Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	6883
Gene name	TATA-box binding protein associated factor 12
Gene symbol	TAF12
Synonyms (NCBI Gene)	TAF2JTAFII20
Chromosome	1
Chromosome location	1p35.3
Summary	Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regu

117 Show/Hide all (117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT040579	hsa-miR-92b-3p	CLASH	23622248
MIRT455602	hsa-miR-548av-5p	PAR-CLIP	23592263
MIRT455600	hsa-miR-548k	PAR-CLIP	23592263
MIRT455601	hsa-miR-8054	PAR-CLIP	23592263
MIRT455599	hsa-miR-5584-5p	PAR-CLIP	23592263
MIRT455598	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT455597	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT455595	hsa-miR-7515	PAR-CLIP	23592263
MIRT455596	hsa-miR-6124	PAR-CLIP	23592263
MIRT455594	hsa-miR-3202	PAR-CLIP	23592263
MIRT455593	hsa-miR-4434	PAR-CLIP	23592263
MIRT455592	hsa-miR-4516	PAR-CLIP	23592263
MIRT455591	hsa-miR-5703	PAR-CLIP	23592263
MIRT455590	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT455589	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT455588	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT455586	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT455587	hsa-miR-4271	PAR-CLIP	23592263
MIRT455585	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT455584	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT455602	hsa-miR-548av-5p	PAR-CLIP	23592263
MIRT455600	hsa-miR-548k	PAR-CLIP	23592263
MIRT455601	hsa-miR-8054	PAR-CLIP	23592263
MIRT455599	hsa-miR-5584-5p	PAR-CLIP	23592263
MIRT455598	hsa-miR-6760-5p	PAR-CLIP	23592263
MIRT455597	hsa-miR-6783-5p	PAR-CLIP	23592263
MIRT455595	hsa-miR-7515	PAR-CLIP	23592263
MIRT455596	hsa-miR-6124	PAR-CLIP	23592263
MIRT455594	hsa-miR-3202	PAR-CLIP	23592263
MIRT455593	hsa-miR-4434	PAR-CLIP	23592263
MIRT455592	hsa-miR-4516	PAR-CLIP	23592263
MIRT455591	hsa-miR-5703	PAR-CLIP	23592263
MIRT455590	hsa-miR-4668-5p	PAR-CLIP	23592263
MIRT455589	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT455588	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT455586	hsa-miR-6878-5p	PAR-CLIP	23592263
MIRT455587	hsa-miR-4271	PAR-CLIP	23592263
MIRT455585	hsa-miR-4725-3p	PAR-CLIP	23592263
MIRT455584	hsa-miR-6780b-5p	PAR-CLIP	23592263
MIRT1408976	hsa-miR-1208	CLIP-seq
MIRT1408977	hsa-miR-1255a	CLIP-seq
MIRT1408978	hsa-miR-1255b	CLIP-seq
MIRT1408979	hsa-miR-1271	CLIP-seq
MIRT1408980	hsa-miR-1273f	CLIP-seq
MIRT1408981	hsa-miR-1297	CLIP-seq
MIRT1408982	hsa-miR-137	CLIP-seq
MIRT1408983	hsa-miR-143	CLIP-seq
MIRT1408984	hsa-miR-182	CLIP-seq
MIRT1408985	hsa-miR-2053	CLIP-seq
MIRT1408986	hsa-miR-26a	CLIP-seq
MIRT1408987	hsa-miR-26b	CLIP-seq
MIRT1408988	hsa-miR-3183	CLIP-seq
MIRT1408989	hsa-miR-4264	CLIP-seq
MIRT1408990	hsa-miR-4465	CLIP-seq
MIRT1408991	hsa-miR-4528	CLIP-seq
MIRT1408992	hsa-miR-4682	CLIP-seq
MIRT1408993	hsa-miR-4704-3p	CLIP-seq
MIRT1408994	hsa-miR-4708-5p	CLIP-seq
MIRT1408995	hsa-miR-4723-3p	CLIP-seq
MIRT1408996	hsa-miR-4770	CLIP-seq
MIRT1408997	hsa-miR-4793-3p	CLIP-seq
MIRT1408998	hsa-miR-4797-3p	CLIP-seq
MIRT1408999	hsa-miR-515-5p	CLIP-seq
MIRT1409000	hsa-miR-569	CLIP-seq
MIRT1409001	hsa-miR-96	CLIP-seq
MIRT1408977	hsa-miR-1255a	CLIP-seq
MIRT1408978	hsa-miR-1255b	CLIP-seq
MIRT1408980	hsa-miR-1273f	CLIP-seq
MIRT2345064	hsa-miR-1279	CLIP-seq
MIRT1408981	hsa-miR-1297	CLIP-seq
MIRT1408983	hsa-miR-143	CLIP-seq
MIRT1408986	hsa-miR-26a	CLIP-seq
MIRT1408987	hsa-miR-26b	CLIP-seq
MIRT2345065	hsa-miR-3148	CLIP-seq
MIRT2345066	hsa-miR-3646	CLIP-seq
MIRT2345067	hsa-miR-410	CLIP-seq
MIRT1408990	hsa-miR-4465	CLIP-seq
MIRT1408992	hsa-miR-4682	CLIP-seq
MIRT1408993	hsa-miR-4704-3p	CLIP-seq
MIRT1408994	hsa-miR-4708-5p	CLIP-seq
MIRT1408996	hsa-miR-4770	CLIP-seq
MIRT1408999	hsa-miR-515-5p	CLIP-seq
MIRT2345068	hsa-miR-520d-5p	CLIP-seq
MIRT2345069	hsa-miR-524-5p	CLIP-seq
MIRT2638151	hsa-miR-1252	CLIP-seq
MIRT2638152	hsa-miR-155	CLIP-seq
MIRT2638153	hsa-miR-200b	CLIP-seq
MIRT2638154	hsa-miR-200c	CLIP-seq
MIRT2638155	hsa-miR-2355-3p	CLIP-seq
MIRT2638156	hsa-miR-323-3p	CLIP-seq
MIRT2638157	hsa-miR-369-3p	CLIP-seq
MIRT2638158	hsa-miR-370	CLIP-seq
MIRT2638159	hsa-miR-374a	CLIP-seq
MIRT2638160	hsa-miR-374b	CLIP-seq
MIRT2638161	hsa-miR-3973	CLIP-seq
MIRT2345067	hsa-miR-410	CLIP-seq
MIRT2638162	hsa-miR-4261	CLIP-seq
MIRT2638163	hsa-miR-429	CLIP-seq
MIRT2638164	hsa-miR-4496	CLIP-seq
MIRT2638165	hsa-miR-4646-3p	CLIP-seq
MIRT1408993	hsa-miR-4704-3p	CLIP-seq
MIRT2345068	hsa-miR-520d-5p	CLIP-seq
MIRT2345069	hsa-miR-524-5p	CLIP-seq
MIRT2638151	hsa-miR-1252	CLIP-seq
MIRT2638152	hsa-miR-155	CLIP-seq
MIRT2638153	hsa-miR-200b	CLIP-seq
MIRT2638154	hsa-miR-200c	CLIP-seq
MIRT2638155	hsa-miR-2355-3p	CLIP-seq
MIRT2638156	hsa-miR-323-3p	CLIP-seq
MIRT2638158	hsa-miR-370	CLIP-seq
MIRT2638161	hsa-miR-3973	CLIP-seq
MIRT2638162	hsa-miR-4261	CLIP-seq
MIRT2638163	hsa-miR-429	CLIP-seq
MIRT2638164	hsa-miR-4496	CLIP-seq
MIRT2638165	hsa-miR-4646-3p	CLIP-seq
MIRT2345068	hsa-miR-520d-5p	CLIP-seq
MIRT2345069	hsa-miR-524-5p	CLIP-seq

