Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	10010
Gene name	TRAF family member associated NFKB activator
Gene symbol	TANK
Synonyms (NCBI Gene)	I-TRAFITRAFTRAF2
Chromosome	2
Chromosome location	2q24.2
Summary	The TRAF (tumor necrosis factor receptor-associated factor) family of proteins associate with and transduce signals from members of the tumor necrosis factor receptor superfamily. The protein encoded by this gene is found in the cytoplasm and can bind to

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Show/Hide all (195)

miRTarBase ID	miRNA	Experiments	Reference
MIRT617696	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT617695	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT617694	hsa-miR-603	HITS-CLIP	21572407
MIRT617692	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT617691	hsa-miR-3941	HITS-CLIP	21572407
MIRT617690	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707128	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707127	hsa-miR-6083	HITS-CLIP	21572407
MIRT617697	hsa-miR-8485	HITS-CLIP	23824327
MIRT617696	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT617695	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT617694	hsa-miR-603	HITS-CLIP	23824327
MIRT617693	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT617692	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT617691	hsa-miR-3941	HITS-CLIP	23824327
MIRT617690	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT617697	hsa-miR-8485	HITS-CLIP	23824327
MIRT617696	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT617695	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT617694	hsa-miR-603	HITS-CLIP	23824327
MIRT617693	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT617692	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT617691	hsa-miR-3941	HITS-CLIP	23824327
MIRT617690	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT617697	hsa-miR-8485	HITS-CLIP	23824327
MIRT617696	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT617695	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT617694	hsa-miR-603	HITS-CLIP	23824327
MIRT617693	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT617691	hsa-miR-3941	HITS-CLIP	23824327
MIRT617697	hsa-miR-8485	HITS-CLIP	23824327
MIRT617696	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT617695	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT617694	hsa-miR-603	HITS-CLIP	23824327
MIRT617693	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT617692	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT617691	hsa-miR-3941	HITS-CLIP	23824327
MIRT617690	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT726394	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726393	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT726392	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726391	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726390	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT726390	hsa-miR-30e-5p	Luciferase reporter assayImmunoprecipitaion (IP)ELISA	32688283
MIRT617696	hsa-miR-329-3p	HITS-CLIP	21572407
MIRT617695	hsa-miR-362-3p	HITS-CLIP	21572407
MIRT617694	hsa-miR-603	HITS-CLIP	21572407
MIRT617692	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT617691	hsa-miR-3941	HITS-CLIP	21572407
MIRT617690	hsa-miR-4789-5p	HITS-CLIP	21572407
MIRT707128	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT707127	hsa-miR-6083	HITS-CLIP	21572407
MIRT617697	hsa-miR-8485	HITS-CLIP	23824327
MIRT617696	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT617695	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT617694	hsa-miR-603	HITS-CLIP	23824327
