VPS25 (vacuolar protein sorting 25 homolog)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 84313
• Gene name: Vacuolar protein sorting 25 homolog
• Gene symbol: VPS25
• Synonyms (NCBI Gene): DERP9, EAP20, FAP20
• Chromosome: 17
• Chromosome location: 17q21.2
• Summary: This gene encodes a protein that is a subunit of the endosomal sorting complex required for transport II (ESCRT-II). This protein complex functions in sorting of ubiquitinated membrane proteins during endocytosis. A pseudogene of this gene is present on c

miRNA Show/Hide all (277)

miRTarBase ID	miRNA	Experiments	Reference
MIRT030413	hsa-miR-24-3p	Microarray	19748357
MIRT1486240	hsa-let-7a	CLIP-seq
MIRT1486241	hsa-let-7b	CLIP-seq
MIRT1486242	hsa-let-7c	CLIP-seq
MIRT1486243	hsa-let-7d	CLIP-seq
MIRT1486244	hsa-let-7e	CLIP-seq
MIRT1486245	hsa-let-7f	CLIP-seq
MIRT1486246	hsa-let-7g	CLIP-seq
MIRT1486247	hsa-let-7i	CLIP-seq
MIRT1486248	hsa-miR-1184	CLIP-seq
MIRT1486249	hsa-miR-1265	CLIP-seq
MIRT1486250	hsa-miR-149	CLIP-seq
MIRT1486251	hsa-miR-2392	CLIP-seq
MIRT1486252	hsa-miR-24	CLIP-seq
MIRT1486253	hsa-miR-3141	CLIP-seq
MIRT1486254	hsa-miR-3153	CLIP-seq
MIRT1486255	hsa-miR-3157-5p	CLIP-seq
MIRT1486256	hsa-miR-3158-3p	CLIP-seq
MIRT1486257	hsa-miR-3173-3p	CLIP-seq
MIRT1486258	hsa-miR-3620	CLIP-seq
MIRT1486259	hsa-miR-3653	CLIP-seq
MIRT1486260	hsa-miR-4284	CLIP-seq
MIRT1486261	hsa-miR-4458	CLIP-seq
MIRT1486262	hsa-miR-4475	CLIP-seq
MIRT1486263	hsa-miR-4500	CLIP-seq
MIRT1486264	hsa-miR-4649-5p	CLIP-seq
MIRT1486265	hsa-miR-4668-5p	CLIP-seq
MIRT1486266	hsa-miR-4685-5p	CLIP-seq
MIRT1486267	hsa-miR-4725-5p	CLIP-seq
MIRT1486268	hsa-miR-4763-5p	CLIP-seq
MIRT1486269	hsa-miR-504	CLIP-seq
MIRT1486270	hsa-miR-98	CLIP-seq
MIRT2146209	hsa-miR-1275	CLIP-seq
MIRT2146210	hsa-miR-1289	CLIP-seq
MIRT2146211	hsa-miR-193a-5p	CLIP-seq
MIRT2146212	hsa-miR-297	CLIP-seq
MIRT2146213	hsa-miR-3120-5p	CLIP-seq
MIRT2146214	hsa-miR-3165	CLIP-seq
MIRT2146215	hsa-miR-3198	CLIP-seq
MIRT2146216	hsa-miR-4260	CLIP-seq
MIRT2146217	hsa-miR-4294	CLIP-seq
MIRT2146218	hsa-miR-4299	CLIP-seq
MIRT2146219	hsa-miR-4309	CLIP-seq
MIRT2146220	hsa-miR-4456	CLIP-seq
MIRT2146221	hsa-miR-4525	CLIP-seq
MIRT2146222	hsa-miR-4665-5p	CLIP-seq
MIRT2146223	hsa-miR-4723-5p	CLIP-seq
MIRT2146224	hsa-miR-488	CLIP-seq
MIRT2146225	hsa-miR-548q	CLIP-seq
MIRT2146226	hsa-miR-567	CLIP-seq
MIRT2146227	hsa-miR-625	CLIP-seq
MIRT2146228	hsa-miR-627	CLIP-seq
MIRT2146229	hsa-miR-9	CLIP-seq
MIRT2146230	hsa-miR-924	CLIP-seq
MIRT2366702	hsa-miR-106a	CLIP-seq
MIRT2366703	hsa-miR-106b	CLIP-seq
MIRT1486248	hsa-miR-1184	CLIP-seq
