VPS37B (VPS37B subunit of ESCRT-I)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 79720
• Gene name: VPS37B subunit of ESCRT-I
• Gene symbol: VPS37B
• Synonyms (NCBI Gene): -
• Chromosome: 12
• Chromosome location: 12q24.31

miRNA Show/Hide all (312)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019654	hsa-miR-378a-3p	Sequencing	20371350
MIRT025496	hsa-miR-34a-5p	Sequencing	20371350
MIRT043537	hsa-miR-331-3p	CLASH	23622248
MIRT039479	hsa-miR-652-3p	CLASH	23622248
MIRT036597	hsa-miR-940	CLASH	23622248
MIRT052888	hsa-miR-3928-3p	CLASH	23622248
MIRT513626	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT513625	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT513624	hsa-miR-130a-3p	PAR-CLIP	23446348
MIRT513623	hsa-miR-130b-3p	PAR-CLIP	23446348
MIRT513622	hsa-miR-301a-3p	PAR-CLIP	23446348
MIRT513621	hsa-miR-301b-3p	PAR-CLIP	23446348
MIRT513620	hsa-miR-3666	PAR-CLIP	23446348
MIRT513619	hsa-miR-4295	PAR-CLIP	23446348
MIRT513618	hsa-miR-454-3p	PAR-CLIP	23446348
MIRT513617	hsa-miR-148a-3p	PAR-CLIP	23446348
MIRT513616	hsa-miR-148b-3p	PAR-CLIP	23446348
MIRT513615	hsa-miR-152-3p	PAR-CLIP	23446348
MIRT513614	hsa-miR-194-3p	PAR-CLIP	23446348
MIRT513613	hsa-miR-1825	PAR-CLIP	23446348
MIRT513612	hsa-miR-518c-5p	PAR-CLIP	23446348
MIRT513611	hsa-miR-4638-3p	PAR-CLIP	23446348
MIRT019654	hsa-miR-378a-3p	PAR-CLIP	23446348
MIRT513610	hsa-miR-378b	PAR-CLIP	23446348
MIRT513609	hsa-miR-378c	PAR-CLIP	23446348
MIRT513608	hsa-miR-378d	PAR-CLIP	23446348
MIRT513607	hsa-miR-378e	PAR-CLIP	23446348
MIRT513606	hsa-miR-378f	PAR-CLIP	23446348
MIRT513604	hsa-miR-378h	PAR-CLIP	23446348
MIRT513605	hsa-miR-378i	PAR-CLIP	23446348
MIRT513603	hsa-miR-422a	PAR-CLIP	23446348
MIRT025496	hsa-miR-34a-5p	PAR-CLIP	23446348
MIRT513602	hsa-miR-34c-5p	PAR-CLIP	23446348
MIRT513601	hsa-miR-449a	PAR-CLIP	23446348
MIRT513600	hsa-miR-449b-5p	PAR-CLIP	23446348
MIRT513599	hsa-miR-296-5p	PAR-CLIP	23446348
MIRT112704	hsa-miR-6724-5p	PAR-CLIP	23446348
MIRT112705	hsa-miR-6773-5p	PAR-CLIP	23446348
MIRT460792	hsa-miR-28-5p	PAR-CLIP	23592263
MIRT460791	hsa-miR-3139	PAR-CLIP	23592263
MIRT460790	hsa-miR-708-5p	PAR-CLIP	23592263
MIRT460788	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT460789	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT036597	hsa-miR-940	PAR-CLIP	23592263
MIRT460787	hsa-miR-4514	PAR-CLIP	23592263
MIRT460786	hsa-miR-4692	PAR-CLIP	23592263
MIRT460785	hsa-miR-3937	PAR-CLIP	23592263
MIRT460784	hsa-miR-4645-5p	PAR-CLIP	23592263
