Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	51160
Gene name	VPS28 subunit of ESCRT-I
Gene symbol	VPS28
Synonyms (NCBI Gene)	CIIA
Chromosome	8
Chromosome location	8q24.3
Summary	This gene encodes a protein subunit of the ESCRT-I complex (endosomal complexes required for transport), which functions in the transport and sorting of proteins into subcellular vesicles. This complex can also be hijacked to facilitate the budding of env

142 Show/Hide all (142)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052309	hsa-let-7b-5p	CLASH	23622248
MIRT043761	hsa-miR-328-3p	CLASH	23622248
MIRT464154	hsa-miR-3174	PAR-CLIP	23592263
MIRT464153	hsa-miR-1324	PAR-CLIP	23592263
MIRT464152	hsa-miR-219a-1-3p	PAR-CLIP	23592263
MIRT464151	hsa-miR-571	PAR-CLIP	23592263
MIRT464150	hsa-miR-3166	PAR-CLIP	23592263
MIRT464149	hsa-miR-4771	PAR-CLIP	23592263
MIRT464148	hsa-miR-6744-5p	PAR-CLIP	23592263
MIRT464147	hsa-miR-1255a	PAR-CLIP	23592263
MIRT464146	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT464145	hsa-miR-376b-5p	PAR-CLIP	23592263
MIRT464144	hsa-miR-376c-5p	PAR-CLIP	23592263
MIRT464143	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT464142	hsa-miR-8056	PAR-CLIP	23592263
MIRT464141	hsa-miR-3911	PAR-CLIP	23592263
MIRT464140	hsa-miR-644a	PAR-CLIP	23592263
MIRT464139	hsa-miR-1273h-3p	PAR-CLIP	23592263
MIRT464138	hsa-miR-4752	PAR-CLIP	23592263
MIRT464137	hsa-miR-6818-5p	PAR-CLIP	23592263
MIRT464136	hsa-miR-147a	PAR-CLIP	23592263
MIRT464135	hsa-miR-509-5p	PAR-CLIP	23592263
MIRT464154	hsa-miR-3174	PAR-CLIP	23592263
MIRT464153	hsa-miR-1324	PAR-CLIP	23592263
MIRT464152	hsa-miR-219a-1-3p	PAR-CLIP	23592263
MIRT464151	hsa-miR-571	PAR-CLIP	23592263
MIRT464150	hsa-miR-3166	PAR-CLIP	23592263
MIRT464149	hsa-miR-4771	PAR-CLIP	23592263
MIRT464148	hsa-miR-6744-5p	PAR-CLIP	23592263
MIRT464147	hsa-miR-1255a	PAR-CLIP	23592263
MIRT464146	hsa-miR-1255b-5p	PAR-CLIP	23592263
MIRT464145	hsa-miR-376b-5p	PAR-CLIP	23592263
MIRT464144	hsa-miR-376c-5p	PAR-CLIP	23592263
MIRT464143	hsa-miR-3691-5p	PAR-CLIP	23592263
MIRT464142	hsa-miR-8056	PAR-CLIP	23592263
MIRT464141	hsa-miR-3911	PAR-CLIP	23592263
MIRT464140	hsa-miR-644a	PAR-CLIP	23592263
MIRT464139	hsa-miR-1273h-3p	PAR-CLIP	23592263
MIRT464138	hsa-miR-4752	PAR-CLIP	23592263
MIRT464137	hsa-miR-6818-5p	PAR-CLIP	23592263
MIRT464136	hsa-miR-147a	PAR-CLIP	23592263
MIRT464135	hsa-miR-509-5p	PAR-CLIP	23592263
MIRT1486429	hsa-miR-1538	CLIP-seq
MIRT1486430	hsa-miR-3150a-3p	CLIP-seq
MIRT1486431	hsa-miR-3151	CLIP-seq
MIRT1486432	hsa-miR-3175	CLIP-seq
MIRT1486433	hsa-miR-3184	CLIP-seq
MIRT1486434	hsa-miR-423-5p	CLIP-seq
MIRT1486435	hsa-miR-4265	CLIP-seq
MIRT1486436	hsa-miR-4296	CLIP-seq
MIRT1486437	hsa-miR-4322	CLIP-seq
MIRT1486438	hsa-miR-4447	CLIP-seq
MIRT1486439	hsa-miR-4472	CLIP-seq
MIRT1486440	hsa-miR-4728-5p	CLIP-seq
MIRT1486441	hsa-miR-4745-3p	CLIP-seq
MIRT1486442	hsa-miR-491-5p	CLIP-seq
MIRT1486443	hsa-miR-493	CLIP-seq
MIRT1486444	hsa-miR-939	CLIP-seq
MIRT2146288	hsa-miR-1234	CLIP-seq
MIRT2146289	hsa-miR-1255b	CLIP-seq
MIRT2146290	hsa-miR-147	CLIP-seq
MIRT2146291	hsa-miR-219-1-3p	CLIP-seq