MIRT617693	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT617692	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT617691	hsa-miR-3941	HITS-CLIP	23824327
MIRT617690	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT617697	hsa-miR-8485	HITS-CLIP	23824327
MIRT617696	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT617695	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT617694	hsa-miR-603	HITS-CLIP	23824327
MIRT617693	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT617692	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT617691	hsa-miR-3941	HITS-CLIP	23824327
MIRT617690	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT617697	hsa-miR-8485	HITS-CLIP	23824327
MIRT617696	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT617695	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT617694	hsa-miR-603	HITS-CLIP	23824327
MIRT617693	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT617691	hsa-miR-3941	HITS-CLIP	23824327
MIRT617697	hsa-miR-8485	HITS-CLIP	23824327
MIRT617696	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT617695	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT617694	hsa-miR-603	HITS-CLIP	23824327
MIRT617693	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT617692	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT617691	hsa-miR-3941	HITS-CLIP	23824327
MIRT617690	hsa-miR-4789-5p	HITS-CLIP	23824327
MIRT1410572	hsa-miR-106a	CLIP-seq
MIRT1410573	hsa-miR-106b	CLIP-seq
MIRT1410574	hsa-miR-1231	CLIP-seq
MIRT1410575	hsa-miR-1297	CLIP-seq
MIRT1410576	hsa-miR-17	CLIP-seq
MIRT1410577	hsa-miR-20a	CLIP-seq
MIRT1410578	hsa-miR-20b	CLIP-seq
MIRT1410579	hsa-miR-26a	CLIP-seq
MIRT1410580	hsa-miR-26b	CLIP-seq
MIRT1410581	hsa-miR-30a	CLIP-seq
MIRT1410582	hsa-miR-30b	CLIP-seq
MIRT1410583	hsa-miR-30c	CLIP-seq
MIRT1410584	hsa-miR-30d	CLIP-seq
MIRT1410585	hsa-miR-30e	CLIP-seq
MIRT1410586	hsa-miR-3145-3p	CLIP-seq
MIRT1410587	hsa-miR-3159	CLIP-seq
MIRT1410588	hsa-miR-329	CLIP-seq
MIRT1410589	hsa-miR-346	CLIP-seq
MIRT1410590	hsa-miR-3607-3p	CLIP-seq
MIRT1410591	hsa-miR-3609	CLIP-seq
MIRT1410592	hsa-miR-4288	CLIP-seq
MIRT1410593	hsa-miR-4464	CLIP-seq
MIRT1410594	hsa-miR-4465	CLIP-seq
MIRT1410595	hsa-miR-4509	CLIP-seq
MIRT1410596	hsa-miR-4699-3p	CLIP-seq
MIRT1410597	hsa-miR-4744	CLIP-seq
MIRT1410598	hsa-miR-4748	CLIP-seq
MIRT1410599	hsa-miR-4781-3p	CLIP-seq
MIRT1410600	hsa-miR-4795-3p	CLIP-seq
MIRT1410601	hsa-miR-4796-3p	CLIP-seq
MIRT1410602	hsa-miR-519d	CLIP-seq
MIRT1410603	hsa-miR-520d-5p	CLIP-seq
MIRT1410604	hsa-miR-524-5p	CLIP-seq
MIRT1410605	hsa-miR-548ah	CLIP-seq
MIRT1410606	hsa-miR-548c-3p	CLIP-seq
MIRT1410607	hsa-miR-632	CLIP-seq
MIRT1410608	hsa-miR-656	CLIP-seq
MIRT1410609	hsa-miR-93	CLIP-seq
MIRT1410610	hsa-miR-224	CLIP-seq
MIRT1410611	hsa-miR-410	CLIP-seq
MIRT1410612	hsa-miR-4452	CLIP-seq
MIRT1410613	hsa-miR-4775	CLIP-seq
MIRT1410614	hsa-miR-590-3p	CLIP-seq
MIRT1410615	hsa-miR-618	CLIP-seq
MIRT1410587	hsa-miR-3159	CLIP-seq
MIRT1410613	hsa-miR-4775	CLIP-seq
MIRT1410575	hsa-miR-1297	CLIP-seq
MIRT2638381	hsa-miR-190	CLIP-seq
MIRT2638382	hsa-miR-190b	CLIP-seq
MIRT2638383	hsa-miR-203	CLIP-seq
MIRT1410579	hsa-miR-26a	CLIP-seq
MIRT1410580	hsa-miR-26b	CLIP-seq
MIRT2638384	hsa-miR-28-3p	CLIP-seq
MIRT1410586	hsa-miR-3145-3p	CLIP-seq
MIRT2638385	hsa-miR-337-3p	CLIP-seq
MIRT2638386	hsa-miR-3646	CLIP-seq
MIRT2638387	hsa-miR-3685	CLIP-seq
MIRT2638388	hsa-miR-376c	CLIP-seq
MIRT2638389	hsa-miR-384	CLIP-seq
MIRT2638390	hsa-miR-3913-3p	CLIP-seq
MIRT2638391	hsa-miR-3942-5p	CLIP-seq
MIRT1410611	hsa-miR-410	CLIP-seq
MIRT2638392	hsa-miR-421	CLIP-seq
MIRT2638393	hsa-miR-4272	CLIP-seq
MIRT1410612	hsa-miR-4452	CLIP-seq
