Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10019
Gene name	SH2B adaptor protein 3
Gene symbol	SH2B3
Synonyms (NCBI Gene)	IDDM20LNK
Chromosome	12
Chromosome location	12q24.12
Summary	This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical ro

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SNP ID	Visualize variation	Clinical significance	Consequence
rs148636776	G>A	Pathogenic	Non coding transcript variant, genic downstream transcript variant, missense variant, coding sequence variant
rs202080221	G>A,C,T	Uncertain-significance, affects, pathogenic	Non coding transcript variant, genic upstream transcript variant, coding sequence variant, missense variant, stop gained
rs587776885	GCGCT>-	Pathogenic	Coding sequence variant, genic upstream transcript variant, frameshift variant, non coding transcript variant
rs1029296641	C>A,T	Likely-pathogenic	Genic downstream transcript variant, non coding transcript variant, missense variant, coding sequence variant

454

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miRTarBase ID	miRNA	Experiments	Reference
MIRT018890	hsa-miR-335-5p	Microarray	18185580
MIRT023128	hsa-miR-124-3p	Microarray	18668037
MIRT023453	hsa-miR-30b-5p	Sequencing	20371350
MIRT024840	hsa-miR-215-5p	Microarray	19074876
MIRT026822	hsa-miR-192-5p	Microarray	19074876
MIRT030230	hsa-miR-26b-5p	Microarray	19088304
MIRT037031	hsa-miR-877-3p	CLASH	23622248
MIRT666441	hsa-miR-4433b-3p	HITS-CLIP	23824327
MIRT666440	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT666439	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT666438	hsa-miR-1248	HITS-CLIP	23824327
MIRT666437	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT666436	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT666435	hsa-miR-4327	HITS-CLIP	23824327
MIRT666434	hsa-miR-1289	HITS-CLIP	23824327
MIRT666433	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT666432	hsa-miR-623	HITS-CLIP	23824327
MIRT666431	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT666430	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT666429	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT666428	hsa-miR-5691	HITS-CLIP	23824327
MIRT666427	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT666426	hsa-miR-1273e	HITS-CLIP	23824327
MIRT666425	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT666424	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT666423	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT666422	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT666421	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT666420	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT638283	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT638282	hsa-miR-3940-3p	HITS-CLIP	23824327
MIRT653878	hsa-miR-25-3p	HITS-CLIP	23824327
MIRT653877	hsa-miR-32-5p	HITS-CLIP	23824327
MIRT653876	hsa-miR-363-3p	HITS-CLIP	23824327
MIRT653875	hsa-miR-367-3p	HITS-CLIP	23824327
MIRT653874	hsa-miR-92a-3p	HITS-CLIP	23824327
MIRT653873	hsa-miR-92b-3p	HITS-CLIP	23824327
MIRT638279	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT638280	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT638278	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT653872	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT638277	hsa-miR-380-5p	HITS-CLIP	23824327
MIRT638276	hsa-miR-563	HITS-CLIP	23824327
MIRT638275	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT638274	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT653871	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT638273	hsa-miR-7703	HITS-CLIP	23824327
MIRT638283	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT638282	hsa-miR-3940-3p	HITS-CLIP	23824327