MIRT460783	hsa-miR-4673	PAR-CLIP	23592263
MIRT460782	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT460781	hsa-miR-4487	PAR-CLIP	23592263
MIRT460780	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT460779	hsa-miR-765	PAR-CLIP	23592263
MIRT460778	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT460777	hsa-miR-8085	PAR-CLIP	23592263
MIRT513625	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT513626	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT513626	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT513625	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT513624	hsa-miR-130a-3p	PAR-CLIP	23446348
MIRT513623	hsa-miR-130b-3p	PAR-CLIP	23446348
MIRT513622	hsa-miR-301a-3p	PAR-CLIP	23446348
MIRT513621	hsa-miR-301b-3p	PAR-CLIP	23446348
MIRT513620	hsa-miR-3666	PAR-CLIP	23446348
MIRT513619	hsa-miR-4295	PAR-CLIP	23446348
MIRT513618	hsa-miR-454-3p	PAR-CLIP	23446348
MIRT513617	hsa-miR-148a-3p	PAR-CLIP	23446348
MIRT513616	hsa-miR-148b-3p	PAR-CLIP	23446348
MIRT513615	hsa-miR-152-3p	PAR-CLIP	23446348
MIRT513614	hsa-miR-194-3p	PAR-CLIP	23446348
MIRT513613	hsa-miR-1825	PAR-CLIP	23446348
MIRT513612	hsa-miR-518c-5p	PAR-CLIP	23446348
MIRT513611	hsa-miR-4638-3p	PAR-CLIP	23446348
MIRT019654	hsa-miR-378a-3p	PAR-CLIP	23446348
MIRT513610	hsa-miR-378b	PAR-CLIP	23446348
MIRT513609	hsa-miR-378c	PAR-CLIP	23446348
MIRT513608	hsa-miR-378d	PAR-CLIP	23446348
MIRT513607	hsa-miR-378e	PAR-CLIP	23446348
MIRT513606	hsa-miR-378f	PAR-CLIP	23446348
MIRT513604	hsa-miR-378h	PAR-CLIP	23446348
MIRT513605	hsa-miR-378i	PAR-CLIP	23446348
MIRT513603	hsa-miR-422a	PAR-CLIP	23446348
MIRT025496	hsa-miR-34a-5p	PAR-CLIP	23446348
MIRT513602	hsa-miR-34c-5p	PAR-CLIP	23446348
MIRT513601	hsa-miR-449a	PAR-CLIP	23446348
MIRT513600	hsa-miR-449b-5p	PAR-CLIP	23446348
MIRT513599	hsa-miR-296-5p	PAR-CLIP	23446348
MIRT112704	hsa-miR-6724-5p	PAR-CLIP	23446348
MIRT112705	hsa-miR-6773-5p	PAR-CLIP	23446348
MIRT460792	hsa-miR-28-5p	PAR-CLIP	23592263
MIRT460791	hsa-miR-3139	PAR-CLIP	23592263
MIRT460790	hsa-miR-708-5p	PAR-CLIP	23592263
MIRT460788	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT460789	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT036597	hsa-miR-940	PAR-CLIP	23592263
MIRT460787	hsa-miR-4514	PAR-CLIP	23592263
MIRT460786	hsa-miR-4692	PAR-CLIP	23592263
MIRT460785	hsa-miR-3937	PAR-CLIP	23592263
MIRT460784	hsa-miR-4645-5p	PAR-CLIP	23592263
MIRT460783	hsa-miR-4673	PAR-CLIP	23592263
MIRT460782	hsa-miR-6746-5p	PAR-CLIP	23592263
