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Gene Gene information from NCBI Gene database.
Entrez ID 10475
Gene name Tripartite motif containing 38
Gene symbol TRIM38
Synonyms (NCBI Gene)
RNF15RORET
Chromosome 6
Chromosome location 6p22.2
Summary This gene encodes a member of the tripartite motif (TRIM) family. The encoded protein contains a RING-type zinc finger, B box-type zinc finger and SPRY domain. The function of this protein has not been identified. A pseudogene of this gene is located on t
miRNA miRNA information provided by mirtarbase database.
235 Show/Hide all (235)
miRTarBase ID miRNA Experiments Reference
MIRT022126 hsa-miR-124-3p Microarray 18668037
MIRT030670 hsa-miR-21-5p Microarray 18591254
MIRT646583 hsa-miR-1827 HITS-CLIP 23824327
MIRT646581 hsa-miR-4775 HITS-CLIP 23824327
MIRT646582 hsa-miR-502-5p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
31 Show/Hide all (31)
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0003713 Function Transcription coactivator activity IDA 23077300
GO:0005515 Function Protein binding IPI 23275563, 25416956, 25910212, 29892012, 31515488, 32296183, 32814053
GO:0005737 Component Cytoplasm IBA
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O00635
Protein name E3 ubiquitin-protein ligase TRIM38 (EC 2.3.2.27) (RING finger protein 15) (Tripartite motif-containing protein 38) (Zinc finger protein RoRet)
Protein function E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity (PubMed:23056470). Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, l
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00622 SPRY 346 → 458 SPRY domain Family
PF00643 zf-B_box 88 → 129 B-box zinc finger Domain
PF13765 PRY 294 → 342 SPRY-associated domain Family
PF15227 zf-C3HC4_4 16 → 62 Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:9149941}.
Sequence
MASTTSTKKMMEEATCSICLSLMTNPVSINCGHSYCHLCITDFFKNPSQKQLRQETFCCP
QC
RAPFHMDSLRPNKQLGSLIEALKETDQEMSCEEHGEQFHLFCEDEGQLICWRCERAPQ
HKGHTTALV
EDVCQGYKEKLQKAVTKLKQLEDRCTEQKLSTAMRITKWKEKVQIQRQKIR
SDFKNLQCFLHEEEKSYLWRLEKEEQQTLSRLRDYEAGLGLKSNELKSHILELEEKCQGS
AQKLLQNVNDTLSRSWAVKLETSEAVSLELHTMCNVSKLYFDVKKMLRSHQVSVTLDPDT
AHHELILSEDRRQVTRGYTQENQDTSSRRFTAFPCVLGCEGF
TSGRRYFEVDVGEGTGWD
LGVCMENVQRGTGMKQEPQSGFWTLRLCKKKGYVALTSPPTSLHLHEQPLLVGIFLDYEA
GVVSFYNGNTGCHIFTFPKASFSDTLRPYFQVYQYSPL
FLPPPGD
Sequence length 465
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Interferon gamma signaling
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
BREAST CANCER — GWAS catalog 36819030
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GOUT — GWAS catalog 40465716
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LUNG CANCER — GWAS catalog 36819030
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OCULAR HYPERTENSION — GWAS catalog 36222912
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PERIPHERAL ARTERIAL DISEASE — GWAS catalog 27082954
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (9)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Arthritis, Gouty Gouty arthritis GWASDB_DG 20884846, 21768215, 23263486
★★★★★
★☆☆☆☆
Found in Text Mining only
Gout Gout GWASDB_DG 20884846, 21768215, 23263486
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Hemochromatosis Hemochromatosis Pubtator 9149941 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Lupus Erythematosus Lupus Erythematosus BEFREE 9149941
★★★★★
★☆☆☆☆
Found in Text Mining only
Lupus Erythematosus, Discoid Lupus Erythematosus BEFREE 9149941
★★★★★
★☆☆☆☆
Found in Text Mining only
Lupus Erythematosus, Systemic Lupus Erythematosus BEFREE 12047754, 9149941
★★★★★
★☆☆☆☆
Found in Text Mining only
Lupus Vulgaris Lupus Vulgaris BEFREE 9149941
★★★★★
★☆☆☆☆
Found in Text Mining only
Peritonitis Peritonitis Pubtator 35022662 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Urinary Bladder Neoplasms Urinary bladder neoplasms Pubtator 34906161 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only