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Gene Gene information from NCBI Gene database.
Entrez ID 10885
Gene name WD repeat domain 3
Gene symbol WDR3
Synonyms (NCBI Gene)
DIP2UTP12
Chromosome 1
Chromosome location 1p12
Summary This gene encodes a nuclear protein containing 10 WD repeats. WD repeats are approximately 30- to 40-amino acid domains containing several conserved residues, which usually include a trp-asp at the C-terminal end. Proteins belonging to the WD repeat famil
miRNA miRNA information provided by mirtarbase database.
404 Show/Hide all (404)
miRTarBase ID miRNA Experiments Reference
MIRT031533 hsa-miR-16-5p Proteomics 18668040
MIRT052227 hsa-let-7b-5p CLASH 23622248
MIRT051837 hsa-let-7c-5p CLASH 23622248
MIRT629606 hsa-miR-329-3p HITS-CLIP 23313552
MIRT629605 hsa-miR-362-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13 Show/Hide all (13)
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IDA
GO:0005654 Component Nucleoplasm TAS
GO:0005730 Component Nucleolus IDA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604737 12755 ENSG00000065183
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UNX4
Protein name WD repeat-containing protein 3
Protein function Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associat
PDB 7MQ8 , 7MQ9 , 7MQA
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00400 WD40 665 → 703 WD domain, G-beta repeat Repeat
PF00400 WD40 581 → 618 WD domain, G-beta repeat Repeat
PF00400 WD40 486 → 524 WD domain, G-beta repeat Repeat
PF00400 WD40 139 → 177 WD domain, G-beta repeat Repeat
PF00400 WD40 181 → 219 WD domain, G-beta repeat Repeat
PF00400 WD40 623 → 661 WD domain, G-beta repeat Repeat
PF00400 WD40 402 → 442 WD domain, G-beta repeat Repeat
PF04003 Utp12 804 → 907 Dip2/Utp12 Family Family
PF12894 ANAPC4_WD40 45 → 118 Anaphase-promoting complex subunit 4 WD40 domain Repeat
Tissue specificity TISSUE SPECIFICITY: Ubiquitous.
Sequence
MGLTKQYLRYVASAVFGVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILI
LQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQL
GG
RLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDT
QHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEPDPKKIKGS
SPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHGTD
SVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIK
TSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRT
LSFSSDNIAVLSAAADSIKIWN
RSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQL
YDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSV
KQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDIS
HDGALIATGSADRNVKIW
GLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW
D
ADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMERE
AEYEESVAKEDQPAVPGETQGDSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAI
CKAAGKEVPLPSNPILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFN
EFIQLGSDVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMA
GLDYLKR
ECEAKSEVMFFADATSHLEEKKRKRKKREKLILTLT
Sequence length 943
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Ribosome biogenesis in eukaryotes Major pathway of rRNA processing in the nucleolus and cytosol