Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10015
Gene name	Programmed cell death 6 interacting protein
Gene symbol	PDCD6IP
Synonyms (NCBI Gene)	AIP1ALIXDRIP4HP95MCPH29
Chromosome	3
Chromosome location	3p22.3
Summary	This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this prote

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Show/Hide all (323)

miRTarBase ID	miRNA	Experiments	Reference
MIRT000888	hsa-miR-15a-5p	Microarray	18362358
MIRT000887	hsa-miR-16-5p	Microarray	18362358
MIRT050434	hsa-miR-23a-3p	CLASH	23622248
MIRT049273	hsa-miR-92a-3p	CLASH	23622248
MIRT046335	hsa-miR-23b-3p	CLASH	23622248
MIRT036759	hsa-miR-760	CLASH	23622248
MIRT1219484	hsa-miR-105	CLIP-seq
MIRT1219485	hsa-miR-1207-3p	CLIP-seq
MIRT1219486	hsa-miR-1207-5p	CLIP-seq
MIRT1219487	hsa-miR-125a-3p	CLIP-seq
MIRT1219488	hsa-miR-137	CLIP-seq
MIRT1219489	hsa-miR-1909	CLIP-seq
MIRT1219490	hsa-miR-1910	CLIP-seq
MIRT1219491	hsa-miR-1914	CLIP-seq
MIRT1219492	hsa-miR-216a	CLIP-seq
MIRT1219493	hsa-miR-217	CLIP-seq
MIRT1219494	hsa-miR-25	CLIP-seq
MIRT1219495	hsa-miR-296-3p	CLIP-seq
MIRT1219496	hsa-miR-297	CLIP-seq
MIRT1219497	hsa-miR-3124-3p	CLIP-seq
MIRT1219498	hsa-miR-3149	CLIP-seq
MIRT1219499	hsa-miR-3151	CLIP-seq
MIRT1219500	hsa-miR-3174	CLIP-seq
MIRT1219501	hsa-miR-3185	CLIP-seq
MIRT1219502	hsa-miR-32	CLIP-seq
MIRT1219503	hsa-miR-323-3p	CLIP-seq
MIRT1219504	hsa-miR-340	CLIP-seq
MIRT1219505	hsa-miR-342-3p	CLIP-seq
MIRT1219506	hsa-miR-363	CLIP-seq
MIRT1219507	hsa-miR-367	CLIP-seq
MIRT1219508	hsa-miR-3685	CLIP-seq
MIRT1219509	hsa-miR-3688-5p	CLIP-seq
MIRT1219510	hsa-miR-384	CLIP-seq
MIRT1219511	hsa-miR-3934	CLIP-seq
MIRT1219512	hsa-miR-4307	CLIP-seq
MIRT1219513	hsa-miR-4427	CLIP-seq
MIRT1219514	hsa-miR-4447	CLIP-seq
MIRT1219515	hsa-miR-4472	CLIP-seq
MIRT1219516	hsa-miR-4474-3p	CLIP-seq
MIRT1219517	hsa-miR-4488	CLIP-seq
MIRT1219518	hsa-miR-4537	CLIP-seq
MIRT1219519	hsa-miR-455-3p	CLIP-seq
MIRT1219520	hsa-miR-4680-3p	CLIP-seq
MIRT1219521	hsa-miR-4697-5p	CLIP-seq
MIRT1219522	hsa-miR-4709-3p	CLIP-seq
MIRT1219523	hsa-miR-4717-3p	CLIP-seq
MIRT1219524	hsa-miR-4736	CLIP-seq
MIRT1219525	hsa-miR-4762-3p	CLIP-seq
MIRT1219526	hsa-miR-4762-5p	CLIP-seq
MIRT1219527	hsa-miR-4763-3p	CLIP-seq
MIRT1219528	hsa-miR-4768-3p	CLIP-seq
MIRT1219529	hsa-miR-4789-5p	CLIP-seq
MIRT1219530	hsa-miR-491-5p	CLIP-seq
