IQCJ-SCHIP1 (IQCJ-SCHIP1 readthrough)

Gene

• Entrez ID: 100505385
• Gene name: IQCJ-SCHIP1 readthrough
• Gene symbol: IQCJ-SCHIP1
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3q25.32-q25.33
• Summary: This locus represents naturally occurring read-through transcription from the neighboring IQ motif containing J (IQCJ) and schwannomin interacting protein 1 (SCHIP1) genes. Alternative splicing results in multiple transcript variants that are composed of

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1069698	hsa-miR-181a	CLIP-seq
MIRT1069699	hsa-miR-181b	CLIP-seq
MIRT1069700	hsa-miR-181c	CLIP-seq
MIRT1069701	hsa-miR-181d	CLIP-seq
MIRT1069702	hsa-miR-196a	CLIP-seq
MIRT1069703	hsa-miR-196b	CLIP-seq
MIRT1069704	hsa-miR-4262	CLIP-seq
MIRT1069705	hsa-miR-4698	CLIP-seq
MIRT1069706	hsa-miR-4719	CLIP-seq
MIRT1069707	hsa-miR-505	CLIP-seq
MIRT1069708	hsa-miR-513b	CLIP-seq
MIRT1069709	hsa-miR-543	CLIP-seq
MIRT1069710	hsa-miR-129-5p	CLIP-seq
MIRT1069711	hsa-miR-1827	CLIP-seq
MIRT1069712	hsa-miR-940	CLIP-seq
MIRT1550179	hsa-miR-139-5p	CLIP-seq
MIRT1069711	hsa-miR-1827	CLIP-seq
MIRT1550180	hsa-miR-4277	CLIP-seq
MIRT1550181	hsa-miR-4659a-3p	CLIP-seq
MIRT1550182	hsa-miR-4659b-3p	CLIP-seq
MIRT1550183	hsa-miR-4778-3p	CLIP-seq
MIRT1550184	hsa-miR-548a-3p	CLIP-seq
MIRT1550185	hsa-miR-548e	CLIP-seq
MIRT1550186	hsa-miR-548f	CLIP-seq
MIRT1550187	hsa-miR-582-5p	CLIP-seq
MIRT1069712	hsa-miR-940	CLIP-seq
MIRT2017159	hsa-miR-200b	CLIP-seq
MIRT2017160	hsa-miR-200c	CLIP-seq
MIRT2017161	hsa-miR-3153	CLIP-seq
MIRT2017162	hsa-miR-429	CLIP-seq
MIRT2017163	hsa-miR-452	CLIP-seq
MIRT2017164	hsa-miR-4668-5p	CLIP-seq
MIRT2017165	hsa-miR-4676-3p	CLIP-seq
MIRT2249125	hsa-miR-4729	CLIP-seq
MIRT1069710	hsa-miR-129-5p	CLIP-seq
MIRT1069711	hsa-miR-1827	CLIP-seq
MIRT1069712	hsa-miR-940	CLIP-seq
MIRT1550184	hsa-miR-548a-3p	CLIP-seq
MIRT1550185	hsa-miR-548e	CLIP-seq
MIRT1550186	hsa-miR-548f	CLIP-seq
MIRT2552706	hsa-miR-140-3p	CLIP-seq
MIRT2552707	hsa-miR-141	CLIP-seq
MIRT2552708	hsa-miR-200a	CLIP-seq
MIRT2552709	hsa-miR-2117	CLIP-seq
MIRT2552710	hsa-miR-3145-3p	CLIP-seq
MIRT2552711	hsa-miR-326	CLIP-seq
MIRT2552712	hsa-miR-330-5p	CLIP-seq
MIRT2552713	hsa-miR-4273	CLIP-seq
MIRT2552714	hsa-miR-4310	CLIP-seq
MIRT2552715	hsa-miR-4453	CLIP-seq
MIRT2552716	hsa-miR-4538	CLIP-seq
MIRT2552717	hsa-miR-4677-5p	CLIP-seq
MIRT2552718	hsa-miR-4766-3p	CLIP-seq
MIRT2552719	hsa-miR-544	CLIP-seq
MIRT2552720	hsa-miR-548p	CLIP-seq
MIRT2552706	hsa-miR-140-3p	CLIP-seq
MIRT2552707	hsa-miR-141	CLIP-seq
MIRT2552708	hsa-miR-200a	CLIP-seq
MIRT2552710	hsa-miR-3145-3p	CLIP-seq
MIRT2552714	hsa-miR-4310	CLIP-seq
MIRT2552718	hsa-miR-4766-3p	CLIP-seq
MIRT2552719	hsa-miR-544	CLIP-seq
MIRT2552720	hsa-miR-548p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25950943
GO:0005737	Component	Cytoplasm	IEA
GO:0005886	Component	Plasma membrane	IBA	21873635
GO:0030054	Component	Cell junction	IBA	21873635
GO:0035332	Process	Positive regulation of hippo signaling	IBA	21873635
GO:0043194	Component	Axon initial segment	ISS
GO:0051494	Process	Negative regulation of cytoskeleton organization	IMP	25950943

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: B3KU38
• Protein name: IQCJ-SCHIP1 readthrough transcript protein
• Protein function: May play a role in action potential conduction in myelinated cells through the organization of molecular complexes at nodes of Ranvier and axon initial segments (PubMed:25950943). May also play a role in axon outgrowth and guidance (By similarit
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15157	IQCJ-SCHIP1	4 → 146	Fusion protein IQCJ-SCHIP1 with IQ-like motif	Family
  PF10148	SCHIP-1	331 → 560	Schwannomin-interacting protein 1	Family

• Tissue specificity: TISSUE SPECIFICITY: Highly expressed in brain and to a lower extent in heart and kidney. {ECO:0000269|PubMed:17045569}.
• Sequence:

  MRLEELKRLQNPLEQVNDGKYSFENHQLAMDAENNIEKYPLNLQPLESKVKIIQRAWREY
  LQRQEPLGKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGSDAGSSSSSSRAS
  SQSNSTKVTPCSECKSSSSPGGSLDLVSALEDYEEPFPVYQKKVIDEWAPEEDGEEEEEE
  DERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNGNLHQHDPQDLRHNG
  NVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAGGLCLQPPDGGTCVPEEPPVPPMDW
  EALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSK
  SGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDT
  TEEESESLDDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEKQNRKKSPVADLLPHMPH
  ISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIESLNEELVQLLLIRDELHTEQDAMLV
  DIEDLTRHAESQQKHMAEKMPAK

• Sequence length: 563

Associated diseases

Unknown
Disease term	Disease name	Evidence	References	Source
Asthma	Childhood asthma		30373671	ClinVar