MIRT460781	hsa-miR-4487	PAR-CLIP	23592263
MIRT460780	hsa-miR-4731-5p	PAR-CLIP	23592263
MIRT460779	hsa-miR-765	PAR-CLIP	23592263
MIRT460778	hsa-miR-6731-5p	PAR-CLIP	23592263
MIRT460777	hsa-miR-8085	PAR-CLIP	23592263
MIRT1486758	hsa-miR-4480	CLIP-seq
MIRT1486759	hsa-miR-450b-5p	CLIP-seq
MIRT1486760	hsa-miR-4659a-3p	CLIP-seq
MIRT1486761	hsa-miR-4659b-3p	CLIP-seq
MIRT1486762	hsa-miR-891b	CLIP-seq
MIRT2146385	hsa-miR-1226	CLIP-seq
MIRT2146386	hsa-miR-1275	CLIP-seq
MIRT2146387	hsa-miR-1291	CLIP-seq
MIRT2146388	hsa-miR-129-3p	CLIP-seq
MIRT2146389	hsa-miR-144	CLIP-seq
MIRT2146390	hsa-miR-19a	CLIP-seq
MIRT2146391	hsa-miR-19b	CLIP-seq
MIRT2146392	hsa-miR-3155	CLIP-seq
MIRT2146393	hsa-miR-3155b	CLIP-seq
MIRT2146394	hsa-miR-3190	CLIP-seq
MIRT2146395	hsa-miR-324-5p	CLIP-seq
MIRT2146396	hsa-miR-3656	CLIP-seq
MIRT2146397	hsa-miR-3667-3p	CLIP-seq
MIRT2146398	hsa-miR-3677-5p	CLIP-seq
MIRT2146399	hsa-miR-3919	CLIP-seq
MIRT2146400	hsa-miR-3934	CLIP-seq
MIRT2146401	hsa-miR-4304	CLIP-seq
MIRT2146402	hsa-miR-4308	CLIP-seq
MIRT2146403	hsa-miR-4436b-5p	CLIP-seq
MIRT2146404	hsa-miR-4446-3p	CLIP-seq
MIRT2146405	hsa-miR-4468	CLIP-seq
MIRT2146406	hsa-miR-4525	CLIP-seq
MIRT2146407	hsa-miR-4665-5p	CLIP-seq
MIRT2146408	hsa-miR-4685-5p	CLIP-seq
MIRT2146409	hsa-miR-4686	CLIP-seq
MIRT2146410	hsa-miR-4723-5p	CLIP-seq
MIRT2146411	hsa-miR-4733-3p	CLIP-seq
MIRT2146412	hsa-miR-4756-3p	CLIP-seq
MIRT2146413	hsa-miR-484	CLIP-seq
MIRT2146414	hsa-miR-552	CLIP-seq
MIRT2146415	hsa-miR-625	CLIP-seq
MIRT2146416	hsa-miR-661	CLIP-seq
MIRT2146417	hsa-miR-766	CLIP-seq
MIRT2146418	hsa-miR-767-3p	CLIP-seq
MIRT2146419	hsa-miR-891a	CLIP-seq
MIRT2146420	hsa-miR-941	CLIP-seq
MIRT2366868	hsa-miR-1	CLIP-seq
MIRT2366869	hsa-miR-101	CLIP-seq
MIRT2366870	hsa-miR-1204	CLIP-seq
MIRT2366871	hsa-miR-1207-5p	CLIP-seq
MIRT2366872	hsa-miR-122	CLIP-seq
MIRT2366873	hsa-miR-1224-5p	CLIP-seq
MIRT2366874	hsa-miR-1233	CLIP-seq
MIRT2366875	hsa-miR-1247	CLIP-seq
MIRT2366876	hsa-miR-1271	CLIP-seq
MIRT2366877	hsa-miR-1273e	CLIP-seq
MIRT2146386	hsa-miR-1275	CLIP-seq
MIRT2146387	hsa-miR-1291	CLIP-seq
MIRT2146388	hsa-miR-129-3p	CLIP-seq
MIRT2366878	hsa-miR-1297	CLIP-seq
MIRT2366879	hsa-miR-1324	CLIP-seq
MIRT2146389	hsa-miR-144	CLIP-seq
MIRT2366880	hsa-miR-1538	CLIP-seq
MIRT2366881	hsa-miR-15a	CLIP-seq
MIRT2366882	hsa-miR-15b	CLIP-seq
MIRT2366883	hsa-miR-16	CLIP-seq
MIRT2366884	hsa-miR-188-3p	CLIP-seq
MIRT2366885	hsa-miR-1915	CLIP-seq
MIRT2366886	hsa-miR-195	CLIP-seq
MIRT2146390	hsa-miR-19a	CLIP-seq
