PIGK (phosphatidylinositol glycan anchor biosynthesis class K)

Gene

• Entrez ID: 10026
• Gene name: Phosphatidylinositol glycan anchor biosynthesis class K
• Gene symbol: PIGK
• Synonyms (NCBI Gene): GPI8, NEDHCAS
• Chromosome: 1
• Chromosome location: 1p31.1
• Summary: This gene encodes a member of the cysteine protease family C13 that is involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This pro

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1233291	hsa-miR-106a	CLIP-seq
MIRT1233292	hsa-miR-106b	CLIP-seq
MIRT1233293	hsa-miR-1185	CLIP-seq
MIRT1233294	hsa-miR-1197	CLIP-seq
MIRT1233295	hsa-miR-1238	CLIP-seq
MIRT1233296	hsa-miR-125a-5p	CLIP-seq
MIRT1233297	hsa-miR-125b	CLIP-seq
MIRT1233298	hsa-miR-1297	CLIP-seq
MIRT1233299	hsa-miR-1298	CLIP-seq
MIRT1233300	hsa-miR-142-5p	CLIP-seq
MIRT1233301	hsa-miR-144	CLIP-seq
MIRT1233302	hsa-miR-17	CLIP-seq
MIRT1233303	hsa-miR-1910	CLIP-seq
MIRT1233304	hsa-miR-203	CLIP-seq
MIRT1233305	hsa-miR-20a	CLIP-seq
MIRT1233306	hsa-miR-20b	CLIP-seq
MIRT1233307	hsa-miR-23a	CLIP-seq
MIRT1233308	hsa-miR-23b	CLIP-seq
MIRT1233309	hsa-miR-23c	CLIP-seq
MIRT1233310	hsa-miR-26a	CLIP-seq
MIRT1233311	hsa-miR-26b	CLIP-seq
MIRT1233312	hsa-miR-300	CLIP-seq
MIRT1233313	hsa-miR-3119	CLIP-seq
MIRT1233314	hsa-miR-3140-5p	CLIP-seq
MIRT1233315	hsa-miR-3609	CLIP-seq
MIRT1233316	hsa-miR-3613-3p	CLIP-seq
MIRT1233317	hsa-miR-3646	CLIP-seq
MIRT1233318	hsa-miR-3679-5p	CLIP-seq
MIRT1233319	hsa-miR-3689a-3p	CLIP-seq
MIRT1233320	hsa-miR-3689c	CLIP-seq
MIRT1233321	hsa-miR-3691-3p	CLIP-seq
MIRT1233322	hsa-miR-381	CLIP-seq
MIRT1233323	hsa-miR-4319	CLIP-seq
MIRT1233324	hsa-miR-4426	CLIP-seq
MIRT1233325	hsa-miR-4427	CLIP-seq
MIRT1233326	hsa-miR-4436a	CLIP-seq
MIRT1233327	hsa-miR-4465	CLIP-seq
MIRT1233328	hsa-miR-4477b	CLIP-seq
MIRT1233329	hsa-miR-4647	CLIP-seq
MIRT1233330	hsa-miR-4662b	CLIP-seq
MIRT1233331	hsa-miR-4666-3p	CLIP-seq
MIRT1233332	hsa-miR-4668-5p	CLIP-seq
MIRT1233333	hsa-miR-4691-5p	CLIP-seq
MIRT1233334	hsa-miR-4712-5p	CLIP-seq
MIRT1233335	hsa-miR-4717-3p	CLIP-seq
MIRT1233336	hsa-miR-4728-5p	CLIP-seq
MIRT1233337	hsa-miR-4732-3p	CLIP-seq
MIRT1233338	hsa-miR-4744	CLIP-seq
MIRT1233339	hsa-miR-4775	CLIP-seq
MIRT1233340	hsa-miR-4795-3p	CLIP-seq
MIRT1233341	hsa-miR-4796-3p	CLIP-seq
MIRT1233342	hsa-miR-513b	CLIP-seq
MIRT1233343	hsa-miR-519d	CLIP-seq
MIRT1233344	hsa-miR-548ah	CLIP-seq
MIRT1233345	hsa-miR-586	CLIP-seq
MIRT1233346	hsa-miR-590-3p	CLIP-seq
MIRT1233347	hsa-miR-642b	CLIP-seq
MIRT1233348	hsa-miR-664	CLIP-seq
MIRT1233349	hsa-miR-670	CLIP-seq