MIRT1219531	hsa-miR-518a-5p	CLIP-seq
MIRT1219532	hsa-miR-527	CLIP-seq
MIRT1219533	hsa-miR-567	CLIP-seq
MIRT1219534	hsa-miR-665	CLIP-seq
MIRT1219535	hsa-miR-764	CLIP-seq
MIRT1219536	hsa-miR-9	CLIP-seq
MIRT1219537	hsa-miR-92a	CLIP-seq
MIRT1219538	hsa-miR-92b	CLIP-seq
MIRT1219484	hsa-miR-105	CLIP-seq
MIRT1219539	hsa-miR-1257	CLIP-seq
MIRT1219540	hsa-miR-1273f	CLIP-seq
MIRT1219541	hsa-miR-1302	CLIP-seq
MIRT1219542	hsa-miR-1322	CLIP-seq
MIRT1219543	hsa-miR-143	CLIP-seq
MIRT1219490	hsa-miR-1910	CLIP-seq
MIRT1219491	hsa-miR-1914	CLIP-seq
MIRT1219492	hsa-miR-216a	CLIP-seq
MIRT1219544	hsa-miR-302f	CLIP-seq
MIRT1219497	hsa-miR-3124-3p	CLIP-seq
MIRT1219545	hsa-miR-3129-3p	CLIP-seq
MIRT1219546	hsa-miR-3137	CLIP-seq
MIRT1219547	hsa-miR-3148	CLIP-seq
MIRT1219503	hsa-miR-323-3p	CLIP-seq
MIRT1219505	hsa-miR-342-3p	CLIP-seq
MIRT1219548	hsa-miR-3607-3p	CLIP-seq
MIRT1219549	hsa-miR-3609	CLIP-seq
MIRT1219550	hsa-miR-3671	CLIP-seq
MIRT1219551	hsa-miR-3688-3p	CLIP-seq
MIRT1219552	hsa-miR-412	CLIP-seq
MIRT1219553	hsa-miR-4298	CLIP-seq
MIRT1219554	hsa-miR-4310	CLIP-seq
MIRT1219555	hsa-miR-4450	CLIP-seq
MIRT1219556	hsa-miR-4468	CLIP-seq
MIRT1219516	hsa-miR-4474-3p	CLIP-seq
MIRT1219557	hsa-miR-451b	CLIP-seq
MIRT1219558	hsa-miR-4527	CLIP-seq
MIRT1219519	hsa-miR-455-3p	CLIP-seq
MIRT1219559	hsa-miR-4648	CLIP-seq
MIRT1219560	hsa-miR-4667-5p	CLIP-seq
MIRT1219561	hsa-miR-4677-3p	CLIP-seq
MIRT1219562	hsa-miR-4679	CLIP-seq
MIRT1219563	hsa-miR-4687-3p	CLIP-seq
MIRT1219564	hsa-miR-4690-5p	CLIP-seq
MIRT1219565	hsa-miR-4694-3p	CLIP-seq
MIRT1219566	hsa-miR-4700-5p	CLIP-seq
MIRT1219567	hsa-miR-4708-5p	CLIP-seq
MIRT1219568	hsa-miR-4709-5p	CLIP-seq
MIRT1219523	hsa-miR-4717-3p	CLIP-seq
MIRT1219526	hsa-miR-4762-5p	CLIP-seq
MIRT1219528	hsa-miR-4768-3p	CLIP-seq
MIRT1219569	hsa-miR-4770	CLIP-seq
MIRT1219531	hsa-miR-518a-5p	CLIP-seq
MIRT1219570	hsa-miR-522	CLIP-seq
MIRT1219532	hsa-miR-527	CLIP-seq
MIRT1219571	hsa-miR-548ah	CLIP-seq
MIRT1219572	hsa-miR-548g	CLIP-seq
MIRT1219573	hsa-miR-548t	CLIP-seq
MIRT1219574	hsa-miR-548u	CLIP-seq
MIRT1219575	hsa-miR-561	CLIP-seq
MIRT1219576	hsa-miR-570	CLIP-seq
MIRT1219577	hsa-miR-607	CLIP-seq
MIRT1219578	hsa-miR-628-5p	CLIP-seq
MIRT1219579	hsa-miR-637	CLIP-seq
MIRT1219580	hsa-miR-647	CLIP-seq
MIRT1219534	hsa-miR-665	CLIP-seq
MIRT1219581	hsa-miR-802	CLIP-seq
MIRT2063437	hsa-miR-1305	CLIP-seq
