Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	7251
Gene name	Tumor susceptibility 101
Gene symbol	TSG101
Synonyms (NCBI Gene)	TSG10VPS23
Chromosome	11
Chromosome location	11p15.1
Summary	The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The

168 Show/Hide all (168)

miRTarBase ID	miRNA	Experiments	Reference
MIRT020275	hsa-miR-130b-3p	Sequencing	20371350
MIRT028151	hsa-miR-93-5p	Sequencing	20371350
MIRT028189	hsa-miR-33a-5p	Sequencing	20371350
MIRT031083	hsa-miR-20a-5p	Reporter assay	21751348
MIRT043363	hsa-miR-331-3p	CLASH	23622248
MIRT492045	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT439387	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT492044	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT031083	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT492043	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT031367	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT492042	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT028151	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT492041	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT492040	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT492039	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT492038	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT492037	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT492035	hsa-miR-4676-5p	PAR-CLIP	21572407
MIRT492036	hsa-miR-575	PAR-CLIP	21572407
MIRT492034	hsa-miR-6847-5p	PAR-CLIP	21572407
MIRT492033	hsa-miR-1185-5p	PAR-CLIP	21572407
MIRT492032	hsa-miR-3679-5p	PAR-CLIP	21572407
MIRT492045	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT439387	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT492044	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT031083	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT492043	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT031367	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT492042	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT028151	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT492041	hsa-miR-548e-5p	PAR-CLIP	23592263
MIRT492040	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT492039	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT492038	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT492037	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT492035	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT492036	hsa-miR-575	PAR-CLIP	23592263
MIRT492034	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT492033	hsa-miR-1185-5p	PAR-CLIP	23592263
MIRT492032	hsa-miR-3679-5p	PAR-CLIP	23592263
MIRT439387	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT031083	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT439387	hsa-miR-106b-5p	HITS-CLIP	22473208
MIRT031367	hsa-miR-17-5p	HITS-CLIP	22473208
MIRT492044	hsa-miR-20b-5p	HITS-CLIP	22473208
MIRT028151	hsa-miR-93-5p	HITS-CLIP	22473208
MIRT492045	hsa-miR-519d-3p	HITS-CLIP	22473208
MIRT726225	hsa-miR-181a-5p	HITS-CLIP	22473208
MIRT726223	hsa-miR-181b-5p	HITS-CLIP	22473208
MIRT726224	hsa-miR-181c-5p	HITS-CLIP	22473208
MIRT726222	hsa-miR-181d-5p	HITS-CLIP	22473208
MIRT031083	hsa-miR-20a-5p	HITS-CLIP	22473208
MIRT492045	hsa-miR-519d-3p	PAR-CLIP	21572407
MIRT439387	hsa-miR-106b-5p	PAR-CLIP	21572407
MIRT492044	hsa-miR-20b-5p	PAR-CLIP	21572407
MIRT031083	hsa-miR-20a-5p	PAR-CLIP	21572407
MIRT492043	hsa-miR-526b-3p	PAR-CLIP	21572407
MIRT031367	hsa-miR-17-5p	PAR-CLIP	21572407
MIRT492042	hsa-miR-106a-5p	PAR-CLIP	21572407
MIRT028151	hsa-miR-93-5p	PAR-CLIP	21572407
MIRT492041	hsa-miR-548e-5p	PAR-CLIP	21572407
MIRT492040	hsa-miR-519a-3p	PAR-CLIP	21572407
MIRT492039	hsa-miR-519b-3p	PAR-CLIP	21572407
MIRT492038	hsa-miR-519c-3p	PAR-CLIP	21572407
MIRT492037	hsa-miR-4797-5p	PAR-CLIP	21572407
