TMEM170B (transmembrane protein 170B)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 100113407 |
| Gene name | Transmembrane protein 170B |
| Gene symbol | TMEM170B |
| Synonyms (NCBI Gene) |
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| Chromosome | 6 |
| Chromosome location | 6p24.2 |
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miRNA
miRNA information provided by mirtarbase database.
659
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
8
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q5T4T1 | ||||||||||
| Protein name | Transmembrane protein 170B | ||||||||||
| Protein function | Negatively regulates the canonical Wnt signaling in breast cancer cells. Exerts an inhibitory effect on breast cancer growth by inhibiting CTNNB1 stabilization and nucleus translocation, which reduces the activity of Wnt targets (PubMed:29367600 | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Expressed in normal breast tissues. Down-regulated in breast cancer cells (at protein level) (PubMed:29367600). {ECO:0000269|PubMed:29367600}. | ||||||||||
| Sequence |
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| Sequence length | 132 | ||||||||||
| Interactions | View interactions | ||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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