Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	10043
Gene name Gene Name - the full gene name approved by the HGNC.	Target of myb1 membrane trafficking protein
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TOM1
Synonyms (NCBI Gene) Gene synonyms aliases	IMD85
Disease Acronyms (UniProt) Disease acronyms from UniProt database	IMD85
Chromosome Chromosome number	22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	22q12.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. S

Show/Hide all(107)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000967	hsa-miR-126-3p	Luciferase reporter assay	18834857
MIRT000967	hsa-miR-126-3p	Luciferase reporter assay, qRT-PCR, Western blot	20083669
MIRT000967	hsa-miR-126-3p	Reporter assay;Western blot	20083669
MIRT028407	hsa-miR-30a-5p	Proteomics	18668040
MIRT046596	hsa-miR-222-3p	CLASH	23622248
MIRT000967	hsa-miR-126-3p	Microarray, qRT-PCR	22815788
MIRT437630	hsa-miR-150-5p	Microarray, qRT-PCR	22815788
MIRT437740	hsa-miR-34a-5p	Microarray, qRT-PCR	22815788
MIRT720989	hsa-miR-6858-3p	HITS-CLIP	19536157
MIRT720988	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT720987	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT720986	hsa-miR-3194-5p	HITS-CLIP	19536157
MIRT720985	hsa-miR-214-5p	HITS-CLIP	19536157
MIRT716272	hsa-miR-1296-3p	HITS-CLIP	19536157
MIRT716271	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT716270	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT716269	hsa-miR-6801-3p	HITS-CLIP	19536157
MIRT716268	hsa-miR-6810-3p	HITS-CLIP	19536157
MIRT716267	hsa-miR-331-3p	HITS-CLIP	19536157
MIRT716266	hsa-miR-345-3p	HITS-CLIP	19536157
MIRT716265	hsa-miR-4786-3p	HITS-CLIP	19536157
MIRT716264	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT716263	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT716262	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT716261	hsa-miR-6762-5p	HITS-CLIP	19536157
MIRT716260	hsa-miR-6845-5p	HITS-CLIP	19536157
MIRT716259	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT716258	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT716257	hsa-miR-3151-5p	HITS-CLIP	19536157
MIRT716256	hsa-miR-7843-3p	HITS-CLIP	19536157
MIRT716255	hsa-miR-1227-5p	HITS-CLIP	19536157
MIRT720989	hsa-miR-6858-3p	HITS-CLIP	19536157
MIRT720988	hsa-miR-6849-3p	HITS-CLIP	19536157
MIRT720987	hsa-miR-6748-3p	HITS-CLIP	19536157
MIRT720986	hsa-miR-3194-5p	HITS-CLIP	19536157
MIRT720985	hsa-miR-214-5p	HITS-CLIP	19536157
MIRT716272	hsa-miR-1296-3p	HITS-CLIP	19536157
MIRT716271	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT716270	hsa-miR-338-3p	HITS-CLIP	19536157
