TAS2R20 (taste 2 receptor member 20)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 259295
• Gene name: Taste 2 receptor member 20
• Gene symbol: TAS2R20
• Synonyms (NCBI Gene): T2R20, T2R49, T2R56, TAS2R49
• Chromosome: 12
• Chromosome location: 12p13.2
• Summary: This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and a

miRNA Show/Hide all (176)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1411537	hsa-miR-1324	CLIP-seq
MIRT1411538	hsa-miR-181a	CLIP-seq
MIRT1411539	hsa-miR-181b	CLIP-seq
MIRT1411540	hsa-miR-181c	CLIP-seq
MIRT1411541	hsa-miR-181d	CLIP-seq
MIRT1411542	hsa-miR-1827	CLIP-seq
MIRT1411543	hsa-miR-2682	CLIP-seq
MIRT1411544	hsa-miR-31	CLIP-seq
MIRT1411545	hsa-miR-3122	CLIP-seq
MIRT1411546	hsa-miR-329	CLIP-seq
MIRT1411547	hsa-miR-335	CLIP-seq
MIRT1411548	hsa-miR-338-3p	CLIP-seq
MIRT1411549	hsa-miR-34a	CLIP-seq
MIRT1411550	hsa-miR-34c-5p	CLIP-seq
MIRT1411551	hsa-miR-3614-5p	CLIP-seq
MIRT1411552	hsa-miR-362-3p	CLIP-seq
MIRT1411553	hsa-miR-3681	CLIP-seq
MIRT1411554	hsa-miR-3689a-3p	CLIP-seq
MIRT1411555	hsa-miR-3689c	CLIP-seq
MIRT1411556	hsa-miR-3690	CLIP-seq
MIRT1411557	hsa-miR-3913-5p	CLIP-seq
MIRT1411558	hsa-miR-3929	CLIP-seq
MIRT1411559	hsa-miR-3941	CLIP-seq
MIRT1411560	hsa-miR-4251	CLIP-seq
MIRT1411561	hsa-miR-4262	CLIP-seq
MIRT1411562	hsa-miR-4303	CLIP-seq
MIRT1411563	hsa-miR-4329	CLIP-seq
MIRT1411564	hsa-miR-4419b	CLIP-seq
MIRT1411565	hsa-miR-4432	CLIP-seq
MIRT1411566	hsa-miR-4435	CLIP-seq
MIRT1411567	hsa-miR-4478	CLIP-seq
MIRT1411568	hsa-miR-449a	CLIP-seq
MIRT1411569	hsa-miR-449b	CLIP-seq
MIRT1411570	hsa-miR-449c	CLIP-seq
MIRT1411571	hsa-miR-4638-3p	CLIP-seq
MIRT1411572	hsa-miR-4649-3p	CLIP-seq
MIRT1411573	hsa-miR-4696	CLIP-seq
MIRT1411574	hsa-miR-4728-5p	CLIP-seq
MIRT1411575	hsa-miR-4786-5p	CLIP-seq
MIRT1411576	hsa-miR-485-5p	CLIP-seq
MIRT1411577	hsa-miR-513a-3p	CLIP-seq
MIRT1411578	hsa-miR-539	CLIP-seq
MIRT1411579	hsa-miR-603	CLIP-seq
MIRT2123579	hsa-miR-1254	CLIP-seq
MIRT2123580	hsa-miR-1289	CLIP-seq
MIRT2123581	hsa-miR-217	CLIP-seq
MIRT2123582	hsa-miR-3116	CLIP-seq
MIRT2123583	hsa-miR-3664-3p	CLIP-seq
MIRT1411556	hsa-miR-3690	CLIP-seq
MIRT1411558	hsa-miR-3929	CLIP-seq
MIRT1411564	hsa-miR-4419b	CLIP-seq
MIRT2123584	hsa-miR-4433	CLIP-seq
MIRT2123585	hsa-miR-4459	CLIP-seq
MIRT1411567	hsa-miR-4478	CLIP-seq
