Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	6429
Gene name	Serine and arginine rich splicing factor 4
Gene symbol	SRSF4
Synonyms (NCBI Gene)	SFRS4SRP75
Chromosome	1
Chromosome location	1p35.3
Summary	This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq, Feb 2009]

219 Show/Hide all (219)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023667	hsa-miR-1-3p	Proteomics	18668040
MIRT039215	hsa-miR-769-5p	CLASH	23622248
MIRT036942	hsa-miR-877-3p	CLASH	23622248
MIRT035954	hsa-miR-1180-3p	CLASH	23622248
MIRT035798	hsa-miR-1913	CLASH	23622248
MIRT520942	hsa-miR-3125	PAR-CLIP	20371350
MIRT520941	hsa-miR-3916	PAR-CLIP	20371350
MIRT520940	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT520939	hsa-miR-6761-5p	PAR-CLIP	20371350
MIRT520938	hsa-miR-6828-5p	PAR-CLIP	20371350
MIRT520937	hsa-miR-376a-5p	PAR-CLIP	20371350
MIRT520936	hsa-miR-302c-5p	PAR-CLIP	20371350
MIRT520935	hsa-miR-4760-5p	PAR-CLIP	20371350
MIRT520934	hsa-miR-8061	PAR-CLIP	20371350
MIRT520933	hsa-miR-520g-5p	PAR-CLIP	20371350
MIRT520944	hsa-miR-329-3p	PAR-CLIP	20371350
MIRT520943	hsa-miR-362-3p	PAR-CLIP	20371350
MIRT520942	hsa-miR-3125	PAR-CLIP	20371350
MIRT520941	hsa-miR-3916	PAR-CLIP	20371350
MIRT520940	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT520939	hsa-miR-6761-5p	PAR-CLIP	20371350
MIRT520938	hsa-miR-6828-5p	PAR-CLIP	20371350
MIRT520937	hsa-miR-376a-5p	PAR-CLIP	20371350
MIRT520936	hsa-miR-302c-5p	PAR-CLIP	20371350
MIRT520935	hsa-miR-4760-5p	PAR-CLIP	20371350
MIRT520934	hsa-miR-8061	PAR-CLIP	20371350
MIRT520933	hsa-miR-520g-5p	PAR-CLIP	20371350
MIRT520944	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT520943	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT520942	hsa-miR-3125	PAR-CLIP	23446348
MIRT520941	hsa-miR-3916	PAR-CLIP	23446348
MIRT520940	hsa-miR-6859-5p	PAR-CLIP	23446348
MIRT520939	hsa-miR-6761-5p	PAR-CLIP	23446348
MIRT520938	hsa-miR-6828-5p	PAR-CLIP	23446348
MIRT520937	hsa-miR-376a-5p	PAR-CLIP	23446348
MIRT520936	hsa-miR-302c-5p	PAR-CLIP	23446348
MIRT520935	hsa-miR-4760-5p	PAR-CLIP	23446348
MIRT520934	hsa-miR-8061	PAR-CLIP	23446348
MIRT520933	hsa-miR-520g-5p	PAR-CLIP	23446348
MIRT520942	hsa-miR-3125	PAR-CLIP	20371350
MIRT520941	hsa-miR-3916	PAR-CLIP	20371350
MIRT520940	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT520939	hsa-miR-6761-5p	PAR-CLIP	20371350
MIRT520938	hsa-miR-6828-5p	PAR-CLIP	20371350
MIRT520937	hsa-miR-376a-5p	PAR-CLIP	20371350
MIRT520936	hsa-miR-302c-5p	PAR-CLIP	20371350
MIRT520935	hsa-miR-4760-5p	PAR-CLIP	20371350
MIRT520934	hsa-miR-8061	PAR-CLIP	20371350
MIRT520933	hsa-miR-520g-5p	PAR-CLIP	20371350
MIRT520944	hsa-miR-329-3p	PAR-CLIP	20371350
MIRT520943	hsa-miR-362-3p	PAR-CLIP	20371350
MIRT520942	hsa-miR-3125	PAR-CLIP	20371350
MIRT520941	hsa-miR-3916	PAR-CLIP	20371350
MIRT520940	hsa-miR-6859-5p	PAR-CLIP	20371350
MIRT520939	hsa-miR-6761-5p	PAR-CLIP	20371350
MIRT520938	hsa-miR-6828-5p	PAR-CLIP	20371350
MIRT520937	hsa-miR-376a-5p	PAR-CLIP	20371350
