Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	8683
Gene name	Serine and arginine rich splicing factor 9
Gene symbol	SRSF9
Synonyms (NCBI Gene)	SFRS9SRp30c
Chromosome	12
Chromosome location	12q24.31
Summary	The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for

210 Show/Hide all (210)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005072	hsa-miR-1-3p	pSILAC	18668040
MIRT005072	hsa-miR-1-3p	Microarray	15685193
MIRT005072	hsa-miR-1-3p	qRT-PCR	21169019
MIRT005072	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT005072	hsa-miR-1-3p	Microarray	15685193
MIRT005072	hsa-miR-1-3p	Proteomics	18668040
MIRT047805	hsa-miR-30d-5p	CLASH	23622248
MIRT041664	hsa-miR-484	CLASH	23622248
MIRT036696	hsa-miR-935	CLASH	23622248
MIRT540902	hsa-miR-4418	PAR-CLIP	21572407
MIRT540901	hsa-miR-509-3-5p	PAR-CLIP	21572407
MIRT540900	hsa-miR-509-5p	PAR-CLIP	21572407
MIRT540899	hsa-miR-6513-3p	PAR-CLIP	21572407
MIRT540898	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT540897	hsa-miR-1288-5p	PAR-CLIP	21572407
MIRT540896	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540894	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT540895	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT540893	hsa-miR-1184	PAR-CLIP	21572407
MIRT540892	hsa-miR-378g	PAR-CLIP	21572407
MIRT540891	hsa-miR-4437	PAR-CLIP	21572407
MIRT540890	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT540889	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT540888	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT540887	hsa-miR-4674	PAR-CLIP	21572407
MIRT540902	hsa-miR-4418	PAR-CLIP	21572407
MIRT540901	hsa-miR-509-3-5p	PAR-CLIP	21572407
MIRT540900	hsa-miR-509-5p	PAR-CLIP	21572407
MIRT540899	hsa-miR-6513-3p	PAR-CLIP	21572407
MIRT540898	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT540897	hsa-miR-1288-5p	PAR-CLIP	21572407
MIRT540896	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540894	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT540895	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT540893	hsa-miR-1184	PAR-CLIP	21572407
MIRT540892	hsa-miR-378g	PAR-CLIP	21572407
MIRT540891	hsa-miR-4437	PAR-CLIP	21572407
MIRT540890	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT540889	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT540888	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT540887	hsa-miR-4674	PAR-CLIP	21572407
MIRT439542	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439542	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT540902	hsa-miR-4418	PAR-CLIP	21572407
MIRT540901	hsa-miR-509-3-5p	PAR-CLIP	21572407
MIRT540900	hsa-miR-509-5p	PAR-CLIP	21572407
MIRT540899	hsa-miR-6513-3p	PAR-CLIP	21572407
MIRT540898	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT540897	hsa-miR-1288-5p	PAR-CLIP	21572407
