Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	9039
Gene name	Ubiquitin like modifier activating enzyme 3
Gene symbol	UBA3
Synonyms (NCBI Gene)	NAE2UBE1ChUBA3
Chromosome	3
Chromosome location	3p14.1
Summary	The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conju

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miRTarBase ID	miRNA	Experiments	Reference
MIRT020498	hsa-miR-155-5p	Proteomics	18668040
MIRT032210	hsa-let-7b-5p	Proteomics	18668040
MIRT1466401	hsa-miR-1256	CLIP-seq
MIRT1466402	hsa-miR-431	CLIP-seq
MIRT1466403	hsa-miR-4642	CLIP-seq
MIRT1466404	hsa-miR-140-5p	CLIP-seq
MIRT1466405	hsa-miR-3120-5p	CLIP-seq
MIRT1466406	hsa-miR-4747-5p	CLIP-seq
MIRT1466407	hsa-miR-4778-5p	CLIP-seq
MIRT1466408	hsa-miR-520d-5p	CLIP-seq
MIRT1466409	hsa-miR-524-5p	CLIP-seq
MIRT2140203	hsa-miR-1245b-3p	CLIP-seq
MIRT2140204	hsa-miR-3591-3p	CLIP-seq
MIRT2140205	hsa-miR-4678	CLIP-seq
MIRT2140203	hsa-miR-1245b-3p	CLIP-seq
MIRT2360959	hsa-miR-1279	CLIP-seq
MIRT2360960	hsa-miR-183	CLIP-seq
MIRT2360961	hsa-miR-30a	CLIP-seq
MIRT2360962	hsa-miR-30b	CLIP-seq
MIRT2360963	hsa-miR-30c	CLIP-seq
MIRT2360964	hsa-miR-30d	CLIP-seq
MIRT2360965	hsa-miR-30e	CLIP-seq
MIRT2360966	hsa-miR-3647-3p	CLIP-seq
MIRT2360967	hsa-miR-3913-3p	CLIP-seq
MIRT2360968	hsa-miR-3973	CLIP-seq
MIRT2360969	hsa-miR-4272	CLIP-seq
MIRT2360970	hsa-miR-489	CLIP-seq
MIRT2360971	hsa-miR-548l	CLIP-seq
MIRT2140203	hsa-miR-1245b-3p	CLIP-seq
MIRT2654445	hsa-miR-1270	CLIP-seq
MIRT2654446	hsa-miR-299-3p	CLIP-seq
MIRT2360961	hsa-miR-30a	CLIP-seq
MIRT2360962	hsa-miR-30b	CLIP-seq
MIRT2360963	hsa-miR-30c	CLIP-seq
MIRT2360964	hsa-miR-30d	CLIP-seq
MIRT2360965	hsa-miR-30e	CLIP-seq
MIRT2360966	hsa-miR-3647-3p	CLIP-seq
MIRT2360967	hsa-miR-3913-3p	CLIP-seq
MIRT2360968	hsa-miR-3973	CLIP-seq
MIRT2360969	hsa-miR-4272	CLIP-seq
MIRT2654447	hsa-miR-4491	CLIP-seq
MIRT2654448	hsa-miR-4641	CLIP-seq
MIRT2654449	hsa-miR-4657	CLIP-seq
MIRT2140205	hsa-miR-4678	CLIP-seq
MIRT2654450	hsa-miR-4683	CLIP-seq
MIRT2654451	hsa-miR-4795-3p	CLIP-seq
MIRT2360970	hsa-miR-489	CLIP-seq
MIRT2360971	hsa-miR-548l	CLIP-seq
MIRT2654452	hsa-miR-587	CLIP-seq
MIRT2654453	hsa-miR-620	CLIP-seq
MIRT2654454	hsa-miR-656	CLIP-seq
MIRT2140203	hsa-miR-1245b-3p	CLIP-seq
MIRT2654445	hsa-miR-1270	CLIP-seq
MIRT2654446	hsa-miR-299-3p	CLIP-seq
MIRT2360961	hsa-miR-30a	CLIP-seq
MIRT2360962	hsa-miR-30b	CLIP-seq
MIRT2360963	hsa-miR-30c	CLIP-seq
MIRT2360964	hsa-miR-30d	CLIP-seq
MIRT2360965	hsa-miR-30e	CLIP-seq
MIRT2360966	hsa-miR-3647-3p	CLIP-seq
MIRT2360967	hsa-miR-3913-3p	CLIP-seq
MIRT2360968	hsa-miR-3973	CLIP-seq
MIRT2360969	hsa-miR-4272	CLIP-seq
MIRT2654447	hsa-miR-4491	CLIP-seq
MIRT2654448	hsa-miR-4641	CLIP-seq
MIRT2654449	hsa-miR-4657	CLIP-seq
MIRT2140205	hsa-miR-4678	CLIP-seq
MIRT2654450	hsa-miR-4683	CLIP-seq
MIRT2654451	hsa-miR-4795-3p	CLIP-seq
MIRT2360970	hsa-miR-489	CLIP-seq
MIRT2360971	hsa-miR-548l	CLIP-seq
MIRT2654452	hsa-miR-587	CLIP-seq
MIRT2654453	hsa-miR-620	CLIP-seq
MIRT2654454	hsa-miR-656	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000278	Process	Mitotic cell cycle	IEA
GO:0005515	Function	Protein binding	IPI	10722740, 15361859, 15694336, 16712842, 19250909, 19549727, 25416956, 32296183, 32814053, 33961781, 35271311
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005829	Component	Cytosol	TAS
GO:0006508	Process	Proteolysis	TAS	9694792
GO:0007113	Process	Endomitotic cell cycle	IEA
GO:0008641	Function	Ubiquitin-like modifier activating enzyme activity	IEA
GO:0016874	Function	Ligase activity	IEA
GO:0019781	Function	NEDD8 activating enzyme activity	IBA
GO:0019781	Function	NEDD8 activating enzyme activity	IDA	12740388
GO:0019781	Function	NEDD8 activating enzyme activity	IDA	10207026
GO:0019781	Function	NEDD8 activating enzyme activity	IEA
GO:0019788	Function	NEDD8 transferase activity	TAS
GO:0032991	Component	Protein-containing complex	IDA	12740388
GO:0032991	Component	Protein-containing complex	IEA
GO:0036211	Process	Protein modification process	TAS	9694792
GO:0042802	Function	Identical protein binding	IPI	25416956, 32296183
GO:0043687	Process	Post-translational protein modification	TAS
GO:0045116	Process	Protein neddylation	IBA
GO:0045116	Process	Protein neddylation	IDA	12740388
GO:0045116	Process	Protein neddylation	IEA
GO:0046982	Function	Protein heterodimerization activity	IPI	12740388
GO:0051726	Process	Regulation of cell cycle	IEA