MIRT638281	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT638279	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT638280	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT638278	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT638277	hsa-miR-380-5p	HITS-CLIP	23824327
MIRT638276	hsa-miR-563	HITS-CLIP	23824327
MIRT638275	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT638274	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT638273	hsa-miR-7703	HITS-CLIP	23824327
MIRT492296	hsa-miR-576-3p	PAR-CLIP	23592263
MIRT492295	hsa-miR-6165	PAR-CLIP	23592263
MIRT492294	hsa-miR-3159	PAR-CLIP	23592263
MIRT492293	hsa-miR-452-3p	PAR-CLIP	23592263
MIRT666441	hsa-miR-4433b-3p	HITS-CLIP	23824327
MIRT666440	hsa-miR-6832-3p	HITS-CLIP	23824327
MIRT666439	hsa-miR-1237-3p	HITS-CLIP	23824327
MIRT666438	hsa-miR-1248	HITS-CLIP	23824327
MIRT666437	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT666436	hsa-miR-4778-3p	HITS-CLIP	23824327
MIRT666435	hsa-miR-4327	HITS-CLIP	23824327
MIRT666434	hsa-miR-1289	HITS-CLIP	23824327
MIRT666433	hsa-miR-6826-3p	HITS-CLIP	23824327
MIRT666432	hsa-miR-623	HITS-CLIP	23824327
MIRT666431	hsa-miR-204-5p	HITS-CLIP	23824327
MIRT666430	hsa-miR-211-5p	HITS-CLIP	23824327
MIRT666429	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT666428	hsa-miR-5691	HITS-CLIP	23824327
MIRT666427	hsa-miR-6805-3p	HITS-CLIP	23824327
MIRT666426	hsa-miR-1273e	HITS-CLIP	23824327
MIRT666425	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT666424	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT666423	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT666422	hsa-miR-6885-3p	HITS-CLIP	23824327
MIRT666421	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT666420	hsa-miR-5584-3p	HITS-CLIP	23824327
MIRT638283	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT638282	hsa-miR-3940-3p	HITS-CLIP	23824327
MIRT653878	hsa-miR-25-3p	HITS-CLIP	23824327
MIRT653877	hsa-miR-32-5p	HITS-CLIP	23824327
MIRT653876	hsa-miR-363-3p	HITS-CLIP	23824327
MIRT653875	hsa-miR-367-3p	HITS-CLIP	23824327
MIRT653874	hsa-miR-92a-3p	HITS-CLIP	23824327
MIRT653873	hsa-miR-92b-3p	HITS-CLIP	23824327
MIRT638279	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT638280	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT638278	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT653872	hsa-miR-767-5p	HITS-CLIP	23824327
MIRT638277	hsa-miR-380-5p	HITS-CLIP	23824327
MIRT638276	hsa-miR-563	HITS-CLIP	23824327
MIRT638275	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT638274	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT653871	hsa-miR-500a-3p	HITS-CLIP	23824327
MIRT638273	hsa-miR-7703	HITS-CLIP	23824327
MIRT638283	hsa-miR-508-5p	HITS-CLIP	23824327
MIRT638282	hsa-miR-3940-3p	HITS-CLIP	23824327
MIRT638281	hsa-miR-1273g-3p	HITS-CLIP	23824327
MIRT638279	hsa-miR-6849-3p	HITS-CLIP	23824327
MIRT638280	hsa-miR-766-3p	HITS-CLIP	23824327
MIRT638278	hsa-miR-4793-3p	HITS-CLIP	23824327
MIRT638277	hsa-miR-380-5p	HITS-CLIP	23824327
MIRT638276	hsa-miR-563	HITS-CLIP	23824327
MIRT638275	hsa-miR-6512-3p	HITS-CLIP	23824327
MIRT638274	hsa-miR-6720-5p	HITS-CLIP	23824327
MIRT638273	hsa-miR-7703	HITS-CLIP	23824327
MIRT492296	hsa-miR-576-3p	PAR-CLIP	23592263
MIRT492295	hsa-miR-6165	PAR-CLIP	23592263
MIRT492294	hsa-miR-3159	PAR-CLIP	23592263
MIRT492293	hsa-miR-452-3p	PAR-CLIP	23592263
MIRT1344137	hsa-miR-1179	CLIP-seq
MIRT1344138	hsa-miR-1193	CLIP-seq
MIRT1344139	hsa-miR-1200	CLIP-seq
MIRT1344140	hsa-miR-1207-5p	CLIP-seq
MIRT1344141	hsa-miR-1245b-3p	CLIP-seq
MIRT1344142	hsa-miR-1252	CLIP-seq
MIRT1344143	hsa-miR-125a-3p	CLIP-seq
MIRT1344144	hsa-miR-1299	CLIP-seq
MIRT1344145	hsa-miR-132	CLIP-seq
MIRT1344146	hsa-miR-134	CLIP-seq
MIRT1344147	hsa-miR-181a	CLIP-seq
MIRT1344148	hsa-miR-181b	CLIP-seq
MIRT1344149	hsa-miR-181c	CLIP-seq
MIRT1344150	hsa-miR-181d	CLIP-seq
MIRT1344151	hsa-miR-212	CLIP-seq