MIRT540896	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540894	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT540895	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT540893	hsa-miR-1184	PAR-CLIP	21572407
MIRT540892	hsa-miR-378g	PAR-CLIP	21572407
MIRT540891	hsa-miR-4437	PAR-CLIP	21572407
MIRT540890	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT540889	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT540888	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT540887	hsa-miR-4674	PAR-CLIP	21572407
MIRT540902	hsa-miR-4418	PAR-CLIP	21572407
MIRT540901	hsa-miR-509-3-5p	PAR-CLIP	21572407
MIRT540900	hsa-miR-509-5p	PAR-CLIP	21572407
MIRT540899	hsa-miR-6513-3p	PAR-CLIP	21572407
MIRT540898	hsa-miR-6890-3p	PAR-CLIP	21572407
MIRT540897	hsa-miR-1288-5p	PAR-CLIP	21572407
MIRT540896	hsa-miR-939-3p	PAR-CLIP	21572407
MIRT540894	hsa-miR-6852-5p	PAR-CLIP	21572407
MIRT540895	hsa-miR-6742-3p	PAR-CLIP	21572407
MIRT540893	hsa-miR-1184	PAR-CLIP	21572407
MIRT540892	hsa-miR-378g	PAR-CLIP	21572407
MIRT540891	hsa-miR-4437	PAR-CLIP	21572407
MIRT540890	hsa-miR-1343-3p	PAR-CLIP	21572407
MIRT540889	hsa-miR-6783-3p	PAR-CLIP	21572407
MIRT540888	hsa-miR-7156-3p	PAR-CLIP	21572407
MIRT540887	hsa-miR-4674	PAR-CLIP	21572407
MIRT1391253	hsa-miR-1	CLIP-seq
MIRT1391254	hsa-miR-1205	CLIP-seq
MIRT1391255	hsa-miR-1267	CLIP-seq
MIRT1391256	hsa-miR-128	CLIP-seq
MIRT1391257	hsa-miR-1299	CLIP-seq
MIRT1391258	hsa-miR-136	CLIP-seq
MIRT736877	hsa-miR-206	CLIP-seq
MIRT1391259	hsa-miR-2278	CLIP-seq
MIRT1391260	hsa-miR-27a	CLIP-seq
MIRT1391261	hsa-miR-27b	CLIP-seq
MIRT1391262	hsa-miR-300	CLIP-seq
MIRT1391263	hsa-miR-3117-5p	CLIP-seq
MIRT1391264	hsa-miR-3158-5p	CLIP-seq
MIRT1391265	hsa-miR-330-3p	CLIP-seq
MIRT1391266	hsa-miR-3617	CLIP-seq
MIRT1391267	hsa-miR-3662	CLIP-seq
MIRT1391268	hsa-miR-3663-3p	CLIP-seq
MIRT1391269	hsa-miR-3668	CLIP-seq
MIRT1391270	hsa-miR-3673	CLIP-seq
MIRT1391271	hsa-miR-381	CLIP-seq
MIRT1391272	hsa-miR-3935	CLIP-seq
MIRT1391273	hsa-miR-411	CLIP-seq
MIRT1391274	hsa-miR-4263	CLIP-seq
MIRT1391275	hsa-miR-4264	CLIP-seq
MIRT1391276	hsa-miR-4303	CLIP-seq
MIRT1391277	hsa-miR-4420	CLIP-seq
MIRT1391278	hsa-miR-4446-5p	CLIP-seq
MIRT1391279	hsa-miR-4517	CLIP-seq
MIRT1391280	hsa-miR-4539	CLIP-seq
MIRT1391281	hsa-miR-4660	CLIP-seq
MIRT1391282	hsa-miR-4666-3p	CLIP-seq
MIRT1391283	hsa-miR-4695-3p	CLIP-seq
MIRT1391284	hsa-miR-4704-3p	CLIP-seq
MIRT1391285	hsa-miR-4732-5p	CLIP-seq
MIRT1391286	hsa-miR-4762-3p	CLIP-seq
MIRT1391287	hsa-miR-4799-5p	CLIP-seq
MIRT1391288	hsa-miR-544	CLIP-seq
MIRT1391289	hsa-miR-548aa	CLIP-seq
MIRT1391290	hsa-miR-576-5p	CLIP-seq
MIRT1391291	hsa-miR-605	CLIP-seq
MIRT1391292	hsa-miR-613	CLIP-seq
MIRT1391293	hsa-miR-641	CLIP-seq
MIRT1391294	hsa-miR-646	CLIP-seq
MIRT1391295	hsa-miR-875-3p	CLIP-seq
MIRT1391253	hsa-miR-1	CLIP-seq
MIRT1391255	hsa-miR-1267	CLIP-seq
MIRT1391256	hsa-miR-128	CLIP-seq
MIRT2117108	hsa-miR-1291	CLIP-seq
MIRT1391257	hsa-miR-1299	CLIP-seq
MIRT1391258	hsa-miR-136	CLIP-seq
MIRT736877	hsa-miR-206	CLIP-seq
