Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	55339
Gene name	WD repeat domain 33
Gene symbol	WDR33
Synonyms (NCBI Gene)	NET14WDC146
Chromosome	2
Chromosome location	2q14.3
Summary	This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein com

186 Show/Hide all (186)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020148	hsa-miR-130b-3p	Sequencing	20371350
MIRT021125	hsa-miR-186-5p	Sequencing	20371350
MIRT023762	hsa-miR-1-3p	Proteomics	18668040
MIRT027636	hsa-miR-98-5p	Microarray	19088304
MIRT028001	hsa-miR-93-5p	Sequencing	20371350
MIRT031149	hsa-miR-19b-3p	Sequencing	20371350
MIRT032334	hsa-let-7b-5p	Proteomics	18668040
MIRT044276	hsa-miR-106b-5p	CLASH	23622248
MIRT040378	hsa-miR-615-3p	CLASH	23622248
MIRT036873	hsa-miR-877-3p	CLASH	23622248
MIRT035775	hsa-miR-1914-3p	CLASH	23622248
MIRT723506	hsa-miR-146a-3p	HITS-CLIP	19536157
MIRT723505	hsa-miR-4766-5p	HITS-CLIP	19536157
MIRT723504	hsa-miR-378a-3p	HITS-CLIP	19536157
MIRT723503	hsa-miR-378b	HITS-CLIP	19536157
MIRT723502	hsa-miR-378c	HITS-CLIP	19536157
MIRT723501	hsa-miR-378d	HITS-CLIP	19536157
MIRT723500	hsa-miR-378e	HITS-CLIP	19536157
MIRT723499	hsa-miR-378f	HITS-CLIP	19536157
MIRT723498	hsa-miR-378h	HITS-CLIP	19536157
MIRT723497	hsa-miR-378i	HITS-CLIP	19536157
MIRT723495	hsa-miR-422a	HITS-CLIP	19536157
MIRT723496	hsa-miR-570-3p	HITS-CLIP	19536157
MIRT723494	hsa-miR-5009-5p	HITS-CLIP	19536157
MIRT723493	hsa-miR-8058	HITS-CLIP	19536157
MIRT723492	hsa-miR-183-5p	HITS-CLIP	19536157
MIRT723491	hsa-miR-1271-5p	HITS-CLIP	19536157
MIRT723490	hsa-miR-96-5p	HITS-CLIP	19536157
MIRT723489	hsa-miR-4431	HITS-CLIP	19536157
MIRT718532	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT718531	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT718530	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT718529	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT718528	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT718527	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT718526	hsa-miR-1913	HITS-CLIP	19536157
MIRT718525	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT718524	hsa-miR-5699-5p	HITS-CLIP	19536157
MIRT718523	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT718522	hsa-miR-3189-5p	HITS-CLIP	19536157
MIRT718521	hsa-miR-3074-5p	HITS-CLIP	19536157
MIRT718520	hsa-miR-7152-5p	HITS-CLIP	19536157
MIRT723506	hsa-miR-146a-3p	HITS-CLIP	19536157
MIRT723505	hsa-miR-4766-5p	HITS-CLIP	19536157
MIRT723504	hsa-miR-378a-3p	HITS-CLIP	19536157
MIRT723503	hsa-miR-378b	HITS-CLIP	19536157
MIRT723502	hsa-miR-378c	HITS-CLIP	19536157