MIRT1410594	hsa-miR-4465	CLIP-seq
MIRT2638394	hsa-miR-4635	CLIP-seq
MIRT2638395	hsa-miR-4703-5p	CLIP-seq
MIRT2638396	hsa-miR-4709-5p	CLIP-seq
MIRT2638397	hsa-miR-4738-3p	CLIP-seq
MIRT2638398	hsa-miR-4803	CLIP-seq
MIRT2638399	hsa-miR-489	CLIP-seq
MIRT2638400	hsa-miR-499-3p	CLIP-seq
MIRT2638401	hsa-miR-499a-3p	CLIP-seq
MIRT2638402	hsa-miR-548ac	CLIP-seq
MIRT2638403	hsa-miR-548ae	CLIP-seq
MIRT2638404	hsa-miR-548aj	CLIP-seq
MIRT2638405	hsa-miR-548am	CLIP-seq
MIRT2638406	hsa-miR-548d-3p	CLIP-seq
MIRT2638407	hsa-miR-548x	CLIP-seq
MIRT2638408	hsa-miR-548z	CLIP-seq
MIRT1410615	hsa-miR-618	CLIP-seq
MIRT1410575	hsa-miR-1297	CLIP-seq
MIRT2638383	hsa-miR-203	CLIP-seq
MIRT1410579	hsa-miR-26a	CLIP-seq
MIRT1410580	hsa-miR-26b	CLIP-seq
MIRT2638384	hsa-miR-28-3p	CLIP-seq
MIRT1410586	hsa-miR-3145-3p	CLIP-seq
MIRT2638385	hsa-miR-337-3p	CLIP-seq
MIRT2638386	hsa-miR-3646	CLIP-seq
MIRT2638387	hsa-miR-3685	CLIP-seq
MIRT2638389	hsa-miR-384	CLIP-seq
MIRT2638390	hsa-miR-3913-3p	CLIP-seq
MIRT2638391	hsa-miR-3942-5p	CLIP-seq
MIRT2638392	hsa-miR-421	CLIP-seq
MIRT2638393	hsa-miR-4272	CLIP-seq
MIRT1410612	hsa-miR-4452	CLIP-seq
MIRT1410594	hsa-miR-4465	CLIP-seq
MIRT2638394	hsa-miR-4635	CLIP-seq
MIRT2638395	hsa-miR-4703-5p	CLIP-seq
MIRT2638396	hsa-miR-4709-5p	CLIP-seq
MIRT2638397	hsa-miR-4738-3p	CLIP-seq
MIRT2638398	hsa-miR-4803	CLIP-seq
MIRT2638399	hsa-miR-489	CLIP-seq
MIRT2638400	hsa-miR-499-3p	CLIP-seq
MIRT2638401	hsa-miR-499a-3p	CLIP-seq
MIRT2638402	hsa-miR-548ac	CLIP-seq
MIRT2638403	hsa-miR-548ae	CLIP-seq
MIRT2638404	hsa-miR-548aj	CLIP-seq
MIRT2638405	hsa-miR-548am	CLIP-seq
MIRT2638406	hsa-miR-548d-3p	CLIP-seq
MIRT2638407	hsa-miR-548x	CLIP-seq
MIRT2638408	hsa-miR-548z	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004843	Function	Cysteine-type deubiquitinase activity	IMP	25861989
GO:0005515	Function	Protein binding	IPI	12005438, 14743216, 17500595, 17568778, 18307994, 20562859, 21212807, 21653829, 21784977, 21903422, 21931555, 21988832, 24008843, 25416956, 25852190, 25861989, 26638075, 28514442, 29251827, 30561431, 32707033, 32814053, 33961781, 34084167
GO:0005737	Component	Cytoplasm	IDA	21931631
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	IMP	25861989
GO:0007165	Process	Signal transduction	TAS	8710854
GO:0008270	Function	Zinc ion binding	IEA
GO:0010804	Process	Negative regulation of tumor necrosis factor-mediated signaling pathway	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	11279055
GO:0032481	Process	Positive regulation of type I interferon production	IDA	14703513, 18636090
GO:0032481	Process	Positive regulation of type I interferon production	IDA	21931631
GO:0032991	Component	Protein-containing complex	IDA	25861989
GO:0035800	Function	Deubiquitinase activator activity	IMP	25861989
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IEA
GO:0043124	Process	Negative regulation of canonical NF-kappaB signal transduction	IMP	25861989
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	NAS	21931631
GO:0060090	Function	Molecular adaptor activity	IDA	21931631
GO:0060337	Process	Type I interferon-mediated signaling pathway	NAS	21931631
GO:0071347	Process	Cellular response to interleukin-1	IMP	25861989
GO:0071356	Process	Cellular response to tumor necrosis factor	IMP	25861989
GO:0071479	Process	Cellular response to ionizing radiation	IMP	25861989
GO:0140678	Function	Molecular function inhibitor activity	IEA
GO:1902554	Component	Serine/threonine protein kinase complex	NAS	21931631
GO:1903003	Process	Positive regulation of protein deubiquitination	IMP	25861989
GO:2000158	Process	Positive regulation of ubiquitin-specific protease activity	IMP	25861989