MIRT1344152	hsa-miR-224	CLIP-seq
MIRT1344153	hsa-miR-23a	CLIP-seq
MIRT1344154	hsa-miR-23b	CLIP-seq
MIRT1344155	hsa-miR-23c	CLIP-seq
MIRT1344156	hsa-miR-3118	CLIP-seq
MIRT1344157	hsa-miR-3180-5p	CLIP-seq
MIRT1344158	hsa-miR-3202	CLIP-seq
MIRT1344159	hsa-miR-326	CLIP-seq
MIRT1344160	hsa-miR-330-5p	CLIP-seq
MIRT1344161	hsa-miR-3591-5p	CLIP-seq
MIRT1344162	hsa-miR-3607-3p	CLIP-seq
MIRT1344163	hsa-miR-3657	CLIP-seq
MIRT1344164	hsa-miR-3665	CLIP-seq
MIRT1344165	hsa-miR-3677-5p	CLIP-seq
MIRT1344166	hsa-miR-3682-3p	CLIP-seq
MIRT1344167	hsa-miR-3686	CLIP-seq
MIRT1344168	hsa-miR-377	CLIP-seq
MIRT1344169	hsa-miR-3908	CLIP-seq
MIRT1344170	hsa-miR-3919	CLIP-seq
MIRT1344171	hsa-miR-3942-5p	CLIP-seq
MIRT1344172	hsa-miR-4255	CLIP-seq
MIRT1344173	hsa-miR-4262	CLIP-seq
MIRT1344174	hsa-miR-4275	CLIP-seq
MIRT1344175	hsa-miR-4300	CLIP-seq
MIRT1344176	hsa-miR-4456	CLIP-seq
MIRT1344177	hsa-miR-4457	CLIP-seq
MIRT1344178	hsa-miR-4476	CLIP-seq
MIRT1344179	hsa-miR-4502	CLIP-seq
MIRT1344180	hsa-miR-4533	CLIP-seq
MIRT1344181	hsa-miR-4667-3p	CLIP-seq
MIRT1344182	hsa-miR-4701-5p	CLIP-seq
MIRT1344183	hsa-miR-4703-5p	CLIP-seq
MIRT1344184	hsa-miR-4718	CLIP-seq
MIRT1344185	hsa-miR-4736	CLIP-seq
MIRT1344186	hsa-miR-4760-3p	CLIP-seq
MIRT1344187	hsa-miR-4763-3p	CLIP-seq
MIRT1344188	hsa-miR-4766-3p	CLIP-seq
MIRT1344189	hsa-miR-4768-5p	CLIP-seq
MIRT1344190	hsa-miR-513b	CLIP-seq
MIRT1344191	hsa-miR-520a-5p	CLIP-seq
MIRT1344192	hsa-miR-525-5p	CLIP-seq
MIRT1344193	hsa-miR-541	CLIP-seq
MIRT1344194	hsa-miR-548n	CLIP-seq
MIRT1344195	hsa-miR-548t	CLIP-seq
MIRT1344196	hsa-miR-564	CLIP-seq
MIRT1344197	hsa-miR-570	CLIP-seq
MIRT1344198	hsa-miR-579	CLIP-seq
MIRT1344199	hsa-miR-588	CLIP-seq
MIRT1344200	hsa-miR-589	CLIP-seq
MIRT1344201	hsa-miR-615-5p	CLIP-seq
MIRT1344202	hsa-miR-651	CLIP-seq
MIRT1344203	hsa-miR-654-5p	CLIP-seq
MIRT1344204	hsa-miR-664	CLIP-seq
MIRT1344205	hsa-miR-875-3p	CLIP-seq
MIRT1344206	hsa-miR-920	CLIP-seq
MIRT1344207	hsa-miR-943	CLIP-seq
MIRT1557020	hsa-miR-4417	CLIP-seq
MIRT1557021	hsa-miR-4428	CLIP-seq
MIRT1922359	hsa-miR-1266	CLIP-seq
MIRT1922360	hsa-miR-4518	CLIP-seq
MIRT1344138	hsa-miR-1193	CLIP-seq
MIRT2101756	hsa-miR-1237	CLIP-seq
MIRT2101757	hsa-miR-1324	CLIP-seq
MIRT2101758	hsa-miR-138	CLIP-seq
MIRT2101759	hsa-miR-300	CLIP-seq
MIRT2101760	hsa-miR-3122	CLIP-seq
MIRT2101761	hsa-miR-3165	CLIP-seq
MIRT1344158	hsa-miR-3202	CLIP-seq
MIRT2101762	hsa-miR-3622a-3p	CLIP-seq
MIRT2101763	hsa-miR-3622b-3p	CLIP-seq
MIRT2101764	hsa-miR-3656	CLIP-seq
MIRT2101765	hsa-miR-3689a-3p	CLIP-seq
MIRT2101766	hsa-miR-3689c	CLIP-seq
MIRT2101767	hsa-miR-381	CLIP-seq
MIRT2101768	hsa-miR-384	CLIP-seq
MIRT2101769	hsa-miR-3913-5p	CLIP-seq
MIRT2101770	hsa-miR-3926	CLIP-seq
MIRT1344175	hsa-miR-4300	CLIP-seq
MIRT2101771	hsa-miR-4436b-5p	CLIP-seq
MIRT2101772	hsa-miR-4505	CLIP-seq
MIRT1344180	hsa-miR-4533	CLIP-seq
MIRT2101773	hsa-miR-4645-5p	CLIP-seq
MIRT2101774	hsa-miR-4662a-5p	CLIP-seq
MIRT2101775	hsa-miR-4673	CLIP-seq
MIRT2101776	hsa-miR-4676-5p	CLIP-seq
MIRT2101777	hsa-miR-4728-5p	CLIP-seq
MIRT2101778	hsa-miR-4755-3p	CLIP-seq
MIRT2101779	hsa-miR-4766-5p	CLIP-seq
MIRT2101780	hsa-miR-4786-5p	CLIP-seq
MIRT2101781	hsa-miR-544b	CLIP-seq
MIRT2101782	hsa-miR-548s	CLIP-seq
MIRT2101783	hsa-miR-550a	CLIP-seq
MIRT2101784	hsa-miR-575	CLIP-seq
MIRT1344206	hsa-miR-920	CLIP-seq
MIRT2101757	hsa-miR-1324	CLIP-seq
MIRT2326130	hsa-miR-145	CLIP-seq
MIRT2326131	hsa-miR-192	CLIP-seq
MIRT2326132	hsa-miR-215	CLIP-seq
MIRT2326133	hsa-miR-30a	CLIP-seq
MIRT2326134	hsa-miR-30b	CLIP-seq
MIRT2326135	hsa-miR-30c	CLIP-seq
MIRT2326136	hsa-miR-30d	CLIP-seq
MIRT2326137	hsa-miR-30e	CLIP-seq
MIRT2101760	hsa-miR-3122	CLIP-seq
MIRT2101761	hsa-miR-3165	CLIP-seq
MIRT2326138	hsa-miR-3178	CLIP-seq
MIRT1344158	hsa-miR-3202	CLIP-seq
MIRT1344162	hsa-miR-3607-3p	CLIP-seq
