ABI1 (abl interactor 1)

Gene

• Entrez ID: 10006
• Gene name: Abl interactor 1
• Gene symbol: ABI1
• Synonyms (NCBI Gene): ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1
• Chromosome: 10
• Chromosome location: 10p12.1
• Summary: This gene encodes a member of the Abelson-interactor family of adaptor proteins. These proteins facilitate signal transduction as components of several multiprotein complexes, and regulate actin polymerization and cytoskeletal remodeling through interacti

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT760233	hsa-miR-302f	CLIP-seq
MIRT760234	hsa-miR-4520a-3p	CLIP-seq
MIRT760235	hsa-miR-568	CLIP-seq
MIRT760236	hsa-miR-578	CLIP-seq
MIRT760237	hsa-miR-643	CLIP-seq
MIRT760238	hsa-miR-935	CLIP-seq
MIRT760239	hsa-miR-1226	CLIP-seq
MIRT760240	hsa-miR-29a	CLIP-seq
MIRT760241	hsa-miR-29b	CLIP-seq
MIRT760242	hsa-miR-29c	CLIP-seq
MIRT760243	hsa-miR-3065-3p	CLIP-seq
MIRT760244	hsa-miR-338-3p	CLIP-seq
MIRT760245	hsa-miR-3613-3p	CLIP-seq
MIRT760246	hsa-miR-3920	CLIP-seq
MIRT760247	hsa-miR-3941	CLIP-seq
MIRT760248	hsa-miR-4256	CLIP-seq
MIRT760249	hsa-miR-4310	CLIP-seq
MIRT760250	hsa-miR-4452	CLIP-seq
MIRT760251	hsa-miR-4474-5p	CLIP-seq
MIRT760252	hsa-miR-4635	CLIP-seq
MIRT760253	hsa-miR-466	CLIP-seq
MIRT760254	hsa-miR-4672	CLIP-seq
MIRT760255	hsa-miR-4719	CLIP-seq
MIRT760256	hsa-miR-4731-3p	CLIP-seq
MIRT760257	hsa-miR-4747-5p	CLIP-seq
MIRT760258	hsa-miR-4762-3p	CLIP-seq
MIRT760259	hsa-miR-4801	CLIP-seq
MIRT760260	hsa-miR-495	CLIP-seq
MIRT760261	hsa-miR-513a-3p	CLIP-seq
MIRT760262	hsa-miR-607	CLIP-seq
MIRT760263	hsa-miR-634	CLIP-seq
MIRT760264	hsa-miR-889	CLIP-seq
MIRT760265	hsa-miR-142-5p	CLIP-seq
MIRT760266	hsa-miR-3123	CLIP-seq
MIRT760267	hsa-miR-3925-5p	CLIP-seq
MIRT760268	hsa-miR-3929	CLIP-seq
MIRT760269	hsa-miR-3976	CLIP-seq
MIRT760270	hsa-miR-4419b	CLIP-seq
MIRT760271	hsa-miR-4478	CLIP-seq
MIRT760256	hsa-miR-4731-3p	CLIP-seq
MIRT760272	hsa-miR-4789-5p	CLIP-seq
MIRT760259	hsa-miR-4801	CLIP-seq
MIRT760261	hsa-miR-513a-3p	CLIP-seq
MIRT760273	hsa-miR-548ae	CLIP-seq
MIRT760274	hsa-miR-548aj	CLIP-seq
MIRT760275	hsa-miR-548am	CLIP-seq
MIRT760276	hsa-miR-548c-3p	CLIP-seq
MIRT760277	hsa-miR-548x	CLIP-seq
MIRT760278	hsa-miR-561	CLIP-seq
MIRT760279	hsa-miR-570	CLIP-seq
MIRT760263	hsa-miR-634	CLIP-seq
MIRT1924163	hsa-miR-802	CLIP-seq
MIRT2165521	hsa-miR-144	CLIP-seq
MIRT2165522	hsa-miR-188-3p	CLIP-seq
MIRT2165523	hsa-miR-2114	CLIP-seq
MIRT2165524	hsa-miR-4652-3p	CLIP-seq
MIRT2165525	hsa-miR-633	CLIP-seq
MIRT760263	hsa-miR-634	CLIP-seq
MIRT2165525	hsa-miR-633	CLIP-seq
MIRT760247	hsa-miR-3941	CLIP-seq
MIRT760250	hsa-miR-4452	CLIP-seq
