CPSF2 (cleavage and polyadenylation specific factor 2)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 53981 |
| Gene name | Cleavage and polyadenylation specific factor 2 |
| Gene symbol | CPSF2 |
| Synonyms (NCBI Gene) |
CPSF100
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| Chromosome | 14 |
| Chromosome location | 14q32.12 |
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miRNA
miRNA information provided by mirtarbase database.
922
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9P2I0 | |||||||||||||||||||||||||
| Protein name | Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) | |||||||||||||||||||||||||
| Protein function | Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cl | |||||||||||||||||||||||||
| PDB | 6URG , 6V4X | |||||||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLL |
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| Sequence length | 782 | |||||||||||||||||||||||||
| Interactions | View interactions | |||||||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with CPSF2 across shared curated disease and pathway associations.
5
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to CPSF2 (see Related Genes above), that are NOT already directly curated for CPSF2 itself -- a lead worth checking, not a confirmed association.
5
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