MIRT492035	hsa-miR-4676-5p	PAR-CLIP	21572407
MIRT492036	hsa-miR-575	PAR-CLIP	21572407
MIRT492034	hsa-miR-6847-5p	PAR-CLIP	21572407
MIRT492033	hsa-miR-1185-5p	PAR-CLIP	21572407
MIRT492032	hsa-miR-3679-5p	PAR-CLIP	21572407
MIRT492045	hsa-miR-519d-3p	PAR-CLIP	23592263
MIRT439387	hsa-miR-106b-5p	PAR-CLIP	23592263
MIRT492044	hsa-miR-20b-5p	PAR-CLIP	23592263
MIRT031083	hsa-miR-20a-5p	PAR-CLIP	23592263
MIRT492043	hsa-miR-526b-3p	PAR-CLIP	23592263
MIRT031367	hsa-miR-17-5p	PAR-CLIP	23592263
MIRT492042	hsa-miR-106a-5p	PAR-CLIP	23592263
MIRT028151	hsa-miR-93-5p	PAR-CLIP	23592263
MIRT492041	hsa-miR-548e-5p	PAR-CLIP	23592263
MIRT492040	hsa-miR-519a-3p	PAR-CLIP	23592263
MIRT492039	hsa-miR-519b-3p	PAR-CLIP	23592263
MIRT492038	hsa-miR-519c-3p	PAR-CLIP	23592263
MIRT492037	hsa-miR-4797-5p	PAR-CLIP	23592263
MIRT492035	hsa-miR-4676-5p	PAR-CLIP	23592263
MIRT492036	hsa-miR-575	PAR-CLIP	23592263
MIRT492034	hsa-miR-6847-5p	PAR-CLIP	23592263
MIRT492033	hsa-miR-1185-5p	PAR-CLIP	23592263
MIRT492032	hsa-miR-3679-5p	PAR-CLIP	23592263
MIRT1458605	hsa-miR-106a	CLIP-seq
MIRT1458606	hsa-miR-106b	CLIP-seq
MIRT1458607	hsa-miR-1185	CLIP-seq
MIRT1458608	hsa-miR-1253	CLIP-seq
MIRT1458609	hsa-miR-17	CLIP-seq
MIRT1458610	hsa-miR-181a	CLIP-seq
MIRT1458611	hsa-miR-181b	CLIP-seq
MIRT1458612	hsa-miR-181c	CLIP-seq
MIRT1458613	hsa-miR-181d	CLIP-seq
MIRT1458614	hsa-miR-20a	CLIP-seq
MIRT1458615	hsa-miR-20b	CLIP-seq
MIRT1458616	hsa-miR-3065-3p	CLIP-seq
MIRT1458617	hsa-miR-3065-5p	CLIP-seq
MIRT1458618	hsa-miR-4262	CLIP-seq
MIRT1458619	hsa-miR-4274	CLIP-seq
MIRT1458620	hsa-miR-4291	CLIP-seq
MIRT1458621	hsa-miR-4519	CLIP-seq
MIRT1458622	hsa-miR-4524	CLIP-seq
MIRT1458623	hsa-miR-491-3p	CLIP-seq
MIRT1458624	hsa-miR-519a	CLIP-seq
MIRT1458625	hsa-miR-519d	CLIP-seq
MIRT1458626	hsa-miR-543	CLIP-seq
MIRT1458627	hsa-miR-561	CLIP-seq
MIRT1458628	hsa-miR-590-3p	CLIP-seq
MIRT1458629	hsa-miR-93	CLIP-seq
MIRT1458605	hsa-miR-106a	CLIP-seq
MIRT1458606	hsa-miR-106b	CLIP-seq
MIRT1458607	hsa-miR-1185	CLIP-seq
MIRT1458609	hsa-miR-17	CLIP-seq
MIRT1458610	hsa-miR-181a	CLIP-seq
MIRT1458611	hsa-miR-181b	CLIP-seq
MIRT1458612	hsa-miR-181c	CLIP-seq
MIRT1458613	hsa-miR-181d	CLIP-seq
MIRT1458614	hsa-miR-20a	CLIP-seq
MIRT1458615	hsa-miR-20b	CLIP-seq
MIRT1458616	hsa-miR-3065-3p	CLIP-seq
MIRT1458618	hsa-miR-4262	CLIP-seq
MIRT1458619	hsa-miR-4274	CLIP-seq
MIRT1458620	hsa-miR-4291	CLIP-seq
MIRT1458621	hsa-miR-4519	CLIP-seq
MIRT1458622	hsa-miR-4524	CLIP-seq
MIRT1458624	hsa-miR-519a	CLIP-seq
MIRT1458625	hsa-miR-519d	CLIP-seq
MIRT1458626	hsa-miR-543	CLIP-seq
MIRT1458627	hsa-miR-561	CLIP-seq
MIRT1458629	hsa-miR-93	CLIP-seq
MIRT1458605	hsa-miR-106a	CLIP-seq
MIRT1458606	hsa-miR-106b	CLIP-seq
MIRT1458607	hsa-miR-1185	CLIP-seq
MIRT1458608	hsa-miR-1253	CLIP-seq
MIRT2358447	hsa-miR-1285	CLIP-seq
MIRT1458609	hsa-miR-17	CLIP-seq
MIRT1458610	hsa-miR-181a	CLIP-seq
MIRT1458611	hsa-miR-181b	CLIP-seq
MIRT1458612	hsa-miR-181c	CLIP-seq
MIRT1458613	hsa-miR-181d	CLIP-seq
MIRT1458614	hsa-miR-20a	CLIP-seq
MIRT1458615	hsa-miR-20b	CLIP-seq
MIRT1458616	hsa-miR-3065-3p	CLIP-seq
MIRT2358448	hsa-miR-3187-5p	CLIP-seq
MIRT2358449	hsa-miR-3653	CLIP-seq
MIRT2358450	hsa-miR-3658	CLIP-seq
MIRT2358451	hsa-miR-3670	CLIP-seq
MIRT2358452	hsa-miR-378g	CLIP-seq
MIRT1458618	hsa-miR-4262	CLIP-seq
MIRT1458619	hsa-miR-4274	CLIP-seq
MIRT1458620	hsa-miR-4291	CLIP-seq
MIRT2358453	hsa-miR-4314	CLIP-seq
MIRT2358454	hsa-miR-4486	CLIP-seq
MIRT1458621	hsa-miR-4519	CLIP-seq
MIRT1458622	hsa-miR-4524	CLIP-seq
MIRT2358455	hsa-miR-4714-3p	CLIP-seq
MIRT2358456	hsa-miR-4778-5p	CLIP-seq
MIRT1458624	hsa-miR-519a	CLIP-seq
MIRT1458625	hsa-miR-519d	CLIP-seq
MIRT1458626	hsa-miR-543	CLIP-seq
MIRT1458627	hsa-miR-561	CLIP-seq
MIRT2358457	hsa-miR-612	CLIP-seq
MIRT1458629	hsa-miR-93	CLIP-seq