MIRT2101762	hsa-miR-3622a-3p	CLIP-seq
MIRT2101763	hsa-miR-3622b-3p	CLIP-seq
MIRT2101764	hsa-miR-3656	CLIP-seq
MIRT1344167	hsa-miR-3686	CLIP-seq
MIRT2101765	hsa-miR-3689a-3p	CLIP-seq
MIRT2101766	hsa-miR-3689c	CLIP-seq
MIRT2101769	hsa-miR-3913-5p	CLIP-seq
MIRT2326139	hsa-miR-4328	CLIP-seq
MIRT1557021	hsa-miR-4428	CLIP-seq
MIRT1344178	hsa-miR-4476	CLIP-seq
MIRT2326140	hsa-miR-4486	CLIP-seq
MIRT2101772	hsa-miR-4505	CLIP-seq
MIRT1344180	hsa-miR-4533	CLIP-seq
MIRT2326141	hsa-miR-4654	CLIP-seq
MIRT2326142	hsa-miR-4693-3p	CLIP-seq
MIRT2101777	hsa-miR-4728-5p	CLIP-seq
MIRT2326143	hsa-miR-4764-5p	CLIP-seq
MIRT2326144	hsa-miR-4769-5p	CLIP-seq
MIRT2326145	hsa-miR-489	CLIP-seq
MIRT1344193	hsa-miR-541	CLIP-seq
MIRT2101781	hsa-miR-544b	CLIP-seq
MIRT2326146	hsa-miR-610	CLIP-seq
MIRT1344203	hsa-miR-654-5p	CLIP-seq
MIRT2101758	hsa-miR-138	CLIP-seq
MIRT2394345	hsa-miR-149	CLIP-seq
MIRT2394346	hsa-miR-196a	CLIP-seq
MIRT2394347	hsa-miR-196b	CLIP-seq
MIRT2394348	hsa-miR-2054	CLIP-seq
MIRT2394349	hsa-miR-24	CLIP-seq
MIRT2394350	hsa-miR-296-3p	CLIP-seq
MIRT2101760	hsa-miR-3122	CLIP-seq
MIRT2101761	hsa-miR-3165	CLIP-seq
MIRT2394351	hsa-miR-331-5p	CLIP-seq
MIRT2394352	hsa-miR-338-3p	CLIP-seq
MIRT1344161	hsa-miR-3591-5p	CLIP-seq
MIRT1344162	hsa-miR-3607-3p	CLIP-seq
MIRT2394353	hsa-miR-3622b-5p	CLIP-seq
MIRT2394354	hsa-miR-3652	CLIP-seq
MIRT2101764	hsa-miR-3656	CLIP-seq
MIRT2101765	hsa-miR-3689a-3p	CLIP-seq
MIRT2101766	hsa-miR-3689c	CLIP-seq
MIRT2394355	hsa-miR-3689d	CLIP-seq
MIRT2394356	hsa-miR-3907	CLIP-seq
MIRT2101769	hsa-miR-3913-5p	CLIP-seq
MIRT2394357	hsa-miR-3927	CLIP-seq
MIRT2394358	hsa-miR-4284	CLIP-seq
MIRT2394359	hsa-miR-4307	CLIP-seq
MIRT2394360	hsa-miR-4310	CLIP-seq
MIRT2394361	hsa-miR-4430	CLIP-seq
MIRT1344178	hsa-miR-4476	CLIP-seq
MIRT2394362	hsa-miR-4494	CLIP-seq
MIRT2101772	hsa-miR-4505	CLIP-seq
MIRT2394363	hsa-miR-4652-3p	CLIP-seq
MIRT2101777	hsa-miR-4728-5p	CLIP-seq
MIRT2394364	hsa-miR-499a-5p	CLIP-seq
MIRT2394365	hsa-miR-548q	CLIP-seq
MIRT2394366	hsa-miR-597	CLIP-seq
MIRT2394367	hsa-miR-636	CLIP-seq
MIRT2394368	hsa-miR-668	CLIP-seq
MIRT2459266	hsa-miR-10a	CLIP-seq
MIRT2459267	hsa-miR-10b	CLIP-seq
MIRT2101760	hsa-miR-3122	CLIP-seq
MIRT2459268	hsa-miR-339-5p	CLIP-seq
MIRT2101765	hsa-miR-3689a-3p	CLIP-seq
MIRT2101766	hsa-miR-3689c	CLIP-seq
MIRT2101769	hsa-miR-3913-5p	CLIP-seq
MIRT2459269	hsa-miR-4421	CLIP-seq
MIRT2101773	hsa-miR-4645-5p	CLIP-seq
MIRT2101774	hsa-miR-4662a-5p	CLIP-seq
MIRT2101775	hsa-miR-4673	CLIP-seq
MIRT2101776	hsa-miR-4676-5p	CLIP-seq
MIRT2459270	hsa-miR-4684-5p	CLIP-seq
MIRT2101777	hsa-miR-4728-5p	CLIP-seq
MIRT2101778	hsa-miR-4755-3p	CLIP-seq
MIRT2459271	hsa-miR-548c-3p	CLIP-seq
MIRT2101784	hsa-miR-575	CLIP-seq
MIRT2459272	hsa-miR-593	CLIP-seq
MIRT2621826	hsa-miR-106a	CLIP-seq
MIRT2621827	hsa-miR-106b	CLIP-seq
MIRT2459266	hsa-miR-10a	CLIP-seq
MIRT2459267	hsa-miR-10b	CLIP-seq
MIRT1344139	hsa-miR-1200	CLIP-seq
MIRT2621828	hsa-miR-1285	CLIP-seq
MIRT2621829	hsa-miR-1301	CLIP-seq
MIRT2101757	hsa-miR-1324	CLIP-seq
MIRT2101758	hsa-miR-138	CLIP-seq
MIRT2394345	hsa-miR-149	CLIP-seq
MIRT2621830	hsa-miR-17	CLIP-seq
MIRT2621831	hsa-miR-1827	CLIP-seq
MIRT2621832	hsa-miR-1913	CLIP-seq
MIRT2394348	hsa-miR-2054	CLIP-seq
MIRT2621833	hsa-miR-20a	CLIP-seq
MIRT2621834	hsa-miR-20b	CLIP-seq
MIRT2621835	hsa-miR-2115	CLIP-seq
MIRT2621836	hsa-miR-219-2-3p	CLIP-seq
MIRT2394349	hsa-miR-24	CLIP-seq
MIRT2621837	hsa-miR-2964a-3p	CLIP-seq
MIRT2621838	hsa-miR-3064-3p	CLIP-seq
MIRT2101760	hsa-miR-3122	CLIP-seq
MIRT2101761	hsa-miR-3165	CLIP-seq
MIRT2621839	hsa-miR-3187-5p	CLIP-seq
MIRT2621840	hsa-miR-3192	CLIP-seq
MIRT2621841	hsa-miR-3194-5p	CLIP-seq
MIRT2621842	hsa-miR-324-3p	CLIP-seq
MIRT2394352	hsa-miR-338-3p	CLIP-seq
MIRT2459268	hsa-miR-339-5p	CLIP-seq
MIRT2621843	hsa-miR-34c-3p	CLIP-seq