MIRT1411571	hsa-miR-4638-3p	CLIP-seq
MIRT2123586	hsa-miR-4691-3p	CLIP-seq
MIRT2123587	hsa-miR-4695-5p	CLIP-seq
MIRT2123588	hsa-miR-4768-3p	CLIP-seq
MIRT1411576	hsa-miR-485-5p	CLIP-seq
MIRT2123589	hsa-miR-510	CLIP-seq
MIRT2123579	hsa-miR-1254	CLIP-seq
MIRT1411542	hsa-miR-1827	CLIP-seq
MIRT2123581	hsa-miR-217	CLIP-seq
MIRT1411543	hsa-miR-2682	CLIP-seq
MIRT2123582	hsa-miR-3116	CLIP-seq
MIRT1411545	hsa-miR-3122	CLIP-seq
MIRT1411547	hsa-miR-335	CLIP-seq
MIRT1411548	hsa-miR-338-3p	CLIP-seq
MIRT1411549	hsa-miR-34a	CLIP-seq
MIRT1411550	hsa-miR-34c-5p	CLIP-seq
MIRT1411551	hsa-miR-3614-5p	CLIP-seq
MIRT1411553	hsa-miR-3681	CLIP-seq
MIRT1411554	hsa-miR-3689a-3p	CLIP-seq
MIRT1411555	hsa-miR-3689c	CLIP-seq
MIRT1411556	hsa-miR-3690	CLIP-seq
MIRT1411557	hsa-miR-3913-5p	CLIP-seq
MIRT1411558	hsa-miR-3929	CLIP-seq
MIRT2345669	hsa-miR-4418	CLIP-seq
MIRT1411564	hsa-miR-4419b	CLIP-seq
MIRT1411566	hsa-miR-4435	CLIP-seq
MIRT1411567	hsa-miR-4478	CLIP-seq
MIRT1411568	hsa-miR-449a	CLIP-seq
MIRT1411569	hsa-miR-449b	CLIP-seq
MIRT1411570	hsa-miR-449c	CLIP-seq
MIRT1411571	hsa-miR-4638-3p	CLIP-seq
MIRT1411572	hsa-miR-4649-3p	CLIP-seq
MIRT1411574	hsa-miR-4728-5p	CLIP-seq
MIRT1411575	hsa-miR-4786-5p	CLIP-seq
MIRT1411576	hsa-miR-485-5p	CLIP-seq
MIRT2345670	hsa-miR-509-3-5p	CLIP-seq
MIRT2345671	hsa-miR-509-5p	CLIP-seq
MIRT1411542	hsa-miR-1827	CLIP-seq
MIRT1411543	hsa-miR-2682	CLIP-seq
MIRT1411549	hsa-miR-34a	CLIP-seq
MIRT1411550	hsa-miR-34c-5p	CLIP-seq
MIRT1411551	hsa-miR-3614-5p	CLIP-seq
MIRT1411553	hsa-miR-3681	CLIP-seq
MIRT1411558	hsa-miR-3929	CLIP-seq
MIRT1411564	hsa-miR-4419b	CLIP-seq
MIRT1411567	hsa-miR-4478	CLIP-seq
MIRT1411568	hsa-miR-449a	CLIP-seq
MIRT1411569	hsa-miR-449b	CLIP-seq
MIRT1411570	hsa-miR-449c	CLIP-seq
MIRT1411572	hsa-miR-4649-3p	CLIP-seq
MIRT1411548	hsa-miR-338-3p	CLIP-seq
MIRT2461148	hsa-miR-3613-3p	CLIP-seq
MIRT2461149	hsa-miR-371-5p	CLIP-seq
MIRT2461150	hsa-miR-371b-5p	CLIP-seq
MIRT1411565	hsa-miR-4432	CLIP-seq
MIRT1411566	hsa-miR-4435	CLIP-seq
MIRT1411575	hsa-miR-4786-5p	CLIP-seq
MIRT1411542	hsa-miR-1827	CLIP-seq
MIRT1411543	hsa-miR-2682	CLIP-seq
MIRT1411544	hsa-miR-31	CLIP-seq
MIRT1411545	hsa-miR-3122	CLIP-seq
MIRT2638572	hsa-miR-3163	CLIP-seq
MIRT1411548	hsa-miR-338-3p	CLIP-seq
MIRT1411549	hsa-miR-34a	CLIP-seq
MIRT1411550	hsa-miR-34c-5p	CLIP-seq
MIRT2461148	hsa-miR-3613-3p	CLIP-seq
MIRT2638573	hsa-miR-3675-3p	CLIP-seq
MIRT1411553	hsa-miR-3681	CLIP-seq
MIRT1411554	hsa-miR-3689a-3p	CLIP-seq
MIRT1411555	hsa-miR-3689c	CLIP-seq
MIRT2461149	hsa-miR-371-5p	CLIP-seq
MIRT2461150	hsa-miR-371b-5p	CLIP-seq
MIRT1411557	hsa-miR-3913-5p	CLIP-seq
MIRT1411558	hsa-miR-3929	CLIP-seq
MIRT1411564	hsa-miR-4419b	CLIP-seq
MIRT1411565	hsa-miR-4432	CLIP-seq
MIRT1411566	hsa-miR-4435	CLIP-seq
MIRT1411567	hsa-miR-4478	CLIP-seq
MIRT1411568	hsa-miR-449a	CLIP-seq
MIRT1411569	hsa-miR-449b	CLIP-seq
MIRT1411570	hsa-miR-449c	CLIP-seq
MIRT1411572	hsa-miR-4649-3p	CLIP-seq
MIRT2638574	hsa-miR-4684-5p	CLIP-seq
MIRT1411573	hsa-miR-4696	CLIP-seq
MIRT1411574	hsa-miR-4728-5p	CLIP-seq
MIRT1411575	hsa-miR-4786-5p	CLIP-seq
MIRT2638575	hsa-miR-4796-5p	CLIP-seq
MIRT2638576	hsa-miR-4803	CLIP-seq
MIRT1411576	hsa-miR-485-5p	CLIP-seq
MIRT2638577	hsa-miR-656	CLIP-seq
MIRT1411542	hsa-miR-1827	CLIP-seq
MIRT1411543	hsa-miR-2682	CLIP-seq
MIRT1411544	hsa-miR-31	CLIP-seq
MIRT1411545	hsa-miR-3122	CLIP-seq
MIRT2638572	hsa-miR-3163	CLIP-seq
MIRT1411548	hsa-miR-338-3p	CLIP-seq
MIRT1411549	hsa-miR-34a	CLIP-seq
MIRT1411550	hsa-miR-34c-5p	CLIP-seq
MIRT2461148	hsa-miR-3613-3p	CLIP-seq
MIRT2638573	hsa-miR-3675-3p	CLIP-seq
MIRT1411554	hsa-miR-3689a-3p	CLIP-seq
MIRT1411555	hsa-miR-3689c	CLIP-seq
MIRT2461149	hsa-miR-371-5p	CLIP-seq
MIRT2461150	hsa-miR-371b-5p	CLIP-seq
MIRT1411557	hsa-miR-3913-5p	CLIP-seq
MIRT1411558	hsa-miR-3929	CLIP-seq
MIRT1411564	hsa-miR-4419b	CLIP-seq
MIRT1411565	hsa-miR-4432	CLIP-seq
MIRT1411566	hsa-miR-4435	CLIP-seq
MIRT1411567	hsa-miR-4478	CLIP-seq
MIRT1411568	hsa-miR-449a	CLIP-seq
MIRT1411569	hsa-miR-449b	CLIP-seq
MIRT1411570	hsa-miR-449c	CLIP-seq
MIRT1411572	hsa-miR-4649-3p	CLIP-seq
MIRT2638574	hsa-miR-4684-5p	CLIP-seq
MIRT1411573	hsa-miR-4696	CLIP-seq
MIRT1411574	hsa-miR-4728-5p	CLIP-seq
MIRT1411575	hsa-miR-4786-5p	CLIP-seq
MIRT2638575	hsa-miR-4796-5p	CLIP-seq
MIRT2638576	hsa-miR-4803	CLIP-seq
MIRT1411576	hsa-miR-485-5p	CLIP-seq
MIRT2638577	hsa-miR-656	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001580	Process	Detection of chemical stimulus involved in sensory perception of bitter taste	IEA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0033038	Function	Bitter taste receptor activity	IEA
GO:0050909	Process	Sensory perception of taste	IEA

Other IDs

• MIM: 613962
• HGNC: 19109
• e!Ensembl: ENSG00000255837

Protein

• UniProt ID: P59543
• Protein name: Taste receptor type 2 member 20 (Taste receptor type 2 member 49) (T2R49) (Taste receptor type 2 member 56) (T2R56)
• Protein function: Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05296	TAS2R	1 → 298	Taste receptor protein (TAS2R)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in subsets of taste receptor cells of the tongue and exclusively in gustducin-positive cells.
• Sequence:

  MMSFLHIVFSILVVVAFILGNFANGFIALINFIAWVKRQKISSADQIIAALAVSRVGLLW
  VILLHWYSTVLNPTSSNLKVIIFISNAWAVTNHFSIWLATSLSIFYLLKIVNFSRLIFHH
  LKRKAKSVVLVIVLGSLFFLVCHLVMKHTYINVWTEECEGNVTWKIKLRNAMHLSNLTVA
  MLANLIPFTLTLISFLLLIYSLCKHLKKMQLHGKGSQDPSTKIHIKALQTVTSFLILLAI
  YFLCLIISFWNFKMRPKEIVLMLCQAFGIIYPSFHSFILIWGNKTLKQTFLSVLWQVTCW
  AKGQNQSTP

• Sequence length: 309

Pathways

KEGG Pathway	Reactome Pathway
Taste transduction	G alpha (i) signalling events
	Class C/3 (Metabotropic glutamate/pheromone receptors)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Prostate cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Craniosynostosis	Craniosynostosis	BEFREE	24415641		★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

TAS2R39 3 shared pathwaysTaste transduction, G alpha (i) signalling events, Class C/3 (Metabotropic glutamate/pheromone receptors) Related via 3 shared pathways including Taste transduction, G alpha (i) signalling events. TAS2R40 3 shared pathwaysTaste transduction, G alpha (i) signalling events, Class C/3 (Metabotropic glutamate/pheromone receptors) Related via 3 shared pathways including Taste transduction, G alpha (i) signalling events. TAS2R41 3 shared pathwaysTaste transduction, G alpha (i) signalling events, Class C/3 (Metabotropic glutamate/pheromone receptors) Related via 3 shared pathways including Taste transduction, G alpha (i) signalling events. TAS2R43 3 shared pathwaysTaste transduction, G alpha (i) signalling events, Class C/3 (Metabotropic glutamate/pheromone receptors) Related via 3 shared pathways including Taste transduction, G alpha (i) signalling events. TAS2R31 3 shared pathwaysTaste transduction, G alpha (i) signalling events, Class C/3 (Metabotropic glutamate/pheromone receptors) Related via 3 shared pathways including Taste transduction, G alpha (i) signalling events.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
TAS2R39	0	[]	3	["Taste transduction","G alpha (i) signalling events","Class C\/3 (Metabotropic glutamate\/pheromone receptors)"]	0	[]
TAS2R40	0	[]	3	["Taste transduction","G alpha (i) signalling events","Class C\/3 (Metabotropic glutamate\/pheromone receptors)"]	0	[]
TAS2R41	0	[]	3	["Taste transduction","G alpha (i) signalling events","Class C\/3 (Metabotropic glutamate\/pheromone receptors)"]	0	[]
TAS2R43	0	[]	3	["Taste transduction","G alpha (i) signalling events","Class C\/3 (Metabotropic glutamate\/pheromone receptors)"]	0	[]
TAS2R31	0	[]	3	["Taste transduction","G alpha (i) signalling events","Class C\/3 (Metabotropic glutamate\/pheromone receptors)"]	0	[]

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TAS2R20.