Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	117157
Gene name	SH2 domain containing 1B
Gene symbol	SH2D1B
Synonyms (NCBI Gene)	EAT2
Chromosome	1
Chromosome location	1q23.3
Summary	By binding phosphotyrosines through its free SRC (MIM 190090) homology-2 (SH2) domain, EAT2 regulates signal transduction through receptors expressed on the surface of antigen-presenting cells (Morra et al., 2001 [PubMed 11689425]).[supplied by OMIM, Mar

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miRTarBase ID	miRNA	Experiments	Reference
MIRT022866	hsa-miR-124-3p	Microarray	18668037
MIRT1344215	hsa-miR-1208	CLIP-seq
MIRT1344216	hsa-miR-197	CLIP-seq
MIRT1344217	hsa-miR-3143	CLIP-seq
MIRT1344218	hsa-miR-3613-3p	CLIP-seq
MIRT1344219	hsa-miR-376c	CLIP-seq
MIRT1344220	hsa-miR-377	CLIP-seq
MIRT1344221	hsa-miR-3941	CLIP-seq
MIRT1344222	hsa-miR-466	CLIP-seq
MIRT1344223	hsa-miR-4672	CLIP-seq
MIRT1344224	hsa-miR-4712-3p	CLIP-seq
MIRT1344225	hsa-miR-4731-3p	CLIP-seq
MIRT1344226	hsa-miR-4768-3p	CLIP-seq
MIRT1344227	hsa-miR-4789-3p	CLIP-seq
MIRT1344228	hsa-miR-4801	CLIP-seq
MIRT1344229	hsa-miR-499-3p	CLIP-seq
MIRT1344230	hsa-miR-499a-3p	CLIP-seq
MIRT1344231	hsa-miR-5096	CLIP-seq
MIRT1344232	hsa-miR-543	CLIP-seq
MIRT1344233	hsa-miR-665	CLIP-seq
MIRT1344234	hsa-miR-935	CLIP-seq
MIRT2326152	hsa-miR-1292	CLIP-seq
MIRT1344219	hsa-miR-376c	CLIP-seq
MIRT1344220	hsa-miR-377	CLIP-seq
MIRT2326153	hsa-miR-4471	CLIP-seq
MIRT1344227	hsa-miR-4789-3p	CLIP-seq
MIRT2459273	hsa-miR-2355-3p	CLIP-seq
MIRT2459274	hsa-miR-4646-3p	CLIP-seq
MIRT2459275	hsa-miR-676	CLIP-seq
MIRT2459273	hsa-miR-2355-3p	CLIP-seq
MIRT2459274	hsa-miR-4646-3p	CLIP-seq
MIRT2459275	hsa-miR-676	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0002250	Process	Adaptive immune response	IEA
GO:0002366	Process	Leukocyte activation involved in immune response	ISS
GO:0002376	Process	Immune system process	IEA
GO:0002717	Process	Positive regulation of natural killer cell mediated immunity	ISS
GO:0005515	Function	Protein binding	IPI	12928397, 16920955, 23322602, 23346089, 24642916, 24728074, 25416956, 25814554, 32296183, 32814053
GO:0005829	Component	Cytosol	TAS
GO:0030674	Function	Protein-macromolecule adaptor activity	TAS	16425036
GO:0045087	Process	Innate immune response	IEA
GO:0045089	Process	Positive regulation of innate immune response	ISS

MIM	HGNC	e!Ensembl
608510	30416	ENSG00000198574

O14796

Protein name

SH2 domain-containing protein 1B (EWS/FLI1-activated transcript 2) (EAT-2)

Protein function

Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as CD84, SLAMF1, LY9 and CD244 (PubMed:11689425). In SLAM signaling seems to cooperate with SH2D1A/SAP. Plays a role in regulation of ef

PDB

5KAZ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00017	SH2	5 → 86	SH2 domain	Domain

Sequence

MDLPYYHGRLTKQDCETLLLKEGVDGNFLLRDSESIPGVLCLCVSFKNIVYTYRIFREKH
GYYRIQTAEGSPKQVFPSLKELISKFEKPNQGMVVHLLKPIKRTSPSLRWRGLKLELETF
VNSNSDYVDVLP

Sequence length

132

Interactions

View interactions

KEGG Pathway	Reactome Pathway
Natural killer cell mediated cytotoxicity	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell

SH2D1B (SH2 domain containing 1B)

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