TLCD4-RWDD3 (TLCD4-RWDD3 readthrough)

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Gene Gene information from NCBI Gene database.
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Entrez ID 100527978
Gene name TLCD4-RWDD3 readthrough
Gene symbol TLCD4-RWDD3
Synonyms (NCBI Gene)
TMEM56-RWDD3
Chromosome 1
Chromosome location 1p21.3
Summary This locus represents naturally occurring read-through transcription between the neighboring TMEM56 (transmembrane protein 56) and RWDD3 (RWD domain containing 3) genes on chromosome 1. The read-through transcript encodes a protein that shares sequence id
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
HGNC N/A HGNC
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
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Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
BIPOLAR DISORDER — GWAS catalog 31043756, 32606422
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CIRRHOSIS OF LIVER — GWAS catalog 20708005
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GENERALIZED ANXIETY DISORDER — GWAS catalog 38063329
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NON-ALCOHOLIC FATTY LIVER DISEASE — GWAS catalog 20708005
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Bipolar Disorder Bipolar Disorder GWASCAT_DG 31043756
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
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CHST2 1 shared diseaseLiver cirrhosis 2 shared evidence sourcesGWAS catalog (Liver cirrhosis), GWAS catalog (Nonalcoholic fatty liver disease) Related via 1 shared disease including Liver cirrhosis — evidence mostly GWAS catalog. DDX60L 1 shared diseaseLiver cirrhosis 2 shared evidence sourcesGWAS catalog (Liver cirrhosis), GWAS catalog (Nonalcoholic fatty liver disease) Related via 1 shared disease including Liver cirrhosis — evidence mostly GWAS catalog. HSD17B13 1 shared diseaseLiver cirrhosis 2 shared evidence sourcesGWAS catalog (Liver cirrhosis), GWAS catalog (Nonalcoholic fatty liver disease) Related via 1 shared disease including Liver cirrhosis — evidence mostly GWAS catalog. LCP1 1 shared diseaseLiver cirrhosis 2 shared evidence sourcesGWAS catalog (Liver cirrhosis), GWAS catalog (Nonalcoholic fatty liver disease) Related via 1 shared disease including Liver cirrhosis — evidence mostly GWAS catalog. SEL1L3 1 shared diseaseLiver cirrhosis 2 shared evidence sourcesGWAS catalog (Liver cirrhosis), GWAS catalog (Nonalcoholic fatty liver disease) Related via 1 shared disease including Liver cirrhosis — evidence mostly GWAS catalog.
Obesity Linked via 1 of 5 related genesDDX60L Psoriasis Linked via 1 of 5 related genesDDX60L Scoliosis Linked via 1 of 5 related genesDDX60L Alzheimer disease Linked via 1 of 5 related genesLCP1 Systemic lupus erythematosus Linked via 1 of 5 related genesLCP1