ARHGEF33 (Rho guanine nucleotide exchange factor 33)

Gene

• Entrez ID: 100271715
• Gene name: Rho guanine nucleotide exchange factor 33
• Gene symbol: ARHGEF33
• Synonyms (NCBI Gene): -
• Chromosome: 2
• Chromosome location: 2p22.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT038759	hsa-miR-93-3p	CLASH	23622248
MIRT515225	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT512269	hsa-miR-6074	HITS-CLIP	21572407
MIRT512268	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707183	hsa-miR-155-3p	HITS-CLIP	21572407
MIRT707182	hsa-miR-3685	HITS-CLIP	21572407
MIRT512267	hsa-miR-1277-3p	HITS-CLIP	21572407
MIRT512266	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT515225	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	20371350
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT515225	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	20371350
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT515225	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	21572407
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT515225	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	21572407
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT515225	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT512269	hsa-miR-6074	PAR-CLIP	23446348
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	23446348
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512269	hsa-miR-6074	PAR-CLIP	23446348
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	23446348
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT515225	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT512269	hsa-miR-6074	HITS-CLIP	21572407
MIRT512268	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707183	hsa-miR-155-3p	HITS-CLIP	21572407
MIRT707182	hsa-miR-3685	HITS-CLIP	21572407
MIRT512267	hsa-miR-1277-3p	HITS-CLIP	21572407
MIRT512266	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT515225	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	20371350
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT515225	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	20371350
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT515225	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	21572407
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT515225	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	21572407
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT515225	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT512269	hsa-miR-6074	PAR-CLIP	23446348
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	23446348
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT512269	hsa-miR-6074	PAR-CLIP	23446348
MIRT512268	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT512267	hsa-miR-1277-3p	PAR-CLIP	23446348
MIRT512266	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT795782	hsa-miR-1264	CLIP-seq
MIRT795783	hsa-miR-136	CLIP-seq
MIRT795784	hsa-miR-192	CLIP-seq
MIRT795785	hsa-miR-215	CLIP-seq
MIRT795786	hsa-miR-2681	CLIP-seq
MIRT795787	hsa-miR-298	CLIP-seq
MIRT795788	hsa-miR-299-5p	CLIP-seq
MIRT795789	hsa-miR-3140-5p	CLIP-seq
MIRT795790	hsa-miR-3155	CLIP-seq
MIRT795791	hsa-miR-3155b	CLIP-seq
MIRT795792	hsa-miR-3158-5p	CLIP-seq
MIRT795793	hsa-miR-3661	CLIP-seq
MIRT795794	hsa-miR-370	CLIP-seq
MIRT795795	hsa-miR-4503	CLIP-seq
MIRT795796	hsa-miR-4680-3p	CLIP-seq
MIRT795797	hsa-miR-4719	CLIP-seq
MIRT795798	hsa-miR-484	CLIP-seq
MIRT795799	hsa-miR-5096	CLIP-seq
MIRT795800	hsa-miR-515-5p	CLIP-seq
MIRT795801	hsa-miR-631	CLIP-seq
MIRT1935039	hsa-miR-1238	CLIP-seq
MIRT1935040	hsa-miR-3117-5p	CLIP-seq
MIRT1935041	hsa-miR-4446-5p	CLIP-seq
MIRT1935042	hsa-miR-4504	CLIP-seq
MIRT1935043	hsa-miR-542-3p	CLIP-seq
MIRT1935044	hsa-miR-579	CLIP-seq
MIRT2174924	hsa-miR-1911	CLIP-seq
MIRT2174925	hsa-miR-200b	CLIP-seq
MIRT2174926	hsa-miR-200c	CLIP-seq
MIRT2174927	hsa-miR-429	CLIP-seq
MIRT2174928	hsa-miR-888	CLIP-seq
MIRT2478192	hsa-miR-3125	CLIP-seq
MIRT2478193	hsa-miR-34a	CLIP-seq
MIRT2478194	hsa-miR-34c-5p	CLIP-seq
MIRT2478195	hsa-miR-3613-3p	CLIP-seq
MIRT2478196	hsa-miR-371b-5p	CLIP-seq
MIRT2478197	hsa-miR-3916	CLIP-seq
MIRT2478198	hsa-miR-3928	CLIP-seq
MIRT2478199	hsa-miR-4261	CLIP-seq
MIRT2478200	hsa-miR-449a	CLIP-seq
MIRT2478201	hsa-miR-449b	CLIP-seq
MIRT2478202	hsa-miR-548ae	CLIP-seq
MIRT2478203	hsa-miR-548aj	CLIP-seq
MIRT2478204	hsa-miR-548am	CLIP-seq
MIRT2478205	hsa-miR-548x	CLIP-seq
MIRT2478206	hsa-miR-875-3p	CLIP-seq
MIRT2478207	hsa-miR-877	CLIP-seq
MIRT2174928	hsa-miR-888	CLIP-seq
MIRT2478192	hsa-miR-3125	CLIP-seq
MIRT2478193	hsa-miR-34a	CLIP-seq
MIRT2478194	hsa-miR-34c-5p	CLIP-seq
MIRT2478195	hsa-miR-3613-3p	CLIP-seq
MIRT2478196	hsa-miR-371b-5p	CLIP-seq
MIRT2478197	hsa-miR-3916	CLIP-seq
MIRT2478198	hsa-miR-3928	CLIP-seq
MIRT2478199	hsa-miR-4261	CLIP-seq
MIRT2478200	hsa-miR-449a	CLIP-seq
MIRT2478201	hsa-miR-449b	CLIP-seq
MIRT2478202	hsa-miR-548ae	CLIP-seq
MIRT2478203	hsa-miR-548aj	CLIP-seq
MIRT2478204	hsa-miR-548am	CLIP-seq
MIRT2478205	hsa-miR-548x	CLIP-seq
MIRT2478206	hsa-miR-875-3p	CLIP-seq
MIRT2478207	hsa-miR-877	CLIP-seq
MIRT2174928	hsa-miR-888	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: A8MVX0
• Protein name: Rho guanine nucleotide exchange factor 33
• Protein function: May act as a guanine-nucleotide releasing factor.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00621	RhoGEF	269 → 438	RhoGEF domain	Domain

