ZC3HAV1 (zinc finger CCCH-type containing, antiviral 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 56829 |
| Gene name | Zinc finger CCCH-type containing, antiviral 1 |
| Gene symbol | ZC3HAV1 |
| Synonyms (NCBI Gene) |
ARTD13FLB6421PARP13ZAPZC3H2ZC3HDC2
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| Chromosome | 7 |
| Chromosome location | 7q34 |
| Summary | This gene encodes a CCCH-type zinc finger protein that is thought to prevent infection by retroviruses. Studies of the rat homolog indicate that the protein may primarily function to inhibit viral gene expression and induce an innate immunity to viral inf |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q7Z2W4 | |||||||||||||||||||||||||
| Protein name | Zinc finger CCCH-type antiviral protein 1 (ADP-ribosyltransferase diphtheria toxin-like 13) (ARTD13) (Inactive Poly [ADP-ribose] polymerase 13) (PARP13) (Zinc finger CCCH domain-containing protein 2) (Zinc finger antiviral protein) (ZAP) | |||||||||||||||||||||||||
| Protein function | Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-sp | |||||||||||||||||||||||||
| PDB | 2X5Y , 4X52 , 6UEI , 6UEJ , 7KZH , 7TGQ , 9BGL | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
MADPEVCCFITKILCAHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAGI |
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| Sequence length | 902 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with ZC3HAV1 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to ZC3HAV1 (see Related Genes above), that are NOT already directly curated for ZC3HAV1 itself -- a lead worth checking, not a confirmed association.
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