Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	100287932
Gene name	Translocase of inner mitochondrial membrane 23
Gene symbol	TIMM23
Synonyms (NCBI Gene)	TIM23
Chromosome	10
Chromosome location	10q11.22
Summary	The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not prote

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miRTarBase ID	miRNA	Experiments	Reference
MIRT026070	hsa-miR-196a-5p	Sequencing	20371350
MIRT032261	hsa-let-7b-5p	Proteomics	18668040
MIRT046055	hsa-miR-125b-5p	CLASH	23622248
MIRT042029	hsa-miR-484	CLASH	23622248
MIRT1425012	hsa-miR-1290	CLIP-seq
MIRT1425013	hsa-miR-130a	CLIP-seq
MIRT1425014	hsa-miR-130b	CLIP-seq
MIRT1425015	hsa-miR-148a	CLIP-seq
MIRT1425016	hsa-miR-148b	CLIP-seq
MIRT1425017	hsa-miR-152	CLIP-seq
MIRT1425018	hsa-miR-196a	CLIP-seq
MIRT1425019	hsa-miR-196b	CLIP-seq
MIRT1425020	hsa-miR-301a	CLIP-seq
MIRT1425021	hsa-miR-301b	CLIP-seq
MIRT1425022	hsa-miR-3123	CLIP-seq
MIRT1425023	hsa-miR-3140-5p	CLIP-seq
MIRT1425024	hsa-miR-3145-5p	CLIP-seq
MIRT1425025	hsa-miR-3157-5p	CLIP-seq
MIRT1425026	hsa-miR-3163	CLIP-seq
MIRT1425027	hsa-miR-3192	CLIP-seq
MIRT1425028	hsa-miR-323-3p	CLIP-seq
MIRT1425029	hsa-miR-340	CLIP-seq
MIRT1425030	hsa-miR-3646	CLIP-seq
MIRT1425031	hsa-miR-3666	CLIP-seq
MIRT1425032	hsa-miR-3673	CLIP-seq
MIRT1425033	hsa-miR-3927	CLIP-seq
MIRT1425034	hsa-miR-4295	CLIP-seq
MIRT1425035	hsa-miR-4314	CLIP-seq
MIRT1425036	hsa-miR-4328	CLIP-seq
MIRT1425037	hsa-miR-4452	CLIP-seq
MIRT1425038	hsa-miR-454	CLIP-seq
MIRT1425039	hsa-miR-4646-5p	CLIP-seq
MIRT1425040	hsa-miR-4650-3p	CLIP-seq
MIRT1425041	hsa-miR-4680-3p	CLIP-seq
MIRT1425042	hsa-miR-4691-3p	CLIP-seq
MIRT1425043	hsa-miR-4724-5p	CLIP-seq
MIRT1425044	hsa-miR-4764-3p	CLIP-seq
MIRT1425045	hsa-miR-4777-5p	CLIP-seq
MIRT1425046	hsa-miR-4790-3p	CLIP-seq
MIRT1425047	hsa-miR-548g	CLIP-seq
MIRT1425048	hsa-miR-582-5p	CLIP-seq
MIRT1425049	hsa-miR-665	CLIP-seq
MIRT1425012	hsa-miR-1290	CLIP-seq
MIRT2127376	hsa-miR-1305	CLIP-seq
MIRT1425013	hsa-miR-130a	CLIP-seq
MIRT1425014	hsa-miR-130b	CLIP-seq
MIRT1425015	hsa-miR-148a	CLIP-seq
MIRT1425016	hsa-miR-148b	CLIP-seq
MIRT1425017	hsa-miR-152	CLIP-seq
MIRT1425018	hsa-miR-196a	CLIP-seq
MIRT1425019	hsa-miR-196b	CLIP-seq
MIRT1425020	hsa-miR-301a	CLIP-seq
MIRT1425021	hsa-miR-301b	CLIP-seq
MIRT2127377	hsa-miR-3120-3p	CLIP-seq
MIRT2127378	hsa-miR-3129-3p	CLIP-seq
MIRT1425028	hsa-miR-323-3p	CLIP-seq
MIRT1425031	hsa-miR-3666	CLIP-seq
MIRT1425032	hsa-miR-3673	CLIP-seq
MIRT1425033	hsa-miR-3927	CLIP-seq