Transcription factor	Regulation	Reference
ATF7	Activation	15735663
ETS1	Unknown	18567809

41 Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000124	Component	SAGA complex	IDA	9674425, 11564863
GO:0000124	Component	SAGA complex	IEA
GO:0000124	Component	SAGA complex	NAS	9674425, 19114550
GO:0003677	Function	DNA binding	IBA
GO:0003677	Function	DNA binding	IDA	15601843
GO:0003677	Function	DNA binding	IEA
GO:0003713	Function	Transcription coactivator activity	IDA	11564863, 17264123
GO:0005515	Function	Protein binding	IPI	7667268, 7729427, 9603525, 11438666, 12237304, 17158164, 17268553, 23292512, 25416956, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	EXP	23332750
GO:0005634	Component	Nucleus	IDA	11564863
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	TAS
GO:0005669	Component	Transcription factor TFIID complex	IBA
GO:0005669	Component	Transcription factor TFIID complex	IDA	14580349, 29111974
GO:0005669	Component	Transcription factor TFIID complex	IEA
GO:0005669	Component	Transcription factor TFIID complex	IPI	23332750
GO:0005669	Component	Transcription factor TFIID complex	ISS
GO:0005669	Component	Transcription factor TFIID complex	TAS	7729427
GO:0006282	Process	Regulation of DNA repair	NAS	11406595, 11564863
GO:0006352	Process	DNA-templated transcription initiation	IDA	9603525
GO:0006352	Process	DNA-templated transcription initiation	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	17694077
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	9603525
GO:0006366	Process	Transcription by RNA polymerase II	TAS	7729427
GO:0006367	Process	Transcription initiation at RNA polymerase II promoter	IDA	9603525
GO:0016251	Function	RNA polymerase II general transcription initiation factor activity	IDA	9603525
GO:0017025	Function	TBP-class protein binding	IBA
GO:0033276	Component	Transcription factor TFTC complex	IDA	9603525
GO:0033276	Component	Transcription factor TFTC complex	NAS	10373431
GO:0042789	Process	MRNA transcription by RNA polymerase II	IDA	17884155
GO:0043484	Process	Regulation of RNA splicing	NAS	11564863
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	18206972
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	17264123
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	IBA
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	IPI	27007846
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	ISS
GO:0060261	Process	Positive regulation of transcription initiation by RNA polymerase II	IDA	17884155
GO:0140297	Function	DNA-binding transcription factor binding	IDA	17264123
GO:0140297	Function	DNA-binding transcription factor binding	IPI	17264123