MIRT760252	hsa-miR-4635	CLIP-seq
MIRT760253	hsa-miR-466	CLIP-seq
MIRT760254	hsa-miR-4672	CLIP-seq
MIRT2383767	hsa-miR-4691-5p	CLIP-seq
MIRT760255	hsa-miR-4719	CLIP-seq
MIRT760256	hsa-miR-4731-3p	CLIP-seq
MIRT760257	hsa-miR-4747-5p	CLIP-seq
MIRT760259	hsa-miR-4801	CLIP-seq
MIRT760265	hsa-miR-142-5p	CLIP-seq
MIRT2467550	hsa-miR-181a	CLIP-seq
MIRT2467551	hsa-miR-181b	CLIP-seq
MIRT2467552	hsa-miR-181c	CLIP-seq
MIRT2467553	hsa-miR-181d	CLIP-seq
MIRT2467554	hsa-miR-199a-3p	CLIP-seq
MIRT2467555	hsa-miR-199b-3p	CLIP-seq
MIRT2467556	hsa-miR-2052	CLIP-seq
MIRT2467557	hsa-miR-208a	CLIP-seq
MIRT2467558	hsa-miR-208b	CLIP-seq
MIRT2165523	hsa-miR-2114	CLIP-seq
MIRT2467559	hsa-miR-23a	CLIP-seq
MIRT2467560	hsa-miR-23b	CLIP-seq
MIRT2467561	hsa-miR-23c	CLIP-seq
MIRT2467562	hsa-miR-3129-5p	CLIP-seq
MIRT2467563	hsa-miR-3144-3p	CLIP-seq
MIRT2467564	hsa-miR-3529	CLIP-seq
MIRT2467565	hsa-miR-361-3p	CLIP-seq
MIRT2467566	hsa-miR-3617	CLIP-seq
MIRT2467567	hsa-miR-3647-3p	CLIP-seq
MIRT2467568	hsa-miR-3653	CLIP-seq
MIRT2467569	hsa-miR-3658	CLIP-seq
MIRT2467570	hsa-miR-3678-3p	CLIP-seq
MIRT2467571	hsa-miR-3679-3p	CLIP-seq
MIRT2467572	hsa-miR-379	CLIP-seq
MIRT2467573	hsa-miR-380	CLIP-seq
MIRT2467574	hsa-miR-3908	CLIP-seq
MIRT2467575	hsa-miR-3927	CLIP-seq
MIRT760268	hsa-miR-3929	CLIP-seq
MIRT2467576	hsa-miR-3942-3p	CLIP-seq
MIRT2467577	hsa-miR-3942-5p	CLIP-seq
MIRT2467578	hsa-miR-4262	CLIP-seq
MIRT2467579	hsa-miR-4277	CLIP-seq
MIRT2467580	hsa-miR-4282	CLIP-seq
MIRT2467581	hsa-miR-4286	CLIP-seq
MIRT2467582	hsa-miR-4325	CLIP-seq
MIRT2467583	hsa-miR-433	CLIP-seq
MIRT760270	hsa-miR-4419b	CLIP-seq
MIRT2467584	hsa-miR-4427	CLIP-seq
MIRT2467585	hsa-miR-4477a	CLIP-seq
MIRT760271	hsa-miR-4478	CLIP-seq
MIRT2467586	hsa-miR-448	CLIP-seq
MIRT2467587	hsa-miR-450b-5p	CLIP-seq
MIRT2467588	hsa-miR-452	CLIP-seq
MIRT760234	hsa-miR-4520a-3p	CLIP-seq
MIRT2165524	hsa-miR-4652-3p	CLIP-seq
MIRT2467589	hsa-miR-4676-3p	CLIP-seq
MIRT2467590	hsa-miR-4680-3p	CLIP-seq
MIRT2467591	hsa-miR-4698	CLIP-seq
MIRT2467592	hsa-miR-4703-5p	CLIP-seq
MIRT2467593	hsa-miR-4766-3p	CLIP-seq
MIRT2467594	hsa-miR-4766-5p	CLIP-seq
MIRT2467595	hsa-miR-4775	CLIP-seq
MIRT2467596	hsa-miR-4793-3p	CLIP-seq
MIRT2467597	hsa-miR-491-3p	CLIP-seq
MIRT2467598	hsa-miR-494	CLIP-seq
MIRT760260	hsa-miR-495	CLIP-seq
MIRT2467599	hsa-miR-499-5p	CLIP-seq
MIRT2467600	hsa-miR-500a	CLIP-seq
MIRT2467601	hsa-miR-507	CLIP-seq
MIRT2467602	hsa-miR-5095	CLIP-seq
MIRT2467603	hsa-miR-514	CLIP-seq
MIRT2467604	hsa-miR-514b-3p	CLIP-seq
MIRT2467605	hsa-miR-548an	CLIP-seq
MIRT760276	hsa-miR-548c-3p	CLIP-seq
MIRT2467606	hsa-miR-552	CLIP-seq
