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Gene Gene information from NCBI Gene database.
Entrez ID 114786
Gene name XK related 4
Gene symbol XKR4
Synonyms (NCBI Gene)
XRG4hXKR4
Chromosome 8
Chromosome location 8q12.1
miRNA miRNA information provided by mirtarbase database.
488 Show/Hide all (488)
miRTarBase ID miRNA Experiments Reference
MIRT017434 hsa-miR-335-5p Microarray 18185580
MIRT629715 hsa-miR-3173-3p HITS-CLIP 23824327
MIRT629714 hsa-miR-6891-5p HITS-CLIP 23824327
MIRT629713 hsa-miR-4779 HITS-CLIP 23824327
MIRT629712 hsa-miR-4436b-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11 Show/Hide all (11)
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 33725486
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane ISS
GO:0006915 Process Apoptotic process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5GH76
Protein name XK-related protein 4 (hXKR4) [Cleaved into: XK-related protein 4, processed form]
Protein function [XK-related protein 4, processed form]: Phospholipid scramblase that promotes phosphatidylserine exposure on apoptotic cell surface (PubMed:25231987, PubMed:33725486). Phosphatidylserine is a specific marker only present at the surface of apopto
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09815 XK-related 113 → 516 XK-related protein Family
Sequence
Sequence length 650
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
Efferocytosis
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
11
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (11)
Phenotype Name Clinical Significance Source Reference Evidence Score
ASTROCYTOMA — GWAS catalog 36810956
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER — GWAS catalog 36810956
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE — GWAS catalog 29212778
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ENDOMETRIOSIS — GWAS catalog 31488892
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
FAMILIAL HEMOLYTIC ANEMIA — GWAS catalog 39024449
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (6)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Attention deficit hyperactivity disorder Attention Deficit Hyperactivity Disorder BEFREE 29311829
★★★★★
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 36549768 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Leukemia, Myelocytic, Acute Leukemia GWASCAT_DG 27903959
★★★★★
★☆☆☆☆
Found in Text Mining only
Neuropathy Neuropathy BEFREE 23776197
★★★★★
★☆☆☆☆
Found in Text Mining only
Papillary thyroid carcinoma Papillary thyroid carcinoma BEFREE 24852370
★★★★★
★☆☆☆☆
Found in Text Mining only
Peripheral Nervous System Diseases Peripheral nervous system disease Pubtator 36549768 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only