MIM	HGNC	e!Ensembl
603893	11562	ENSG00000136560

Q92844

Protein name

TRAF family member-associated NF-kappa-B activator (TRAF-interacting protein) (I-TRAF)

Protein function

Adapter protein involved in I-kappa-B-kinase (IKK) regulation which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Acts as a regulator of TRAF function by maintaining them in a latent state. Blocks TRAF2 binding

PDB

1KZZ , 1L0A , 5H10

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12845	TBD	132 → 186	TBD domain	Family

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MDKNIGEQLNKAYEAFRQACMDRDSAVKELQQKTENYEQRIREQQEQLSLQQTIIDKLKS
QLLLVNSTQDNNYGCVPLLEDSETRKNNLTLDQPQDKVISGIAREKLPKVRRQEVSSPRK
ETSARSLGSPLLHERGNIEKTFWDLKEEFHKICMLAKAQKDHLSKLNIPDTATETQCSVP
IQCTDKTDKQEALFKPQAKDDINRGAPSITSVTPRGLCRDEEDTSFESLSKFNVKFPPMD
NDSTFLHSTPERPGILSPATSEAVCQEKFNMEFRDNPGNFVKTEETLFEIQGIDPIASAI
QNLKTTDKTKPSNLVNTCIRTTLDRAACLPPGDHNALYVNSFPLLDPSDAPFPSLDSPGK
AIRGPQQPIWKPFPNQDSDSVVLSGTDSELHIPRVCEFCQAVFPPSITSRGDFLRHLNSH
FNGET

Sequence length

425

Interactions

View interactions

	KEGG		Reactome
	Autophagy - animal NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway Amyotrophic lateral sclerosis Pathways of neurodegeneration - multiple diseases Lipid and atherosclerosis		TICAM1-dependent activation of IRF3/IRF7 TRAF6 mediated IRF7 activation Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Cervical cancer	Benign	rs114477833	RCV005903453
Uterine corpus endometrial carcinoma	Benign	rs114477833	RCV005903454

Show/Hide Text Mining Associations (2)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	23634849
Inflammation	Associate	21935477

TANK (TRAF family member associated NFKB activator)