Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein
Entrez ID	10036
Gene name	Chromatin assembly factor 1 subunit A
Gene symbol	CHAF1A
Synonyms (NCBI Gene)	CAF-1CAF1CAF1BCAF1P150P150
Chromosome	19
Chromosome location	19p13.3
Summary	Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 20

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001559	hsa-miR-155-5p	pSILAC	18668040
MIRT016160	hsa-miR-590-3p	Sequencing	20371350
MIRT001559	hsa-miR-155-5p	Proteomics;Other	18668040
MIRT032279	hsa-let-7b-5p	Proteomics	18668040
MIRT049115	hsa-miR-92a-3p	CLASH	23622248
MIRT151700	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT151690	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT151700	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT151689	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT151710	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT151693	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT151722	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT151690	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT151691	hsa-miR-26a-5p	HITS-CLIP	22473208
MIRT151692	hsa-miR-26b-5p	HITS-CLIP	22473208
MIRT888517	hsa-miR-106a	CLIP-seq
MIRT888518	hsa-miR-106b	CLIP-seq
MIRT888519	hsa-miR-1204	CLIP-seq
MIRT888520	hsa-miR-1275	CLIP-seq
MIRT888521	hsa-miR-1286	CLIP-seq
MIRT888522	hsa-miR-1293	CLIP-seq
MIRT888523	hsa-miR-155	CLIP-seq
MIRT888524	hsa-miR-17	CLIP-seq
MIRT888525	hsa-miR-20a	CLIP-seq
MIRT888526	hsa-miR-20b	CLIP-seq
MIRT888527	hsa-miR-2110	CLIP-seq
MIRT888528	hsa-miR-216a	CLIP-seq
MIRT888529	hsa-miR-302a	CLIP-seq
MIRT888530	hsa-miR-302b	CLIP-seq
MIRT888531	hsa-miR-302c	CLIP-seq
MIRT888532	hsa-miR-302d	CLIP-seq
MIRT888533	hsa-miR-302e	CLIP-seq
MIRT888534	hsa-miR-3129-3p	CLIP-seq
MIRT888535	hsa-miR-3130-3p	CLIP-seq
MIRT888536	hsa-miR-3150a-3p	CLIP-seq
MIRT888537	hsa-miR-3175	CLIP-seq
MIRT888538	hsa-miR-323-5p	CLIP-seq
MIRT888539	hsa-miR-337-3p	CLIP-seq
MIRT888540	hsa-miR-338-3p	CLIP-seq
MIRT888541	hsa-miR-3656	CLIP-seq
MIRT888542	hsa-miR-372	CLIP-seq
MIRT888543	hsa-miR-373	CLIP-seq
MIRT888544	hsa-miR-3937	CLIP-seq
MIRT888545	hsa-miR-3941	CLIP-seq
MIRT888546	hsa-miR-4260	CLIP-seq
MIRT888547	hsa-miR-4435	CLIP-seq
MIRT888548	hsa-miR-4436a	CLIP-seq
MIRT888549	hsa-miR-4477a	CLIP-seq
MIRT888550	hsa-miR-4483	CLIP-seq
MIRT888551	hsa-miR-4525	CLIP-seq
MIRT888552	hsa-miR-4530	CLIP-seq
MIRT888553	hsa-miR-466	CLIP-seq
MIRT888554	hsa-miR-4665-5p	CLIP-seq
MIRT888555	hsa-miR-4672	CLIP-seq
MIRT888556	hsa-miR-4680-5p	CLIP-seq
MIRT888557	hsa-miR-4685-5p	CLIP-seq
MIRT888558	hsa-miR-4717-5p	CLIP-seq
MIRT888559	hsa-miR-4723-5p	CLIP-seq
MIRT888560	hsa-miR-4755-3p	CLIP-seq
MIRT888561	hsa-miR-4793-3p	CLIP-seq
MIRT888562	hsa-miR-519d	CLIP-seq
MIRT888563	hsa-miR-520a-3p	CLIP-seq
MIRT888564	hsa-miR-520b	CLIP-seq
MIRT888565	hsa-miR-520c-3p	CLIP-seq
MIRT888566	hsa-miR-520d-3p	CLIP-seq
MIRT888567	hsa-miR-520d-5p	CLIP-seq
MIRT888568	hsa-miR-520e	CLIP-seq
MIRT888569	hsa-miR-520g	CLIP-seq
MIRT888570	hsa-miR-520h	CLIP-seq
MIRT888571	hsa-miR-524-5p	CLIP-seq
MIRT888572	hsa-miR-625	CLIP-seq
MIRT888573	hsa-miR-635	CLIP-seq
MIRT888574	hsa-miR-93	CLIP-seq
MIRT888575	hsa-miR-939	CLIP-seq
MIRT888534	hsa-miR-3129-3p	CLIP-seq
MIRT888536	hsa-miR-3150a-3p	CLIP-seq
MIRT888537	hsa-miR-3175	CLIP-seq
MIRT888539	hsa-miR-337-3p	CLIP-seq
MIRT888540	hsa-miR-338-3p	CLIP-seq
MIRT888552	hsa-miR-4530	CLIP-seq
MIRT2199806	hsa-miR-4729	CLIP-seq
MIRT2199807	hsa-miR-4760-3p	CLIP-seq
MIRT2199808	hsa-miR-4785	CLIP-seq
MIRT2199809	hsa-miR-579	CLIP-seq
MIRT2199810	hsa-miR-627	CLIP-seq
MIRT2199811	hsa-miR-664	CLIP-seq
MIRT888575	hsa-miR-939	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	IDA	9614144, 14718166
GO:0003682	Function	Chromatin binding	TAS	7600578
GO:0005515	Function	Protein binding	IPI	15805117, 16826239, 17474147, 19498464, 20562864, 20936779, 21570500, 23075851, 24981860, 25416956, 26496610, 27705803, 31980649, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0006260	Process	DNA replication	IEA
GO:0006281	Process	DNA repair	IEA
GO:0006325	Process	Chromatin organization	IEA
GO:0006334	Process	Nucleosome assembly	IBA
GO:0006334	Process	Nucleosome assembly	IDA	14718166
GO:0006335	Process	DNA replication-dependent chromatin assembly	IDA	8858152, 9614144
GO:0006974	Process	DNA damage response	IEA
GO:0032991	Component	Protein-containing complex	IDA	14718166
GO:0033186	Component	CAF-1 complex	IBA
GO:0033186	Component	CAF-1 complex	IDA	8858152
GO:0033186	Component	CAF-1 complex	IPI	9614144
GO:0042802	Function	Identical protein binding	IPI	16826239
GO:0051082	Function	Unfolded protein binding	TAS	7600578
GO:0070087	Function	Chromo shadow domain binding	IPI	15882967