MIRT1425034	hsa-miR-4295	CLIP-seq
MIRT1425036	hsa-miR-4328	CLIP-seq
MIRT1425038	hsa-miR-454	CLIP-seq
MIRT1425048	hsa-miR-582-5p	CLIP-seq
MIRT2127379	hsa-miR-607	CLIP-seq
MIRT1425049	hsa-miR-665	CLIP-seq
MIRT1425012	hsa-miR-1290	CLIP-seq
MIRT1425013	hsa-miR-130a	CLIP-seq
MIRT1425014	hsa-miR-130b	CLIP-seq
MIRT1425015	hsa-miR-148a	CLIP-seq
MIRT1425016	hsa-miR-148b	CLIP-seq
MIRT1425017	hsa-miR-152	CLIP-seq
MIRT1425020	hsa-miR-301a	CLIP-seq
MIRT1425021	hsa-miR-301b	CLIP-seq
MIRT2127377	hsa-miR-3120-3p	CLIP-seq
MIRT1425028	hsa-miR-323-3p	CLIP-seq
MIRT1425030	hsa-miR-3646	CLIP-seq
MIRT1425031	hsa-miR-3666	CLIP-seq
MIRT1425032	hsa-miR-3673	CLIP-seq
MIRT2349183	hsa-miR-3689a-5p	CLIP-seq
MIRT2349184	hsa-miR-3689b	CLIP-seq
MIRT2349185	hsa-miR-3689e	CLIP-seq
MIRT2349186	hsa-miR-3689f	CLIP-seq
MIRT1425034	hsa-miR-4295	CLIP-seq
MIRT1425036	hsa-miR-4328	CLIP-seq
MIRT1425038	hsa-miR-454	CLIP-seq
MIRT1425046	hsa-miR-4790-3p	CLIP-seq
MIRT2349187	hsa-miR-545	CLIP-seq
MIRT1425048	hsa-miR-582-5p	CLIP-seq
MIRT2642452	hsa-miR-1206	CLIP-seq
MIRT2642453	hsa-miR-1275	CLIP-seq
MIRT2642454	hsa-miR-140-5p	CLIP-seq
MIRT1425023	hsa-miR-3140-5p	CLIP-seq
MIRT2642455	hsa-miR-3150b-3p	CLIP-seq
MIRT2642456	hsa-miR-3156-5p	CLIP-seq
MIRT1425027	hsa-miR-3192	CLIP-seq
MIRT2642457	hsa-miR-3925-3p	CLIP-seq
MIRT2642458	hsa-miR-4276	CLIP-seq
MIRT1425035	hsa-miR-4314	CLIP-seq
MIRT1425037	hsa-miR-4452	CLIP-seq
MIRT2642459	hsa-miR-4525	CLIP-seq
MIRT1425039	hsa-miR-4646-5p	CLIP-seq
MIRT2642460	hsa-miR-4665-5p	CLIP-seq
MIRT1425041	hsa-miR-4680-3p	CLIP-seq
MIRT2642461	hsa-miR-4696	CLIP-seq
MIRT2642462	hsa-miR-4723-5p	CLIP-seq
MIRT2642463	hsa-miR-4773	CLIP-seq
MIRT2642464	hsa-miR-4784	CLIP-seq
MIRT2642465	hsa-miR-510	CLIP-seq
MIRT2642466	hsa-miR-512-5p	CLIP-seq
MIRT2642467	hsa-miR-520a-5p	CLIP-seq
MIRT2642468	hsa-miR-525-5p	CLIP-seq
MIRT2642469	hsa-miR-570	CLIP-seq
MIRT2642470	hsa-miR-625	CLIP-seq
MIRT2642471	hsa-miR-766	CLIP-seq
MIRT2642452	hsa-miR-1206	CLIP-seq
MIRT2642453	hsa-miR-1275	CLIP-seq
MIRT2642454	hsa-miR-140-5p	CLIP-seq
MIRT1425023	hsa-miR-3140-5p	CLIP-seq
MIRT2642455	hsa-miR-3150b-3p	CLIP-seq
MIRT2642456	hsa-miR-3156-5p	CLIP-seq
MIRT2693193	hsa-miR-3174	CLIP-seq
MIRT1425027	hsa-miR-3192	CLIP-seq
MIRT2642457	hsa-miR-3925-3p	CLIP-seq
MIRT2642458	hsa-miR-4276	CLIP-seq
MIRT1425035	hsa-miR-4314	CLIP-seq
MIRT1425037	hsa-miR-4452	CLIP-seq
MIRT2642459	hsa-miR-4525	CLIP-seq
MIRT1425039	hsa-miR-4646-5p	CLIP-seq
MIRT2642460	hsa-miR-4665-5p	CLIP-seq
