Gene Gene information from NCBI Gene database.
Entrez ID 100507436
Gene name MHC class I polypeptide-related sequence A
Gene symbol MICA
Synonyms (NCBI Gene)
MIC-APERB11.1
Chromosome 6
Chromosome location 6p21.33
Summary This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglo
miRNA miRNA information provided by mirtarbase database.
556
miRTarBase ID miRNA Experiments Reference
MIRT001998 hcmv-miR-UL112-3p Luciferase reporter assay 17641203
MIRT004677 hsa-miR-520b flowLuciferase reporter assayqRT-PCR 19109132
MIRT004677 hsa-miR-520b flowLuciferase reporter assayqRT-PCR 19109132
MIRT002551 hsa-miR-373-3p Microarray 15685193
MIRT054070 hsa-miR-302c-3p 5.0 23820258
Transcription factors Transcription factors information provided by TRRUST V2 database.
7
Transcription factor Regulation Reference
HDAC1 Unknown 17625602
HIF1A Activation 21092233
HSF1 Activation 19139882
NFKB1 Unknown 15494508
RELA Unknown 15494508
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
36
GO ID Ontology Definition Evidence Reference
GO:0001913 Process T cell mediated cytotoxicity IDA 10426993
GO:0002250 Process Adaptive immune response IEA
GO:0002376 Process Immune system process IEA
GO:0002418 Process Immune response to tumor cell IDA 10359807
GO:0005515 Function Protein binding IPI 11323699, 21712812
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600169 7090 ENSG00000204520
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q29983
Protein name MHC class I polypeptide-related sequence A (MIC-A)
Protein function Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells (PubMed:11491531, PubMe
PDB 1B3J , 1HYR , 7FI5 , 7FI6 , 7FI7 , 7FI8 , 7FI9 , 8TLZ , 8TM0 , 8TM2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00129 MHC_I 24 200 Class I Histocompatibility antigen, domains alpha 1 and 2 Domain
PF07654 C1-set 208 289 Immunoglobulin C1-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's
Sequence
Sequence length 383
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Natural killer cell mediated cytotoxicity
Kaposi sarcoma-associated herpesvirus infection
  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
15
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Adrenocortical carcinoma, hereditary Likely benign rs181430930 RCV005927434
Chronic lymphocytic leukemia/small lymphocytic lymphoma Likely benign rs181430930 RCV005927445
Clear cell carcinoma of kidney Likely benign rs181430930 RCV005927435
Colon adenocarcinoma Likely benign rs181430930 RCV005927432
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Addison Disease Associate 19820007, 24614117
Agranulocytosis Associate 26070312, 27157822
Alopecia Areata Associate 16417220
AMR Syndrome Associate 21199204
Arthritis Juvenile Associate 37741520
Arthritis Psoriatic Associate 30177859
Arthritis Rheumatoid Associate 11407684, 12878725, 14730600, 19409079, 32123296, 32831971
Asthma Associate 27439200
Atherosclerosis Associate 22170063
Autoimmune Diseases Associate 15055739, 16178876, 16417220, 19662431, 21506888, 36958849