MIRT1233350	hsa-miR-770-5p	CLIP-seq
MIRT1233351	hsa-miR-93	CLIP-seq
MIRT1233352	hsa-miR-944	CLIP-seq
MIRT1233294	hsa-miR-1197	CLIP-seq
MIRT2068653	hsa-miR-4729	CLIP-seq
MIRT2068654	hsa-miR-507	CLIP-seq
MIRT2068655	hsa-miR-557	CLIP-seq
MIRT2295736	hsa-miR-141	CLIP-seq
MIRT2295737	hsa-miR-197	CLIP-seq
MIRT2295738	hsa-miR-200a	CLIP-seq
MIRT2295739	hsa-miR-27a	CLIP-seq
MIRT2295740	hsa-miR-27b	CLIP-seq
MIRT2295741	hsa-miR-299-5p	CLIP-seq
MIRT2295742	hsa-miR-361-3p	CLIP-seq
MIRT2295743	hsa-miR-3622a-3p	CLIP-seq
MIRT2295744	hsa-miR-3622b-3p	CLIP-seq
MIRT2295745	hsa-miR-4511	CLIP-seq
MIRT2295746	hsa-miR-4677-3p	CLIP-seq
MIRT2295747	hsa-miR-4778-5p	CLIP-seq
MIRT2295748	hsa-miR-493	CLIP-seq
MIRT2295749	hsa-miR-494	CLIP-seq
MIRT2295750	hsa-miR-513a-5p	CLIP-seq
MIRT2295751	hsa-miR-548b-3p	CLIP-seq
MIRT2295752	hsa-miR-581	CLIP-seq
MIRT2392507	hsa-miR-3121-3p	CLIP-seq
MIRT2392508	hsa-miR-4436b-3p	CLIP-seq
MIRT2392509	hsa-miR-4514	CLIP-seq
MIRT2392510	hsa-miR-4692	CLIP-seq
MIRT2392511	hsa-miR-4761-3p	CLIP-seq
MIRT2593648	hsa-miR-1270	CLIP-seq
MIRT2593649	hsa-miR-1275	CLIP-seq
MIRT2593650	hsa-miR-130a	CLIP-seq
MIRT2593651	hsa-miR-130b	CLIP-seq
MIRT2593652	hsa-miR-140-3p	CLIP-seq
MIRT2593653	hsa-miR-148a	CLIP-seq
MIRT2593654	hsa-miR-148b	CLIP-seq
MIRT2593655	hsa-miR-152	CLIP-seq
MIRT2593656	hsa-miR-1827	CLIP-seq
MIRT2593657	hsa-miR-19a	CLIP-seq
MIRT2593658	hsa-miR-19b	CLIP-seq
MIRT1233304	hsa-miR-203	CLIP-seq
MIRT2593659	hsa-miR-21	CLIP-seq
MIRT2593660	hsa-miR-219-5p	CLIP-seq
MIRT2593661	hsa-miR-221	CLIP-seq
MIRT2593662	hsa-miR-222	CLIP-seq
MIRT2593663	hsa-miR-223	CLIP-seq
MIRT1233307	hsa-miR-23a	CLIP-seq
MIRT1233308	hsa-miR-23b	CLIP-seq
MIRT1233309	hsa-miR-23c	CLIP-seq
MIRT2593664	hsa-miR-2467-3p	CLIP-seq
MIRT1233312	hsa-miR-300	CLIP-seq
MIRT2593665	hsa-miR-301a	CLIP-seq
MIRT2593666	hsa-miR-301b	CLIP-seq
MIRT2593667	hsa-miR-302a	CLIP-seq
MIRT2593668	hsa-miR-302b	CLIP-seq
MIRT2593669	hsa-miR-302c	CLIP-seq
MIRT2593670	hsa-miR-302d	CLIP-seq
MIRT2593671	hsa-miR-302e	CLIP-seq
MIRT2593672	hsa-miR-3065-5p	CLIP-seq
MIRT2593673	hsa-miR-3117-5p	CLIP-seq
MIRT2593674	hsa-miR-3120-3p	CLIP-seq
MIRT2593675	hsa-miR-3125	CLIP-seq
MIRT2593676	hsa-miR-3127-3p	CLIP-seq
MIRT2593677	hsa-miR-3133	CLIP-seq
MIRT2593678	hsa-miR-3143	CLIP-seq
MIRT2593679	hsa-miR-3148	CLIP-seq
MIRT2593680	hsa-miR-3150b-3p	CLIP-seq
MIRT2593681	hsa-miR-338-5p	CLIP-seq
MIRT2593682	hsa-miR-3651	CLIP-seq
MIRT2593683	hsa-miR-3666	CLIP-seq
MIRT2593684	hsa-miR-3678-3p	CLIP-seq
MIRT2593685	hsa-miR-3685	CLIP-seq
