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Gene Gene information from NCBI Gene database.
Entrez ID 10929
Gene name Serine and arginine rich splicing factor 8
Gene symbol SRSF8
Synonyms (NCBI Gene)
DSM-1SFRS2BSRP46
Chromosome 11
Chromosome location 11q21
Summary This gene encodes a member of a family of proteins containing a ribonucleoprotein (RNP)-type RNA binding motif and a carboxyl-terminal arginine-serine-rich (RS) domain. The encoded protein functions as a pre-mRNA splicing factor. There is a pseudogene for
miRNA miRNA information provided by mirtarbase database.
540 Show/Hide all (540)
miRTarBase ID miRNA Experiments Reference
MIRT1391127 hsa-miR-1206 CLIP-seq
MIRT1391128 hsa-miR-122 CLIP-seq
MIRT1391129 hsa-miR-1228 CLIP-seq
MIRT1391130 hsa-miR-1257 CLIP-seq
MIRT1391131 hsa-miR-125a-3p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14 Show/Hide all (14)
GO ID Ontology Definition Evidence Reference
GO:0000381 Process Regulation of alternative mRNA splicing, via spliceosome IBA
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IEA
GO:0003729 Function MRNA binding IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603269 16988 ENSG00000263465
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9BRL6
Protein name Serine/arginine-rich splicing factor 8 (Pre-mRNA-splicing factor SRP46) (Splicing factor SRp46) (Splicing factor, arginine/serine-rich 2B)
Protein function Involved in pre-mRNA alternative splicing.
PDB 2DNM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 16 → 86 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Tissue specificity TISSUE SPECIFICITY: Strongly expressed in pancreas, spleen and prostate. Weakly expressed in lung, liver and thymus. {ECO:0000269|PubMed:9671500}.
Sequence
MSCGRPPPDVDGMITLKVDNLTYRTSPDSLRRVFEKYGRVGDVYIPREPHTKAPRGFAFV
RFHDRRDAQDAEAAMDGAELDGRELR
VQVARYGRRDLPRSRQGEPRGRSRGGGYGRRSRS
YGRRSRSPRRRHRSRSRGPSCSRSRSRSRYRGSRYSRSPYSRSPYSRSRYSRSPYSRSRY
RESRYGGSHYSSSGYSNSRYSRYHSSRSHSKSGSSTSSRSASTSKSSSARRSKSSSVSRS
RSRSRSSSMTRSPPRVSKRKSKSRSRSKRPPKSPEEEGQMSS
Sequence length 282
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway
Spliceosome
Herpes simplex virus 1 infection