WDR75 (WD repeat domain 75)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84128
• Gene name: WD repeat domain 75
• Gene symbol: WDR75
• Synonyms (NCBI Gene): NET16, UTP17
• Chromosome: 2
• Chromosome location: 2q32.2

miRNA Show/Hide all (102)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028674	hsa-miR-30a-5p	Proteomics	18668040
MIRT031984	hsa-miR-16-5p	Proteomics	18668040
MIRT032487	hsa-let-7b-5p	Proteomics	18668040
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT664004	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT664003	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT664002	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT664001	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT664000	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT663999	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT663998	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT663997	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT663996	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT663995	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT663993	hsa-miR-7977	HITS-CLIP	23824327
MIRT663994	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT663992	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT663991	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT663990	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT663989	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT663988	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT663987	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT663986	hsa-miR-3689c	HITS-CLIP	23824327
MIRT663984	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT663985	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT663983	hsa-miR-1228-5p	HITS-CLIP	23824327
MIRT663982	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT663981	hsa-miR-3122	HITS-CLIP	23824327
MIRT663980	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT663979	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT663978	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT664004	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT664003	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT664002	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT664001	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT664000	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT663999	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT663998	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT663997	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT663996	hsa-miR-541-3p	HITS-CLIP	23824327
MIRT663995	hsa-miR-654-5p	HITS-CLIP	23824327
MIRT663993	hsa-miR-7977	HITS-CLIP	23824327
MIRT663994	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT663992	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT663991	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT663990	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT663989	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT663988	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT663987	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT663986	hsa-miR-3689c	HITS-CLIP	23824327
MIRT663984	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT663985	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT663983	hsa-miR-1228-5p	HITS-CLIP	23824327
MIRT663982	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT663981	hsa-miR-3122	HITS-CLIP	23824327
MIRT663980	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT663979	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT663978	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT620356	hsa-miR-4762-5p	HITS-CLIP	23824327
MIRT620355	hsa-miR-6506-3p	HITS-CLIP	23824327
MIRT620354	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620353	hsa-miR-3671	HITS-CLIP	23824327
MIRT620352	hsa-miR-607	HITS-CLIP	23824327
MIRT620351	hsa-miR-552-5p	HITS-CLIP	23824327
MIRT620350	hsa-miR-3119	HITS-CLIP	23824327
MIRT1491445	hsa-miR-3613-3p	CLIP-seq
MIRT1491446	hsa-miR-4666-3p	CLIP-seq
MIRT2148148	hsa-miR-4661-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	17699751
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0032040	Component	Small-subunit processome	IDA	34516797
GO:0032040	Component	Small-subunit processome	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042274	Process	Ribosomal small subunit biogenesis	IDA	34516797
GO:0045943	Process	Positive regulation of transcription by RNA polymerase I	IBA
GO:0045943	Process	Positive regulation of transcription by RNA polymerase I	IEA
GO:0045943	Process	Positive regulation of transcription by RNA polymerase I	IMP	17699751
GO:2000234	Process	Positive regulation of rRNA processing	IBA
GO:2000234	Process	Positive regulation of rRNA processing	IMP	17699751

Other IDs

• MIM: 620341
• HGNC: 25725
• e!Ensembl: ENSG00000115368

Protein

• UniProt ID: Q8IWA0
• Protein name: WD repeat-containing protein 75 (U3 small nucleolar RNA-associated protein 17 homolog)
• Protein function: Ribosome biogenesis factor. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and
• PDB: 7MQ8 , 7MQ9 , 7MQA
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00400	WD40	47 → 86	WD domain, G-beta repeat	Repeat
  PF00400	WD40	192 → 231	WD domain, G-beta repeat	Repeat

• Sequence:

  MVEEENIRVVRCGGSELNFRRAVFSADSKYIFCVSGDFVKVYSTVTEECVHILHGHRNLV
  TGIQLNPNNHLQLYSCSLDGTIKLWDYIDGILIKTFIVGCKLHALFTLAQAEDSVFVIVN
  KEKPDIFQLVSVKLPKSSSQEVEAKELSFVLDYINQSPKCIAFGNEGVYVAAVREFYLSV
  YFFKKKTTSRFTLSSSRNKKHAKNNFTCVACHPTEDCIASGHMDGKIRLWRNFYDDKKYT
  YTCLHWHHDMVMDLAFSVTGTSLLSGGRESVLVEWRDATEKNKEFLPRLGATIEHISVSP
  AGDLFCTSHSDNKIIIIHRNLEASAVIQGLVKDRSIFTGLMIDPRTKALVLNGKPGHLQF
  YSLQSDKQLYNLDIIQQEYINDYGLIQIELTKAAFGCFGNWLATVEQRQEKETELELQMK
  LWMYNKKTQGFILNTKINMPHEDCITALCFCNAEKSEQPTLVTASKDGYFKVWILTDDSD
  IYKKAVGWTCDFVGSYHKYQATNCCFSEDGSLLAVSFEEIVTIWDSVTWELKCTFCQRAG
  KIRHLCFGRLTCSKYLLGATENGILCCWNLLSCALEWNAKLNVRVMEPDPNSENIAAISQ
  SSVGSDLFVFKPSEPRPLYIQKGISREKVQWGVFVPRDVPESFTSEAYQWLNRSQFYFLT
  KSQSLLTFSTKSPEEKLTPTSKQLLAEESLPTTPFYFILGKHRQQQDEKLNETLENELVQ
  LPLTENIPAISELLHTPAHVLPSAAFLCSMFVNSLLLSKETKSAKEIPEDVDMEEEKESE
  DSDEENDFTEKVQDTSNTGLGEDIIHQLSKSEEKELRKFRKIDYSWIAAL

• Sequence length: 830

Pathways

KEGG Pathway:

Ribosome biogenesis in eukaryotes

Reactome Pathway:

Major pathway of rRNA processing in the nucleolus and cytosol

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
BREAST CANCER	—	GWAS catalog	29059683	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	29059683	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BRONCHIAL DISEASE	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	29658574	Associate	★☆☆☆☆ Found in Text Mining only
Necrosis	Necrosis	Pubtator	39438952	Associate	★☆☆☆☆ Found in Text Mining only
Sepsis	Sepsis	Pubtator	39438952	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

RCL1 2 shared pathwaysRibosome biogenesis in eukaryotes, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including Ribosome biogenesis in eukaryotes, Major pathway of rRNA processing in the nucleolus and cytosol. MPHOSPH10 2 shared pathwaysRibosome biogenesis in eukaryotes, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including Ribosome biogenesis in eukaryotes, Major pathway of rRNA processing in the nucleolus and cytosol. EMG1 2 shared pathwaysRibosome biogenesis in eukaryotes, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including Ribosome biogenesis in eukaryotes, Major pathway of rRNA processing in the nucleolus and cytosol. TBL3 2 shared pathwaysRibosome biogenesis in eukaryotes, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including Ribosome biogenesis in eukaryotes, Major pathway of rRNA processing in the nucleolus and cytosol. UTP14A 2 shared pathwaysRibosome biogenesis in eukaryotes, Major pathway of rRNA processing in the nucleolus and cytosol Related via 2 shared pathways including Ribosome biogenesis in eukaryotes, Major pathway of rRNA processing in the nucleolus and cytosol.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
RCL1	0	[]	2	["Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]
MPHOSPH10	0	[]	2	["Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]
EMG1	0	[]	2	["Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]
TBL3	0	[]	2	["Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]
UTP14A	0	[]	2	["Ribosome biogenesis in eukaryotes","Major pathway of rRNA processing in the nucleolus and cytosol"]	0	[]

Diseases Linked via Similar Genes

Alzheimer disease Linked via 1 of 5 related genesRCL1 Bipolar disorder Linked via 1 of 5 related genesRCL1 Dementia Linked via 1 of 5 related genesRCL1 Major depressive disorder Linked via 1 of 5 related genesRCL1 Nasopharyngeal neoplasms Linked via 1 of 5 related genesRCL1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Alzheimer disease	1	["RCL1"]
Bipolar disorder	1	["RCL1"]
Dementia	1	["RCL1"]
Major depressive disorder	1	["RCL1"]
Nasopharyngeal neoplasms	1	["RCL1"]