MIRT2146391	hsa-miR-19b	CLIP-seq
MIRT2366887	hsa-miR-202	CLIP-seq
MIRT2366888	hsa-miR-206	CLIP-seq
MIRT2366889	hsa-miR-2277-3p	CLIP-seq
MIRT2366890	hsa-miR-2278	CLIP-seq
MIRT2366891	hsa-miR-2682	CLIP-seq
MIRT2366892	hsa-miR-26a	CLIP-seq
MIRT2366893	hsa-miR-26b	CLIP-seq
MIRT2366894	hsa-miR-3065-3p	CLIP-seq
MIRT2366895	hsa-miR-3127-5p	CLIP-seq
MIRT2366896	hsa-miR-3136-3p	CLIP-seq
MIRT2366897	hsa-miR-3144-5p	CLIP-seq
MIRT2146392	hsa-miR-3155	CLIP-seq
MIRT2146393	hsa-miR-3155b	CLIP-seq
MIRT2366898	hsa-miR-3156-3p	CLIP-seq
MIRT2366899	hsa-miR-3163	CLIP-seq
MIRT2366900	hsa-miR-3175	CLIP-seq
MIRT2366901	hsa-miR-3180	CLIP-seq
MIRT2366902	hsa-miR-3180-3p	CLIP-seq
MIRT2366903	hsa-miR-3185	CLIP-seq
MIRT2146394	hsa-miR-3190	CLIP-seq
MIRT2366904	hsa-miR-3191	CLIP-seq
MIRT2366905	hsa-miR-3196	CLIP-seq
MIRT2366906	hsa-miR-3198	CLIP-seq
MIRT2366907	hsa-miR-3199	CLIP-seq
MIRT2366908	hsa-miR-320a	CLIP-seq
MIRT2366909	hsa-miR-320b	CLIP-seq
MIRT2366910	hsa-miR-320c	CLIP-seq
MIRT2366911	hsa-miR-320d	CLIP-seq
MIRT2146395	hsa-miR-324-5p	CLIP-seq
MIRT2366912	hsa-miR-335	CLIP-seq
MIRT2366913	hsa-miR-34a	CLIP-seq
MIRT2366914	hsa-miR-3653	CLIP-seq
MIRT2366915	hsa-miR-3658	CLIP-seq
MIRT2146397	hsa-miR-3667-3p	CLIP-seq
MIRT2366916	hsa-miR-3675-5p	CLIP-seq
MIRT2146398	hsa-miR-3677-5p	CLIP-seq
MIRT2366917	hsa-miR-3688-5p	CLIP-seq
MIRT2366918	hsa-miR-3714	CLIP-seq
MIRT2366919	hsa-miR-377	CLIP-seq
MIRT2366920	hsa-miR-378	CLIP-seq
MIRT2366921	hsa-miR-3918	CLIP-seq
MIRT2146400	hsa-miR-3934	CLIP-seq
MIRT2366922	hsa-miR-3940-3p	CLIP-seq
MIRT2366923	hsa-miR-3944-5p	CLIP-seq
MIRT2366924	hsa-miR-424	CLIP-seq
MIRT2366925	hsa-miR-4271	CLIP-seq
MIRT2366926	hsa-miR-4277	CLIP-seq
MIRT2366927	hsa-miR-4285	CLIP-seq
MIRT2366928	hsa-miR-4301	CLIP-seq
MIRT2146401	hsa-miR-4304	CLIP-seq
MIRT2366929	hsa-miR-4309	CLIP-seq
MIRT2366930	hsa-miR-4420	CLIP-seq
MIRT2366931	hsa-miR-4429	CLIP-seq
MIRT2366932	hsa-miR-4447	CLIP-seq
MIRT2366933	hsa-miR-4465	CLIP-seq
MIRT2146405	hsa-miR-4468	CLIP-seq
MIRT2366934	hsa-miR-4472	CLIP-seq
MIRT2366935	hsa-miR-4474-3p	CLIP-seq
MIRT2366936	hsa-miR-449b	CLIP-seq
MIRT2366937	hsa-miR-449c	CLIP-seq
MIRT2366938	hsa-miR-4515	CLIP-seq
MIRT2366939	hsa-miR-451b	CLIP-seq
MIRT2146406	hsa-miR-4525	CLIP-seq
MIRT2366940	hsa-miR-4636	CLIP-seq
MIRT2366941	hsa-miR-4642	CLIP-seq
MIRT2366942	hsa-miR-4643	CLIP-seq
MIRT2366943	hsa-miR-4651	CLIP-seq
MIRT2366944	hsa-miR-4652-5p	CLIP-seq
MIRT2366945	hsa-miR-4662a-3p	CLIP-seq
MIRT2146407	hsa-miR-4665-5p	CLIP-seq