MIRT2366704	hsa-miR-1254	CLIP-seq
MIRT2366705	hsa-miR-1279	CLIP-seq
MIRT2366706	hsa-miR-142-5p	CLIP-seq
MIRT1486250	hsa-miR-149	CLIP-seq
MIRT2366707	hsa-miR-17	CLIP-seq
MIRT2366708	hsa-miR-20a	CLIP-seq
MIRT2366709	hsa-miR-20b	CLIP-seq
MIRT1486252	hsa-miR-24	CLIP-seq
MIRT2146212	hsa-miR-297	CLIP-seq
MIRT2366710	hsa-miR-299-5p	CLIP-seq
MIRT2366711	hsa-miR-3116	CLIP-seq
MIRT1486256	hsa-miR-3158-3p	CLIP-seq
MIRT2366712	hsa-miR-3202	CLIP-seq
MIRT2366713	hsa-miR-340	CLIP-seq
MIRT2366714	hsa-miR-3609	CLIP-seq
MIRT2366715	hsa-miR-361-3p	CLIP-seq
MIRT2366716	hsa-miR-3679-3p	CLIP-seq
MIRT1486260	hsa-miR-4284	CLIP-seq
MIRT2366717	hsa-miR-4533	CLIP-seq
MIRT1486266	hsa-miR-4685-5p	CLIP-seq
MIRT1486267	hsa-miR-4725-5p	CLIP-seq
MIRT2366718	hsa-miR-4755-3p	CLIP-seq
MIRT1486268	hsa-miR-4763-5p	CLIP-seq
MIRT2366719	hsa-miR-4789-3p	CLIP-seq
MIRT2366720	hsa-miR-4796-3p	CLIP-seq
MIRT1486269	hsa-miR-504	CLIP-seq
MIRT2366721	hsa-miR-519d	CLIP-seq
MIRT2366722	hsa-miR-548ah	CLIP-seq
MIRT2146226	hsa-miR-567	CLIP-seq
MIRT2366723	hsa-miR-661	CLIP-seq
MIRT2366724	hsa-miR-93	CLIP-seq
MIRT1486240	hsa-let-7a	CLIP-seq
MIRT1486241	hsa-let-7b	CLIP-seq
MIRT1486242	hsa-let-7c	CLIP-seq
MIRT1486243	hsa-let-7d	CLIP-seq
MIRT1486244	hsa-let-7e	CLIP-seq
MIRT1486245	hsa-let-7f	CLIP-seq
MIRT1486246	hsa-let-7g	CLIP-seq
MIRT1486247	hsa-let-7i	CLIP-seq
MIRT1486248	hsa-miR-1184	CLIP-seq
MIRT2660203	hsa-miR-1226	CLIP-seq
MIRT2660204	hsa-miR-1253	CLIP-seq
MIRT2366704	hsa-miR-1254	CLIP-seq
MIRT1486249	hsa-miR-1265	CLIP-seq
MIRT2660205	hsa-miR-1273d	CLIP-seq
MIRT2146209	hsa-miR-1275	CLIP-seq
MIRT2366705	hsa-miR-1279	CLIP-seq
MIRT2146210	hsa-miR-1289	CLIP-seq
MIRT2660206	hsa-miR-1321	CLIP-seq
MIRT1486250	hsa-miR-149	CLIP-seq
MIRT2146211	hsa-miR-193a-5p	CLIP-seq
MIRT2660207	hsa-miR-2355-5p	CLIP-seq
MIRT1486251	hsa-miR-2392	CLIP-seq
MIRT1486252	hsa-miR-24	CLIP-seq
MIRT2660208	hsa-miR-2861	CLIP-seq
MIRT2660209	hsa-miR-29a	CLIP-seq
MIRT2660210	hsa-miR-29b	CLIP-seq
MIRT2660211	hsa-miR-29c	CLIP-seq
MIRT2660212	hsa-miR-3065-3p	CLIP-seq
MIRT2366711	hsa-miR-3116	CLIP-seq
MIRT2146213	hsa-miR-3120-5p	CLIP-seq
MIRT1486253	hsa-miR-3141	CLIP-seq
MIRT1486254	hsa-miR-3153	CLIP-seq
MIRT2660213	hsa-miR-3154	CLIP-seq
MIRT1486255	hsa-miR-3157-5p	CLIP-seq
MIRT1486256	hsa-miR-3158-3p	CLIP-seq
MIRT2146214	hsa-miR-3165	CLIP-seq
MIRT2660214	hsa-miR-3169	CLIP-seq
MIRT1486257	hsa-miR-3173-3p	CLIP-seq
MIRT2660215	hsa-miR-3185	CLIP-seq
MIRT2146215	hsa-miR-3198	CLIP-seq
MIRT2366712	hsa-miR-3202	CLIP-seq
MIRT2660216	hsa-miR-338-3p	CLIP-seq
MIRT2660217	hsa-miR-342-5p	CLIP-seq