MIRT1391259	hsa-miR-2278	CLIP-seq
MIRT1391260	hsa-miR-27a	CLIP-seq
MIRT1391261	hsa-miR-27b	CLIP-seq
MIRT1391263	hsa-miR-3117-5p	CLIP-seq
MIRT2117109	hsa-miR-328	CLIP-seq
MIRT1391265	hsa-miR-330-3p	CLIP-seq
MIRT2117110	hsa-miR-3529	CLIP-seq
MIRT1391267	hsa-miR-3662	CLIP-seq
MIRT1391268	hsa-miR-3663-3p	CLIP-seq
MIRT1391269	hsa-miR-3668	CLIP-seq
MIRT1391270	hsa-miR-3673	CLIP-seq
MIRT2117111	hsa-miR-379	CLIP-seq
MIRT1391272	hsa-miR-3935	CLIP-seq
MIRT1391273	hsa-miR-411	CLIP-seq
MIRT1391275	hsa-miR-4264	CLIP-seq
MIRT1391276	hsa-miR-4303	CLIP-seq
MIRT1391277	hsa-miR-4420	CLIP-seq
MIRT2117112	hsa-miR-4451	CLIP-seq
MIRT1391279	hsa-miR-4517	CLIP-seq
MIRT2117113	hsa-miR-4650-3p	CLIP-seq
MIRT1391283	hsa-miR-4695-3p	CLIP-seq
MIRT1391284	hsa-miR-4704-3p	CLIP-seq
MIRT1391285	hsa-miR-4732-5p	CLIP-seq
MIRT1391291	hsa-miR-605	CLIP-seq
MIRT1391292	hsa-miR-613	CLIP-seq
MIRT1391294	hsa-miR-646	CLIP-seq
MIRT1391295	hsa-miR-875-3p	CLIP-seq
MIRT1391253	hsa-miR-1	CLIP-seq
MIRT1391254	hsa-miR-1205	CLIP-seq
MIRT1391255	hsa-miR-1267	CLIP-seq
MIRT1391256	hsa-miR-128	CLIP-seq
MIRT2117108	hsa-miR-1291	CLIP-seq
MIRT1391257	hsa-miR-1299	CLIP-seq
MIRT1391258	hsa-miR-136	CLIP-seq
MIRT736877	hsa-miR-206	CLIP-seq
MIRT1391259	hsa-miR-2278	CLIP-seq
MIRT1391260	hsa-miR-27a	CLIP-seq
MIRT1391261	hsa-miR-27b	CLIP-seq
MIRT1391262	hsa-miR-300	CLIP-seq
MIRT1391263	hsa-miR-3117-5p	CLIP-seq
MIRT1391264	hsa-miR-3158-5p	CLIP-seq
MIRT2117109	hsa-miR-328	CLIP-seq
MIRT1391265	hsa-miR-330-3p	CLIP-seq
MIRT2117110	hsa-miR-3529	CLIP-seq
MIRT1391267	hsa-miR-3662	CLIP-seq
MIRT1391268	hsa-miR-3663-3p	CLIP-seq
MIRT1391269	hsa-miR-3668	CLIP-seq
MIRT1391270	hsa-miR-3673	CLIP-seq
MIRT2117111	hsa-miR-379	CLIP-seq
MIRT1391271	hsa-miR-381	CLIP-seq
MIRT2339470	hsa-miR-3924	CLIP-seq
MIRT1391272	hsa-miR-3935	CLIP-seq
MIRT1391273	hsa-miR-411	CLIP-seq
MIRT1391274	hsa-miR-4263	CLIP-seq
MIRT1391275	hsa-miR-4264	CLIP-seq
MIRT1391276	hsa-miR-4303	CLIP-seq
MIRT1391277	hsa-miR-4420	CLIP-seq
MIRT2117112	hsa-miR-4451	CLIP-seq
MIRT1391279	hsa-miR-4517	CLIP-seq
MIRT1391280	hsa-miR-4539	CLIP-seq
MIRT2117113	hsa-miR-4650-3p	CLIP-seq
MIRT1391282	hsa-miR-4666-3p	CLIP-seq
MIRT1391283	hsa-miR-4695-3p	CLIP-seq
MIRT1391284	hsa-miR-4704-3p	CLIP-seq
MIRT1391285	hsa-miR-4732-5p	CLIP-seq
MIRT1391286	hsa-miR-4762-3p	CLIP-seq
MIRT1391287	hsa-miR-4799-5p	CLIP-seq
MIRT1391288	hsa-miR-544	CLIP-seq
MIRT1391289	hsa-miR-548aa	CLIP-seq
MIRT1391290	hsa-miR-576-5p	CLIP-seq
MIRT1391291	hsa-miR-605	CLIP-seq
MIRT1391292	hsa-miR-613	CLIP-seq
MIRT1391295	hsa-miR-875-3p	CLIP-seq
MIRT1391255	hsa-miR-1267	CLIP-seq
MIRT1391256	hsa-miR-128	CLIP-seq
MIRT1391258	hsa-miR-136	CLIP-seq
MIRT1391260	hsa-miR-27a	CLIP-seq
MIRT1391261	hsa-miR-27b	CLIP-seq
MIRT1391274	hsa-miR-4263	CLIP-seq
MIRT1391275	hsa-miR-4264	CLIP-seq
MIRT1391283	hsa-miR-4695-3p	CLIP-seq
MIRT1391284	hsa-miR-4704-3p	CLIP-seq
MIRT1391287	hsa-miR-4799-5p	CLIP-seq
MIRT1391290	hsa-miR-576-5p	CLIP-seq