MIRT2593686	hsa-miR-3690	CLIP-seq
MIRT2593687	hsa-miR-3714	CLIP-seq
MIRT2593688	hsa-miR-372	CLIP-seq
MIRT2593689	hsa-miR-373	CLIP-seq
MIRT2593690	hsa-miR-380	CLIP-seq
MIRT1233322	hsa-miR-381	CLIP-seq
MIRT2593691	hsa-miR-384	CLIP-seq
MIRT2593692	hsa-miR-3916	CLIP-seq
MIRT2593693	hsa-miR-3925-5p	CLIP-seq
MIRT2593694	hsa-miR-3928	CLIP-seq
MIRT2593695	hsa-miR-3942-5p	CLIP-seq
MIRT2593696	hsa-miR-3974	CLIP-seq
MIRT2593697	hsa-miR-409-3p	CLIP-seq
MIRT2593698	hsa-miR-411	CLIP-seq
MIRT2593699	hsa-miR-4254	CLIP-seq
MIRT2593700	hsa-miR-4265	CLIP-seq
MIRT2593701	hsa-miR-4266	CLIP-seq
MIRT2593702	hsa-miR-4282	CLIP-seq
MIRT2593703	hsa-miR-4289	CLIP-seq
MIRT2593704	hsa-miR-4295	CLIP-seq
MIRT2593705	hsa-miR-4296	CLIP-seq
MIRT2593706	hsa-miR-4307	CLIP-seq
MIRT2593707	hsa-miR-4311	CLIP-seq
MIRT2593708	hsa-miR-4322	CLIP-seq
MIRT2593709	hsa-miR-4422	CLIP-seq
MIRT2593710	hsa-miR-4424	CLIP-seq
MIRT1233328	hsa-miR-4477b	CLIP-seq
MIRT2593711	hsa-miR-4490	CLIP-seq
MIRT2593712	hsa-miR-4493	CLIP-seq
MIRT2593713	hsa-miR-4495	CLIP-seq
MIRT2593714	hsa-miR-4525	CLIP-seq
MIRT2593715	hsa-miR-4536	CLIP-seq
MIRT2593716	hsa-miR-454	CLIP-seq
MIRT2593717	hsa-miR-4648	CLIP-seq
MIRT2593718	hsa-miR-4649-3p	CLIP-seq
MIRT2593719	hsa-miR-4654	CLIP-seq
MIRT2593720	hsa-miR-4663	CLIP-seq
MIRT2593721	hsa-miR-4665-5p	CLIP-seq
MIRT1233331	hsa-miR-4666-3p	CLIP-seq
MIRT2593722	hsa-miR-4682	CLIP-seq
MIRT2593723	hsa-miR-4683	CLIP-seq
MIRT2593724	hsa-miR-4694-3p	CLIP-seq
MIRT2593725	hsa-miR-4695-3p	CLIP-seq
MIRT2593726	hsa-miR-4695-5p	CLIP-seq
MIRT2593727	hsa-miR-4697-3p	CLIP-seq
MIRT2593728	hsa-miR-4703-5p	CLIP-seq
MIRT1233335	hsa-miR-4717-3p	CLIP-seq
MIRT2593729	hsa-miR-4723-5p	CLIP-seq
MIRT2593730	hsa-miR-4752	CLIP-seq
MIRT2593731	hsa-miR-4753-5p	CLIP-seq
MIRT2593732	hsa-miR-4762-5p	CLIP-seq
MIRT2593733	hsa-miR-4769-5p	CLIP-seq
MIRT2593734	hsa-miR-4773	CLIP-seq
MIRT2593735	hsa-miR-4774-5p	CLIP-seq
MIRT1233339	hsa-miR-4775	CLIP-seq
MIRT2593736	hsa-miR-4779	CLIP-seq
MIRT2593737	hsa-miR-4782-3p	CLIP-seq
MIRT2593738	hsa-miR-4784	CLIP-seq
MIRT1233340	hsa-miR-4795-3p	CLIP-seq
MIRT2593739	hsa-miR-4797-3p	CLIP-seq
MIRT2593740	hsa-miR-4803	CLIP-seq
MIRT2295749	hsa-miR-494	CLIP-seq
MIRT2593741	hsa-miR-495	CLIP-seq
MIRT2593742	hsa-miR-510	CLIP-seq
MIRT2593743	hsa-miR-511	CLIP-seq
MIRT2593744	hsa-miR-512-5p	CLIP-seq
MIRT2593745	hsa-miR-519a	CLIP-seq
MIRT2593746	hsa-miR-519b-3p	CLIP-seq
MIRT2593747	hsa-miR-519c-3p	CLIP-seq
MIRT2593748	hsa-miR-520a-3p	CLIP-seq
MIRT2593749	hsa-miR-520b	CLIP-seq
MIRT2593750	hsa-miR-520c-3p	CLIP-seq