MIRT723501	hsa-miR-378d	HITS-CLIP	19536157
MIRT723500	hsa-miR-378e	HITS-CLIP	19536157
MIRT723499	hsa-miR-378f	HITS-CLIP	19536157
MIRT723498	hsa-miR-378h	HITS-CLIP	19536157
MIRT723497	hsa-miR-378i	HITS-CLIP	19536157
MIRT723495	hsa-miR-422a	HITS-CLIP	19536157
MIRT723496	hsa-miR-570-3p	HITS-CLIP	19536157
MIRT723494	hsa-miR-5009-5p	HITS-CLIP	19536157
MIRT723493	hsa-miR-8058	HITS-CLIP	19536157
MIRT723492	hsa-miR-183-5p	HITS-CLIP	19536157
MIRT723491	hsa-miR-1271-5p	HITS-CLIP	19536157
MIRT723490	hsa-miR-96-5p	HITS-CLIP	19536157
MIRT723489	hsa-miR-4431	HITS-CLIP	19536157
MIRT718532	hsa-miR-3606-3p	HITS-CLIP	19536157
MIRT718531	hsa-miR-513a-3p	HITS-CLIP	19536157
MIRT718530	hsa-miR-513c-3p	HITS-CLIP	19536157
MIRT718529	hsa-miR-4722-3p	HITS-CLIP	19536157
MIRT718528	hsa-miR-6727-3p	HITS-CLIP	19536157
MIRT718527	hsa-miR-6747-3p	HITS-CLIP	19536157
MIRT718526	hsa-miR-1913	HITS-CLIP	19536157
MIRT718525	hsa-miR-324-3p	HITS-CLIP	19536157
MIRT718524	hsa-miR-5699-5p	HITS-CLIP	19536157
MIRT718523	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT718522	hsa-miR-3189-5p	HITS-CLIP	19536157
MIRT718521	hsa-miR-3074-5p	HITS-CLIP	19536157
MIRT718520	hsa-miR-7152-5p	HITS-CLIP	19536157
MIRT1490068	hsa-miR-188-3p	CLIP-seq
MIRT1490069	hsa-miR-4643	CLIP-seq
MIRT1490070	hsa-miR-4714-3p	CLIP-seq
MIRT1490071	hsa-miR-4717-3p	CLIP-seq
MIRT1490072	hsa-miR-505	CLIP-seq
MIRT1490073	hsa-miR-532-3p	CLIP-seq
MIRT1490074	hsa-miR-1197	CLIP-seq
MIRT1490075	hsa-miR-124	CLIP-seq
MIRT1490076	hsa-miR-125a-3p	CLIP-seq
MIRT1490077	hsa-miR-1266	CLIP-seq
MIRT1490078	hsa-miR-1343	CLIP-seq
MIRT1490079	hsa-miR-181a	CLIP-seq
MIRT1490080	hsa-miR-181b	CLIP-seq
MIRT1490081	hsa-miR-181c	CLIP-seq
MIRT1490082	hsa-miR-181d	CLIP-seq
MIRT1490083	hsa-miR-1910	CLIP-seq
MIRT1490084	hsa-miR-198	CLIP-seq
MIRT1490085	hsa-miR-2115	CLIP-seq
MIRT1490086	hsa-miR-214	CLIP-seq
MIRT1490087	hsa-miR-3122	CLIP-seq
MIRT1490088	hsa-miR-3123	CLIP-seq
MIRT1490089	hsa-miR-3619-5p	CLIP-seq
MIRT1490090	hsa-miR-3660	CLIP-seq
MIRT1490091	hsa-miR-3689a-3p	CLIP-seq
MIRT1490092	hsa-miR-3689c	CLIP-seq
MIRT1490093	hsa-miR-3714	CLIP-seq
MIRT1490094	hsa-miR-376a	CLIP-seq
MIRT1490095	hsa-miR-376b	CLIP-seq
MIRT1490096	hsa-miR-376c	CLIP-seq
MIRT1490097	hsa-miR-3910	CLIP-seq
MIRT1490098	hsa-miR-3913-5p	CLIP-seq
MIRT1490099	hsa-miR-3921	CLIP-seq
MIRT1490100	hsa-miR-3925-5p	CLIP-seq
MIRT1490101	hsa-miR-3934	CLIP-seq
MIRT1490102	hsa-miR-3974	CLIP-seq
MIRT1490103	hsa-miR-3976	CLIP-seq
MIRT1490104	hsa-miR-412	CLIP-seq
MIRT1490105	hsa-miR-4259	CLIP-seq
MIRT1490106	hsa-miR-4260	CLIP-seq
MIRT1490107	hsa-miR-4262	CLIP-seq