MIRT2366946	hsa-miR-4667-5p	CLIP-seq
MIRT2146408	hsa-miR-4685-5p	CLIP-seq
MIRT2146409	hsa-miR-4686	CLIP-seq
MIRT2366947	hsa-miR-4694-3p	CLIP-seq
MIRT2366948	hsa-miR-4699-5p	CLIP-seq
MIRT2366949	hsa-miR-4700-5p	CLIP-seq
MIRT2366950	hsa-miR-4717-3p	CLIP-seq
MIRT2146410	hsa-miR-4723-5p	CLIP-seq
MIRT2366951	hsa-miR-4725-3p	CLIP-seq
MIRT2366952	hsa-miR-4730	CLIP-seq
MIRT2366953	hsa-miR-4736	CLIP-seq
MIRT2366954	hsa-miR-4743	CLIP-seq
MIRT2366955	hsa-miR-4745-3p	CLIP-seq
MIRT2366956	hsa-miR-4751	CLIP-seq
MIRT2366957	hsa-miR-4757-5p	CLIP-seq
MIRT2366958	hsa-miR-4763-3p	CLIP-seq
MIRT2366959	hsa-miR-4772-3p	CLIP-seq
MIRT2366960	hsa-miR-4799-5p	CLIP-seq
MIRT2146413	hsa-miR-484	CLIP-seq
MIRT2366961	hsa-miR-497	CLIP-seq
MIRT2366962	hsa-miR-518a-5p	CLIP-seq
MIRT2366963	hsa-miR-522	CLIP-seq
MIRT2366964	hsa-miR-527	CLIP-seq
MIRT2366965	hsa-miR-532-3p	CLIP-seq
MIRT2366966	hsa-miR-548an	CLIP-seq
MIRT2366967	hsa-miR-548c-3p	CLIP-seq
MIRT2366968	hsa-miR-564	CLIP-seq
MIRT2366969	hsa-miR-570	CLIP-seq
MIRT2366970	hsa-miR-582-5p	CLIP-seq
MIRT2366971	hsa-miR-608	CLIP-seq
MIRT2366972	hsa-miR-613	CLIP-seq
MIRT2146415	hsa-miR-625	CLIP-seq
MIRT2366973	hsa-miR-637	CLIP-seq
MIRT2366974	hsa-miR-658	CLIP-seq
MIRT2366975	hsa-miR-663b	CLIP-seq
MIRT2366976	hsa-miR-7	CLIP-seq
MIRT2366977	hsa-miR-708	CLIP-seq
MIRT2366978	hsa-miR-760	CLIP-seq
MIRT2366979	hsa-miR-764	CLIP-seq
MIRT2146417	hsa-miR-766	CLIP-seq
MIRT2146418	hsa-miR-767-3p	CLIP-seq
MIRT2366980	hsa-miR-935	CLIP-seq
MIRT2366981	hsa-miR-936	CLIP-seq
MIRT2146420	hsa-miR-941	CLIP-seq
MIRT2366982	hsa-miR-96	CLIP-seq
MIRT2146388	hsa-miR-129-3p	CLIP-seq
MIRT2146399	hsa-miR-3919	CLIP-seq
MIRT2146412	hsa-miR-4756-3p	CLIP-seq
MIRT2146387	hsa-miR-1291	CLIP-seq
MIRT2146388	hsa-miR-129-3p	CLIP-seq
MIRT2366901	hsa-miR-3180	CLIP-seq
MIRT2366902	hsa-miR-3180-3p	CLIP-seq
MIRT2660512	hsa-miR-3184	CLIP-seq
MIRT2366905	hsa-miR-3196	CLIP-seq
MIRT2660513	hsa-miR-3620	CLIP-seq
MIRT2660514	hsa-miR-3622a-5p	CLIP-seq
MIRT2366920	hsa-miR-378	CLIP-seq
MIRT2660515	hsa-miR-423-5p	CLIP-seq
MIRT2146402	hsa-miR-4308	CLIP-seq
MIRT2660516	hsa-miR-4423-3p	CLIP-seq
MIRT2660517	hsa-miR-4467	CLIP-seq
MIRT2660518	hsa-miR-4508	CLIP-seq
MIRT2660519	hsa-miR-4728-5p	CLIP-seq
MIRT2366957	hsa-miR-4757-5p	CLIP-seq
MIRT2660520	hsa-miR-542-3p	CLIP-seq
MIRT2146388	hsa-miR-129-3p	CLIP-seq
MIRT2660513	hsa-miR-3620	CLIP-seq
MIRT2660514	hsa-miR-3622a-5p	CLIP-seq
MIRT2660516	hsa-miR-4423-3p	CLIP-seq
MIRT2660517	hsa-miR-4467	CLIP-seq