MIRT2593751	hsa-miR-520d-3p	CLIP-seq
MIRT2593752	hsa-miR-520e	CLIP-seq
MIRT2593753	hsa-miR-545	CLIP-seq
MIRT2593754	hsa-miR-548aa	CLIP-seq
MIRT2593755	hsa-miR-548ac	CLIP-seq
MIRT2593756	hsa-miR-548ag	CLIP-seq
MIRT2593757	hsa-miR-548ai	CLIP-seq
MIRT2593758	hsa-miR-548d-3p	CLIP-seq
MIRT2593759	hsa-miR-548m	CLIP-seq
MIRT2593760	hsa-miR-548p	CLIP-seq
MIRT2593761	hsa-miR-548z	CLIP-seq
MIRT2593762	hsa-miR-549	CLIP-seq
MIRT2593763	hsa-miR-567	CLIP-seq
MIRT2593764	hsa-miR-578	CLIP-seq
MIRT2295752	hsa-miR-581	CLIP-seq
MIRT2593765	hsa-miR-584	CLIP-seq
MIRT1233346	hsa-miR-590-3p	CLIP-seq
MIRT2593766	hsa-miR-590-5p	CLIP-seq
MIRT2593767	hsa-miR-591	CLIP-seq
MIRT2593768	hsa-miR-618	CLIP-seq
MIRT2593769	hsa-miR-620	CLIP-seq
MIRT2593770	hsa-miR-625	CLIP-seq
MIRT2593771	hsa-miR-651	CLIP-seq
MIRT2593772	hsa-miR-656	CLIP-seq
MIRT2593773	hsa-miR-7	CLIP-seq
MIRT2593774	hsa-miR-765	CLIP-seq
MIRT2593775	hsa-miR-9	CLIP-seq
MIRT2593776	hsa-miR-938	CLIP-seq
MIRT2593648	hsa-miR-1270	CLIP-seq
MIRT2593649	hsa-miR-1275	CLIP-seq
MIRT2593650	hsa-miR-130a	CLIP-seq
MIRT2593651	hsa-miR-130b	CLIP-seq
MIRT2593652	hsa-miR-140-3p	CLIP-seq
MIRT2593653	hsa-miR-148a	CLIP-seq
MIRT2593654	hsa-miR-148b	CLIP-seq
MIRT2593655	hsa-miR-152	CLIP-seq
MIRT2593656	hsa-miR-1827	CLIP-seq
MIRT2593657	hsa-miR-19a	CLIP-seq
MIRT2593658	hsa-miR-19b	CLIP-seq
MIRT1233304	hsa-miR-203	CLIP-seq
MIRT2593659	hsa-miR-21	CLIP-seq
MIRT2593660	hsa-miR-219-5p	CLIP-seq
MIRT2593661	hsa-miR-221	CLIP-seq
MIRT2593662	hsa-miR-222	CLIP-seq
MIRT2593663	hsa-miR-223	CLIP-seq
MIRT1233307	hsa-miR-23a	CLIP-seq
MIRT1233308	hsa-miR-23b	CLIP-seq
MIRT1233309	hsa-miR-23c	CLIP-seq
MIRT2593664	hsa-miR-2467-3p	CLIP-seq
MIRT1233312	hsa-miR-300	CLIP-seq
MIRT2593665	hsa-miR-301a	CLIP-seq
MIRT2593666	hsa-miR-301b	CLIP-seq
MIRT2593667	hsa-miR-302a	CLIP-seq
MIRT2593668	hsa-miR-302b	CLIP-seq
MIRT2593669	hsa-miR-302c	CLIP-seq
MIRT2593670	hsa-miR-302d	CLIP-seq
MIRT2593671	hsa-miR-302e	CLIP-seq
MIRT2593672	hsa-miR-3065-5p	CLIP-seq
MIRT2593673	hsa-miR-3117-5p	CLIP-seq
MIRT2593674	hsa-miR-3120-3p	CLIP-seq
MIRT2593675	hsa-miR-3125	CLIP-seq
MIRT2593676	hsa-miR-3127-3p	CLIP-seq
MIRT2687869	hsa-miR-3129-3p	CLIP-seq
MIRT2593677	hsa-miR-3133	CLIP-seq
MIRT2687870	hsa-miR-3140-3p	CLIP-seq
MIRT1233314	hsa-miR-3140-5p	CLIP-seq
MIRT2593678	hsa-miR-3143	CLIP-seq
MIRT2593679	hsa-miR-3148	CLIP-seq
MIRT2593680	hsa-miR-3150b-3p	CLIP-seq
MIRT2593681	hsa-miR-338-5p	CLIP-seq
MIRT2593682	hsa-miR-3651	CLIP-seq
MIRT2593683	hsa-miR-3666	CLIP-seq
MIRT2593684	hsa-miR-3678-3p	CLIP-seq