MIRT1344161	hsa-miR-3591-5p	CLIP-seq
MIRT2621844	hsa-miR-3605-5p	CLIP-seq
MIRT1344162	hsa-miR-3607-3p	CLIP-seq
MIRT2621845	hsa-miR-3613-3p	CLIP-seq
MIRT2101762	hsa-miR-3622a-3p	CLIP-seq
MIRT2101763	hsa-miR-3622b-3p	CLIP-seq
MIRT2394353	hsa-miR-3622b-5p	CLIP-seq
MIRT2394354	hsa-miR-3652	CLIP-seq
MIRT2101764	hsa-miR-3656	CLIP-seq
MIRT1344166	hsa-miR-3682-3p	CLIP-seq
MIRT2101765	hsa-miR-3689a-3p	CLIP-seq
MIRT2101766	hsa-miR-3689c	CLIP-seq
MIRT2394355	hsa-miR-3689d	CLIP-seq
MIRT2621846	hsa-miR-371-5p	CLIP-seq
MIRT2621847	hsa-miR-371b-5p	CLIP-seq
MIRT2621848	hsa-miR-378g	CLIP-seq
MIRT2394356	hsa-miR-3907	CLIP-seq
MIRT2101769	hsa-miR-3913-5p	CLIP-seq
MIRT2621849	hsa-miR-3943	CLIP-seq
MIRT2621850	hsa-miR-411	CLIP-seq
MIRT1344172	hsa-miR-4255	CLIP-seq
MIRT2394358	hsa-miR-4284	CLIP-seq
MIRT2621851	hsa-miR-4303	CLIP-seq
MIRT2621852	hsa-miR-4313	CLIP-seq
MIRT2621853	hsa-miR-4314	CLIP-seq
MIRT2621854	hsa-miR-4325	CLIP-seq
MIRT2459269	hsa-miR-4421	CLIP-seq
MIRT2394361	hsa-miR-4430	CLIP-seq
MIRT2621855	hsa-miR-4449	CLIP-seq
MIRT1344178	hsa-miR-4476	CLIP-seq
MIRT2326140	hsa-miR-4486	CLIP-seq
MIRT2394362	hsa-miR-4494	CLIP-seq
MIRT1344179	hsa-miR-4502	CLIP-seq
MIRT2101772	hsa-miR-4505	CLIP-seq
MIRT2621856	hsa-miR-4539	CLIP-seq
MIRT2101773	hsa-miR-4645-5p	CLIP-seq
MIRT2621857	hsa-miR-4646-5p	CLIP-seq
MIRT2101774	hsa-miR-4662a-5p	CLIP-seq
MIRT2101775	hsa-miR-4673	CLIP-seq
MIRT2101776	hsa-miR-4676-5p	CLIP-seq
MIRT2459270	hsa-miR-4684-5p	CLIP-seq
MIRT2101777	hsa-miR-4728-5p	CLIP-seq
MIRT2621858	hsa-miR-4740-3p	CLIP-seq
MIRT2101778	hsa-miR-4755-3p	CLIP-seq
MIRT2621859	hsa-miR-4762-3p	CLIP-seq
MIRT2394364	hsa-miR-499a-5p	CLIP-seq
MIRT2621860	hsa-miR-5047	CLIP-seq
MIRT2621861	hsa-miR-516a-3p	CLIP-seq
MIRT2621862	hsa-miR-519d	CLIP-seq
MIRT2101781	hsa-miR-544b	CLIP-seq
MIRT2459271	hsa-miR-548c-3p	CLIP-seq
MIRT2394365	hsa-miR-548q	CLIP-seq
MIRT1344195	hsa-miR-548t	CLIP-seq
MIRT2101784	hsa-miR-575	CLIP-seq
MIRT1344200	hsa-miR-589	CLIP-seq
MIRT2459272	hsa-miR-593	CLIP-seq
MIRT2621863	hsa-miR-612	CLIP-seq
MIRT2394367	hsa-miR-636	CLIP-seq
MIRT2394368	hsa-miR-668	CLIP-seq
MIRT2621864	hsa-miR-765	CLIP-seq
MIRT2621865	hsa-miR-93	CLIP-seq
MIRT2621866	hsa-miR-936	CLIP-seq
MIRT2459266	hsa-miR-10a	CLIP-seq
MIRT2459267	hsa-miR-10b	CLIP-seq
MIRT2101757	hsa-miR-1324	CLIP-seq
MIRT2101758	hsa-miR-138	CLIP-seq
MIRT2394348	hsa-miR-2054	CLIP-seq
MIRT2101760	hsa-miR-3122	CLIP-seq
MIRT2101761	hsa-miR-3165	CLIP-seq
MIRT2621841	hsa-miR-3194-5p	CLIP-seq
MIRT2394352	hsa-miR-338-3p	CLIP-seq
MIRT2459268	hsa-miR-339-5p	CLIP-seq
MIRT2621844	hsa-miR-3605-5p	CLIP-seq
MIRT2101762	hsa-miR-3622a-3p	CLIP-seq
MIRT2101763	hsa-miR-3622b-3p	CLIP-seq
MIRT2394353	hsa-miR-3622b-5p	CLIP-seq
MIRT2394354	hsa-miR-3652	CLIP-seq
MIRT2101764	hsa-miR-3656	CLIP-seq
MIRT2101765	hsa-miR-3689a-3p	CLIP-seq
MIRT2101766	hsa-miR-3689c	CLIP-seq
MIRT2394356	hsa-miR-3907	CLIP-seq
MIRT2101769	hsa-miR-3913-5p	CLIP-seq
MIRT2621849	hsa-miR-3943	CLIP-seq
MIRT2621850	hsa-miR-411	CLIP-seq
MIRT2621851	hsa-miR-4303	CLIP-seq
MIRT2621852	hsa-miR-4313	CLIP-seq
MIRT2459269	hsa-miR-4421	CLIP-seq
MIRT2394361	hsa-miR-4430	CLIP-seq
MIRT2621855	hsa-miR-4449	CLIP-seq
MIRT2101772	hsa-miR-4505	CLIP-seq
MIRT2101773	hsa-miR-4645-5p	CLIP-seq
MIRT2101774	hsa-miR-4662a-5p	CLIP-seq
MIRT2101775	hsa-miR-4673	CLIP-seq
MIRT2101776	hsa-miR-4676-5p	CLIP-seq
MIRT2459270	hsa-miR-4684-5p	CLIP-seq
MIRT2101777	hsa-miR-4728-5p	CLIP-seq
MIRT2621858	hsa-miR-4740-3p	CLIP-seq
MIRT2101778	hsa-miR-4755-3p	CLIP-seq
MIRT2621859	hsa-miR-4762-3p	CLIP-seq
MIRT2101781	hsa-miR-544b	CLIP-seq
MIRT2459271	hsa-miR-548c-3p	CLIP-seq
MIRT2394365	hsa-miR-548q	CLIP-seq
MIRT2101784	hsa-miR-575	CLIP-seq
MIRT2459272	hsa-miR-593	CLIP-seq
MIRT2394367	hsa-miR-636	CLIP-seq
MIRT2621864	hsa-miR-765	CLIP-seq
MIRT2621866	hsa-miR-936	CLIP-seq