MIM	HGNC	e!Ensembl
603172	12470	ENSG00000144744

Q8TBC4

Protein name

NEDD8-activating enzyme E1 catalytic subunit (EC 6.2.1.64) (NEDD8-activating enzyme E1C) (Ubiquitin-activating enzyme E1C) (Ubiquitin-like modifier-activating enzyme 3) (Ubiquitin-activating enzyme 3)

Protein function

Catalytic subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester a

PDB

1R4M , 1R4N , 1TT5 , 1Y8X , 1YOV , 2LQ7 , 2NVU , 3DBH , 3DBL , 3DBR , 3FN1 , 3GZN , 5JJM

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00899	ThiF	53 → 369	ThiF family	Domain
PF08825	E2_bind	375 → 461	E2 binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:10207026}.

Sequence

MADGEEPEKKRRRIEELLAEKMAVDGGCGDTGDWEGRWNHVKKFLERSGPFTHPDFEPST
ESLQFLLDTCKVLVIGAGGLGCELLKNLALSGFRQIHVIDMDTIDVSNLNRQFLFRPKDI
GRPKAEVAAEFLNDRVPNCNVVPHFNKIQDFNDTFYRQFHIIVCGLDSIIARRWINGMLI
SLLNYEDGVLDPSSIVPLIDGGTEGFKGNARVILPGMTACIECTLELYPPQVNFPMCTIA
SMPRLPEHCIEYVRMLQWPKEQPFGEGVPLDGDDPEHIQWIFQKSLERASQYNIRGVTYR
LTQGVVKRIIPAVASTNAVIAAVCATEVFKIATSAYIPLNNYLVFNDVDGLYTYTFEAER
KENCPACSQLPQNIQFSPSAKLQEVLDYLTNSASLQMKSPAITATLEGKNRTLYLQSVTS
IEERTRPNLSKTLKELGLVDGQELAVADVTTPQTVLFKLHFTS

Sequence length

463

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Ubiquitin mediated proteolysis	Dectin-1 mediated noncanonical NF-kB signaling
	NIK-->noncanonical NF-kB signaling
	Neddylation
	Antigen processing: Ubiquitination & Proteasome degradation

UBA3 (ubiquitin like modifier activating enzyme 3)

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