MIRT2593685	hsa-miR-3685	CLIP-seq
MIRT2593686	hsa-miR-3690	CLIP-seq
MIRT2593687	hsa-miR-3714	CLIP-seq
MIRT2593688	hsa-miR-372	CLIP-seq
MIRT2593689	hsa-miR-373	CLIP-seq
MIRT2593690	hsa-miR-380	CLIP-seq
MIRT1233322	hsa-miR-381	CLIP-seq
MIRT2593691	hsa-miR-384	CLIP-seq
MIRT2593692	hsa-miR-3916	CLIP-seq
MIRT2593693	hsa-miR-3925-5p	CLIP-seq
MIRT2593694	hsa-miR-3928	CLIP-seq
MIRT2593695	hsa-miR-3942-5p	CLIP-seq
MIRT2593696	hsa-miR-3974	CLIP-seq
MIRT2593697	hsa-miR-409-3p	CLIP-seq
MIRT2593698	hsa-miR-411	CLIP-seq
MIRT2593699	hsa-miR-4254	CLIP-seq
MIRT2593701	hsa-miR-4266	CLIP-seq
MIRT2593702	hsa-miR-4282	CLIP-seq
MIRT2593703	hsa-miR-4289	CLIP-seq
MIRT2593704	hsa-miR-4295	CLIP-seq
MIRT2593706	hsa-miR-4307	CLIP-seq
MIRT2593707	hsa-miR-4311	CLIP-seq
MIRT2593709	hsa-miR-4422	CLIP-seq
MIRT1233325	hsa-miR-4427	CLIP-seq
MIRT2687871	hsa-miR-4446-5p	CLIP-seq
MIRT1233328	hsa-miR-4477b	CLIP-seq
MIRT2593711	hsa-miR-4490	CLIP-seq
MIRT2593712	hsa-miR-4493	CLIP-seq
MIRT2593713	hsa-miR-4495	CLIP-seq
MIRT2687872	hsa-miR-4503	CLIP-seq
MIRT2593714	hsa-miR-4525	CLIP-seq
MIRT2593715	hsa-miR-4536	CLIP-seq
MIRT2593716	hsa-miR-454	CLIP-seq
MIRT2593718	hsa-miR-4649-3p	CLIP-seq
MIRT2593720	hsa-miR-4663	CLIP-seq
MIRT2593721	hsa-miR-4665-5p	CLIP-seq
MIRT1233331	hsa-miR-4666-3p	CLIP-seq
MIRT2593723	hsa-miR-4683	CLIP-seq
MIRT2593724	hsa-miR-4694-3p	CLIP-seq
MIRT2593725	hsa-miR-4695-3p	CLIP-seq
MIRT2593726	hsa-miR-4695-5p	CLIP-seq
MIRT2593727	hsa-miR-4697-3p	CLIP-seq
MIRT2593728	hsa-miR-4703-5p	CLIP-seq
MIRT1233334	hsa-miR-4712-5p	CLIP-seq
MIRT2593729	hsa-miR-4723-5p	CLIP-seq
MIRT2593730	hsa-miR-4752	CLIP-seq
MIRT2593731	hsa-miR-4753-5p	CLIP-seq
MIRT2593732	hsa-miR-4762-5p	CLIP-seq
MIRT2593734	hsa-miR-4773	CLIP-seq
MIRT2593735	hsa-miR-4774-5p	CLIP-seq
MIRT1233339	hsa-miR-4775	CLIP-seq
MIRT2593736	hsa-miR-4779	CLIP-seq
MIRT2593737	hsa-miR-4782-3p	CLIP-seq
MIRT2593738	hsa-miR-4784	CLIP-seq
MIRT1233340	hsa-miR-4795-3p	CLIP-seq
MIRT2593739	hsa-miR-4797-3p	CLIP-seq
MIRT2593740	hsa-miR-4803	CLIP-seq
MIRT2295749	hsa-miR-494	CLIP-seq
MIRT2593741	hsa-miR-495	CLIP-seq
MIRT2593742	hsa-miR-510	CLIP-seq
MIRT2593743	hsa-miR-511	CLIP-seq
MIRT2593744	hsa-miR-512-5p	CLIP-seq
MIRT2593745	hsa-miR-519a	CLIP-seq
MIRT2593746	hsa-miR-519b-3p	CLIP-seq
MIRT2593747	hsa-miR-519c-3p	CLIP-seq
MIRT2593748	hsa-miR-520a-3p	CLIP-seq
MIRT2593749	hsa-miR-520b	CLIP-seq
MIRT2593750	hsa-miR-520c-3p	CLIP-seq
MIRT2593751	hsa-miR-520d-3p	CLIP-seq
MIRT2593752	hsa-miR-520e	CLIP-seq
MIRT2593753	hsa-miR-545	CLIP-seq