MIM	HGNC	e!Ensembl
601246	1910	ENSG00000167670

Q13111

Protein name

Chromatin assembly factor 1 subunit A (CAF-1 subunit A) (Chromatin assembly factor I p150 subunit) (CAF-I 150 kDa subunit) (CAF-I p150) (hp150)

Protein function

Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly s

PDB

7Y5K , 7Y5L , 7Y5O , 7Y5U , 7Y5V , 7Y60 , 7Y61 , 8IQF , 8IQG , 8J6S , 8J6T

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15557	CAF1-p150_N	1 → 226	CAF1 complex subunit p150, region binding to PCNA	Domain
PF11600	CAF-1_p150	320 → 479		Disordered
PF12253	CAF1A	558 → 632	Chromatin assembly factor 1 subunit A	Family
PF15539	CAF1-p150_C2	665 → 954	CAF1 complex subunit p150, region binding to CAF1-p60 at C-term	Domain

Sequence

MLEELECGAPGARGAATAMDCKDRPAFPVKKLIQARLPFKRLNLVPKGKADDMSDDQGTS
VQSKSPDLEASLDTLENNCHVGSDIDFRPKLVNGKGPLDNFLRNRIETSIGQSTVIIDLT
EDSNEQPDSLVDHNKLNSEASPSREAINGQREDTGDQQGLLKAIQNDKLAFPGETLSDIP
CKTEEEGVGCGGAGRRGDSQECSPRSCPELTSGPRMCPRKEQDSWSEAGGILFKGKVPMV
VLQDILAVRPPQIKSLPATPQGKNMTPESEVLESFPEEDSVLSHSSLSSPSSTSSPEGPP
APPKQHSSTSPFPTSTPLRRITKKFVKGSTEKNKLRLQRDQERLGKQLKLRAEREEKEKL
KEEAKRAKEEAKKKKEEEKELKEKERREKREKDEKEKAEKQRLKEERRKERQEALEAKLE
EKRKKEEEKRLREEEKRIKAEKAEITRFFQKPKTPQAPKTLAGSCGKFAPFEIKEHMVLA
PRRRTAFHPDLCSQLDQLLQQQSGEFSFLKDLKGRQPLRSGPTHVSTRNADIFNSDVVIV
ERGKGDGVPERRKFGRMKLLQFCENHRPAYWGTWNKKTALIRARDPWAQDTKLLDYEVDS
DEEWEEEEPGESLSHSEGDDDDDMGEDEDEDDGFFVPHGYLSEDEGVTEECADPENHKVR
QKLKAKEWDEFLAKGKRFRVLQPVKIGCVWAADRDCAGDDLKVLQQFAACFLETLPAQEE
QTPKASKRERRDEQILAQLLPLLHGNVNGSKVIIREFQEHCRRGLLSNHTGSPRSPSTTY
LHTPTPSEDAAIPSKSRLKRLISENSVYEKRPDFRMCWYVHPQVLQSFQQEHLPVPCQWS
YVTSVPSAPKEDSGSVPSTGPSQGTPISLKRKSAGSMCITQFMKKRRHDGQIGAEDMDGF
QADTEEEEEEEGDCMIVDVPDAAEVQAPCGAASGAGGGVGVDTGKATLTASPLGAS

Sequence length

956

Interactions

View interactions

CHAF1A (chromatin assembly factor 1 subunit A)