MIRT2467607	hsa-miR-557	CLIP-seq
MIRT760278	hsa-miR-561	CLIP-seq
MIRT2467608	hsa-miR-590-3p	CLIP-seq
MIRT2467609	hsa-miR-600	CLIP-seq
MIRT760262	hsa-miR-607	CLIP-seq
MIRT2165525	hsa-miR-633	CLIP-seq
MIRT2467610	hsa-miR-641	CLIP-seq
MIRT2467611	hsa-miR-642b	CLIP-seq
MIRT2467612	hsa-miR-656	CLIP-seq
MIRT1924163	hsa-miR-802	CLIP-seq
MIRT760238	hsa-miR-935	CLIP-seq
MIRT2467613	hsa-miR-936	CLIP-seq
MIRT760265	hsa-miR-142-5p	CLIP-seq
MIRT2467550	hsa-miR-181a	CLIP-seq
MIRT2467551	hsa-miR-181b	CLIP-seq
MIRT2467552	hsa-miR-181c	CLIP-seq
MIRT2467553	hsa-miR-181d	CLIP-seq
MIRT2165522	hsa-miR-188-3p	CLIP-seq
MIRT2467554	hsa-miR-199a-3p	CLIP-seq
MIRT2467555	hsa-miR-199b-3p	CLIP-seq
MIRT2467557	hsa-miR-208a	CLIP-seq
MIRT2467558	hsa-miR-208b	CLIP-seq
MIRT2165523	hsa-miR-2114	CLIP-seq
MIRT2674117	hsa-miR-2276	CLIP-seq
MIRT2467559	hsa-miR-23a	CLIP-seq
MIRT2467560	hsa-miR-23b	CLIP-seq
MIRT2467561	hsa-miR-23c	CLIP-seq
MIRT2467562	hsa-miR-3129-5p	CLIP-seq
MIRT2467563	hsa-miR-3144-3p	CLIP-seq
MIRT2467564	hsa-miR-3529	CLIP-seq
MIRT2467565	hsa-miR-361-3p	CLIP-seq
MIRT2467566	hsa-miR-3617	CLIP-seq
MIRT2467567	hsa-miR-3647-3p	CLIP-seq
MIRT2467568	hsa-miR-3653	CLIP-seq
MIRT2467569	hsa-miR-3658	CLIP-seq
MIRT2467570	hsa-miR-3678-3p	CLIP-seq
MIRT2467571	hsa-miR-3679-3p	CLIP-seq
MIRT2467572	hsa-miR-379	CLIP-seq
MIRT2467573	hsa-miR-380	CLIP-seq
MIRT2467575	hsa-miR-3927	CLIP-seq
MIRT760268	hsa-miR-3929	CLIP-seq
MIRT2467577	hsa-miR-3942-5p	CLIP-seq
MIRT2467578	hsa-miR-4262	CLIP-seq
MIRT2467579	hsa-miR-4277	CLIP-seq
MIRT2467580	hsa-miR-4282	CLIP-seq
MIRT2467581	hsa-miR-4286	CLIP-seq
MIRT2467583	hsa-miR-433	CLIP-seq
MIRT760270	hsa-miR-4419b	CLIP-seq
MIRT2467584	hsa-miR-4427	CLIP-seq
MIRT2467585	hsa-miR-4477a	CLIP-seq
MIRT760271	hsa-miR-4478	CLIP-seq
MIRT2467586	hsa-miR-448	CLIP-seq
MIRT760234	hsa-miR-4520a-3p	CLIP-seq
MIRT2165524	hsa-miR-4652-3p	CLIP-seq
MIRT2674118	hsa-miR-4668-3p	CLIP-seq
MIRT2467590	hsa-miR-4680-3p	CLIP-seq
MIRT2467591	hsa-miR-4698	CLIP-seq
MIRT2467592	hsa-miR-4703-5p	CLIP-seq
MIRT2467594	hsa-miR-4766-5p	CLIP-seq
MIRT2674119	hsa-miR-4772-3p	CLIP-seq
MIRT2674120	hsa-miR-4800-3p	CLIP-seq
MIRT2467597	hsa-miR-491-3p	CLIP-seq
MIRT2467598	hsa-miR-494	CLIP-seq
MIRT760260	hsa-miR-495	CLIP-seq
MIRT2467599	hsa-miR-499-5p	CLIP-seq
MIRT2467600	hsa-miR-500a	CLIP-seq
MIRT2467602	hsa-miR-5095	CLIP-seq
MIRT2467603	hsa-miR-514	CLIP-seq
MIRT2467604	hsa-miR-514b-3p	CLIP-seq
MIRT2467605	hsa-miR-548an	CLIP-seq
MIRT760276	hsa-miR-548c-3p	CLIP-seq
MIRT2467606	hsa-miR-552	CLIP-seq
MIRT760278	hsa-miR-561	CLIP-seq
MIRT760236	hsa-miR-578	CLIP-seq
MIRT2467608	hsa-miR-590-3p	CLIP-seq