MIRT2063438	hsa-miR-141	CLIP-seq
MIRT1219490	hsa-miR-1910	CLIP-seq
MIRT2063439	hsa-miR-200a	CLIP-seq
MIRT1219493	hsa-miR-217	CLIP-seq
MIRT1219503	hsa-miR-323-3p	CLIP-seq
MIRT1219504	hsa-miR-340	CLIP-seq
MIRT2063440	hsa-miR-3545-3p	CLIP-seq
MIRT2063441	hsa-miR-3614-5p	CLIP-seq
MIRT2063442	hsa-miR-3646	CLIP-seq
MIRT2063443	hsa-miR-3662	CLIP-seq
MIRT2063444	hsa-miR-3665	CLIP-seq
MIRT1219550	hsa-miR-3671	CLIP-seq
MIRT1219519	hsa-miR-455-3p	CLIP-seq
MIRT1219528	hsa-miR-4768-3p	CLIP-seq
MIRT2063445	hsa-miR-4775	CLIP-seq
MIRT1219529	hsa-miR-4789-5p	CLIP-seq
MIRT1219531	hsa-miR-518a-5p	CLIP-seq
MIRT1219532	hsa-miR-527	CLIP-seq
MIRT2063446	hsa-miR-590-3p	CLIP-seq
MIRT1219577	hsa-miR-607	CLIP-seq
MIRT2063447	hsa-miR-657	CLIP-seq
MIRT1219534	hsa-miR-665	CLIP-seq
MIRT2063448	hsa-miR-875-5p	CLIP-seq
MIRT1219484	hsa-miR-105	CLIP-seq
MIRT2291905	hsa-miR-1255a	CLIP-seq
MIRT2291906	hsa-miR-1255b	CLIP-seq
MIRT1219542	hsa-miR-1322	CLIP-seq
MIRT1219488	hsa-miR-137	CLIP-seq
MIRT2063438	hsa-miR-141	CLIP-seq
MIRT2291907	hsa-miR-181a	CLIP-seq
MIRT2291908	hsa-miR-181b	CLIP-seq
MIRT2291909	hsa-miR-181c	CLIP-seq
MIRT2291910	hsa-miR-181d	CLIP-seq
MIRT1219490	hsa-miR-1910	CLIP-seq
MIRT2063439	hsa-miR-200a	CLIP-seq
MIRT1219493	hsa-miR-217	CLIP-seq
MIRT2291911	hsa-miR-221	CLIP-seq
MIRT2291912	hsa-miR-222	CLIP-seq
MIRT1219494	hsa-miR-25	CLIP-seq
MIRT1219497	hsa-miR-3124-3p	CLIP-seq
MIRT2291913	hsa-miR-3140-5p	CLIP-seq
MIRT1219547	hsa-miR-3148	CLIP-seq
MIRT1219499	hsa-miR-3151	CLIP-seq
MIRT2291914	hsa-miR-3153	CLIP-seq
MIRT1219502	hsa-miR-32	CLIP-seq
MIRT1219503	hsa-miR-323-3p	CLIP-seq
MIRT2063441	hsa-miR-3614-5p	CLIP-seq
MIRT1219506	hsa-miR-363	CLIP-seq
MIRT2063442	hsa-miR-3646	CLIP-seq
MIRT2063443	hsa-miR-3662	CLIP-seq
MIRT2063444	hsa-miR-3665	CLIP-seq
MIRT1219507	hsa-miR-367	CLIP-seq
MIRT1219550	hsa-miR-3671	CLIP-seq
MIRT1219508	hsa-miR-3685	CLIP-seq
MIRT2291915	hsa-miR-3691-3p	CLIP-seq
MIRT2291916	hsa-miR-378	CLIP-seq
MIRT2291917	hsa-miR-378b	CLIP-seq
MIRT2291918	hsa-miR-378c	CLIP-seq
MIRT2291919	hsa-miR-378d	CLIP-seq
MIRT2291920	hsa-miR-378e	CLIP-seq
MIRT2291921	hsa-miR-378f	CLIP-seq
MIRT2291922	hsa-miR-378h	CLIP-seq
MIRT2291923	hsa-miR-378i	CLIP-seq
MIRT1219510	hsa-miR-384	CLIP-seq
MIRT1219552	hsa-miR-412	CLIP-seq
MIRT2291924	hsa-miR-422a	CLIP-seq
MIRT2291925	hsa-miR-4262	CLIP-seq
MIRT2291926	hsa-miR-4293	CLIP-seq