MIRT1490108	hsa-miR-4277	CLIP-seq
MIRT1490109	hsa-miR-4495	CLIP-seq
MIRT1490110	hsa-miR-4518	CLIP-seq
MIRT1490111	hsa-miR-4526	CLIP-seq
MIRT1490069	hsa-miR-4643	CLIP-seq
MIRT1490112	hsa-miR-4653-5p	CLIP-seq
MIRT1490113	hsa-miR-466	CLIP-seq
MIRT1490114	hsa-miR-4716-5p	CLIP-seq
MIRT1490115	hsa-miR-4717-5p	CLIP-seq
MIRT1490116	hsa-miR-4719	CLIP-seq
MIRT1490117	hsa-miR-4728-5p	CLIP-seq
MIRT1490118	hsa-miR-4768-5p	CLIP-seq
MIRT1490119	hsa-miR-4789-3p	CLIP-seq
MIRT1490120	hsa-miR-486-3p	CLIP-seq
MIRT1490121	hsa-miR-506	CLIP-seq
MIRT1490122	hsa-miR-510	CLIP-seq
MIRT1490123	hsa-miR-512-5p	CLIP-seq
MIRT1490124	hsa-miR-513b	CLIP-seq
MIRT1490125	hsa-miR-520a-5p	CLIP-seq
MIRT1490126	hsa-miR-525-5p	CLIP-seq
MIRT1490127	hsa-miR-548aa	CLIP-seq
MIRT1490128	hsa-miR-548g	CLIP-seq
MIRT1490129	hsa-miR-548m	CLIP-seq
MIRT1490130	hsa-miR-571	CLIP-seq
MIRT1490131	hsa-miR-589	CLIP-seq
MIRT1490132	hsa-miR-761	CLIP-seq
MIRT1490133	hsa-miR-764	CLIP-seq
MIRT2368151	hsa-miR-106a	CLIP-seq
MIRT2368152	hsa-miR-106b	CLIP-seq
MIRT2368153	hsa-miR-1257	CLIP-seq
MIRT2368154	hsa-miR-1283	CLIP-seq
MIRT2368155	hsa-miR-129-3p	CLIP-seq
MIRT2368156	hsa-miR-17	CLIP-seq
MIRT2368157	hsa-miR-1825	CLIP-seq
MIRT2368158	hsa-miR-199a-5p	CLIP-seq
MIRT2368159	hsa-miR-199b-5p	CLIP-seq
MIRT2368160	hsa-miR-20a	CLIP-seq
MIRT2368161	hsa-miR-20b	CLIP-seq
MIRT2368162	hsa-miR-3185	CLIP-seq
MIRT2368163	hsa-miR-3609	CLIP-seq
MIRT2368164	hsa-miR-4677-3p	CLIP-seq
MIRT2368165	hsa-miR-4796-3p	CLIP-seq
MIRT2368166	hsa-miR-4803	CLIP-seq
MIRT2368167	hsa-miR-519d	CLIP-seq
MIRT2368168	hsa-miR-548ah	CLIP-seq
MIRT2368169	hsa-miR-93	CLIP-seq
MIRT2368170	hsa-miR-938	CLIP-seq
MIRT2463397	hsa-miR-1321	CLIP-seq
MIRT2463398	hsa-miR-3162-5p	CLIP-seq
MIRT2463399	hsa-miR-3929	CLIP-seq
MIRT2463400	hsa-miR-4419b	CLIP-seq
MIRT2463401	hsa-miR-4478	CLIP-seq
MIRT2463402	hsa-miR-4540	CLIP-seq
MIRT2463403	hsa-miR-4633-5p	CLIP-seq
MIRT2463404	hsa-miR-4739	CLIP-seq
MIRT2463405	hsa-miR-4756-5p	CLIP-seq
MIRT2463406	hsa-miR-485-5p	CLIP-seq
MIRT2463407	hsa-miR-532-5p	CLIP-seq
MIRT2661827	hsa-miR-3137	CLIP-seq
MIRT2661828	hsa-miR-3686	CLIP-seq
MIRT2661829	hsa-miR-382	CLIP-seq
MIRT2661830	hsa-miR-4452	CLIP-seq
MIRT2661831	hsa-miR-4652-3p	CLIP-seq
MIRT2661832	hsa-miR-4670-3p	CLIP-seq
MIRT1490075	hsa-miR-124	CLIP-seq
MIRT2368154	hsa-miR-1283	CLIP-seq
MIRT2695202	hsa-miR-3117-5p	CLIP-seq
MIRT2695203	hsa-miR-330-3p	CLIP-seq
MIRT1490093	hsa-miR-3714	CLIP-seq
MIRT1490097	hsa-miR-3910	CLIP-seq
MIRT1490121	hsa-miR-506	CLIP-seq
MIRT2695204	hsa-miR-520d-5p	CLIP-seq
MIRT2695205	hsa-miR-524-5p	CLIP-seq