MIRT716269	hsa-miR-6801-3p	HITS-CLIP	19536157
MIRT716268	hsa-miR-6810-3p	HITS-CLIP	19536157
MIRT716267	hsa-miR-331-3p	HITS-CLIP	19536157
MIRT716266	hsa-miR-345-3p	HITS-CLIP	19536157
MIRT716265	hsa-miR-4786-3p	HITS-CLIP	19536157
MIRT716264	hsa-miR-324-5p	HITS-CLIP	19536157
MIRT716263	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT716262	hsa-miR-296-5p	HITS-CLIP	19536157
MIRT716261	hsa-miR-6762-5p	HITS-CLIP	19536157
MIRT716260	hsa-miR-6845-5p	HITS-CLIP	19536157
MIRT716259	hsa-miR-128-1-5p	HITS-CLIP	19536157
MIRT716258	hsa-miR-128-2-5p	HITS-CLIP	19536157
MIRT716257	hsa-miR-3151-5p	HITS-CLIP	19536157
MIRT716256	hsa-miR-7843-3p	HITS-CLIP	19536157
MIRT716255	hsa-miR-1227-5p	HITS-CLIP	19536157
MIRT1446243	hsa-miR-1252	CLIP-seq
MIRT1446244	hsa-miR-2392	CLIP-seq
MIRT1446245	hsa-miR-3125	CLIP-seq
MIRT1446246	hsa-miR-3616-3p	CLIP-seq
MIRT1446247	hsa-miR-3916	CLIP-seq
MIRT1446248	hsa-miR-4428	CLIP-seq
MIRT1446249	hsa-miR-4476	CLIP-seq
MIRT1446250	hsa-miR-4533	CLIP-seq
MIRT1446251	hsa-miR-4534	CLIP-seq
MIRT1446252	hsa-miR-4802-5p	CLIP-seq
MIRT2133407	hsa-miR-1184	CLIP-seq
MIRT2133408	hsa-miR-1827	CLIP-seq
MIRT2133409	hsa-miR-2278	CLIP-seq
MIRT2133410	hsa-miR-3153	CLIP-seq
MIRT2133411	hsa-miR-3156-3p	CLIP-seq
MIRT2133412	hsa-miR-3173-3p	CLIP-seq
MIRT2133413	hsa-miR-361-3p	CLIP-seq
MIRT2133414	hsa-miR-4301	CLIP-seq
MIRT2133415	hsa-miR-4418	CLIP-seq
MIRT2133416	hsa-miR-509-3-5p	CLIP-seq
MIRT2133417	hsa-miR-509-5p	CLIP-seq
MIRT2354599	hsa-miR-1207-3p	CLIP-seq
MIRT2354600	hsa-miR-4691-3p	CLIP-seq
MIRT2354601	hsa-miR-4731-5p	CLIP-seq
MIRT2133408	hsa-miR-1827	CLIP-seq
MIRT2133409	hsa-miR-2278	CLIP-seq
MIRT2133412	hsa-miR-3173-3p	CLIP-seq
MIRT2396200	hsa-miR-3612	CLIP-seq
MIRT2396201	hsa-miR-4695-5p	CLIP-seq
MIRT2396202	hsa-miR-650	CLIP-seq
MIRT2693856	hsa-miR-1203	CLIP-seq
MIRT2693857	hsa-miR-1538	CLIP-seq
MIRT2693858	hsa-miR-3179	CLIP-seq
MIRT2693859	hsa-miR-3189-3p	CLIP-seq
MIRT2693860	hsa-miR-34a	CLIP-seq
MIRT2693861	hsa-miR-34c-3p	CLIP-seq
MIRT2693862	hsa-miR-34c-5p	CLIP-seq
MIRT2693863	hsa-miR-3622b-5p	CLIP-seq
MIRT2693864	hsa-miR-4253	CLIP-seq
MIRT2693865	hsa-miR-4260	CLIP-seq
MIRT2693866	hsa-miR-4265	CLIP-seq
MIRT2693867	hsa-miR-4296	CLIP-seq
MIRT2693868	hsa-miR-4302	CLIP-seq
MIRT2693869	hsa-miR-4322	CLIP-seq
MIRT2693870	hsa-miR-4417	CLIP-seq
MIRT2693871	hsa-miR-4437	CLIP-seq
MIRT2693872	hsa-miR-4448	CLIP-seq
MIRT2693873	hsa-miR-449a	CLIP-seq
MIRT2693874	hsa-miR-449b	CLIP-seq
MIRT2693875	hsa-miR-4674	CLIP-seq
MIRT2693876	hsa-miR-4745-3p	CLIP-seq
MIRT2693877	hsa-miR-486-3p	CLIP-seq
MIRT2693878	hsa-miR-760	CLIP-seq