MIRT1219513	hsa-miR-4427	CLIP-seq
MIRT1219514	hsa-miR-4447	CLIP-seq
MIRT1219515	hsa-miR-4472	CLIP-seq
MIRT1219517	hsa-miR-4488	CLIP-seq
MIRT2291927	hsa-miR-4535	CLIP-seq
MIRT1219519	hsa-miR-455-3p	CLIP-seq
MIRT2291928	hsa-miR-4638-3p	CLIP-seq
MIRT2291929	hsa-miR-4641	CLIP-seq
MIRT1219521	hsa-miR-4697-5p	CLIP-seq
MIRT1219568	hsa-miR-4709-5p	CLIP-seq
MIRT2291930	hsa-miR-4753-3p	CLIP-seq
MIRT1219528	hsa-miR-4768-3p	CLIP-seq
MIRT2063445	hsa-miR-4775	CLIP-seq
MIRT1219529	hsa-miR-4789-5p	CLIP-seq
MIRT1219530	hsa-miR-491-5p	CLIP-seq
MIRT2291931	hsa-miR-492	CLIP-seq
MIRT2291932	hsa-miR-548v	CLIP-seq
MIRT2291933	hsa-miR-599	CLIP-seq
MIRT1219577	hsa-miR-607	CLIP-seq
MIRT2063447	hsa-miR-657	CLIP-seq
MIRT1219534	hsa-miR-665	CLIP-seq
MIRT1219537	hsa-miR-92a	CLIP-seq
MIRT1219538	hsa-miR-92b	CLIP-seq
MIRT1219488	hsa-miR-137	CLIP-seq
MIRT1219489	hsa-miR-1909	CLIP-seq
MIRT2291911	hsa-miR-221	CLIP-seq
MIRT2291912	hsa-miR-222	CLIP-seq
MIRT1219494	hsa-miR-25	CLIP-seq
MIRT1219495	hsa-miR-296-3p	CLIP-seq
MIRT1219502	hsa-miR-32	CLIP-seq
MIRT1219506	hsa-miR-363	CLIP-seq
MIRT1219507	hsa-miR-367	CLIP-seq
MIRT2392243	hsa-miR-4446-5p	CLIP-seq
MIRT2392244	hsa-miR-4755-5p	CLIP-seq
MIRT2291932	hsa-miR-548v	CLIP-seq
MIRT2291933	hsa-miR-599	CLIP-seq
MIRT1219537	hsa-miR-92a	CLIP-seq
MIRT1219538	hsa-miR-92b	CLIP-seq
MIRT2431952	hsa-miR-4803	CLIP-seq
MIRT2456051	hsa-miR-4476	CLIP-seq
MIRT2456052	hsa-miR-651	CLIP-seq
MIRT1219484	hsa-miR-105	CLIP-seq
MIRT1219541	hsa-miR-1302	CLIP-seq
MIRT2589570	hsa-miR-134	CLIP-seq
MIRT2589571	hsa-miR-15a	CLIP-seq
MIRT2589572	hsa-miR-15b	CLIP-seq
MIRT2589573	hsa-miR-16	CLIP-seq
MIRT2589574	hsa-miR-195	CLIP-seq
MIRT2589575	hsa-miR-2052	CLIP-seq
MIRT1219492	hsa-miR-216a	CLIP-seq
MIRT2291911	hsa-miR-221	CLIP-seq
MIRT2291912	hsa-miR-222	CLIP-seq
MIRT2589576	hsa-miR-2276	CLIP-seq
MIRT2589577	hsa-miR-2355-5p	CLIP-seq
MIRT2589578	hsa-miR-2909	CLIP-seq
MIRT2589579	hsa-miR-3118	CLIP-seq
MIRT2589580	hsa-miR-3121-3p	CLIP-seq
MIRT1219497	hsa-miR-3124-3p	CLIP-seq
MIRT2291914	hsa-miR-3153	CLIP-seq
MIRT2589581	hsa-miR-3162-5p	CLIP-seq
MIRT2589582	hsa-miR-3163	CLIP-seq
MIRT2589583	hsa-miR-3164	CLIP-seq
MIRT2589584	hsa-miR-3179	CLIP-seq
MIRT2589585	hsa-miR-3190	CLIP-seq
MIRT1219505	hsa-miR-342-3p	CLIP-seq
MIRT2589586	hsa-miR-3607-5p	CLIP-seq
MIRT2589587	hsa-miR-3679-3p	CLIP-seq
MIRT2589588	hsa-miR-424	CLIP-seq