Show/Hide all (53)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001780	Process	Neutrophil homeostasis	IEA
GO:0001780	Process	Neutrophil homeostasis	ISS	27430239
GO:0002262	Process	Myeloid cell homeostasis	IEA
GO:0005068	Function	Transmembrane receptor protein tyrosine kinase adaptor activity	IBA
GO:0005173	Function	Stem cell factor receptor binding	IEA
GO:0005173	Function	Stem cell factor receptor binding	ISS
GO:0005515	Function	Protein binding	IPI	16273093, 24728074
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0008285	Process	Negative regulation of cell population proliferation	ISS
GO:0030097	Process	Hemopoiesis	IEA
GO:0030159	Function	Signaling receptor complex adaptor activity	IEA
GO:0030159	Function	Signaling receptor complex adaptor activity	ISS
GO:0035162	Process	Embryonic hemopoiesis	IEA
GO:0035162	Process	Embryonic hemopoiesis	ISS
GO:0035556	Process	Intracellular signal transduction	IBA
GO:0035556	Process	Intracellular signal transduction	IEA
GO:0035591	Function	Signaling adaptor activity	IEA
GO:0035702	Process	Monocyte homeostasis	IEA
GO:0035702	Process	Monocyte homeostasis	ISS	27430239
GO:0035855	Process	Megakaryocyte development	IEA
GO:0035855	Process	Megakaryocyte development	ISS
GO:0036016	Process	Cellular response to interleukin-3	IEA
GO:0036016	Process	Cellular response to interleukin-3	ISS
GO:0038163	Process	Thrombopoietin-mediated signaling pathway	IDA	20404132
GO:0038163	Process	Thrombopoietin-mediated signaling pathway	IEA
GO:0038163	Process	Thrombopoietin-mediated signaling pathway	ISS
GO:0038163	Process	Thrombopoietin-mediated signaling pathway	TAS	27430239
GO:0043409	Process	Negative regulation of MAPK cascade	IEA
GO:0043409	Process	Negative regulation of MAPK cascade	ISS
GO:0046426	Process	Negative regulation of receptor signaling pathway via JAK-STAT	IMP	20404132
GO:0048821	Process	Erythrocyte development	IMP	20404132
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
GO:0051898	Process	Negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISS
GO:0060218	Process	Hematopoietic stem cell differentiation	IEA
GO:0060761	Process	Negative regulation of response to cytokine stimulus	IEA
GO:0060761	Process	Negative regulation of response to cytokine stimulus	IMP	20404132
GO:0061515	Process	Myeloid cell development	IEA
GO:0070100	Process	Negative regulation of chemokine-mediated signaling pathway	IEA
GO:0070100	Process	Negative regulation of chemokine-mediated signaling pathway	ISS
GO:0090331	Process	Negative regulation of platelet aggregation	IEA
GO:0090331	Process	Negative regulation of platelet aggregation	ISS	27430239
GO:1900235	Process	Negative regulation of Kit signaling pathway	IEA
GO:1900235	Process	Negative regulation of Kit signaling pathway	ISS
GO:1904893	Process	Negative regulation of receptor signaling pathway via STAT	IEA
GO:1904893	Process	Negative regulation of receptor signaling pathway via STAT	ISS
GO:1990782	Function	Protein tyrosine kinase binding	IEA
GO:1990782	Function	Protein tyrosine kinase binding	ISS
GO:1990869	Process	Cellular response to chemokine	IEA
GO:1990869	Process	Cellular response to chemokine	ISS

