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Gene Gene information from NCBI Gene database.
Entrez ID 9295
Gene name Serine and arginine rich splicing factor 11
Gene symbol SRSF11
Synonyms (NCBI Gene)
NET2SFRS11dJ677H15.2p54
Chromosome 1
Chromosome location 1p31.1
Summary This gene encodes 54-kD nuclear protein that contains an arginine/serine-rich region similar to segments found in pre-mRNA splicing factors. Although the function of this protein is not yet known, structure and immunolocalization data suggest that it may
miRNA miRNA information provided by mirtarbase database.
538 Show/Hide all (538)
miRTarBase ID miRNA Experiments Reference
MIRT004025 hsa-miR-376a-5p Luciferase reporter assay 17322061
MIRT004025 hsa-miR-376a-5p Luciferase reporter assay 17322061
MIRT019666 hsa-miR-376a-3p Reporter assay 17322061
MIRT030735 hsa-miR-21-5p Microarray 18591254
MIRT045297 hsa-miR-186-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
15 Show/Hide all (15)
GO ID Ontology Definition Evidence Reference
GO:0003676 Function Nucleic acid binding IEA
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003723 Function RNA binding IBA
GO:0003723 Function RNA binding IEA
GO:0005515 Function Protein binding IPI 20195357, 21988832, 25416956, 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602010 10782 ENSG00000116754
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q05519
Protein name Serine/arginine-rich splicing factor 11 (Arginine-rich 54 kDa nuclear protein) (p54) (Splicing factor, arginine/serine-rich 11)
Protein function May function in pre-mRNA splicing.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00076 RRM_1 35 → 106 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Domain
Sequence
MSNTTVVPSTAGPGPSGGPGGGGGGGGGGGGTEVIQVTNVSPSASSEQMRTLFGFLGKID
ELRLFPPDDSPLPVSSRVCFVKFHDPDSAVVAQHLTNTVFVDRALI
VVPYAEGVIPDEAK
ALSLLAPANAVAGLLPGGGLLPTPNPLTQIGAVPLAALGAPTLDPALAALGLPGANLNSQ
SLAADQLLKLMSTVDPKLNHVAAGLVSPSLKSDTSSKEIEEAMKRVREAQSLISAAIEPD
KKEEKRRHSRSRSRSRRRRTPSSSRHRRSRSRSRRRSHSKSRSRRRSKSPRRRRSHSRER
GRRSRSTSKTRDKKKEDKEKKRSKTPPKSYSTARRSRSASRERRRRRSRSGTRSPKKPRS
PKRKLSRSPSPRRHKKEKKKDKDKERSRDERERSTSKKKKSKDKEKDRERKSESDKDVKQ
VTRDYDEEEQGYDSEKEKKEEKKPIETGSPKTKECSVEKGTGDSLRESKVNGDDHHEEDM
DMSD
Sequence length 484
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA 3'-end processing
RNA Polymerase II Transcription Termination
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Autism spectrum disorder Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SRSF11-related disorder Uncertain significance; Likely benign ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Show/Hide Text Mining Associations (17)
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Carcinogenesis Carcinogenesis Pubtator 37013774 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Carcinoma Ductal Breast Ductal carcinoma of breast Pubtator 37013774 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Cognition Disorders Cognitive disorder BEFREE 31269452
★★★★★
★☆☆☆☆
Found in Text Mining only
Colonic Neoplasms Colonic neoplasm Pubtator 37013774 Inhibit
★★★★★
★☆☆☆☆
Found in Text Mining only
Colorectal Neoplasms Colorectal neoplasm Pubtator 36394206 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Impaired cognition Impaired Cognition BEFREE 31269452
★★★★★
★☆☆☆☆
Found in Text Mining only
Insomnia Fatal Familial Insomnia Pubtator 37626863 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant tumor of colon Colonic Neoplasms BEFREE 29176719
★★★★★
★☆☆☆☆
Found in Text Mining only
Meningioma Meningioma BEFREE 31172282
★★★★★
★☆☆☆☆
Found in Text Mining only
Mouth Neoplasms Mouth neoplasm Pubtator 39227899 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only