MIRT2589589	hsa-miR-4270	CLIP-seq
MIRT2589590	hsa-miR-4290	CLIP-seq
MIRT1219553	hsa-miR-4298	CLIP-seq
MIRT2589591	hsa-miR-4441	CLIP-seq
MIRT2589592	hsa-miR-4457	CLIP-seq
MIRT2589593	hsa-miR-4461	CLIP-seq
MIRT2589594	hsa-miR-4491	CLIP-seq
MIRT2589595	hsa-miR-4501	CLIP-seq
MIRT2589596	hsa-miR-452	CLIP-seq
MIRT1219518	hsa-miR-4537	CLIP-seq
MIRT2589597	hsa-miR-4657	CLIP-seq
MIRT2589598	hsa-miR-4676-3p	CLIP-seq
MIRT1219561	hsa-miR-4677-3p	CLIP-seq
MIRT1219562	hsa-miR-4679	CLIP-seq
MIRT2589599	hsa-miR-4688	CLIP-seq
MIRT1219523	hsa-miR-4717-3p	CLIP-seq
MIRT2589600	hsa-miR-4731-3p	CLIP-seq
MIRT2589601	hsa-miR-4738-3p	CLIP-seq
MIRT1219525	hsa-miR-4762-3p	CLIP-seq
MIRT1219526	hsa-miR-4762-5p	CLIP-seq
MIRT2589602	hsa-miR-4766-5p	CLIP-seq
MIRT2589603	hsa-miR-4772-3p	CLIP-seq
MIRT2589604	hsa-miR-4801	CLIP-seq
MIRT2431952	hsa-miR-4803	CLIP-seq
MIRT2589605	hsa-miR-495	CLIP-seq
MIRT2589606	hsa-miR-497	CLIP-seq
MIRT2589607	hsa-miR-544	CLIP-seq
MIRT2589608	hsa-miR-545	CLIP-seq
MIRT1219574	hsa-miR-548u	CLIP-seq
MIRT2291932	hsa-miR-548v	CLIP-seq
MIRT2589609	hsa-miR-568	CLIP-seq
MIRT2589610	hsa-miR-580	CLIP-seq
MIRT2291933	hsa-miR-599	CLIP-seq
MIRT2589611	hsa-miR-891b	CLIP-seq
MIRT1219536	hsa-miR-9	CLIP-seq
MIRT2589612	hsa-miR-943	CLIP-seq
MIRT1219486	hsa-miR-1207-5p	CLIP-seq
MIRT1219487	hsa-miR-125a-3p	CLIP-seq
MIRT2589571	hsa-miR-15a	CLIP-seq
MIRT2589572	hsa-miR-15b	CLIP-seq
MIRT2589573	hsa-miR-16	CLIP-seq
MIRT2589574	hsa-miR-195	CLIP-seq
MIRT1219492	hsa-miR-216a	CLIP-seq
MIRT2291911	hsa-miR-221	CLIP-seq
MIRT2291912	hsa-miR-222	CLIP-seq
MIRT2589577	hsa-miR-2355-5p	CLIP-seq
MIRT1219497	hsa-miR-3124-3p	CLIP-seq
MIRT2291914	hsa-miR-3153	CLIP-seq
MIRT1219500	hsa-miR-3174	CLIP-seq
MIRT1219505	hsa-miR-342-3p	CLIP-seq
MIRT2589587	hsa-miR-3679-3p	CLIP-seq
MIRT1219509	hsa-miR-3688-5p	CLIP-seq
MIRT1219511	hsa-miR-3934	CLIP-seq
MIRT2589588	hsa-miR-424	CLIP-seq
MIRT2589590	hsa-miR-4290	CLIP-seq
MIRT1219518	hsa-miR-4537	CLIP-seq
MIRT2687302	hsa-miR-4704-5p	CLIP-seq
MIRT1219523	hsa-miR-4717-3p	CLIP-seq
MIRT1219524	hsa-miR-4736	CLIP-seq
MIRT1219526	hsa-miR-4762-5p	CLIP-seq
MIRT1219527	hsa-miR-4763-3p	CLIP-seq
MIRT2589606	hsa-miR-497	CLIP-seq
MIRT2589608	hsa-miR-545	CLIP-seq
MIRT2291932	hsa-miR-548v	CLIP-seq
MIRT2291933	hsa-miR-599	CLIP-seq
MIRT1219535	hsa-miR-764	CLIP-seq
MIRT1219536	hsa-miR-9	CLIP-seq