MIRT2593754	hsa-miR-548aa	CLIP-seq
MIRT2593755	hsa-miR-548ac	CLIP-seq
MIRT2593756	hsa-miR-548ag	CLIP-seq
MIRT2593757	hsa-miR-548ai	CLIP-seq
MIRT2593758	hsa-miR-548d-3p	CLIP-seq
MIRT2593759	hsa-miR-548m	CLIP-seq
MIRT2593760	hsa-miR-548p	CLIP-seq
MIRT2593761	hsa-miR-548z	CLIP-seq
MIRT2593762	hsa-miR-549	CLIP-seq
MIRT2593763	hsa-miR-567	CLIP-seq
MIRT2593764	hsa-miR-578	CLIP-seq
MIRT2295752	hsa-miR-581	CLIP-seq
MIRT2593765	hsa-miR-584	CLIP-seq
MIRT1233346	hsa-miR-590-3p	CLIP-seq
MIRT2593766	hsa-miR-590-5p	CLIP-seq
MIRT2593767	hsa-miR-591	CLIP-seq
MIRT2593768	hsa-miR-618	CLIP-seq
MIRT2593769	hsa-miR-620	CLIP-seq
MIRT2593770	hsa-miR-625	CLIP-seq
MIRT2593771	hsa-miR-651	CLIP-seq
MIRT2593772	hsa-miR-656	CLIP-seq
MIRT2687873	hsa-miR-659	CLIP-seq
MIRT2593773	hsa-miR-7	CLIP-seq
MIRT2593774	hsa-miR-765	CLIP-seq
MIRT1233350	hsa-miR-770-5p	CLIP-seq
MIRT2593775	hsa-miR-9	CLIP-seq
MIRT2593776	hsa-miR-938	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003923	Function	GPI-anchor transamidase activity	IBA
GO:0003923	Function	GPI-anchor transamidase activity	IDA	35551457, 37684232
GO:0003923	Function	GPI-anchor transamidase activity	IEA
GO:0003923	Function	GPI-anchor transamidase activity	IMP	10793132
GO:0003923	Function	GPI-anchor transamidase activity	TAS
GO:0005515	Function	Protein binding	IPI	10793132, 11483512, 12802054, 28514442, 33961781
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	NAS	12802054
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006506	Process	GPI anchor biosynthetic process	IEA
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0016255	Process	Attachment of GPI anchor to protein	IBA
GO:0016255	Process	Attachment of GPI anchor to protein	IDA	9356492, 10793132, 12802054, 34576938, 35165458, 35551457, 37684232
GO:0016255	Process	Attachment of GPI anchor to protein	IEA
GO:0016255	Process	Attachment of GPI anchor to protein	NAS	12802054
GO:0016255	Process	Attachment of GPI anchor to protein	TAS	11483512
GO:0016740	Function	Transferase activity	IEA
GO:0034235	Function	GPI anchor binding	TAS	10793132
GO:0042765	Component	GPI-anchor transamidase complex	IBA
GO:0042765	Component	GPI-anchor transamidase complex	IDA	11483512, 12582175, 12802054, 34576938, 35165458, 35551457, 37684232
GO:0042765	Component	GPI-anchor transamidase complex	IEA
GO:0042765	Component	GPI-anchor transamidase complex	IMP	10793132
GO:0042765	Component	GPI-anchor transamidase complex	IPI	12802054
GO:0180046	Process	GPI anchored protein biosynthesis	IDA	35165458, 35551457