• Sequence:

  MEKTKTKQGENEHMPVNNPSTQIYQLQALASELKTGFTEAMQELSRIQHGEYALEEKVKS
  CRCSMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKA
  KKTQKEEHSSQAGPAQAQGSPFRSINIPEPVLPSEDFTNLLPSQAYEKAQESRSVHVGDS
  NVKGMMGPGVNPTTPEAEENLKSCLSADIQSKGHLPSGMWRQPKDGKEWGEEYVTKDHPD
  KLKEAGQGRHSSLENVLCETSLAAKRQTVALELLESERKYVINISLILKIKATFQGSDGK
  RNSKERSLFPGSLRYLVQQHLDLLHALQERVLKWPRQGVLGDLFLKLTNDENNFLDYYVA
  YLRDLPECISLVHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKFTEQEHPDY
  YLLLVCVQRLRVFISHYTLLFQCNEDLLIQKRKKLKKSSMAKLYKGLASQCANAGQDASP
  TAGPEAVRDTGIHSEELLQPYPSAPSSGPAITHLMPPVKKSQQQQSLMESMQPGKPSDWE
  LEGRKHERPESLLAPTQFCAAEQDVKALAGPLQAIPEMDFESSPAEPLGNVERSLRAPAE
  LLPDARGFVPAAYEEFEYGGEIFALPAPYDEEPFQAPALFENCSPASSESSLDICFLRPV
  SFAMEAERPEHPLQPLPKSATSPAGSSSAYKLEAAAQAHGKAKPLSRSLKEFPRAPPADG
  VAPRLYSTRSSSGGRAPIKAERAAQAHGPAAAAVAARGASRTFFPQQRSQSEKQTYLEVR
  REMHLEDTTRFCPKEERESEQTSFSDQNPRQDQKGGFRSSFRKLFKKKNGNATGEDFCGP
  WGWW

• Sequence length: 844

Pathways

Reactome:

NRAGE signals death through JNK
Rho GTPase cycle
G alpha (12/13) signalling events