MIRT520936	hsa-miR-302c-5p	PAR-CLIP	20371350
MIRT520935	hsa-miR-4760-5p	PAR-CLIP	20371350
MIRT520934	hsa-miR-8061	PAR-CLIP	20371350
MIRT520933	hsa-miR-520g-5p	PAR-CLIP	20371350
MIRT520944	hsa-miR-329-3p	PAR-CLIP	23446348
MIRT520943	hsa-miR-362-3p	PAR-CLIP	23446348
MIRT520942	hsa-miR-3125	PAR-CLIP	23446348
MIRT520941	hsa-miR-3916	PAR-CLIP	23446348
MIRT520940	hsa-miR-6859-5p	PAR-CLIP	23446348
MIRT520939	hsa-miR-6761-5p	PAR-CLIP	23446348
MIRT520938	hsa-miR-6828-5p	PAR-CLIP	23446348
MIRT520937	hsa-miR-376a-5p	PAR-CLIP	23446348
MIRT520936	hsa-miR-302c-5p	PAR-CLIP	23446348
MIRT520935	hsa-miR-4760-5p	PAR-CLIP	23446348
MIRT520934	hsa-miR-8061	PAR-CLIP	23446348
MIRT520933	hsa-miR-520g-5p	PAR-CLIP	23446348
MIRT1390769	hsa-miR-1205	CLIP-seq
MIRT1390770	hsa-miR-1238	CLIP-seq
MIRT1390771	hsa-miR-139-5p	CLIP-seq
MIRT1390772	hsa-miR-217	CLIP-seq
MIRT1390773	hsa-miR-218	CLIP-seq
MIRT1390774	hsa-miR-3115	CLIP-seq
MIRT1390775	hsa-miR-3145-5p	CLIP-seq
MIRT1390776	hsa-miR-3148	CLIP-seq
MIRT1390777	hsa-miR-3163	CLIP-seq
MIRT1390778	hsa-miR-3188	CLIP-seq
MIRT1390779	hsa-miR-337-3p	CLIP-seq
MIRT1390780	hsa-miR-338-5p	CLIP-seq
MIRT1390781	hsa-miR-34b	CLIP-seq
MIRT1390782	hsa-miR-3614-5p	CLIP-seq
MIRT1390783	hsa-miR-3665	CLIP-seq
MIRT1390784	hsa-miR-3685	CLIP-seq
MIRT1390785	hsa-miR-3688-3p	CLIP-seq
MIRT1390786	hsa-miR-384	CLIP-seq
MIRT1390787	hsa-miR-4282	CLIP-seq
MIRT1390788	hsa-miR-4418	CLIP-seq
MIRT1390789	hsa-miR-4459	CLIP-seq
MIRT1390790	hsa-miR-4476	CLIP-seq
MIRT1390791	hsa-miR-4493	CLIP-seq
MIRT1390792	hsa-miR-450b-5p	CLIP-seq
MIRT1390793	hsa-miR-4668-5p	CLIP-seq
MIRT1390794	hsa-miR-4680-5p	CLIP-seq
MIRT1390795	hsa-miR-4695-5p	CLIP-seq
MIRT1390796	hsa-miR-4696	CLIP-seq
MIRT1390797	hsa-miR-4705	CLIP-seq
MIRT1390798	hsa-miR-4755-3p	CLIP-seq
MIRT1390799	hsa-miR-483-5p	CLIP-seq
MIRT1390800	hsa-miR-508-5p	CLIP-seq
MIRT1390801	hsa-miR-509-3-5p	CLIP-seq
MIRT1390802	hsa-miR-509-5p	CLIP-seq
MIRT1390803	hsa-miR-513b	CLIP-seq
MIRT1390804	hsa-miR-548q	CLIP-seq
MIRT1390805	hsa-miR-618	CLIP-seq
MIRT1390806	hsa-miR-657	CLIP-seq
MIRT1390807	hsa-miR-665	CLIP-seq
MIRT1390808	hsa-miR-889	CLIP-seq
MIRT1390773	hsa-miR-218	CLIP-seq
MIRT1390775	hsa-miR-3145-5p	CLIP-seq
MIRT2116971	hsa-miR-329	CLIP-seq
MIRT1390781	hsa-miR-34b	CLIP-seq
MIRT1390782	hsa-miR-3614-5p	CLIP-seq
MIRT2116972	hsa-miR-4278	CLIP-seq
MIRT2116973	hsa-miR-4424	CLIP-seq
MIRT2116974	hsa-miR-4653-3p	CLIP-seq
MIRT2116975	hsa-miR-4694-3p	CLIP-seq
MIRT1390797	hsa-miR-4705	CLIP-seq
MIRT2116976	hsa-miR-4761-3p	CLIP-seq
MIRT1390800	hsa-miR-508-5p	CLIP-seq
MIRT2116977	hsa-miR-522	CLIP-seq
MIRT2116978	hsa-miR-548c-3p	CLIP-seq
MIRT2116979	hsa-miR-548u	CLIP-seq
MIRT2339383	hsa-miR-1261	CLIP-seq
MIRT1390773	hsa-miR-218	CLIP-seq
MIRT2339384	hsa-miR-3120-3p	CLIP-seq
MIRT1390778	hsa-miR-3188	CLIP-seq
MIRT2339385	hsa-miR-3201	CLIP-seq
MIRT2116971	hsa-miR-329	CLIP-seq
MIRT2339386	hsa-miR-335	CLIP-seq
MIRT1390781	hsa-miR-34b	CLIP-seq