MIRT2146292	hsa-miR-3144-5p	CLIP-seq
MIRT2146293	hsa-miR-3158-5p	CLIP-seq
MIRT2146294	hsa-miR-4514	CLIP-seq
MIRT2146295	hsa-miR-4692	CLIP-seq
MIRT2146296	hsa-miR-4730	CLIP-seq
MIRT2146297	hsa-miR-644	CLIP-seq
MIRT2146298	hsa-miR-665	CLIP-seq
MIRT2146288	hsa-miR-1234	CLIP-seq
MIRT2146289	hsa-miR-1255b	CLIP-seq
MIRT2146290	hsa-miR-147	CLIP-seq
MIRT2146291	hsa-miR-219-1-3p	CLIP-seq
MIRT2146292	hsa-miR-3144-5p	CLIP-seq
MIRT2146293	hsa-miR-3158-5p	CLIP-seq
MIRT2146294	hsa-miR-4514	CLIP-seq
MIRT2146295	hsa-miR-4692	CLIP-seq
MIRT2146296	hsa-miR-4730	CLIP-seq
MIRT2146297	hsa-miR-644	CLIP-seq
MIRT2146298	hsa-miR-665	CLIP-seq
MIRT2146288	hsa-miR-1234	CLIP-seq
MIRT2146289	hsa-miR-1255b	CLIP-seq
MIRT2146290	hsa-miR-147	CLIP-seq
MIRT2146291	hsa-miR-219-1-3p	CLIP-seq
MIRT2146293	hsa-miR-3158-5p	CLIP-seq
MIRT2146294	hsa-miR-4514	CLIP-seq
MIRT2146295	hsa-miR-4692	CLIP-seq
MIRT2146297	hsa-miR-644	CLIP-seq
MIRT2146288	hsa-miR-1234	CLIP-seq
MIRT2660363	hsa-miR-1237	CLIP-seq
MIRT2146289	hsa-miR-1255b	CLIP-seq
MIRT2660364	hsa-miR-1281	CLIP-seq
MIRT2146290	hsa-miR-147	CLIP-seq
MIRT2660365	hsa-miR-1913	CLIP-seq
MIRT2660366	hsa-miR-19a	CLIP-seq
MIRT2660367	hsa-miR-19b	CLIP-seq
MIRT2146291	hsa-miR-219-1-3p	CLIP-seq
MIRT2146292	hsa-miR-3144-5p	CLIP-seq
MIRT2146293	hsa-miR-3158-5p	CLIP-seq
MIRT2660368	hsa-miR-3182	CLIP-seq
MIRT2660369	hsa-miR-324-3p	CLIP-seq
MIRT2660370	hsa-miR-371-3p	CLIP-seq
MIRT2660371	hsa-miR-371b-3p	CLIP-seq
MIRT2660372	hsa-miR-4494	CLIP-seq
MIRT2146294	hsa-miR-4514	CLIP-seq
MIRT2660373	hsa-miR-4522	CLIP-seq
MIRT2146295	hsa-miR-4692	CLIP-seq
MIRT2660374	hsa-miR-4708-3p	CLIP-seq
MIRT2146296	hsa-miR-4730	CLIP-seq
MIRT2660375	hsa-miR-499a-5p	CLIP-seq
MIRT2660376	hsa-miR-515-3p	CLIP-seq
MIRT2660377	hsa-miR-519e	CLIP-seq
MIRT2146297	hsa-miR-644	CLIP-seq
MIRT2146298	hsa-miR-665	CLIP-seq
MIRT2660378	hsa-miR-938	CLIP-seq
MIRT2146288	hsa-miR-1234	CLIP-seq
MIRT2660363	hsa-miR-1237	CLIP-seq
MIRT2146289	hsa-miR-1255b	CLIP-seq
MIRT2660364	hsa-miR-1281	CLIP-seq
MIRT2146290	hsa-miR-147	CLIP-seq
MIRT2660365	hsa-miR-1913	CLIP-seq
MIRT2660366	hsa-miR-19a	CLIP-seq
MIRT2660367	hsa-miR-19b	CLIP-seq
MIRT2146291	hsa-miR-219-1-3p	CLIP-seq
MIRT2146292	hsa-miR-3144-5p	CLIP-seq
MIRT2146293	hsa-miR-3158-5p	CLIP-seq
MIRT2660368	hsa-miR-3182	CLIP-seq
MIRT2660369	hsa-miR-324-3p	CLIP-seq
MIRT2660370	hsa-miR-371-3p	CLIP-seq
MIRT2660371	hsa-miR-371b-3p	CLIP-seq
MIRT2660372	hsa-miR-4494	CLIP-seq
MIRT2146294	hsa-miR-4514	CLIP-seq
MIRT2660373	hsa-miR-4522	CLIP-seq
MIRT2146295	hsa-miR-4692	CLIP-seq
MIRT2660374	hsa-miR-4708-3p	CLIP-seq
MIRT2146296	hsa-miR-4730	CLIP-seq
MIRT2660375	hsa-miR-499a-5p	CLIP-seq
MIRT2660376	hsa-miR-515-3p	CLIP-seq
MIRT2660377	hsa-miR-519e	CLIP-seq
MIRT2146297	hsa-miR-644	CLIP-seq
MIRT2146298	hsa-miR-665	CLIP-seq
MIRT2660378	hsa-miR-938	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000813	Component	ESCRT I complex	IBA
GO:0000813	Component	ESCRT I complex	IDA	18005716, 20654576, 21757351, 22232651
GO:0000813	Component	ESCRT I complex	IEA
GO:0000813	Component	ESCRT I complex	IPI	18005716, 21757351, 32424346