MIRT2660218	hsa-miR-3612	CLIP-seq
MIRT2366715	hsa-miR-361-3p	CLIP-seq
MIRT2660219	hsa-miR-3614-3p	CLIP-seq
MIRT2660220	hsa-miR-3675-5p	CLIP-seq
MIRT2366716	hsa-miR-3679-3p	CLIP-seq
MIRT2660221	hsa-miR-3689a-3p	CLIP-seq
MIRT2660222	hsa-miR-3689c	CLIP-seq
MIRT2660223	hsa-miR-3907	CLIP-seq
MIRT2660224	hsa-miR-3936	CLIP-seq
MIRT2660225	hsa-miR-3977	CLIP-seq
MIRT2660226	hsa-miR-3978	CLIP-seq
MIRT2660227	hsa-miR-4251	CLIP-seq
MIRT2146216	hsa-miR-4260	CLIP-seq
MIRT1486260	hsa-miR-4284	CLIP-seq
MIRT2660228	hsa-miR-4287	CLIP-seq
MIRT2660229	hsa-miR-4292	CLIP-seq
MIRT2660230	hsa-miR-4293	CLIP-seq
MIRT2146217	hsa-miR-4294	CLIP-seq
MIRT2146218	hsa-miR-4299	CLIP-seq
MIRT2660231	hsa-miR-4308	CLIP-seq
MIRT2146219	hsa-miR-4309	CLIP-seq
MIRT2660232	hsa-miR-4324	CLIP-seq
MIRT2660233	hsa-miR-4436a	CLIP-seq
MIRT2660234	hsa-miR-4455	CLIP-seq
MIRT2146220	hsa-miR-4456	CLIP-seq
MIRT1486261	hsa-miR-4458	CLIP-seq
MIRT2660235	hsa-miR-4469	CLIP-seq
MIRT2660236	hsa-miR-4476	CLIP-seq
MIRT1486263	hsa-miR-4500	CLIP-seq
MIRT2660237	hsa-miR-4509	CLIP-seq
MIRT2660238	hsa-miR-4515	CLIP-seq
MIRT2146221	hsa-miR-4525	CLIP-seq
MIRT2660239	hsa-miR-4530	CLIP-seq
MIRT2366717	hsa-miR-4533	CLIP-seq
MIRT1486264	hsa-miR-4649-5p	CLIP-seq
MIRT2660240	hsa-miR-4651	CLIP-seq
MIRT2660241	hsa-miR-4661-3p	CLIP-seq
MIRT2660242	hsa-miR-4664-5p	CLIP-seq
MIRT2146222	hsa-miR-4665-5p	CLIP-seq
MIRT1486265	hsa-miR-4668-5p	CLIP-seq
MIRT2660243	hsa-miR-4685-3p	CLIP-seq
MIRT1486266	hsa-miR-4685-5p	CLIP-seq
MIRT2660244	hsa-miR-4713-5p	CLIP-seq
MIRT2146223	hsa-miR-4723-5p	CLIP-seq
MIRT1486267	hsa-miR-4725-5p	CLIP-seq
MIRT2660245	hsa-miR-4726-3p	CLIP-seq
MIRT2660246	hsa-miR-4728-5p	CLIP-seq
MIRT2660247	hsa-miR-4739	CLIP-seq
MIRT2660248	hsa-miR-4747-3p	CLIP-seq
MIRT2366718	hsa-miR-4755-3p	CLIP-seq
MIRT2660249	hsa-miR-4756-5p	CLIP-seq
MIRT1486268	hsa-miR-4763-5p	CLIP-seq
MIRT2146224	hsa-miR-488	CLIP-seq
MIRT1486269	hsa-miR-504	CLIP-seq
MIRT2660250	hsa-miR-539	CLIP-seq
MIRT2146225	hsa-miR-548q	CLIP-seq
MIRT2660251	hsa-miR-608	CLIP-seq
MIRT2146227	hsa-miR-625	CLIP-seq
MIRT2146228	hsa-miR-627	CLIP-seq
MIRT2660252	hsa-miR-646	CLIP-seq
MIRT2660253	hsa-miR-650	CLIP-seq
MIRT2366723	hsa-miR-661	CLIP-seq
MIRT2660254	hsa-miR-765	CLIP-seq
MIRT2660255	hsa-miR-875-3p	CLIP-seq
MIRT2146229	hsa-miR-9	CLIP-seq
MIRT2146230	hsa-miR-924	CLIP-seq
MIRT1486270	hsa-miR-98	CLIP-seq
MIRT1486248	hsa-miR-1184	CLIP-seq
MIRT2660203	hsa-miR-1226	CLIP-seq
MIRT2660204	hsa-miR-1253	CLIP-seq
MIRT2366704	hsa-miR-1254	CLIP-seq
MIRT2660205	hsa-miR-1273d	CLIP-seq
MIRT2146209	hsa-miR-1275	CLIP-seq