Show/Hide all(21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	14563850, 14613930, 16412388, 19798056, 25416956, 26320582, 31515488
GO:0005737	Component	Cytoplasm	IDA	16412388
GO:0005768	Component	Endosome	IBA	21873635
GO:0005768	Component	Endosome	IDA	16412388
GO:0005769	Component	Early endosome	IDA	14613930
GO:0005829	Component	Cytosol	IDA	14613930
GO:0005886	Component	Plasma membrane	TAS
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006897	Process	Endocytosis	NAS	10329004
GO:0007165	Process	Signal transduction	IBA	21873635
GO:0015031	Process	Protein transport	NAS	14613930
GO:0016020	Component	Membrane	IBA	21873635
GO:0016020	Component	Membrane	IDA	14613930
GO:0016197	Process	Endosomal transport	NAS	14613930
GO:0016197	Process	Endosomal transport	TAS	10329004
GO:0030276	Function	Clathrin binding	IBA	21873635
GO:0030276	Function	Clathrin binding	IDA	16412388
GO:0035577	Component	Azurophil granule membrane	TAS
GO:0035579	Component	Specific granule membrane	TAS
GO:0043312	Process	Neutrophil degranulation	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

MIM	HGNC	e!Ensembl
604700	11982	ENSG00000100284

Protein

UniProt ID

O60784

Protein name

Target of Myb1 membrane trafficking protein (Target of Myb protein 1)

Protein function

Adapter protein that plays a role in the intracellular membrane trafficking of ubiquitinated proteins, thereby participating in autophagy, ubiquitination-dependent signaling and receptor recycling pathways (PubMed:14563850, PubMed:15047686, PubM

PDB

1ELK , 1WRD , 2N2N , 2N9D , 6J56

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00790	VHS	7 → 148	VHS domain	Domain
PF03127	GAT	228 → 303	GAT domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed. Highly expressed in skeletal muscle, heart, placenta and liver. {ECO:0000269|PubMed:10329004}.

Sequence

MDFLLGNPFSSPVGQRIEKATDGSLQSEDWALNMEICDIINETEEGPKDALRAVKKRIVG
NKNFHEVMLALTVLETCVKNCGHRFHVLVASQDFVESVLVRTILPKNNPPTIVHDKVLNL
IQSWADAFRSSPDLTGVVTIYEDLRRKGLEFPMTDLDMLSPIHTPQRTVFNSETQSGQDS
VGTDSSQQEDSGQHAAPLPAPPILSGDTPIAPTPEQIGKLRSELEMVSGNVRVMSEMLTE
LVPTQAEPADLELLQELNRTCRAMQQRVLELIPQIANEQLTEELLIVNDNLNNVFLRHER
FERFRTGQTTKAPSEAEPAADLIDMGPDPAATGNLSSQLAGMNLGSSSVRAGLQSLEASG
RLEDEFDMFALTRGSSLADQRKEVKYEAPQATDGLAGALDARQQSTGAIPVTQACLMEDI
EQWLSTDVGNDAEEPKGVTSEEFDKFLEERAKAADRLPNLSSPSAEGPPGPPSGPAPRKK
TQEKDDDMLFAL

Sequence length

492

Interactions

View interactions

	Reactome
			Neutrophil degranulation

Show/Hide Causal Diseases (1)

Disease term	Disease name	dbSNP ID	References
Causal
Multiple myeloma	Multiple Myeloma	rs11540652, rs78311289, rs121913482, rs397507340, rs121913343, rs121913240, rs121913529, rs730882018, rs1057517992, rs121913527, rs756183569, rs746646631, rs1574706907, rs372078034, rs745380962 View all (38 more)	26007630, 27363682

Show/Hide Unknown Diseases (6)

Disease term	Disease name	References	Source
Unknown
Major affective disorder	MAJOR AFFECTIVE DISORDER 2	17671966	ClinVar
Immunodeficiency	immunodeficiency 85 and autoimmunity		GenCC
Diabetes	Diabetes		GWAS
Inflammatory Bowel Disease	Inflammatory Bowel Disease		GWAS
Ulcerative colitis	Ulcerative colitis		GWAS
Psoriasis	Psoriasis		GWAS

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text Mining
Cystic Fibrosis	Associate	20083669
Immune Dysregulation Polyendocrinopathy Enteropathy X Linked Syndrome	Associate	33864888

TOM1 (target of myb1 membrane trafficking protein)