Transcription factor	Regulation	Reference
MAZ	Activation	21556761
TTF2	Unknown	21556761

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000813	Component	ESCRT I complex	IBA
GO:0000813	Component	ESCRT I complex	IDA	18005716, 20654576, 21757351, 22232651
GO:0000813	Component	ESCRT I complex	IEA
GO:0000813	Component	ESCRT I complex	IPI	18005716, 21757351, 32424346
GO:0000813	Component	ESCRT I complex	ISS
GO:0000813	Component	ESCRT I complex	TAS	20588296, 21118109
GO:0001558	Process	Regulation of cell growth	IEA
GO:0003677	Function	DNA binding	TAS	10888872
GO:0003714	Function	Transcription corepressor activity	IEA
GO:0003714	Function	Transcription corepressor activity	TAS	10888872
GO:0005515	Function	Protein binding	IPI	12802020, 12900395, 14505570, 14519844, 15033475, 15218037, 15611048, 16118794, 16189514, 16973552, 17174262, 17350572, 17853893, 18005716, 18077552, 18641129, 19060904, 19549727, 20176808, 21070952, 22315426, 25416956, 26871637, 27107012, 28514442, 31515488, 32296183, 33961781, 350
GO:0005634	Component	Nucleus	IEA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	18077552
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	ISS
GO:0005768	Component	Endosome	IDA	17940959
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IDA	11916981, 17229889
GO:0005770	Component	Late endosome	IMP	15126635
GO:0005771	Component	Multivesicular body	TAS	15611048
GO:0005813	Component	Centrosome	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005886	Component	Plasma membrane	IDA	17940959
GO:0006858	Process	Extracellular transport	IMP	22315426
GO:0007175	Process	Negative regulation of epidermal growth factor-activated receptor activity	IMP	16973552
GO:0008285	Process	Negative regulation of cell population proliferation	IEA
GO:0008333	Process	Endosome to lysosome transport	IBA
GO:0010008	Component	Endosome membrane	NAS	32424346
GO:0010008	Component	Endosome membrane	TAS
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016236	Process	Macroautophagy	IEA
GO:0016236	Process	Macroautophagy	TAS	20588296
GO:0019076	Process	Viral release from host cell	IMP	11595185, 15218037
GO:0030154	Process	Cell differentiation	IEA
GO:0030216	Process	Keratinocyte differentiation	IEA
GO:0031625	Function	Ubiquitin protein ligase binding	IPI	17229889
GO:0031901	Component	Early endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	IEA
GO:0036258	Process	Multivesicular body assembly	IEA
GO:0036258	Process	Multivesicular body assembly	NAS	32424346
GO:0036258	Process	Multivesicular body assembly	TAS	20588296
GO:0039702	Process	Viral budding via host ESCRT complex	IEA
GO:0039702	Process	Viral budding via host ESCRT complex	TAS	20588296
GO:0042059	Process	Negative regulation of epidermal growth factor receptor signaling pathway	IMP	16554368
GO:0042803	Function	Protein homodimerization activity	IPI	14519844
GO:0043130	Function	Ubiquitin binding	IBA
GO:0043130	Function	Ubiquitin binding	IDA	11595185, 11916981, 20654576
