Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
1003
Gene name Gene Name - the full gene name approved by the HGNC.
Cadherin 5
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CDH5
Synonyms (NCBI Gene) Gene synonyms aliases
7B4, CD144
Chromosome Chromosome number
16
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
16q21
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006257 hsa-miR-211-5p Luciferase reporter assay 22235338
MIRT006257 hsa-miR-211-5p Luciferase reporter assay 22235338
MIRT006257 hsa-miR-211-5p Luciferase reporter assay 22235338
MIRT017265 hsa-miR-335-5p Microarray 18185580
MIRT021947 hsa-miR-128-3p Microarray 17612493
Transcription factors
Transcription factor Regulation Reference
ERG Unknown 19359602
KLF4 Activation 20724706
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000902 Process Cell morphogenesis IBA 21873635
GO:0001932 Process Regulation of protein phosphorylation IDA 23159740
GO:0001944 Process Vasculature development IBA 21873635
GO:0001955 Process Blood vessel maturation IEA
GO:0005102 Function Signaling receptor binding IPI 12088286
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
601120 1764 ENSG00000179776
Protein
UniProt ID P33151
Protein name Cadherin-5 (7B4 antigen) (Vascular endothelial cadherin) (VE-cadherin) (CD antigen CD144)
Protein function Cadherins are calcium-dependent cell adhesion proteins (By similarity). They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:212
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00028 Cadherin 52 142 Cadherin domain Domain
PF00028 Cadherin 156 249 Cadherin domain Domain
PF00028 Cadherin 263 364 Cadherin domain Domain
PF00028 Cadherin 377 470 Cadherin domain Domain
PF00028 Cadherin 483 576 Cadherin domain Domain
PF01049 Cadherin_C 621 777 Cadherin cytoplasmic region Family
Tissue specificity TISSUE SPECIFICITY: Expressed in endothelial cells (at protein level) (PubMed:27338829). Expressed in the brain (PubMed:2059658). {ECO:0000269|PubMed:2059658, ECO:0000269|PubMed:27338829}.
Sequence
Sequence length 784
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Cell adhesion molecules
Adherens junction
Leukocyte transendothelial migration
Fluid shear stress and atherosclerosis
  Adherens junctions interactions
VEGFR2 mediated vascular permeability
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
18507500
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
18507500
Colorectal cancer Colorectal Carcinoma rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800
View all (467 more)
18507500
Colorectal neoplasms Colorectal Neoplasms rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049
View all (1682 more)
18507500
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 26683690
Adenocarcinoma of Lung Associate 33062704, 33661044, 33728331, 35242247, 35635202, 36529788
Adenomatous Polyposis Coli Associate 33108070
Alveolar capillary dysplasia Associate 38029923
Antiphospholipid Syndrome Stimulate 11937138
Antiphospholipid Syndrome Associate 38155384
Aphasia Conduction Associate 40065360
Arthritis Juvenile Associate 33144896
Arthritis Rheumatoid Associate 21905018
Atrioventricular Block Associate 39354406