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Gene Gene information from NCBI Gene database.
Entrez ID 7334
Gene name Ubiquitin conjugating enzyme E2 N
Gene symbol UBE2N
Synonyms (NCBI Gene)
HEL-S-71UBC13UBCHBENUBCHBEN; UBC13UbcH-benUbcH13
Chromosome 12
Chromosome location 12q22
Summary The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju
miRNA miRNA information provided by mirtarbase database.
515 Show/Hide all (515)
miRTarBase ID miRNA Experiments Reference
MIRT021990 hsa-miR-128-3p Microarray 17612493
MIRT024180 hsa-miR-221-3p Sequencing 20371350
MIRT027911 hsa-miR-96-5p Sequencing 20371350
MIRT045605 hsa-miR-149-5p CLASH 23622248
MIRT037679 hsa-miR-744-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
63 Show/Hide all (63)
GO ID Ontology Definition Evidence Reference
GO:0000151 Component Ubiquitin ligase complex IDA 16307917
GO:0000166 Function Nucleotide binding IEA
GO:0000209 Process Protein polyubiquitination IEA
GO:0000209 Process Protein polyubiquitination IMP 17349954
GO:0000724 Process Double-strand break repair via homologous recombination IMP 17349954
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603679 12492 ENSG00000177889
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P61088
Protein name Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)
Protein function The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activat
PDB 1J7D , 2C2V , 3HCT , 3HCU , 3VON , 3W31 , 4DHI , 4DHJ , 4DHZ , 4IP3 , 4NR3 , 4NRG , 4NRI , 4ONL , 4ONM , 4ONN , 4ORH , 4TKP , 4WHV , 5AIT , 5AIU , 5EYA , 5H7S , 5VNZ , 5VO0 , 5YWR , 6D6I , 6JKY , 6KFP , 6KG6 , 6KL4 , 6LP2 , 6P5B , 6S53 , 6ULH , 6UMP , 6UMS , 7BBD , 7BBF , 7BXG , 9BIV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00179 UQ_con 7 → 144 Ubiquitin-conjugating enzyme Domain
Sequence
Sequence length 152
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Ubiquitin mediated proteolysis ISG15 antiviral mechanism
Shigellosis NOD1/2 Signaling Pathway
  TICAM1, RIP1-mediated IKK complex recruitment
  Downstream TCR signaling
  FCERI mediated NF-kB activation
  TAK1 activates NFkB by phosphorylation and activation of IKKs complex
  activated TAK1 mediates p38 MAPK activation
  JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
  CLEC7A (Dectin-1) signaling
  Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
  Nonhomologous End-Joining (NHEJ)
  Processing of DNA double-strand break ends
  Formation of Incision Complex in GG-NER
  G2/M DNA damage checkpoint
  E3 ubiquitin ligases ubiquitinate target proteins
  Interleukin-1 signaling
  IRAK1 recruits IKK complex
  IKK complex recruitment mediated by RIP1
  Aggrephagy
  TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
  IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
  Antigen processing: Ubiquitination & Proteasome degradation