MIRT2366705	hsa-miR-1279	CLIP-seq
MIRT2146210	hsa-miR-1289	CLIP-seq
MIRT2660206	hsa-miR-1321	CLIP-seq
MIRT2146211	hsa-miR-193a-5p	CLIP-seq
MIRT2660207	hsa-miR-2355-5p	CLIP-seq
MIRT2660208	hsa-miR-2861	CLIP-seq
MIRT2660209	hsa-miR-29a	CLIP-seq
MIRT2660210	hsa-miR-29b	CLIP-seq
MIRT2660211	hsa-miR-29c	CLIP-seq
MIRT2660212	hsa-miR-3065-3p	CLIP-seq
MIRT2366711	hsa-miR-3116	CLIP-seq
MIRT2146213	hsa-miR-3120-5p	CLIP-seq
MIRT2660213	hsa-miR-3154	CLIP-seq
MIRT1486256	hsa-miR-3158-3p	CLIP-seq
MIRT2146214	hsa-miR-3165	CLIP-seq
MIRT2660214	hsa-miR-3169	CLIP-seq
MIRT2146215	hsa-miR-3198	CLIP-seq
MIRT2366712	hsa-miR-3202	CLIP-seq
MIRT2660216	hsa-miR-338-3p	CLIP-seq
MIRT2660217	hsa-miR-342-5p	CLIP-seq
MIRT2660218	hsa-miR-3612	CLIP-seq
MIRT2366715	hsa-miR-361-3p	CLIP-seq
MIRT2660219	hsa-miR-3614-3p	CLIP-seq
MIRT1486259	hsa-miR-3653	CLIP-seq
MIRT2660220	hsa-miR-3675-5p	CLIP-seq
MIRT2366716	hsa-miR-3679-3p	CLIP-seq
MIRT2660221	hsa-miR-3689a-3p	CLIP-seq
MIRT2660222	hsa-miR-3689c	CLIP-seq
MIRT2660224	hsa-miR-3936	CLIP-seq
MIRT2660226	hsa-miR-3978	CLIP-seq
MIRT2660227	hsa-miR-4251	CLIP-seq
MIRT2146216	hsa-miR-4260	CLIP-seq
MIRT2660230	hsa-miR-4293	CLIP-seq
MIRT2146217	hsa-miR-4294	CLIP-seq
MIRT2146218	hsa-miR-4299	CLIP-seq
MIRT2660231	hsa-miR-4308	CLIP-seq
MIRT2146219	hsa-miR-4309	CLIP-seq
MIRT2660232	hsa-miR-4324	CLIP-seq
MIRT2660233	hsa-miR-4436a	CLIP-seq
MIRT2660234	hsa-miR-4455	CLIP-seq
MIRT2146220	hsa-miR-4456	CLIP-seq
MIRT2660236	hsa-miR-4476	CLIP-seq
MIRT2660237	hsa-miR-4509	CLIP-seq
MIRT2660238	hsa-miR-4515	CLIP-seq
MIRT2146221	hsa-miR-4525	CLIP-seq
MIRT2660239	hsa-miR-4530	CLIP-seq
MIRT2366717	hsa-miR-4533	CLIP-seq
MIRT2660240	hsa-miR-4651	CLIP-seq
MIRT2660241	hsa-miR-4661-3p	CLIP-seq
MIRT2660242	hsa-miR-4664-5p	CLIP-seq
MIRT2146222	hsa-miR-4665-5p	CLIP-seq
MIRT1486266	hsa-miR-4685-5p	CLIP-seq
MIRT2146223	hsa-miR-4723-5p	CLIP-seq
MIRT2660245	hsa-miR-4726-3p	CLIP-seq
MIRT2660246	hsa-miR-4728-5p	CLIP-seq
MIRT2660247	hsa-miR-4739	CLIP-seq
MIRT2660248	hsa-miR-4747-3p	CLIP-seq
MIRT2366718	hsa-miR-4755-3p	CLIP-seq
MIRT2660249	hsa-miR-4756-5p	CLIP-seq
MIRT1486268	hsa-miR-4763-5p	CLIP-seq
MIRT2146224	hsa-miR-488	CLIP-seq
MIRT2660250	hsa-miR-539	CLIP-seq
MIRT2146225	hsa-miR-548q	CLIP-seq
MIRT2660251	hsa-miR-608	CLIP-seq
MIRT2146227	hsa-miR-625	CLIP-seq
MIRT2146228	hsa-miR-627	CLIP-seq
MIRT2660252	hsa-miR-646	CLIP-seq
MIRT2660253	hsa-miR-650	CLIP-seq
MIRT2366723	hsa-miR-661	CLIP-seq
MIRT2660254	hsa-miR-765	CLIP-seq
MIRT2660255	hsa-miR-875-3p	CLIP-seq
MIRT2146229	hsa-miR-9	CLIP-seq
MIRT2146230	hsa-miR-924	CLIP-seq