MIM	HGNC	e!Ensembl
605093	29605	ENSG00000111252

Q9UQQ2

Protein name

SH2B adapter protein 3 (Lymphocyte adapter protein) (Lymphocyte-specific adapter protein Lnk) (Signal transduction protein Lnk)

Protein function

Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF08916	Phe_ZIP	25 → 80	Phenylalanine zipper	Domain
PF00169	PH	202 → 307	PH domain	Domain
PF00017	SH2	364 → 441	SH2 domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Preferentially expressed by lymphoid cell lines.

Sequence

MNGPALQPSSPSSAPSASPAAAPRGWSEFCELHAVAAARELARQYWLFAREHPQHAPLRA
ELVSLQFTDLFQRYFCREVRDGRAPGRDYRDTGRGPPAKAEASPEPGPGPAAPGLPKARS
SEELAPPRPPGPCSFQHFRRSLRHIFRRRSAGELPAAHTAAAPGTPGEAAETPARPGLAK
KFLPWSLAREPPPEALKEAVLRYSLADEASMDSGARWQRGRLALRRAPGPDGPDRVLELF
DPPKSSRPKLQAACSSIQEVRWCTRLEMPDNLYTFVLKVKDRTDIIFEVGDEQQLNSWMA
ELSECTGRGLESTEAEMHIPSALEPSTSSSPRGSTDSLNQGASPGGLLDPACQKTDHFLS
CYPWFHGPISRVKAAQLVQLQGPDAHGVFLVRQSETRRGEYVLTFNFQGIAKHLRLSLTE
RGQCRVQHLHFPSVVDMLHHFQRSPIPLECGAACDVRLSSYVVVVSQPPGSCNTVLFPFS
LPHWDSESLPHWGSELGLPHLSSSGCPRGLSPEGLPGRSSPPEQIFHLVPSPEELANSLQ
HLEHEPVNRARDSDYEMDSSSRSHLRAIDNQYTPL

Sequence length

575

Interactions

View interactions

	KEGG		Reactome
	Neurotrophin signaling pathway		Regulation of KIT signaling Factors involved in megakaryocyte development and platelet production

Show/Hide Causal Diseases (3)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Hereditary cancer-predisposing syndrome	Pathogenic	rs2500219496	RCV002472256
Primary familial polycythemia due to EPO receptor mutation	Pathogenic	rs376261237	RCV002250348
Primary myelofibrosis	Likely pathogenic; Pathogenic	rs751076276, rs587776885	RCV003990125 RCV000023397