MIM	HGNC	e!Ensembl
600773	11545	ENSG00000120656

Q16514

Protein name

Transcription initiation factor TFIID subunit 12 (Transcription initiation factor TFIID 20/15 kDa subunits) (TAFII-20/TAFII-15) (TAFII20/TAFII15)

Protein function

The TFIID basal transcription factor complex plays a major role in the initiation of RNA polymerase II (Pol II)-dependent transcription (PubMed:33795473). TFIID recognizes and binds promoters with or without a TATA box via its subunit TBP, a TAT

PDB

1H3O , 6MZC , 6MZD , 6MZL , 6MZM , 7EDX , 7EG7 , 7EG8 , 7EG9 , 7EGA , 7EGB , 7EGC , 7EGD , 7EGE , 7EGF , 7EGG , 7EGI , 7EGJ , 7ENA , 7ENC , 7KTR , 7KTS , 8GXQ , 8GXS , 8H7G , 8WAK , 8WAL , 8WAN , 8WAO , 8WAP , 8WAQ , 8WAR , 8WAS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03847	TFIID_20kDa	59 → 126	Transcription initiation factor TFIID subunit A	Domain

Tissue specificity

TISSUE SPECIFICITY: Ubiquitous.

Sequence

MNQFGPSALINLSNFSSIKPEPASTPPQGSMANSTAVVKIPGTPGAGGRLSPENNQVLTK
KKLQDLVREVDPNEQLDEDVEEMLLQIADDFIESVVTAACQLARHRKSSTLEVKDVQLHL
ERQWNMWIPGFGSEEIRPYKKACTTEAHKQRMALIRKTTKK

Sequence length

161

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Basal transcription factors	RNA Polymerase II Pre-transcription Events
	Regulation of TP53 Activity through Phosphorylation
	RNA Polymerase II Promoter Escape
	RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
	RNA Polymerase II Transcription Initiation
	RNA Polymerase II Transcription Initiation And Promoter Clearance

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	31049640	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (11)
Amyotrophic Lateral Sclerosis, Familial	Amyotrophic lateral sclerosis	BEFREE	21344536		★★★★★ ★☆☆☆☆ Found in Text Mining only
Chromosomal Instability	Chromosomal instability	Pubtator	27551064	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	18360708, 18567809	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	36551275	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	29316427		★★★★★ ★☆☆☆☆ Found in Text Mining only
liposarcoma	Liposarcoma	BEFREE	21344536		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	17623797		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteitis Deformans	Paget disease	BEFREE	23426901		★★★★★ ★☆☆☆☆ Found in Text Mining only
Paget Disease	Paget disease	BEFREE	23426901		★★★★★ ★☆☆☆☆ Found in Text Mining only
Papilloma Choroid Plexus	Choroid plexus papilloma	Pubtator	36551275	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	BEFREE	21344536		★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
TAF1L	[]	7	["Basal transcription factors","RNA Polymerase II Pre-transcription Events","Regulation of TP53 Activity through Phosphorylation","RNA Polymerase II Promoter Escape","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening","RNA Polymerase II Transcription Initiation","RNA Polymerase II Transcription Initiation And Promoter Clearance"]	[]
TAF7L	[]	7	["Basal transcription factors","RNA Polymerase II Pre-transcription Events","Regulation of TP53 Activity through Phosphorylation","RNA Polymerase II Promoter Escape","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening","RNA Polymerase II Transcription Initiation","RNA Polymerase II Transcription Initiation And Promoter Clearance"]	[]
TAF1	[]	7	["Basal transcription factors","RNA Polymerase II Pre-transcription Events","Regulation of TP53 Activity through Phosphorylation","RNA Polymerase II Promoter Escape","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening","RNA Polymerase II Transcription Initiation","RNA Polymerase II Transcription Initiation And Promoter Clearance"]	[]
TAF2	[]	7	["Basal transcription factors","RNA Polymerase II Pre-transcription Events","Regulation of TP53 Activity through Phosphorylation","RNA Polymerase II Promoter Escape","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening","RNA Polymerase II Transcription Initiation","RNA Polymerase II Transcription Initiation And Promoter Clearance"]	[]
TAF4	[]	7	["Basal transcription factors","RNA Polymerase II Pre-transcription Events","Regulation of TP53 Activity through Phosphorylation","RNA Polymerase II Promoter Escape","RNA Polymerase II Transcription Pre-Initiation And Promoter Opening","RNA Polymerase II Transcription Initiation","RNA Polymerase II Transcription Initiation And Promoter Clearance"]	[]

TAF12 (TATA-box binding protein associated factor 12)

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