Gene ontology (GO) Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000814	Component	ESCRT II complex	IBA
GO:0000814	Component	ESCRT II complex	IDA	16973552
GO:0000814	Component	ESCRT II complex	IEA
GO:0000814	Component	ESCRT II complex	IPI	18539118
GO:0000814	Component	ESCRT II complex	TAS	20588296
GO:0005198	Function	Structural molecule activity	IBA
GO:0005515	Function	Protein binding	IPI	14505570, 14519844, 16189514, 16730941, 16856878, 16973552, 17010938, 21516116, 25416956, 28514442, 29892012, 31515488, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	16371348
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005737	Component	Cytoplasm	IDA	16973552
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005829	Component	Cytosol	IDA	17010938
GO:0005829	Component	Cytosol	TAS
GO:0007175	Process	Negative regulation of epidermal growth factor-activated receptor activity	IMP	16973552
GO:0010008	Component	Endosome membrane	IDA	16371348, 16973552
GO:0010008	Component	Endosome membrane	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016236	Process	Macroautophagy	IEA
GO:0016236	Process	Macroautophagy	TAS	20588296
GO:0036258	Process	Multivesicular body assembly	NAS	18539118
GO:0036258	Process	Multivesicular body assembly	TAS	20588296
GO:0042803	Function	Protein homodimerization activity	IBA
GO:0042803	Function	Protein homodimerization activity	IPI	14519844
GO:0043328	Process	Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA
GO:0043328	Process	Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	NAS	18539118
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0071985	Process	Multivesicular body sorting pathway	IEA
GO:0090148	Process	Membrane fission	NAS	18539118