GO:0000813	Component	ESCRT I complex	ISS
GO:0000813	Component	ESCRT I complex	TAS	20588296
GO:0005515	Function	Protein binding	IPI	11134028, 14505570, 14519844, 15218037, 16189514, 19060904, 21516116, 25416956, 25959826, 26871637, 28514442, 31515488, 32296183, 32814053, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IDA	18077552
GO:0005768	Component	Endosome	IDA	11134028, 17940959
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IDA	11916981
GO:0005829	Component	Cytosol	IDA	11134028
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IDA	17940959
GO:0005886	Component	Plasma membrane	IEA
GO:0010008	Component	Endosome membrane	IDA	11134028
GO:0010008	Component	Endosome membrane	NAS	32424346
GO:0010008	Component	Endosome membrane	TAS
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016236	Process	Macroautophagy	IEA
GO:0016236	Process	Macroautophagy	TAS	20588296
GO:0031397	Process	Negative regulation of protein ubiquitination	IDA	18077552
GO:0031902	Component	Late endosome membrane	IEA
GO:0032509	Process	Endosome transport via multivesicular body sorting pathway	IEA
GO:0036258	Process	Multivesicular body assembly	IEA
GO:0036258	Process	Multivesicular body assembly	NAS	32424346
GO:0036258	Process	Multivesicular body assembly	TAS	20588296
GO:0039702	Process	Viral budding via host ESCRT complex	IEA
GO:0039702	Process	Viral budding via host ESCRT complex	TAS	20588296
GO:0043130	Function	Ubiquitin binding	IDA	11916981
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IC	20654576
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP	21757351
GO:0043328	Process	Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA
GO:0043328	Process	Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	NAS	32424346
GO:0044877	Function	Protein-containing complex binding	IBA
GO:0045732	Process	Positive regulation of protein catabolic process	IMP	11916981
GO:0070062	Component	Extracellular exosome	HDA	19056867, 19199708, 20458337, 23533145
GO:0090148	Process	Membrane fission	NAS	32424346
GO:2000397	Process	Positive regulation of ubiquitin-dependent endocytosis	IMP	11916981

MIM	HGNC	e!Ensembl
611952	18178	ENSG00000160948

Q9UK41

Protein name

Vacuolar protein sorting-associated protein 28 homolog (H-Vps28) (ESCRT-I complex subunit VPS28)

Protein function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process.

PDB

6VME

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03997	VPS28	39 → 219	VPS28 protein	Family

Sequence

MFHGIPATPGIGAPGNKPELYEEVKLYKNAREREKYDNMAELFAVVKTMQALEKAYIKDC
VSPSEYTAACSRLLVQYKAAFRQVQGSEISSIDEFCRKFRLDCPLAMERIKEDRPITIKD
DKGNLNRCIADVVSLFITVMDKLRLEIRAMDEIQPDLRELMETMHRMSHLPPDFEGRQTV
SQWLQTLSGMSASDELDDSQVRQMLFDLESAYNAFNRFLHA

Sequence length

221

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Endocytosis	Budding and maturation of HIV virion
	Membrane binding and targetting of GAG proteins
	Endosomal Sorting Complex Required For Transport (ESCRT)
	HCMV Late Events

VPS28 (VPS28 subunit of ESCRT-I)

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