seq
MIRT1324806	hsa-miR-16	CLIP-seq
MIRT1324808	hsa-miR-195	CLIP-seq
MIRT1324810	hsa-miR-2052	CLIP-seq
MIRT1324822	hsa-miR-3149	CLIP-seq
MIRT1324827	hsa-miR-3181	CLIP-seq
MIRT1324877	hsa-miR-3620	CLIP-seq
MIRT1324878	hsa-miR-3655	CLIP-seq
MIRT1324835	hsa-miR-424	CLIP-seq
MIRT1324837	hsa-miR-4299	CLIP-seq
MIRT1324838	hsa-miR-4307	CLIP-seq
MIRT1324851	hsa-miR-4722-5p	CLIP-seq
MIRT1324853	hsa-miR-4747-5p	CLIP-seq
MIRT1324859	hsa-miR-497	CLIP-seq
MIRT1324863	hsa-miR-617	CLIP-seq
MIRT1324886	hsa-miR-646	CLIP-seq

Show/Hide all(25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004839	Function	Ubiquitin activating enzyme activity	TAS	10187858
GO:0005515	Function	Protein binding	IPI	10187858, 15660128, 16189514, 20164921, 26496610, 28514442, 31515488, 32296183
GO:0005634	Component	Nucleus	HDA	16791210
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0008022	Function	Protein C-terminus binding	IDA	10187858
GO:0008047	Function	Enzyme activator activity	TAS	9920803
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016925	Process	Protein sumoylation	IBA	21873635
GO:0016925	Process	Protein sumoylation	IDA	15660128, 20164921
GO:0016925	Process	Protein sumoylation	IEA
GO:0016925	Process	Protein sumoylation	IMP	21968017
GO:0016925	Process	Protein sumoylation	TAS
GO:0018215	Process	Protein phosphopantetheinylation	IEA
GO:0019948	Function	SUMO activating enzyme activity	IDA	10187858, 20164921
GO:0031510	Component	SUMO activating enzyme complex	IBA	21873635
GO:0031510	Component	SUMO activating enzyme complex	IDA	10187858, 15660128, 20164921
GO:0032446	Process	Protein modification by small protein conjugation	IBA	21873635
GO:0033235	Process	Positive regulation of protein sumoylation	IDA	10187858
GO:0043008	Function	ATP-dependent protein binding	IDA	10187858
GO:0044388	Function	Small protein activating enzyme binding	IPI	15660128
GO:0046982	Function	Protein heterodimerization activity	IPI	20164921
GO:0050790	Process	Regulation of catalytic activity	IEA
GO:1903955	Process	Positive regulation of protein targeting to mitochondrion	HMP	24270810

MIM	HGNC	e!Ensembl
613294	30660	ENSG00000142230

Protein

UniProt ID

Q9UBE0

Protein name

SUMO-activating enzyme subunit 1 (Ubiquitin-like 1-activating enzyme E1A) [Cleaved into: SUMO-activating enzyme subunit 1, N-terminally processed]

Protein function

The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue

PDB

1Y8Q , 1Y8R , 3KYC , 3KYD , 6CWY , 6CWZ , 6XOG , 6XOH , 6XOI , 8VY5

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00899	ThiF	19 → 340	ThiF family	Domain

Tissue specificity

TISSUE SPECIFICITY: Expression level increases during S phase and drops in G2 phase (at protein level). {ECO:0000269|PubMed:11481243}.

Sequence

MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK

Sequence length

346

Interactions

View interactions

	KEGG		Reactome
	Ubiquitin mediated proteolysis		SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9)

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Multiple sclerosis	Multiple Sclerosis	rs104895219, rs483353022, rs483353023, rs483353028, rs483353029, rs483353024, rs483353030, rs3207617, rs483353031, rs483353032, rs483353033, rs483353034, rs483353035, rs483353036, rs483353039 View all (4 more)	21833088, 26920376

Show/Hide Unknown Diseases (2)

Disease term	Disease name	Source
Unknown
Multiple Sclerosis	Multiple Sclerosis	GWAS
Alzheimer disease	Alzheimer disease	GWAS

Show/Hide Text Mining Associations (13)

Disease Name	Relationship Type	References
Associations from Text Mining
Autism Spectrum Disorder	Associate	23275889
Breast Neoplasms	Associate	39742381
Carcinoma Hepatocellular	Associate	33477333, 36748193
Carcinoma Non Small Cell Lung	Associate	35606717
Cholangiocarcinoma	Associate	37705041
Glioma	Associate	19544381
Glioma	Stimulate	33477333
Lymphatic Metastasis	Associate	39742381
Neoplasm Metastasis	Associate	39742381
Neoplasms	Associate	19544381, 33477333, 39742381
Oncogene Addiction	Stimulate	33477333
Pancreatic Neoplasms	Stimulate	40302186
Skin Diseases	Associate	30140893

SAE1 (SUMO1 activating enzyme subunit 1)