Other IDs

• MIM: 610907
• HGNC: 28122
• e!Ensembl: ENSG00000131475

Protein

• UniProt ID: Q9BRG1
• Protein name: Vacuolar protein-sorting-associated protein 25 (hVps25) (Dermal papilla-derived protein 9) (ELL-associated protein of 20 kDa) (ESCRT-II complex subunit VPS25)
• Protein function: Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembr
• PDB: 2ZME , 3CUQ , 3HTU
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05871	ESCRT-II	10 → 145	ESCRT-II complex subunit	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed at the mRNA level in kidney, liver, pancreas, and placenta. Lower levels of expression are found in heart, skeletal muscle, brain and lung. {ECO:0000269|PubMed:16889659}.
• Sequence:

  MAMSFEWPWQYRFPPFFTLQPNVDTRQKQLAAWCSLVLSFCRLHKQSSMTVMEAQESPLF
  NNVKLQRKLPVESIQIVLEELRKKGNLEWLDKSKSSFLIMWRRPEEWGKLIYQWVSRSGQ
  NNSVFTLYELTNGEDTEDEEFHGLDEATLLRALQALQQEHKAEIITVSDGRGVKFF

• Sequence length: 176

Pathways

KEGG Pathway	Reactome Pathway
Endocytosis	Endosomal Sorting Complex Required For Transport (ESCRT)
	HCMV Late Events

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
VPS25-related neurodevelopmental delay	Likely pathogenic	rs2543968571	RCV004577399	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cholangiocarcinoma	Cholangiocarcinoma	Pubtator	35672673	Associate	★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	40149859	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

SNF8 3 shared pathwaysEndocytosis, Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Late Events Related via 3 shared pathways including Endocytosis, Endosomal Sorting Complex Required For Transport (ESCRT). VPS36 3 shared pathwaysEndocytosis, Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Late Events Related via 3 shared pathways including Endocytosis, Endosomal Sorting Complex Required For Transport (ESCRT). VPS37A 3 shared pathwaysEndocytosis, Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Late Events Related via 3 shared pathways including Endocytosis, Endosomal Sorting Complex Required For Transport (ESCRT). VPS37D 3 shared pathwaysEndocytosis, Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Late Events Related via 3 shared pathways including Endocytosis, Endosomal Sorting Complex Required For Transport (ESCRT). VPS28 3 shared pathwaysEndocytosis, Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Late Events Related via 3 shared pathways including Endocytosis, Endosomal Sorting Complex Required For Transport (ESCRT).

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
SNF8	0	[]	3	["Endocytosis","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events"]	0	[]
VPS36	0	[]	3	["Endocytosis","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events"]	0	[]
VPS37A	0	[]	3	["Endocytosis","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events"]	0	[]
VPS37D	0	[]	3	["Endocytosis","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events"]	0	[]
VPS28	0	[]	3	["Endocytosis","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events"]	0	[]

Diseases Linked via Similar Genes

Diabetes mellitus type 2 Linked via 2 of 5 related genesSNF8, VPS37D Neurodevelopmental disorder Linked via 1 of 5 related genesSNF8 Developmental and epileptic encephalopathy Linked via 1 of 5 related genesSNF8 Hirschsprung disease Linked via 1 of 5 related genesSNF8 Non-specific syndromic intellectual disability Linked via 1 of 5 related genesSNF8

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Diabetes mellitus type 2	2	["SNF8","VPS37D"]
Neurodevelopmental disorder	1	["SNF8"]
Developmental and epileptic encephalopathy	1	["SNF8"]
Hirschsprung disease	1	["SNF8"]
Non-specific syndromic intellectual disability	1	["SNF8"]