A1BG (alpha-1-B glycoprotein)

Gene

• Entrez ID: 1
• Gene name: Alpha-1-B glycoprotein
• Gene symbol: A1BG
• Synonyms (NCBI Gene): A1B, ABG, GAB, HYST2477
• Chromosome: 19
• Chromosome location: 19q13.43
• Summary: The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins. [provided by RefSeq, Jul 2008]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT683088	hsa-miR-141-3p	HITS-CLIP	23706177
MIRT683087	hsa-miR-200a-3p	HITS-CLIP	23706177
MIRT683086	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT683085	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT683084	hsa-miR-6742-3p	HITS-CLIP	23706177
MIRT683083	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT683082	hsa-miR-4772-3p	HITS-CLIP	23706177
MIRT683081	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT683080	hsa-miR-6776-5p	HITS-CLIP	23706177
MIRT683079	hsa-miR-4645-3p	HITS-CLIP	23706177
MIRT683078	hsa-miR-661	HITS-CLIP	23706177
MIRT683077	hsa-miR-1288-3p	HITS-CLIP	23706177
MIRT683076	hsa-miR-542-3p	HITS-CLIP	23706177
MIRT683075	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT683074	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT683073	hsa-miR-7703	HITS-CLIP	23706177
MIRT683072	hsa-miR-1262	HITS-CLIP	23706177
MIRT683071	hsa-miR-4701-3p	HITS-CLIP	23706177
MIRT683070	hsa-miR-6736-5p	HITS-CLIP	23706177
MIRT683069	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT732287	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732287	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732287	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT732287	hsa-miR-5582-5p	Luciferase reporter assay, qRT-PCR, Western blot	27475256
MIRT683088	hsa-miR-141-3p	HITS-CLIP	23706177
MIRT683087	hsa-miR-200a-3p	HITS-CLIP	23706177
MIRT683086	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT683085	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT683084	hsa-miR-6742-3p	HITS-CLIP	23706177
MIRT683083	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT683082	hsa-miR-4772-3p	HITS-CLIP	23706177
MIRT683081	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT683080	hsa-miR-6776-5p	HITS-CLIP	23706177
MIRT683079	hsa-miR-4645-3p	HITS-CLIP	23706177
MIRT683078	hsa-miR-661	HITS-CLIP	23706177
MIRT683077	hsa-miR-1288-3p	HITS-CLIP	23706177
MIRT683076	hsa-miR-542-3p	HITS-CLIP	23706177
MIRT683075	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT683074	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT683073	hsa-miR-7703	HITS-CLIP	23706177
MIRT683072	hsa-miR-1262	HITS-CLIP	23706177
MIRT683071	hsa-miR-4701-3p	HITS-CLIP	23706177
MIRT683070	hsa-miR-6736-5p	HITS-CLIP	23706177
MIRT683069	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT1923096	hsa-miR-3126-5p	CLIP-seq
MIRT1923097	hsa-miR-4419a	CLIP-seq
MIRT1923098	hsa-miR-4510	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002764	Process	Immune response-regulating signaling pathway	IBA
GO:0005576	Component	Extracellular region	HDA	27068509, 27559042
GO:0005576	Component	Extracellular region	IDA	3458201
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	TAS
GO:0005615	Component	Extracellular space	HDA	16502470
GO:0005886	Component	Plasma membrane	IBA
GO:0031093	Component	Platelet alpha granule lumen	TAS
GO:0034774	Component	Secretory granule lumen	TAS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0072562	Component	Blood microparticle	HDA	22516433
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

Other IDs

• MIM: 138670
• HGNC: 5
• e!Ensembl: ENSG00000121410

Protein

• UniProt ID: P04217
• Protein name: Alpha-1B-glycoprotein (Alpha-1-B glycoprotein)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13895	Ig_2	209 → 301	Immunoglobulin domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Plasma.
• Sequence:

  MSMLVVFLLLWGVTWGPVTEAAIFYETQPSLWAESESLLKPLANVTLTCQAHLETPDFQL
  FKNGVAQEPVHLDSPAIKHQFLLTGDTQGRYRCRSGLSTGWTQLSKLLELTGPKSLPAPW
  LSMAPVSWITPGLKTTAVCRGVLRGVTFLLRREGDHEFLEVPEAQEDVEATFPVHQPGNY
  SCSYRTDGEGALSEPSATVTIEELAAPPPPVLMHHGESSQVLHPGNKVTLTCVAPLSGVD
  FQLRRGEKELLVPRSSTSPDRIFFHLNAVALGDGGHYTCRYRLHDNQNGWSGDSAPVELI
  LSDETLPAPEFSPEPESGRALRLRCLAPLEGARFALVREDRGGRRVHRFQSPAGTEALFE
  LHNISVADSANYSCVYVDLKPPFGGSAPSERLELHVDGPPPRPQLRATWSGAVLAGRDAV
  LRCEGPIPDVTFELLREGETKAVKTVRTPGAAANLELIFVGPQHAGNYRCRYRSWVPHTF
  ESELSDPVELLVAES

• Sequence length: 495

Pathways

Reactome:

Platelet degranulation
Neutrophil degranulation