Gene ontology (GO) Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000813	Component	ESCRT I complex	IBA
GO:0000813	Component	ESCRT I complex	IDA	18005716, 22232651, 22405001
GO:0000813	Component	ESCRT I complex	IEA
GO:0000813	Component	ESCRT I complex	IPI	18005716, 21757351, 32424346
GO:0000813	Component	ESCRT I complex	TAS	20588296
GO:0005515	Function	Protein binding	IPI	15218037, 18005716, 19129479, 21516116, 25416956, 26871637, 28514442, 31515488, 32296183, 33961781, 35271311
GO:0005737	Component	Cytoplasm	IDA	15218037
GO:0005768	Component	Endosome	IDA	17940959
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IDA	17940959
GO:0006612	Process	Protein targeting to membrane	IBA
GO:0006623	Process	Protein targeting to vacuole	IBA
GO:0010008	Component	Endosome membrane	IDA	15218037
GO:0010008	Component	Endosome membrane	NAS	32424346
GO:0010008	Component	Endosome membrane	TAS
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016236	Process	Macroautophagy	IEA
GO:0016236	Process	Macroautophagy	TAS	20588296
GO:0019076	Process	Viral release from host cell	IMP	15218037
GO:0030496	Component	Midbody	IDA	19129479
GO:0031902	Component	Late endosome membrane	IEA
GO:0036258	Process	Multivesicular body assembly	IEA
GO:0036258	Process	Multivesicular body assembly	NAS	32424346
GO:0036258	Process	Multivesicular body assembly	TAS	20588296
GO:0039702	Process	Viral budding via host ESCRT complex	IEA
GO:0039702	Process	Viral budding via host ESCRT complex	TAS	20588296
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IBA
GO:0043328	Process	Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	NAS	32424346
GO:0048306	Function	Calcium-dependent protein binding	IEA
GO:0048306	Function	Calcium-dependent protein binding	IPI	23924735
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0090148	Process	Membrane fission	NAS	32424346
GO:1903774	Process	Positive regulation of viral budding via host ESCRT complex	IMP	15218037

