Gene Gene information from NCBI Gene database.
Entrez ID 100113407
Gene name Transmembrane protein 170B
Gene symbol TMEM170B
Synonyms (NCBI Gene)
-
Chromosome 6
Chromosome location 6p24.2
miRNA miRNA information provided by mirtarbase database.
659
miRTarBase ID miRNA Experiments Reference
MIRT018133 hsa-miR-335-5p Microarray 18185580
MIRT022096 hsa-miR-128-3p Sequencing 20371350
MIRT027363 hsa-miR-101-3p Sequencing 20371350
MIRT028738 hsa-miR-27a-3p Sequencing 20371350
MIRT041741 hsa-miR-484 CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 29367600
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IDA 29367600
GO:0005886 Component Plasma membrane IEA
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5T4T1
Protein name Transmembrane protein 170B
Protein function Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets (PubMed:29367600
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10190 Tmemb_170 27 132 Putative transmembrane protein 170 Family
Tissue specificity TISSUE SPECIFICITY: Expressed in normal breast tissues. Down-regulated in breast cancer cells (at protein level) (PubMed:29367600). {ECO:0000269|PubMed:29367600}.
Sequence
Sequence length 132
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ATTENTION DEFICIT HYPERACTIVITY DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CUTANEOUS MELANOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations