TIFA (TRAF interacting protein with forkhead associated domain)
|
Gene
Gene information from NCBI Gene database.
|
|
| Entrez ID | 92610 |
| Gene name | TRAF interacting protein with forkhead associated domain |
| Gene symbol | TIFA |
| Synonyms (NCBI Gene) |
T2BPT6BPTIFAA
|
| Chromosome | 4 |
| Chromosome location | 4q25 |
| Summary | This gene encodes an adapter protein involved in adaptive and innate immunity. This protein includes a forkhead-associated (FHA) domain that specifically binds to phosphorylated serine and threonine residues. In response to bacterial infection, the encode |
|
miRNA
miRNA information provided by mirtarbase database.
358
|
|||||||||||||||||||||||||
|
|||||||||||||||||||||||||
|
Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
16
|
|||||||||||||||||||||||||||||||
|
|||||||||||||||||||||||||||||||
|
Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
|
|||||||
|
|||||||
|
Protein
Protein information from UniProt database.
|
|||||||||||
|
UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
|
Q96CG3 | ||||||||||
| Protein name | TRAF-interacting protein with FHA domain-containing protein A (Putative MAPK-activating protein PM14) (Putative NF-kappa-B-activating protein 20) (TRAF2-binding protein) | ||||||||||
| Protein function | Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (PubMed:12566447, PubMed:15492226, PubMed:26068852, PubM | ||||||||||
| PDB | 4YM4 , 4ZGI , 5ZUJ , 6A33 | ||||||||||
| Family and domains |
Pfam
|
||||||||||
| Sequence |
MTSFEDADTEETVTCLQMTVYHPGQLQCGIFQSISFNREKLPSSEVVKFGRNSNICHYTF |
||||||||||
| Sequence length | 184 | ||||||||||
| Interactions | View interactions | ||||||||||
|
Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
|
|||||
|
|||||
|
Related Genes
Genes most often co-reported with TIFA across shared curated disease and pathway associations.
5
|
|
|
Diseases Linked via Similar Genes
Diseases curated for genes most similar to TIFA (see Related Genes above), that are NOT already directly curated for TIFA itself -- a lead worth checking, not a confirmed association.
5
|
|