MIRT2467609	hsa-miR-600	CLIP-seq
MIRT760262	hsa-miR-607	CLIP-seq
MIRT2165525	hsa-miR-633	CLIP-seq
MIRT2467610	hsa-miR-641	CLIP-seq
MIRT2467611	hsa-miR-642b	CLIP-seq
MIRT760237	hsa-miR-643	CLIP-seq
MIRT2467612	hsa-miR-656	CLIP-seq
MIRT760238	hsa-miR-935	CLIP-seq
MIRT2467613	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001756	Process	Somitogenesis	IEA
GO:0001764	Process	Neuron migration	IBA
GO:0005515	Function	Protein binding	IPI	9010225, 9593709, 11418237, 12681507, 14565974, 15289329, 16417406, 17101133, 17395426, 18328268, 20598684, 21078624, 21173240, 21320496, 26496610, 31980649, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005783	Component	Endoplasmic reticulum	TAS	9593709
GO:0005829	Component	Cytosol	TAS	9010225
GO:0005856	Component	Cytoskeleton	IEA
GO:0007169	Process	Cell surface receptor protein tyrosine kinase signaling pathway	TAS	9010225
GO:0008092	Function	Cytoskeletal protein binding	TAS	9593709
GO:0008154	Process	Actin polymerization or depolymerization	NAS	11516653
GO:0008285	Process	Negative regulation of cell population proliferation	TAS	9010225
GO:0014069	Component	Postsynaptic density	IEA
GO:0017124	Function	SH3 domain binding	IEA
GO:0017124	Function	SH3 domain binding	IPI	19798448
GO:0030027	Component	Lamellipodium	IBA
GO:0030027	Component	Lamellipodium	IDA	11516653, 17101133
GO:0030027	Component	Lamellipodium	IEA
GO:0030175	Component	Filopodium	IEA
GO:0030296	Function	Protein tyrosine kinase activator activity	IEA
GO:0030296	Function	Protein tyrosine kinase activator activity	ISS
GO:0030426	Component	Growth cone	IEA
GO:0031209	Component	SCAR complex	IBA
GO:0031209	Component	SCAR complex	IDA	21107423, 26428302
GO:0031209	Component	SCAR complex	IEA
GO:0031252	Component	Cell leading edge	IEA
GO:0032433	Component	Filopodium tip	IDA	11516653
GO:0032433	Component	Filopodium tip	IEA
GO:0035591	Function	Signaling adaptor activity	IBA
GO:0035591	Function	Signaling adaptor activity	IDA	17101133
GO:0035591	Function	Signaling adaptor activity	IEA
GO:0035591	Function	Signaling adaptor activity	ISS
GO:0035855	Process	Megakaryocyte development	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0045202	Component	Synapse	IEA
GO:0045296	Function	Cadherin binding	HDA	25468996
GO:0048813	Process	Dendrite morphogenesis	IEA
GO:0048858	Process	Cell projection morphogenesis	IBA
GO:0061098	Process	Positive regulation of protein tyrosine kinase activity	IDA	17101133
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0072673	Process	Lamellipodium morphogenesis	IEA
GO:0098858	Component	Actin-based cell projection	IBA