GO:0043130	Function	Ubiquitin binding	TAS	15611048
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IC	20654576
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IDA	15611048
GO:0043162	Process	Ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP	21757351
GO:0043328	Process	Protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	NAS	32424346
GO:0043405	Process	Regulation of MAP kinase activity	IMP	17714434
GO:0044877	Function	Protein-containing complex binding	IDA	16973552
GO:0046755	Process	Viral budding	IEA
GO:0046755	Process	Viral budding	IMP	15126635, 18005716
GO:0046755	Process	Viral budding	ISS
GO:0046790	Function	Virion binding	IDA	11595185
GO:0048306	Function	Calcium-dependent protein binding	IPI	19520058
GO:0051301	Process	Cell division	IEA
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145
GO:0070062	Component	Extracellular exosome	IDA	15326289, 16501490, 23092844
GO:0070062	Component	Extracellular exosome	IEA
GO:0090148	Process	Membrane fission	NAS	32424346
GO:0090543	Component	Flemming body	IEA
GO:0097352	Process	Autophagosome maturation	TAS	21118109
GO:1903543	Process	Positive regulation of exosomal secretion	IMP	22660413, 24105262
GO:1903551	Process	Regulation of extracellular exosome assembly	IMP	24105262
GO:1903774	Process	Positive regulation of viral budding via host ESCRT complex	IMP	11595185, 15218037
GO:1990182	Process	Exosomal secretion	IEA
GO:2000397	Process	Positive regulation of ubiquitin-dependent endocytosis	IEA

MIM	HGNC	e!Ensembl
601387	15971	ENSG00000074319

Q99816

Protein name

Tumor susceptibility gene 101 protein (ESCRT-I complex subunit TSG101)

Protein function

Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association b

PDB

1KPP , 1KPQ , 1M4P , 1M4Q , 1S1Q , 2F0R , 3IV1 , 3OBQ , 3OBS , 3OBU , 3OBX , 3P9G , 3P9H , 4EJE , 4YC1 , 4ZNY , 5VKG , 6UD0 , 6VME , 7NLC , 7ZLX

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05743	UEV	21 → 141	UEV domain	Domain
PF09454	Vps23_core	316 → 379	Vps23 core domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Heart, brain, placenta, lung, liver, skeletal, kidney and pancreas.

Sequence

MAVSESQLKKMVSKYKYRDLTVRETVNVITLYKDLKPVLDSYVFNDGSSRELMNLTGTIP
VPYRGNTYNIPICLWLLDTYPYNPPICFVKPTSSMTIKTGKHVDANGKIYLPYLHEWKHP
QSDLLGLIQVMIVVFGDEPPVFSRPISASYPPYQATGPPNTSYMPGMPGGISPYPSGYPP
NPSGYPGCPYPPGGPYPATTSSQYPSQPPVTTVGPSRDGTISEDTIRASLISAVSDKLRW
RMKEEMDRAQAELNALKRTEEDLKKGHQKLEEMVTRLDQEVAEVDKNIELLKKKDEELSS
ALEKMENQSENNDIDEVIIPTAPLYKQILNLYAEENAIEDTIFYLGEALRRGVIDLDVFL
KHVRLLSRKQFQLRALMQKARKTAGLSDLY

Sequence length

390

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Viral life cycle - HIV-1	Budding and maturation of HIV virion
Virion - Hepatitis viruses	Membrane binding and targetting of GAG proteins
Endocytosis	Endosomal Sorting Complex Required For Transport (ESCRT)
	HCMV Late Events

TSG101 (tumor susceptibility 101)

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