Other IDs

• MIM: 610037
• HGNC: 25754
• e!Ensembl: ENSG00000139722

Protein

• UniProt ID: Q9H9H4
• Protein name: Vacuolar protein sorting-associated protein 37B (hVps37B) (ESCRT-I complex subunit VPS37B)
• Protein function: Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation. {ECO:0000269|PubMed:152180
• PDB: 6VME
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07200	Mod_r	11 → 156	Modifier of rudimentary (Mod(r)) protein	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed in macrophages and lymphocytes. {ECO:0000269|PubMed:15218037}.
• Sequence:

  MAGAGSEARFAGLSLVQLNELLEDEGQLTEMVQKMEETQNVQLNKEMTLASNRSLAEGNL
  LYQPQLDTLKARLTQKYQELQVLFEAYQIKKTKLDRQSSSASLETLLALLQAEGAKIEED
  TENMAEKFLDGELPLDSFIDVYQSKRKLAHMRRVKIEKLQEMVLKGQRLPQALAPLPPRL
  PELAPTAPLPYPAPEASGPPAVAPRRIPPPPPPVPAGRLATPFTAAMSSGQAVPYPGLQC
  PPLPPRVGLPTQQGFSSQFVSPYPPPLPQRPPPRLPPHQPGFILQ

• Sequence length: 285

Pathways

KEGG Pathway	Reactome Pathway
Endocytosis	Budding and maturation of HIV virion
	Membrane binding and targetting of GAG proteins
	Endosomal Sorting Complex Required For Transport (ESCRT)
	HCMV Late Events

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
ATRIAL FIBRILLATION	—	GWAS catalog	40050429, 40645996	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	35835914	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	31377428	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

VPS37A 5 shared pathwaysEndocytosis, Budding and maturation of HIV virion, Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Late Events, Membrane binding and targetting of GAG proteins Related via 5 shared pathways including Endocytosis, Budding and maturation of HIV virion. VPS37D 5 shared pathwaysEndocytosis, Budding and maturation of HIV virion, Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Late Events, Membrane binding and targetting of GAG proteins Related via 5 shared pathways including Endocytosis, Budding and maturation of HIV virion. VPS28 5 shared pathwaysEndocytosis, Budding and maturation of HIV virion, Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Late Events, Membrane binding and targetting of GAG proteins Related via 5 shared pathways including Endocytosis, Budding and maturation of HIV virion. VPS37C 5 shared pathwaysEndocytosis, Budding and maturation of HIV virion, Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Late Events, Membrane binding and targetting of GAG proteins Related via 5 shared pathways including Endocytosis, Budding and maturation of HIV virion. MVB12B 5 shared pathwaysEndocytosis, Budding and maturation of HIV virion, Endosomal Sorting Complex Required For Transport (ESCRT), HCMV Late Events, Membrane binding and targetting of GAG proteins Related via 5 shared pathways including Endocytosis, Budding and maturation of HIV virion.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
VPS37A	0	[]	5	["Endocytosis","Budding and maturation of HIV virion","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events","Membrane binding and targetting of GAG proteins"]	0	[]
VPS37D	0	[]	5	["Endocytosis","Budding and maturation of HIV virion","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events","Membrane binding and targetting of GAG proteins"]	0	[]
VPS28	0	[]	5	["Endocytosis","Budding and maturation of HIV virion","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events","Membrane binding and targetting of GAG proteins"]	0	[]
VPS37C	0	[]	5	["Endocytosis","Budding and maturation of HIV virion","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events","Membrane binding and targetting of GAG proteins"]	0	[]
MVB12B	0	[]	5	["Endocytosis","Budding and maturation of HIV virion","Endosomal Sorting Complex Required For Transport (ESCRT)","HCMV Late Events","Membrane binding and targetting of GAG proteins"]	0	[]

Diseases Linked via Similar Genes

Spastic paraplegia Linked via 1 of 5 related genesVPS37A Paraplegia Linked via 1 of 5 related genesVPS37A Hereditary spastic paraplegia Linked via 1 of 5 related genesVPS37A complex hereditary spastic paraplegia Linked via 1 of 5 related genesVPS37A Cancer Linked via 1 of 5 related genesVPS37D

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Spastic paraplegia	1	["VPS37A"]
Paraplegia	1	["VPS37A"]
Hereditary spastic paraplegia	1	["VPS37A"]
complex hereditary spastic paraplegia	1	["VPS37A"]
Cancer	1	["VPS37D"]