18 Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000381	Process	Regulation of alternative mRNA splicing, via spliceosome	IBA
GO:0003676	Function	Nucleic acid binding	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IEA
GO:0003729	Function	MRNA binding	IBA
GO:0005515	Function	Protein binding	IPI	10196175, 10749975, 19523114, 32296183, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005730	Component	Nucleolus	IDA
GO:0006376	Process	MRNA splice site recognition	IEA
GO:0006376	Process	MRNA splice site recognition	TAS	7556075
GO:0006397	Process	MRNA processing	IEA
GO:0006397	Process	MRNA processing	TAS	7556075
GO:0008380	Process	RNA splicing	IEA
GO:0016607	Component	Nuclear speck	IBA
GO:0019904	Function	Protein domain specific binding	IPI	10749975
GO:0048025	Process	Negative regulation of mRNA splicing, via spliceosome	IDA	15009664

MIM	HGNC	e!Ensembl
601943	10791	ENSG00000111786

Q13242

Protein name

Serine/arginine-rich splicing factor 9 (Pre-mRNA-splicing factor SRp30C) (Splicing factor, arginine/serine-rich 9)

Protein function

Plays a role in constitutive splicing and can modulate the selection of alternative splice sites. Represses the splicing of MAPT/Tau exon 10. {ECO:0000269|PubMed:10196175, ECO:0000269|PubMed:11875052, ECO:0000269|PubMed:12024014, ECO:0000269|Pub

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00076	RRM_1	16 → 83	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain
PF00076	RRM_1	113 → 176	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed at high levels in the heart, kidney, pancreas and placenta, and at lower levels in the brain, liver, lung and skeletal muscle. {ECO:0000269|PubMed:10196175}.

Sequence

MSGWADERGGEGDGRIYVGNLPTDVREKDLEDLFYKYGRIREIELKNRHGLVPFAFVRFE
DPRDAEDAIYGRNGYDYGQCRLRVEFPRTYGGRGGWPRGGRNGPPTRRSDFRVLVSGLPP
SGSWQDLKDHMREAGDVCYADVQKDGVGMVEYLRKEDMEYALRKLDDTKFRSHEGETSYI
RVYPERSTSYGYSRSRSGSRGRDSPYQSRGSPHYFSPFRPY

Sequence length

221

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Spliceosome	Transport of Mature mRNA derived from an Intron-Containing Transcript
Herpes simplex virus 1 infection	mRNA Splicing - Major Pathway
	mRNA 3'-end processing
	RNA Polymerase II Transcription Termination

Related Gene	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Names
SRSF3	[]	6	["Spliceosome","Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	[]
SRSF4	[]	6	["Spliceosome","Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	[]
SRSF5	[]	6	["Spliceosome","Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	[]
SRSF2	[]	6	["Spliceosome","Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	[]
SRSF6	[]	6	["Spliceosome","Herpes simplex virus 1 infection","mRNA Splicing - Major Pathway","Transport of Mature mRNA derived from an Intron-Containing Transcript","mRNA 3'-end processing","RNA Polymerase II Transcription Termination"]	[]

SRSF9 (serine and arginine rich splicing factor 9)

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