Other IDs

• MIM: 605087
• HGNC: 8965
• e!Ensembl: ENSG00000142892

Protein

• UniProt ID: Q92643
• Protein name: GPI-anchor transamidase (EC 2.6.1.-) (GPI-anchor transamidase component PIGK, catalytic subunit) (GPI8 homolog) (hGPI8) (Phosphatidylinositol-glycan biosynthesis class K protein) (PIG-K)
• Protein function: Catalytic subunit of the glycosylphosphatidylinositol-anchor (GPI-anchor) transamidase (GPI-T) complex that catalyzes the formation of the linkage between a proprotein and a GPI-anchor and participates in GPI anchored protein biosynthesis (PubMe
• PDB: 7W72, 7WLD, 8IMX, 8IMY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01650	Peptidase_C13	45 → 306	Peptidase C13 family	Family

• Sequence:

  MAVTDSLSRAATVLATVLLLSFGSVAASHIEDQAEQFFRSGHTNNWAVLVCTSRFWFNYR
  HVANTLSVYRSVKRLGIPDSHIVLMLADDMACNPRNPKPATVFSHKNMELNVYGDDVEVD
  YRSYEVTVENFLRVLTGRIPPSTPRSKRLLSDDRSNILIYMTGHGGNGFLKFQDSEEITN
  IELADAFEQMWQKRRYNELLFIIDTCQGASMYERFYSPNIMALASSQVGEDSLSHQPDPA
  IGVHLMDRYTFYVLEFLEEINPASQTNMNDLFQVCPKSLCVSTPGHRTDLFQRDPKNVLI
  TDFFGSVRKVEITTETIKLQQDSEIMESSYKEDQMDEKLMEPLKYAEQLPVAQIIHQKPK
  LKDWHPPGGFILGLWALIIMVFFKTYGIKHMKFIF

• Sequence length: 395

Pathways

KEGG:

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
Metabolic pathways

Reactome:

Attachment of GPI anchor to uPAR

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Neurodevelopmental disorder with hypotonia and cerebellar atrophy, with or without seizures	Pathogenic	rs747692385, rs2100594030, rs778946833, rs1654968072, rs1656295216, rs772948495, rs1164656857, rs1656391998, rs1656392054	RCV001684645 RCV001684646 RCV004586276 RCV001095378 RCV001095379 RCV001095380 RCV001095381 RCV001095382 RCV001095383	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DISORDER OF DEVELOPMENT OR MORPHOGENESIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Relationship Type	References	Evidence Score
Breast Neoplasms	Associate	18487995	★☆☆☆☆ Found in Text Mining only
Cerebellar Ataxia	Associate	32220290	★☆☆☆☆ Found in Text Mining only
Cerebellar Diseases	Associate	32220290	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Inhibit	36405728	★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Associate	32220290	★☆☆☆☆ Found in Text Mining only
Epilepsy	Associate	32220290	★☆☆☆☆ Found in Text Mining only
Facial Dysmorphism with Multiple Malformations	Associate	32220290	★☆☆☆☆ Found in Text Mining only
Glycosylphosphatidylinositol deficiency	Associate	32220290	★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Associate	32220290	★☆☆☆☆ Found in Text Mining only
Lymphoma	Associate	18487995	★☆☆☆☆ Found in Text Mining only
Muscle Hypotonia	Associate	32220290	★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	36405728	★☆☆☆☆ Found in Text Mining only