Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
100507436
Gene name Gene Name - the full gene name approved by the HGNC.
MHC class I polypeptide-related sequence A
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
MICA
Synonyms (NCBI Gene) Gene synonyms aliases
MIC-A, PERB11.1
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.33
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglo
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT001998 hcmv-miR-UL112-3p Luciferase reporter assay 17641203
MIRT004677 hsa-miR-520b flow, Luciferase reporter assay, qRT-PCR 19109132
MIRT004677 hsa-miR-520b flow, Luciferase reporter assay, qRT-PCR 19109132
MIRT002551 hsa-miR-373-3p Microarray 15685193
MIRT054070 hsa-miR-302c-3p 5.0 23820258
Transcription factors
Transcription factor Regulation Reference
HDAC1 Unknown 17625602
HIF1A Activation 21092233
HSF1 Activation 19139882
NFKB1 Unknown 15494508
RELA Unknown 15494508
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001913 Process T cell mediated cytotoxicity IDA 10426993
GO:0002418 Process Immune response to tumor cell IDA 10359807
GO:0005515 Function Protein binding IPI 11323699, 21712812
GO:0005615 Component Extracellular space IBA 21873635
GO:0005615 Component Extracellular space IDA 18676862
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
600169 7090 ENSG00000204520
Protein
UniProt ID Q29983
Protein name MHC class I polypeptide-related sequence A (MIC-A)
Protein function Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells (PubMed:11491531, PubMe
PDB 1B3J , 1HYR , 7FI5 , 7FI6 , 7FI7 , 7FI8 , 7FI9 , 8TLZ , 8TM0 , 8TM2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00129 MHC_I 24 200 Class I Histocompatibility antigen, domains alpha 1 and 2 Domain
PF07654 C1-set 208 289 Immunoglobulin C1-set domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed with the exception of the central nervous system where it is absent. Expressed predominantly in gastric epithelium and also in monocytes, keratinocytes, endothelial cells, fibroblasts and in the outer layer of Hassal's
Sequence
Sequence length 383
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Natural killer cell mediated cytotoxicity
Kaposi sarcoma-associated herpesvirus infection
  Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Behcet syndrome Behcet Syndrome rs886040969, rs886039866, rs746055479, rs752615209, rs774164456, rs751454741 23041938
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
17632545
Rheumatoid arthritis Rheumatoid Arthritis rs587776843 21653640, 19503088, 21156761
Unknown
Disease term Disease name Evidence References Source
Cervical Cancer Cervical Cancer Our screens identified 10 miRNAs that enhance fitness of HeLa cells and have been reported to be up-regulated in cervical cancer (Table2). GWAS, CBGDA
Ankylosing Spondylitis Ankylosing Spondylitis GWAS
Asthma Asthma GWAS
Allergic Sensitization Allergic Sensitization GWAS
Associations from Text Mining
Disease Name Relationship Type References
Addison Disease Associate 19820007, 24614117
Agranulocytosis Associate 26070312, 27157822
Alopecia Areata Associate 16417220
AMR Syndrome Associate 21199204
Arthritis Juvenile Associate 37741520
Arthritis Psoriatic Associate 30177859
Arthritis Rheumatoid Associate 11407684, 12878725, 14730600, 19409079, 32123296, 32831971
Asthma Associate 27439200
Atherosclerosis Associate 22170063
Autoimmune Diseases Associate 15055739, 16178876, 16417220, 19662431, 21506888, 36958849