Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
10052
Gene name Gene Name - the full gene name approved by the HGNC.
Gap junction protein gamma 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GJC1
Synonyms (NCBI Gene) Gene synonyms aliases
CX45, GJA7
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q21.31
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alte
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT025645 hsa-miR-7-5p Microarray 19073608
MIRT037775 hsa-miR-671-3p CLASH 23622248
MIRT053733 hsa-miR-630 Microarray 22942087
MIRT1019851 hsa-miR-122 CLIP-seq
MIRT1019852 hsa-miR-1256 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001570 Process Vasculogenesis IEA
GO:0005216 Function Ion channel activity IEA
GO:0005243 Function Gap junction channel activity IBA 21873635
GO:0005515 Function Protein binding IPI 32296183
GO:0005789 Component Endoplasmic reticulum membrane TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608655 4280 ENSG00000182963
Protein
UniProt ID P36383
Protein name Gap junction gamma-1 protein (Connexin-45) (Cx45) (Gap junction alpha-7 protein)
Protein function One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
PDB 3SHW
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00029 Connexin 2 255 Connexin Family
Sequence
Sequence length 396
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Electric Transmission Across Gap Junctions
Gap junction assembly
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Hypertension Hypertensive disease rs13306026 19109587
Unknown
Disease term Disease name Evidence References Source
Oligodendroglioma Oligodendroglioma GWAS
Associations from Text Mining
Disease Name Relationship Type References
Brain Ischemia Associate 19794823
Colorectal Neoplasms Inhibit 21406965
Colorectal Neoplasms Associate 21636702
Dysferlinopathy Associate 27229680
Hereditary leiomyomatosis and renal cell cancer Associate 11379007
Inflammation Associate 25529637
Leukemia Myeloid Acute Associate 25529637
Myocardial Ischemia Associate 19794823
Nephrosis congenital Associate 32471989, 33172216
Osteoarthritis Stimulate 23416160