MIRT2339387	hsa-miR-3545-3p	CLIP-seq
MIRT1390782	hsa-miR-3614-5p	CLIP-seq
MIRT2339388	hsa-miR-4265	CLIP-seq
MIRT2339389	hsa-miR-4267	CLIP-seq
MIRT2116972	hsa-miR-4278	CLIP-seq
MIRT2339390	hsa-miR-4296	CLIP-seq
MIRT2339391	hsa-miR-4318	CLIP-seq
MIRT2339392	hsa-miR-4322	CLIP-seq
MIRT2339393	hsa-miR-4417	CLIP-seq
MIRT2116973	hsa-miR-4424	CLIP-seq
MIRT2339394	hsa-miR-4519	CLIP-seq
MIRT2339395	hsa-miR-4640-5p	CLIP-seq
MIRT2116974	hsa-miR-4653-3p	CLIP-seq
MIRT1390794	hsa-miR-4680-5p	CLIP-seq
MIRT2339396	hsa-miR-4693-5p	CLIP-seq
MIRT2116975	hsa-miR-4694-3p	CLIP-seq
MIRT2339397	hsa-miR-4726-5p	CLIP-seq
MIRT2116976	hsa-miR-4761-3p	CLIP-seq
MIRT2339398	hsa-miR-4791	CLIP-seq
MIRT2116977	hsa-miR-522	CLIP-seq
MIRT2116978	hsa-miR-548c-3p	CLIP-seq
MIRT2339399	hsa-miR-548p	CLIP-seq
MIRT2116979	hsa-miR-548u	CLIP-seq
MIRT2339400	hsa-miR-563	CLIP-seq
MIRT2339401	hsa-miR-892a	CLIP-seq
MIRT1390771	hsa-miR-139-5p	CLIP-seq
MIRT1390773	hsa-miR-218	CLIP-seq
MIRT1390774	hsa-miR-3115	CLIP-seq
MIRT1390775	hsa-miR-3145-5p	CLIP-seq
MIRT1390779	hsa-miR-337-3p	CLIP-seq
MIRT1390781	hsa-miR-34b	CLIP-seq
MIRT1390782	hsa-miR-3614-5p	CLIP-seq
MIRT1390784	hsa-miR-3685	CLIP-seq
MIRT1390785	hsa-miR-3688-3p	CLIP-seq
MIRT1390786	hsa-miR-384	CLIP-seq
MIRT2339388	hsa-miR-4265	CLIP-seq
MIRT2339390	hsa-miR-4296	CLIP-seq
MIRT2339391	hsa-miR-4318	CLIP-seq
MIRT2339392	hsa-miR-4322	CLIP-seq
MIRT2339393	hsa-miR-4417	CLIP-seq
MIRT2339395	hsa-miR-4640-5p	CLIP-seq
MIRT1390794	hsa-miR-4680-5p	CLIP-seq
MIRT2339396	hsa-miR-4693-5p	CLIP-seq
MIRT1390797	hsa-miR-4705	CLIP-seq
MIRT2339397	hsa-miR-4726-5p	CLIP-seq
MIRT1390800	hsa-miR-508-5p	CLIP-seq
MIRT2395207	hsa-miR-582-5p	CLIP-seq
MIRT1390805	hsa-miR-618	CLIP-seq
MIRT2339401	hsa-miR-892a	CLIP-seq
MIRT2633162	hsa-miR-299-3p	CLIP-seq
MIRT2339386	hsa-miR-335	CLIP-seq
MIRT2633163	hsa-miR-339-5p	CLIP-seq
MIRT2339387	hsa-miR-3545-3p	CLIP-seq
MIRT2633164	hsa-miR-3670	CLIP-seq
MIRT2633165	hsa-miR-4491	CLIP-seq
MIRT2633166	hsa-miR-4496	CLIP-seq
MIRT2633167	hsa-miR-4650-5p	CLIP-seq
MIRT2633168	hsa-miR-4657	CLIP-seq
MIRT1390794	hsa-miR-4680-5p	CLIP-seq
MIRT2116975	hsa-miR-4694-3p	CLIP-seq
MIRT2633169	hsa-miR-4753-5p	CLIP-seq
MIRT1390798	hsa-miR-4755-3p	CLIP-seq
MIRT2116976	hsa-miR-4761-3p	CLIP-seq
MIRT2633170	hsa-miR-4766-5p	CLIP-seq
MIRT2116977	hsa-miR-522	CLIP-seq
MIRT2339399	hsa-miR-548p	CLIP-seq
MIRT2339400	hsa-miR-563	CLIP-seq
MIRT2633162	hsa-miR-299-3p	CLIP-seq
MIRT2339386	hsa-miR-335	CLIP-seq
MIRT2339387	hsa-miR-3545-3p	CLIP-seq
MIRT2633165	hsa-miR-4491	CLIP-seq
MIRT2633166	hsa-miR-4496	CLIP-seq
MIRT2633167	hsa-miR-4650-5p	CLIP-seq
MIRT2633168	hsa-miR-4657	CLIP-seq
MIRT1390794	hsa-miR-4680-5p	CLIP-seq
MIRT2116975	hsa-miR-4694-3p	CLIP-seq
MIRT2633169	hsa-miR-4753-5p	CLIP-seq
MIRT1390798	hsa-miR-4755-3p	CLIP-seq
MIRT2116976	hsa-miR-4761-3p	CLIP-seq
MIRT2633170	hsa-miR-4766-5p	CLIP-seq
MIRT2116977	hsa-miR-522	CLIP-seq
MIRT2339399	hsa-miR-548p	CLIP-seq
MIRT2339400	hsa-miR-563	CLIP-seq