Show/Hide all (49)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000281	Process	Mitotic cytokinesis	IBA
GO:0000281	Process	Mitotic cytokinesis	IDA	18641129
GO:0000915	Process	Actomyosin contractile ring assembly	ISS
GO:0001772	Component	Immunological synapse	IDA	19706535
GO:0005515	Function	Protein binding	IPI	11883939, 12860994, 14505570, 14519844, 17196169, 17350572, 17853893, 18434552, 18511562, 18641129, 18940611, 19706535, 20176808, 20670214, 21889351, 21911577, 21988832, 22484091, 22641034, 22660413, 23088713, 25118280, 25416956, 25667979, 25686249, 26496610, 31413325, 31515488, 352
GO:0005576	Component	Extracellular region	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IBA
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005923	Component	Bicellular tight junction	IEA
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0006915	Process	Apoptotic process	IEA
GO:0006997	Process	Nucleus organization	IMP	20616062
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	20616062
GO:0010824	Process	Regulation of centrosome duplication	IMP	20616062
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016236	Process	Macroautophagy	ISS
GO:0031871	Function	Proteinase activated receptor binding	IPI	22547407
GO:0036258	Process	Multivesicular body assembly	NAS	20588296
GO:0039702	Process	Viral budding via host ESCRT complex	IGI	24107264
GO:0039702	Process	Viral budding via host ESCRT complex	NAS	20588296
GO:0042470	Component	Melanosome	IEA
GO:0042641	Component	Actomyosin	ISS
GO:0042803	Function	Protein homodimerization activity	IPI	14505570, 14519844
GO:0045199	Process	Maintenance of epithelial cell apical/basal polarity	ISS
GO:0046755	Process	Viral budding	IDA	18641129
GO:0048306	Function	Calcium-dependent protein binding	IPI	19520058, 23924735
GO:0051260	Process	Protein homooligomerization	IDA	18641129
GO:0051301	Process	Cell division	IEA
GO:0061952	Process	Midbody abscission	IMP	20616062
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 23533145
GO:0070062	Component	Extracellular exosome	IDA	15326289, 16501490, 21276792, 23092844
GO:0070161	Component	Anchoring junction	IEA
GO:0070830	Process	Bicellular tight junction assembly	ISS
GO:0070971	Component	Endoplasmic reticulum exit site	IMP	16957052
GO:0090543	Component	Flemming body	IDA	18641129
GO:0090543	Component	Flemming body	IEA
GO:0090559	Process	Regulation of membrane permeability	ISS
GO:0090611	Process	Ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway	IMP	22547407
GO:0097734	Process	Extracellular exosome biogenesis	ISS
GO:1901673	Process	Regulation of mitotic spindle assembly	IMP	20616062
GO:1903543	Process	Positive regulation of exosomal secretion	IMP	22660413
GO:1903551	Process	Regulation of extracellular exosome assembly	IMP	24105262
GO:1903553	Process	Positive regulation of extracellular exosome assembly	IMP	22660413
GO:1903561	Component	Extracellular vesicle	HDA	24769233

