Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 92610
Gene name TRAF interacting protein with forkhead associated domain
Gene symbol TIFA
Synonyms (NCBI Gene)
T2BPT6BPTIFAA
Chromosome 4
Chromosome location 4q25
Summary This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encode
miRNA miRNA information provided by mirtarbase database.
358 Show/Hide all (358)
miRTarBase ID miRNA Experiments Reference
MIRT024752 hsa-miR-215-5p Microarray 19074876
MIRT026675 hsa-miR-192-5p Microarray 19074876
MIRT456669 hsa-miR-302f PAR-CLIP 23592263
MIRT456668 hsa-miR-1910-3p PAR-CLIP 23592263
MIRT456667 hsa-miR-6511a-5p PAR-CLIP 23592263
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16 Show/Hide all (16)
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0002753 Process Cytoplasmic pattern recognition receptor signaling pathway IBA
GO:0002753 Process Cytoplasmic pattern recognition receptor signaling pathway IDA 26068852, 28222186, 28877472, 30111836
GO:0005515 Function Protein binding IPI 11798190, 15047173, 16189514, 16643855, 25416956, 26068852, 27107012, 30111836, 31515488, 32101751, 32296183, 33961781
GO:0005737 Component Cytoplasm IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
609028 19075 ENSG00000145365
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96CG3
Protein name TRAF-interacting protein with FHA domain-containing protein A (Putative MAPK-activating protein PM14) (Putative NF-kappa-B-activating protein 20) (TRAF2-binding protein)
Protein function Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (PubMed:12566447, PubMed:15492226, PubMed:26068852, PubM
PDB 4YM4 , 4ZGI , 5ZUJ , 6A33
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00498 FHA 47 → 120 FHA domain Family
Sequence
MTSFEDADTEETVTCLQMTVYHPGQLQCGIFQSISFNREKLPSSEVVKFGRNSNICHYTF
QDKQVSRVQFSLQLFKKFNSSVLSFEIKNMSKKTNLIVDSRELGYLNKMDLPYRCMVRFG

EYQFLMEKEDGESLEFFETQFILSPRSLLQENNWPPHRPIPEYGTYSLCSSQSSSPTEMD
ENES
Sequence length 184
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Shigellosis Alpha-protein kinase 1 signaling pathway