The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju
miRNAmiRNA information provided by mirtarbase database.
Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
The UBE2V1-UBE2N and UBE2V2-UBE2N heterodimers catalyze the synthesis of non-canonical 'Lys-63'-linked polyubiquitin chains. This type of polyubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activat
["Shigellosis","Formation of Incision Complex in GG-NER","Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks","Nonhomologous End-Joining (NHEJ)","Processing of DNA double-strand break ends","G2\/M DNA damage checkpoint","E3 ubiquitin ligases ubiquitinate target proteins"]
["Shigellosis","Downstream TCR signaling","Interleukin-1 signaling","NOD1\/2 Signaling Pathway","TAK1 activates NFkB by phosphorylation and activation of IKKs complex","activated TAK1 mediates p38 MAPK activation","JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"]
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Diseases Linked via Similar GenesDiseases curated for genes most similar to UBE2N (see Related Genes above), that are NOT already directly curated for UBE2N itself -- a lead worth checking, not a confirmed association.