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Familial cancer of breast	Likely benign	rs548854518	RCV005871419
Familial myelofibrosis	Uncertain significance	rs1871229237	RCV003120366
Hepatoblastoma	Conflicting classifications of pathogenicity	rs202080221	RCV001843460
Hereditary cancer	Conflicting classifications of pathogenicity	rs939947819, rs202080221	RCV003492897 RCV004700273
Multiple myeloma	Uncertain significance	rs1029296641	RCV000984129
SH2B3-related disorder	Benign; Uncertain significance; Likely benign; Conflicting classifications of pathogenicity	rs7972796, rs111360561, rs531965947, rs1471634898, rs12371484, rs376914049, rs754838420, rs548854518, rs779556283, rs7963692, rs79819500, rs147318193	RCV003921303 RCV003401738 RCV003402632 RCV003394427 RCV003919379 RCV004756546 RCV003944591 RCV003949366 RCV003966970 RCV003912654 RCV003936094 RCV003923105
Thrombocythemia 1	Benign; Uncertain significance; Conflicting classifications of pathogenicity	rs3184504, rs531156627, rs202080221, rs72650673, rs148636776	RCV002488461 RCV003150832 RCV000023398 RCV000763792 RCV000760174
Uterine corpus endometrial carcinoma	Conflicting classifications of pathogenicity	rs79819500	RCV005908638

Show/Hide Text Mining Associations (66)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenoma Islet Cell	Associate	36622793
Amyotrophic Lateral Sclerosis	Associate	22916186
Antiphospholipid Syndrome	Associate	23844121
Arthritis Juvenile	Associate	20647273
Arthritis Rheumatoid	Associate	33482886
Aspergillosis	Associate	37277724
Autoimmune Diseases	Associate	22493691, 24074872, 32879140
Autoimmune Lymphoproliferative Syndrome	Associate	36123612, 37277724
Bacterial Infections	Associate	20560212
Bone Marrow Failure Disorders	Associate	32098966
Breast Neoplasms	Associate	31428775
Carcinoma Renal Cell	Associate	36059531
Cardiovascular Diseases	Associate	31428775
Celiac Disease	Associate	19073967, 20560212, 22087237
Cell Transformation Viral	Associate	28513614
Colorectal Neoplasms	Associate	26553438
Colorectal Neoplasms	Inhibit	31706103
Coronary Artery Disease	Associate	24725463
Coronary Artery Disease Autosomal Dominant 1	Associate	22216278
Coronary Disease	Associate	31428775
Diabetes Mellitus	Associate	26891449, 28520980, 36150053
Diabetes Mellitus Type 1	Associate	21270831, 21829393, 21873553, 25422107, 26405073, 28438156, 29018046, 33446885, 34858326, 36150053, 36622793, 38453145
Diabetic Nephropathies	Associate	32778679
Disease	Associate	33446885
Drug Related Side Effects and Adverse Reactions	Inhibit	27995954
Endometrial Neoplasms	Associate	30093612
Eosinophilia	Associate	29088303
Fibrosis	Stimulate	32629392
Heart Diseases	Associate	27322554
Hematologic Diseases	Associate	31706103
Heredodegenerative Disorders Nervous System	Associate	26677855
Hypereosinophilic Syndrome	Associate	29088303
Hypothyroidism	Associate	22493691
Inflammation	Associate	31428775, 37967238
Insulin Resistance	Stimulate	27459314
Leukemia	Associate	19375649
Leukemia Biphenotypic Acute	Associate	30816328
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	27111338
Leukemia Myeloid Acute	Associate	19375649, 32098966
Leukemia Myelomonocytic Juvenile	Associate	36123612
Leukemia T Cell	Associate	30816328
Lupus Erythematosus Systemic	Associate	19838195
Lymphoma B Cell	Associate	36123612
Lymphoma T Cell Cutaneous	Associate	33792220
Myelodysplastic Syndromes	Associate	19375649, 32098966
Myocardial Infarction	Associate	24725463
Myocardial Stunning	Associate	32629392
Mysophobia	Associate	20560212
Neoplasms	Associate	20404132, 26450985, 27111338, 27365426, 27449473, 28513614, 30816328, 31428775, 31706103, 32098966
Neoplasms	Stimulate	27995954
Nonsyndromic Holoprosencephaly	Associate	28781130
Peripheral Arterial Disease	Associate	31070467, 34601942
Polycystic Ovary Syndrome	Associate	27459314, 37967238
Polycythemia	Associate	21990094, 27651169
Polycythemia Vera	Associate	22611155, 27111338
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	27322554, 28408464
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	22237106
Pressure Ulcer	Associate	27736895
Primary Myelofibrosis	Associate	27111338
Sarcoidosis	Associate	26051272
Stroke	Associate	36958462, 40596960
Thrombocythemia Essential	Associate	26450985, 27111338, 27991718
Thrombosis	Associate	23844121
Thyroid Diseases	Associate	22493691
Uniparental Disomy	Stimulate	28513614
Venous Thromboembolism	Associate	31420334

SH2B3 (SH2B adaptor protein 3)