TMCO5A (transmembrane and coiled-coil domains 5A)

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Gene Gene information from NCBI Gene database.
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Entrez ID 145942
Gene name Transmembrane and coiled-coil domains 5A
Gene symbol TMCO5A
Synonyms (NCBI Gene)
TMCO5
Chromosome 15
Chromosome location 15q14
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT720516 hsa-miR-6750-3p HITS-CLIP 19536157
MIRT720515 hsa-miR-28-3p HITS-CLIP 19536157
MIRT720514 hsa-miR-1972 HITS-CLIP 19536157
MIRT720513 hsa-miR-345-5p HITS-CLIP 19536157
MIRT720512 hsa-miR-4764-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 32296183
GO:0005634 Component Nucleus IEA
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0016020 Component Membrane IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q8N6Q1
Protein name Transmembrane and coiled-coil domain-containing protein 5A
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF14992 TMCO5 13 → 287 TMCO5 family Family
Sequence 
MEISRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVE
DEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQSS
PDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYIKKYQETLKKIEEE
LEALFLEREVSKLVSMNPVEKEHTSQNNEGTPTQKTARLFSKKIFCCLFFITLFFIRLLS
YMFFHVRFINPDLLVNVLPKVLGRSTLWKLRCFFFPSLTLETEDMLPH
Sequence length 288
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Show/Hide Unknown Diseases (17)
Phenotype Name Clinical Significance Source Reference Evidence Score
ANOREXIA NERVOSA — GWAS catalog 31835028
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER — GWAS catalog 31835028
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER — GWAS catalog 31835028
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER — GWAS catalog 31835028, 31926635
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CHRONIC OBSTRUCTIVE PULMONARY DISEASE — GWAS catalog 37069358
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
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C8orf90 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. DGKI 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. HSPE1-MOB4 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. MOB4 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog. NAA40 3 shared diseasesAnorexia nervosa, Tourette syndrome, Obsessive-compulsive disorder 3 shared evidence sourcesGWAS catalog (Anorexia nervosa), GWAS catalog (Obsessive-compulsive disorder), GWAS catalog (Tourette syndrome) Related via 3 shared diseases including Anorexia nervosa, Tourette syndrome — evidence mostly GWAS catalog.
Alzheimer disease Linked via 2 of 5 related genesC8orf90, DGKI Obesity Linked via 2 of 5 related genesC8orf90, DGKI Central nervous system cancer Linked via 1 of 5 related genesDGKI Glioblastoma Linked via 1 of 5 related genesDGKI Glioma Linked via 1 of 5 related genesDGKI