MIM	HGNC	e!Ensembl
608074	8766	ENSG00000170248

Q8WUM4

Protein name

Programmed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95)

Protein function

Multifunctional protein involved in endocytosis, multivesicular body biogenesis, membrane repair, cytokinesis, apoptosis and maintenance of tight junction integrity. Class E VPS protein involved in concentration and sorting of cargo proteins of

PDB

2OEV , 2OEW , 2OEX , 2OJQ , 2R02 , 2R03 , 2R05 , 2XS1 , 2XS8 , 2ZNE , 3C3O , 3C3Q , 3C3R , 3E1R , 3WUV , 4JJY , 5V3R , 5WA1 , 6KP3

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03097	BRO1	4 → 378	BRO1-like domain	Domain
PF13949	ALIX_LYPXL_bnd	412 → 701	ALIX V-shaped domain binding to HIV	Domain

Sequence

MATFISVQLKKTSEVDLAKPLVKFIQQTYPSGGEEQAQYCRAAEELSKLRRAAVGRPLDK
HEGALETLLRYYDQICSIEPKFPFSENQICLTFTWKDAFDKGSLFGGSVKLALASLGYEK
SCVLFNCAALASQIAAEQNLDNDEGLKIAAKHYQFASGAFLHIKETVLSALSREPTVDIS
PDTVGTLSLIMLAQAQEVFFLKATRDKMKDAIIAKLANQAADYFGDAFKQCQYKDTLPKE
VFPVLAAKHCIMQANAEYHQSILAKQQKKFGEEIARLQHAAELIKTVASRYDEYVNVKDF
SDKINRALAAAKKDNDFIYHDRVPDLKDLDPIGKATLVKSTPVNVPISQKFTDLFEKMVP
VSVQQSLAAYNQRKADLVNRSIAQMREATTLANGVLASLNLPAAIEDVSGDTVPQSILTK
SRSVIEQGGIQTVDQLIKELPELLQRNREILDESLRLLDEEEATDNDLRAKFKERWQRTP
SNELYKPLRAEGTNFRTVLDKAVQADGQVKECYQSHRDTIVLLCKPEPELNAAIPSANPA
KTMQGSEVVNVLKSLLSNLDEVKKEREGLENDLKSVNFDMTSKFLTALAQDGVINEEALS
VTELDRVYGGLTTKVQESLKKQEGLLKNIQVSHQEFSKMKQSNNEANLREEVLKNLATAY
DNFVELVANLKEGTKFYNELTEILVRFQNKCSDIVFARKTERDELLKDLQQSIAREPSAP
SIPTPAYQSSPAGGHAPTPPTPAPRTMPPTKPQPPARPPPPVLPANRAPSATAPSPVGAG
TAAPAPSQTPGSAPPPQAQGPPYPTYPGYPGYCQMPMPMGYNPYAYGQYNMPYPPVYHQS
PGQAPYPGPQQPSYPFPQPPQQSYYPQQ

Sequence length

868

Interactions

View interactions

	KEGG		Reactome
	Viral life cycle - HIV-1 Virion - Hepatitis viruses Endocytosis		Budding and maturation of HIV virion Uptake and function of anthrax toxins

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Microcephaly 29, primary, autosomal recessive	Pathogenic	rs2491384447	RCV002285037

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Gastric cancer	Uncertain significance	rs760399252	RCV005939384

Show/Hide Text Mining Associations (24)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenoma	Inhibit	27150162
alpha 1 Antitrypsin Deficiency Autosomal Recessive	Associate	25102091
Autistic Disorder	Associate	37794117
Breast Neoplasms	Associate	17591932, 26063962, 29348172
Carcinoma Non Small Cell Lung	Associate	24870593, 37925421
Colorectal Neoplasms	Inhibit	27150162
Death	Associate	37794117
Depressive Disorder Major	Associate	35821008
Epilepsy Post Traumatic	Associate	29188495
Glioblastoma	Associate	27770278
Glomerulonephritis Membranous	Associate	33139753
Hepatitis C	Stimulate	33785040
HIV Infections	Associate	33058236
Hypoxia	Inhibit	34907783
Hypoxia	Associate	36052865
Lymphatic Metastasis	Associate	37925421
Melanoma	Associate	15366927
Mental Disorders	Associate	37794117
Neoplasms	Associate	16319398, 17591932, 27150162, 28076321
Prostatic Neoplasms	Associate	24391718, 26473288
Prostatic Neoplasms	Stimulate	34724861
Refractive Errors	Associate	36596879
Schizophrenia	Associate	37794117
Urethral Neoplasms	Associate	38480462

PDCD6IP (programmed cell death 6 interacting protein)