Other IDs

• MIM: 603050
• HGNC: 11320
• e!Ensembl: ENSG00000136754

Protein

• UniProt ID: Q8IZP0
• Protein name: Abl interactor 1 (Abelson interactor 1) (Abi-1) (Abl-binding protein 4) (AblBP4) (Eps8 SH3 domain-binding protein) (Eps8-binding protein) (Nap1-binding protein) (Nap1BP) (Spectrin SH3 domain-binding protein 1) (e3B1)
• Protein function: May act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. May play a role in regulation of EGF-induced Erk pathway activation. Involved in cytoskeletal reorganization and
• PDB: 7LXE
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07815	Abi_HHR	93 → 170	Abl-interactor HHR	Family
  PF00018	SH3_1	452 → 497	SH3 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed, with highest expression in brain. {ECO:0000269|PubMed:11418237}.
• Sequence:

  MAELQMLLEEEIPSGKRALIESYQNLTRVADYCENNYIQATDKRKALEETKAYTTQSLAS
  VAYQINALANNVLQLLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR
  THKIIAPANMERPVRYIRKPIDYTVLDDVGHGVKWLKAKHGNNQPARTGTLSRTNPPTQK
  PPSPPMSGRGTLGRNTPYKTLEPVKPPTVPNDYMTSPARLGSQHSPGRTASLNQRPRTHS
  GSSGGSGSRENSGSSSIGIPIAVPTPSPPTIGPENISVPPPSGAPPAPPLAPLLPVSTVI
  AAPGSAPGSQYGTMTRQISRHNSTTSSTSSGGYRRTPSVTAQFSAQPHVNGGPLYSQNSI
  SIAPPPPPMPQLTPQIPLTGFVARVQENIADSPTPPPPPPPDDIPMFDDSPPPPPPPPVD
  YEDEEAAVVQYNDPYADGDPAWAPKNYIEKVVAIYDYTKDKDDELSFMEGAIIYVIKKND
  DGWYEGVCNRVTGLFPGNYVESIMHYTD

• Sequence length: 508

Pathways

KEGG:

Pathogenic Escherichia coli infection
Salmonella infection

Reactome:

Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs
FCGR3A-mediated phagocytosis