MIRT1425041	hsa-miR-4680-3p	CLIP-seq
MIRT2642461	hsa-miR-4696	CLIP-seq
MIRT2642462	hsa-miR-4723-5p	CLIP-seq
MIRT2642463	hsa-miR-4773	CLIP-seq
MIRT2642464	hsa-miR-4784	CLIP-seq
MIRT2642465	hsa-miR-510	CLIP-seq
MIRT2642466	hsa-miR-512-5p	CLIP-seq
MIRT2642467	hsa-miR-520a-5p	CLIP-seq
MIRT2642468	hsa-miR-525-5p	CLIP-seq
MIRT2642469	hsa-miR-570	CLIP-seq
MIRT2642470	hsa-miR-625	CLIP-seq
MIRT2642471	hsa-miR-766	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15044455, 23260140, 23263864, 32296183, 32814053, 37160114
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	10339406, 20053669, 25997101
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	10339406
GO:0005743	Component	Mitochondrial inner membrane	TAS	14726512
GO:0005744	Component	TIM23 mitochondrial import inner membrane translocase complex	IBA
GO:0005744	Component	TIM23 mitochondrial import inner membrane translocase complex	IDA	10339406, 30598479
GO:0005744	Component	TIM23 mitochondrial import inner membrane translocase complex	IEA
GO:0005744	Component	TIM23 mitochondrial import inner membrane translocase complex	NAS	10339406
GO:0005758	Component	Mitochondrial intermembrane space	IDA	15044455
GO:0006626	Process	Protein targeting to mitochondrion	TAS	10339406
GO:0006886	Process	Intracellular protein transport	NAS	10339406
GO:0008320	Function	Protein transmembrane transporter activity	IBA
GO:0008320	Function	Protein transmembrane transporter activity	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0030150	Process	Protein import into mitochondrial matrix	IBA
GO:0030150	Process	Protein import into mitochondrial matrix	IEA
GO:0061734	Process	Type 2 mitophagy	IMP	37160114

MIM	HGNC	e!Ensembl
605034	17312	ENSG00000265354

O14925

Protein name

Mitochondrial import inner membrane translocase subunit Tim23

Protein function

Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (PubMed:10339406). Has a role in the activation of stress-induced mitophagy by pro

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02466	Tim17	76 → 188		Family

Sequence

MEGGGGSGNKTTGGLAGFFGAGGAGYSHADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEF
ILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMV
TRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARG
GLTGLTLTSLYALYNNWEHMKGSLLQQSL

Sequence length

209

Interactions

View interactions

	Reactome
			Mitochondrial protein import

TIMM23 (translocase of inner mitochondrial membrane 23)