12 Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0003723	Function	RNA binding	HDA	22681889
GO:0005581	Component	Collagen trimer	IEA
GO:0005634	Component	Nucleus	IDA	11162572
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005847	Component	MRNA cleavage and polyadenylation specificity factor complex	IBA
GO:0006301	Process	Postreplication repair	NAS	11162572
GO:0006397	Process	MRNA processing	IEA
GO:0007283	Process	Spermatogenesis	NAS	11162572
GO:0031124	Process	MRNA 3'-end processing	IEA

MIM	HGNC	e!Ensembl
618082	25651	ENSG00000136709

Q9C0J8

Protein name

pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa)

Protein function

Essential for both cleavage and polyadenylation of pre-mRNA 3' ends.

PDB

6BLY , 6BM0 , 6DNH , 6F9N , 6FUW , 6URG , 6URO , 8E3I , 8E3Q , 8R8R

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00400	WD40	192 → 230	WD domain, G-beta repeat	Repeat
PF00400	WD40	234 → 268	WD domain, G-beta repeat	Repeat
PF00400	WD40	278 → 316	WD domain, G-beta repeat	Repeat
PF00400	WD40	367 → 403	WD domain, G-beta repeat	Repeat
PF00400	WD40	321 → 360	WD domain, G-beta repeat	Repeat

Tissue specificity

TISSUE SPECIFICITY: Most highly expressed in testis. {ECO:0000269|PubMed:11162572}.

Sequence

MATEIGSPPRFFHMPRFQHQAPRQLFYKRPDFAQQQAMQQLTFDGKRMRKAVNRKTIDYN
PSVIKYLENRIWQRDQRDMRAIQPDAGYYNDLVPPIGMLNNPMNAVTTKFVRTSTNKVKC
PVFVVRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTAD
HGGYVKYWQSNMNNVKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERIL
RGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNG
NWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWH
VGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLL
PGMSEDGVEYDDLEPNSLAVIPGMGIPEQLKLAMEQEQMGKDESNEIEMTIPGLDWGMEE
VMQKDQKKVPQKKVPYAKPIPAQFQQAWMQNKVPIPAPNEVLNDRKEDIKLEEKKKTQAE
IEQEMATLQYTNPQLLEQLKIERLAQKQVEQIQPPPSSGTPLLGPQPFPGQGPMSQIPQG
FQQPHPSQQMPMNMAQMGPPGPQGQFRPPGPQGQMGPQGPPLHQGGGGPQGFMGPQGPQG
PPQGLPRPQDMHGPQGMQRHPGPHGPLGPQGPPGPQGSSGPQGHMGPQGPPGPQGHIGPQ
GPPGPQGHLGPQGPPGTQGMQGPPGPRGMQGPPHPHGIQGGPGSQGIQGPVSQGPLMGLN
PRGMQGPPGPRENQGPAPQGMIMGHPPQEMRGPHPPGGLLGHGPQEMRGPQEIRGMQGPP
PQGSMLGPPQELRGPPGSQSQQGPPQGSLGPPPQGGMQGPPGPQGQQNPARGPHPSQGPI
PFQQQKTPLLGDGPRAPFNQEGQSTGPPPLIPGLGQQGAQGRIPPLNPGQGPGPNKGDSR
GPPNHHMGPMSERRHEQSGGPEHGPERGPFRGGQDCRGPPDRRGPHPDFPDDFSRPDDFH
PDKRFGHRLREFEGRGGPLPQEEKWRRGGPGPPFPPDHREFSEGDGRGAARGPPGAWEGR
RPGDERFPRDPEDPRFRGRREESFRRGAPPRHEGRAPPRGRDGFPGPEDFGPEENFDASE
EAARGRDLRGRGRGTPRGGRKGLLPTPDEFPRFEGGRKPDSWDGNREPGPGHEHFRDTPR
PDHPPHDGHSPASRERSSSLQGMDMASLPPRKRPWHDGPGTSEHREMEAPGGPSEDRGGK
GRGGPGPAQRVPKSGRSSSLDGEHHDGYHRDEPFGGPPGSGTPSRGGRSGSNWGRGSNMN
SGPPRRGASRGGGRGR

Sequence length

1336

Interactions

View interactions

KEGG Pathway	Reactome Pathway
mRNA surveillance pathway	Transport of Mature mRNA Derived from an Intronless Transcript
	mRNA Splicing - Major Pathway
	mRNA 3'-end processing
	RNA Polymerase II Transcription Termination
	Processing of Intronless Pre-mRNAs

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CORONARY ARTERY DISEASE	—	GWAS catalog	29212778	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	37354922	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	30991224	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
CPSF3	[]	6	["mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA Derived from an Intronless Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Processing of Intronless Pre-mRNAs"]	[]
CPSF2	[]	6	["mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA Derived from an Intronless Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Processing of Intronless Pre-mRNAs"]	[]
CPSF1	[]	6	["mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA Derived from an Intronless Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Processing of Intronless Pre-mRNAs"]	[]
FIP1L1	[]	6	["mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA Derived from an Intronless Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Processing of Intronless Pre-mRNAs"]	[]
SYMPK	[]	6	["mRNA surveillance pathway","mRNA Splicing - Major Pathway","Transport of Mature mRNA Derived from an Intronless Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination","Processing of Intronless Pre-mRNAs"]	[]

WDR33 (WD repeat domain 33)

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