22 Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000375	Process	RNA splicing, via transesterification reactions	IEA
GO:0000375	Process	RNA splicing, via transesterification reactions	TAS	8321209
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IBA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	16189514, 22365833, 31515488, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8321209
GO:0005654	Component	Nucleoplasm	TAS
GO:0006397	Process	MRNA processing	IEA
GO:0006397	Process	MRNA processing	TAS	8321209
GO:0008380	Process	RNA splicing	IEA
GO:0008380	Process	RNA splicing	TAS	8321209
GO:0016607	Component	Nuclear speck	IBA
GO:0016607	Component	Nuclear speck	IDA
GO:0016607	Component	Nuclear speck	IEA
GO:0032868	Process	Response to insulin	IEA
GO:0048025	Process	Negative regulation of mRNA splicing, via spliceosome	IDA	15009664
GO:0048025	Process	Negative regulation of mRNA splicing, via spliceosome	IEA
GO:1990825	Function	Sequence-specific mRNA binding	IEA

MIM	HGNC	e!Ensembl
601940	10786	ENSG00000116350

Q08170

Protein name

Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)

Protein function

Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	4 → 66	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	106 → 171	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Sequence

MPRVYIGRLSYQARERDVERFFKGYGKILEVDLKNGYGFVEFDDLRDADDAVYELNGKDL
CGERVIVEHARGPRRDGSYGSGRSGYGYRRSGRDKYGPPTRTEYRLIVENLSSRCSWQDL
KDYMRQAGEVTYADAHKGRKNEGVIEFVSYSDMKRALEKLDGTEVNGRKIRLVEDKPGSR
RRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRS
RSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKS
RSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRS
REESRSRSRSRSKSERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKS
ESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSAS
RSPSRSRSRSHSRS

Sequence length

494

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Spliceosome	Transport of Mature mRNA derived from an Intron-Containing Transcript
Herpes simplex virus 1 infection	mRNA Splicing - Major Pathway
	mRNA 3'-end processing
	RNA Polymerase II Transcription Termination

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
SRSF3	[]	6	["Spliceosome","Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	[]
SRSF5	[]	6	["Spliceosome","Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	[]
SRSF9	[]	6	["Spliceosome","Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	[]
SRSF2	[]	6	["Spliceosome","Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	[]
SRSF6	[]	6	["Spliceosome","Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	[]

SRSF4 (serine and arginine rich splicing factor 4)

Bookmark This Gene